Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion
Authors
Keywords
-
Journal
Scientific Reports
Volume 7, Issue 1, Pages -
Publisher
Springer Nature
Online
2017-06-29
DOI
10.1038/s41598-017-04730-5
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Coordinated activation of mitochondrial respiration and exocytosis mediated by PKC signaling in pancreatic β cells
- (2017) Jaime Santo-Domingo et al. FASEB JOURNAL
- Altered Plasma Levels of Glucagon, GLP-1 and Glicentin During OGTT in Adolescents With Obesity and Type 2 Diabetes
- (2016) Hannes Manell et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Initial hyperinsulinemia and subsequent β-cell dysfunction is associated with elevated palmitate levels
- (2016) Johan Staaf et al. PEDIATRIC RESEARCH
- Free fatty acid receptor 1 (FFAR1/GPR40) signaling affects insulin secretion by enhancing mitochondrial respiration during palmitate exposure
- (2015) Hjalti Kristinsson et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Influence of endogenous NEFA on beta cell function in humans
- (2015) Eleni Rebelos et al. DIABETOLOGIA
- β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1
- (2015) Arturo D. Mancini et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of a series of 2-(pyridinyl)pyrimidines as potent antagonists of GPR40
- (2015) Michael J. Waring et al. MedChemComm
- Calcium Co-regulates Oxidative Metabolism and ATP Synthase-dependent Respiration in Pancreatic Beta Cells
- (2014) Umberto De Marchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Early postprandial glucagon surge affects postprandial glucose levels in obese and non-obese patients with type 2 diabetes
- (2013) Junji Kozawa et al. ENDOCRINE JOURNAL
- FFAR1 Is Involved in Both the Acute and Chronic Effects of Palmitate on Insulin Secretion
- (2013) Hjalti Kristinsson et al. ENDOCRINOLOGY
- GPR40 protein levels are crucial to the regulation of stimulated hormone secretion in pancreatic islets. Lessons from spontaneous obesity-prone and non-obese type 2 diabetes in rats
- (2013) Sandra Meidute Abaraviciene et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Regulation of Insulin Secretion in Human Pancreatic Islets
- (2012) Patrik Rorsman et al. Annual Review of Physiology
- Long-term in vitro treatment of INS-1 rat pancreatic β-cells by unsaturated free fatty acids protects cells against gluco- and lipotoxicities via activation of GPR40 receptors
- (2012) Ya Tuo et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1
- (2012) M. Ferdaoussi et al. DIABETOLOGIA
- The role of dysregulated glucagon secretion in type 2 diabetes
- (2011) D. D'Alessio DIABETES OBESITY & METABOLISM
- Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?
- (2011) J. N. Walker et al. DIABETES OBESITY & METABOLISM
- Disturbances of Basal and Postprandial Insulin Secretion and Clearance in Obese Patients with Type 2 Diabetes Mellitus
- (2011) J. Erdmann et al. HORMONE AND METABOLIC RESEARCH
- A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion
- (2011) Philippe Ravassard et al. JOURNAL OF CLINICAL INVESTIGATION
- Acute stimulation of glucagon secretion by linoleic acid results from GPR40 activation and [Ca2+]i increase in pancreatic islet α-cells
- (2011) Li Wang et al. JOURNAL OF ENDOCRINOLOGY
- Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells
- (2011) Ernest Sargsyan et al. Lipids in Health and Disease
- GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis
- (2010) Yang Z. De Marinis et al. Cell Metabolism
- Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets
- (2009) T. Alquier et al. DIABETES
- G-protein-coupled receptor 40 (GPR40) expression and its regulation in human pancreatic islets: The role of type 2 diabetes and fatty acids
- (2009) S. Del Guerra et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Selective Small-Molecule Agonists of G Protein-Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice
- (2008) C. P. Tan et al. DIABETES
- Islet Oxygen Consumption and Insulin Secretion Tightly Coupled to Calcium Derived from L-type Calcium Channels but Not from the Endoplasmic Reticulum
- (2008) Merle Gilbert et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of ATP-sensitive potassium channels in rat pancreatic β-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway
- (2008) Yu-Feng Zhao et al. JOURNAL OF ENDOCRINOLOGY
- Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes
- (2008) Ivan Quesada et al. JOURNAL OF ENDOCRINOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation