Glucose-induced insulin secretion in isolated human islets: Does it truly reflect β-cell function in vivo?

Mechanisms controlling pancreatic islet cell function in insulin secretion

(2021) Jonathan E. Campbell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Time Course of Normalization of Functional β-Cell Capacity in the Diabetes Remission Clinical Trial After Weight Loss in Type 2 Diabetes

(2020) Sviatlana V. Zhyzhneuskaya et al.   DIABETES CARE

From Genetic Association to Molecular Mechanisms for Islet-cell Dysfunction in Type 2 Diabetes

(2020) Katia K. Mattis et al.   JOURNAL OF MOLECULAR BIOLOGY

Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells

(2020) Mototsugu Nagao et al.   DIABETES

High residual C-peptide likely contributes to glycemic control in type 1 diabetes

(2020) Michael R. Rickels et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

(2020) Décio L. Eizirik et al.   Nature Reviews Endocrinology

A direct look at the dysfunction and pathology of the β cells in human type 2 diabetes

(2020) Piero Marchetti et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

(2020) Christian M. Cohrs et al.   Cell Reports

Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis

(2020) Julia K. Panzer et al.   JCI Insight

Functional loss of pancreatic islets in type 2 diabetes: How can we halt it?

(2020) Nicola Marrano et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes

(2020) Scott A. Campbell et al.   Molecular Metabolism

Calcium signaling and secretory granule pool dynamics underlie biphasic insulin secretion and its amplification: experiments and modeling

(2019) Morten Gram Pedersen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Heterogeneity of the Human Pancreatic Islet

(2019) Michael P. Dybala et al.   DIABETES

Metabolomics Analysis of Nutrient Metabolism in β-Cells

(2019) Peter Spégel et al.   JOURNAL OF MOLECULAR BIOLOGY

Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes

(2019) Richard N. Bergman et al.   DIABETES

Lipid-associated metabolic signalling networks in pancreatic beta cell function

(2019) Marc Prentki et al.   DIABETOLOGIA

Ion Channels of the Islets in Type 2 Diabetes

(2019) David Jacobson et al.   JOURNAL OF MOLECULAR BIOLOGY

Glucagon-like peptide 1 (GLP-1)

(2019) T.D. Müller et al.   Molecular Metabolism

Cause or effect? A review of clinical data demonstrating beta cell dysfunction prior to the clinical onset of type 1 diabetes

(2019) Emily K. Sims et al.   Molecular Metabolism

Heterogeneity of human pancreatic β-cells

(2019) Giselle Dominguez-Gutierrez et al.   Molecular Metabolism

Sex differences in metabolic regulation and diabetes susceptibility

(2019) Blandine Tramunt et al.   DIABETOLOGIA

GNAS gene is an important regulator of insulin secretory capacity in pancreatic β-cells

(2019) Jalal Taneera et al.   GENE

Concentration-Dependency and Time Profile of Insulin Secretion: Dynamic Perifusion Studies With Human and Murine Islets

(2019) Oscar Alcazar et al.   Frontiers in Endocrinology

Enhanced expression of β cell CaV3.1 channels impairs insulin release and glucose homeostasis

(2019) Jia Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The challenge of correctly reporting hormones content and secretion in isolated human islets

(2019) Jean-Claude Henquin   Molecular Metabolism

Elevated Medium-Chain Acylcarnitines Are Associated With Gestational Diabetes Mellitus and Early Progression to Type 2 Diabetes and Induce Pancreatic β-Cell Dysfunction

(2018) Battsetseg Batchuluun et al.   DIABETES

CDKN2A/BT2D Genome-Wide Association Study Risk SNPs Impact Locus Gene Expression and Proliferation in Human Islets

(2018) Yahui Kong et al.   DIABETES

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men

(2018) Patrik Rorsman et al.   PHYSIOLOGICAL REVIEWS

Expression profiles of stress-related genes in islets from donors with progressively impaired glucose metabolism

(2018) Marcus Lundberg et al.   Islets

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

(2018) Marcela Brissova et al.   Cell Reports

Sex differences underlying pancreatic islet biology and its dysfunction

(2018) Maureen Gannon et al.   Molecular Metabolism

MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues β-cell dysfunction caused by Hdac7 upregulation

(2018) Mahboubeh Daneshpajooh et al.   ACTA DIABETOLOGICA

Oxygen Perfusion (Persufflation) of Human Pancreata Enhances Insulin Secretion and Attenuates Islet Proinflammatory Signaling

(2018) Amy C. Kelly et al.   TRANSPLANTATION

Use of human islets to understand islet biology and diabetes: progress, challenges and suggestions

(2018) Nathaniel J. Hart et al.   DIABETOLOGIA

A call for improved reporting of human islet characteristics in research articles

(2018) Vincent Poitout et al.   DIABETOLOGIA

Surgical treatment of congenital hyperinsulinism: Results from 500 pancreatectomies in neonates and children

(2018) N. Scott Adzick et al.   JOURNAL OF PEDIATRIC SURGERY

β Cells Persist in T1D Pancreata Without Evidence of Ongoing β-Cell Turnover or Neogenesis

(2017) Carol J Lam et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mechanisms of the amplifying pathway of insulin secretion in the β cell

(2017) Michael A. Kalwat et al.   PHARMACOLOGY & THERAPEUTICS

Neonatal Diabetes and the K ATP Channel: From Mutation to Therapy

(2017) Frances M. Ashcroft et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes

(2017) A. S. Axelsson et al.   Nature Communications

The triggering pathway to insulin secretion: Functional similarities and differences between the human and the mouse β cells and their translational relevance

(2017) Maša Skelin Klemen et al.   Islets

The dynamic plasticity of insulin production in β-cells

(2017) Brandon B. Boland et al.   Molecular Metabolism

Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism

(2017) Kirsten Roomp et al.   PLoS One

SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells

(2017) Mourad Ferdaoussi et al.   Scientific Reports

A comparative analysis of human and mouse islet G-protein coupled receptor expression

(2017) Stefan Amisten et al.   Scientific Reports

Insulin, glucagon and somatostatin stores in the pancreas of subjects with type-2 diabetes and their lean and obese non-diabetic controls

(2017) Jean-Claude Henquin et al.   Scientific Reports

Impact of a mild decrease in fasting plasma glucose on β-cell function in healthy subjects and patients with type 2 diabetes

(2016) Marta Seghieri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Linearity of β-cell response across the metabolic spectrum and to pharmacology: insights from a graded glucose infusion-based investigation series

(2016) Sudha S. Shankar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATPChannel Activity

(2016) Trillian Gregg et al.   DIABETES

Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells

(2016) Subhankar Dolai et al.   DIABETES

Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore

(2016) James Lyon et al.   ENDOCRINOLOGY

Perspective on the Genetics and Diagnosis of Congenital Hyperinsulinism Disorders

(2016) Charles A. Stanley   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Dynamics and Regulation of Insulin Secretion in Pancreatic Islets from Normal Young Children

(2016) Jean-Claude Henquin et al.   PLoS One

Dynamics of glucose-induced insulin secretion in normal human islets

(2015) Jean-Claude Henquin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

(2015) Guy A. Rutter et al.   BIOCHEMICAL JOURNAL

Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro

(2015) Lars Krogvold et al.   DIABETES

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes

(2015) Leslie S. Satin et al.   MOLECULAR ASPECTS OF MEDICINE

Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion

(2015) Frank Schwede et al.   MOLECULAR ENDOCRINOLOGY

Sex-Specific Differences in Lipid and Glucose Metabolism

(2015) Oleg Varlamov et al.   Frontiers in Endocrinology

Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes

(2014) Patrick Gilon et al.   CELL CALCIUM

β-Cell Function, Incretin Effect, and Incretin Hormones in Obese Youth Along the Span of Glucose Tolerance From Normal to Prediabetes to Type 2 Diabetes

(2014) Sara F. Michaliszyn et al.   DIABETES

Summary of the Keystone Islet Workshop (April 2014): The Increasing Demand for Human Islet Availability in Diabetes Research

(2014) R. N. Kulkarni et al.   DIABETES

Prevalence of Detectable C-Peptide According to Age at Diagnosis and Duration of Type 1 Diabetes

(2014) Asa K. Davis et al.   DIABETES CARE

Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes

(2014) Matthew J. Butcher et al.   DIABETOLOGIA

Hyperinsulinaemic Hypoglycaemia

(2014) V. Arya et al.   HORMONE AND METABOLIC RESEARCH

Syntaxin 4 Up-Regulation Increases Efficiency of Insulin Release in Pancreatic Islets From Humans With and Without Type 2 Diabetes Mellitus

(2014) Eunjin Oh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Improved physiological properties of gravity-enforced reassembled rat and human pancreatic pseudo-islets

(2014) R. A. Zuellig et al.   Journal of Tissue Engineering and Regenerative Medicine

β-Cell function in type 2 diabetes

(2014) Ele Ferrannini et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Young capillary vessels rejuvenate aged pancreatic islets

(2014) Joana Almaça et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Signaling in Fuel-Induced Insulin Secretion

(2013) Marc Prentki et al.   Cell Metabolism

The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells

(2013) Richard A. Oram et al.   DIABETOLOGIA

Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion

(2013) J. M. Locke et al.   DIABETOLOGIA

Functional Plasticity of the Human Infant β-Cell Exocytotic Phenotype

(2013) Jocelyn E. Manning Fox et al.   ENDOCRINOLOGY

Change in β-Cell Mass in Japanese Nondiabetic Obese Individuals

(2013) Kinsei Kou et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Ion channels and regulation of insulin secretion in human β-cells

(2013) Leonid E. Fridlyand et al.   Islets

Congenital Hyperinsulinism Caused by Hexokinase I Expression or Glucokinase-Activating Mutation in a Subset of  -Cells

(2012) J.-C. Henquin et al.   DIABETES

Reduced Insulin Exocytosis in Human Pancreatic  -Cells With Gene Variants Linked to Type 2 Diabetes

(2012) A. H. Rosengren et al.   DIABETES

GLP-1 Receptor Antagonist Exendin-(9-39) Elevates Fasting Blood Glucose Levels in Congenital Hyperinsulinism Owing to Inactivating Mutations in the ATP-Sensitive K+ Channel

(2012) A. C. Calabria et al.   DIABETES

Distinct  -Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance

(2012) M. Kanat et al.   DIABETES

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretionin Vitro

(2012) Norman Simpson et al.   MOLECULAR ENDOCRINOLOGY

Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics

(2011) Nicolai M. Doliba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?

(2011) J. N. Walker et al.   DIABETES OBESITY & METABOLISM

Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

(2011) E. L. Lim et al.   DIABETOLOGIA

Morphological Mosaicism of the Pancreatic Islets: A Novel Anatomopathological Form of Persistent Hyperinsulinemic Hypoglycemia of Infancy

(2011) C. Sempoux et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

In vitro insulin secretion by pancreatic tissue from infants with diazoxide-resistant congenital hyperinsulinism deviates from model predictions

(2011) Jean-Claude Henquin et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamics of insulin secretion and the clinical implications for obesity and diabetes

(2011) Susumu Seino et al.   JOURNAL OF CLINICAL INVESTIGATION

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

Sex differences in glucose levels: a consequence of physiology or methodological convenience? The Inter99 study

(2010) K. Færch et al.   DIABETOLOGIA

Glucose-responsive beta cells in islets isolated from a patient with long-standing type 1 diabetes mellitus

(2010) J. N. Walker et al.   DIABETOLOGIA

Mechanism and Effects of Glucose Absorption during an Oral Glucose Tolerance Test Among Females and Males

(2010) Christian Anderwald et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The direct effects of GLP-1 and GIP, alone or in combination, on human pancreatic islets

(2010) R. Lupi et al.   REGULATORY PEPTIDES

Influence of Donor Age on Islet Isolation and Transplantation Outcome

(2010) Nadja Niclauss et al.   TRANSPLANTATION

Impaired insulin turnover in islets from type 2 diabetic patients

(2010) Florian Ehehalt et al.   Islets

Different Effects of FK506, Rapamycin, and Mycophenolate Mofetil on Glucose-Stimulated Insulin Release and Apoptosis in Human Islets

(2009) James D. Johnson et al.   CELL TRANSPLANTATION

Shortcomings of current models of glucose-induced insulin secretion

(2009) J. C. Henquin et al.   DIABETES OBESITY & METABOLISM

The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality

(2009) S. E. Kahn et al.   DIABETOLOGIA

Glucose Generates Coincident Insulin and Somatostatin Pulses and Antisynchronous Glucagon Pulses from Human Pancreatic Islets

(2009) Bo Hellman et al.   ENDOCRINOLOGY

Pulsatility of insulin release – a clinically important phenomenon

(2009) Bo Hellman   UPSALA JOURNAL OF MEDICAL SCIENCES

Voltage-Gated Ion Channels in Human Pancreatic  -Cells: Electrophysiological Characterization and Role in Insulin Secretion

(2008) M. Braun et al.   DIABETES

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

Relationships between insulin secretion after intravenous and oral glucose administration in subjects with glucose tolerance ranging from normal to overt diabetes

(2008) A. Mari et al.   DIABETIC MEDICINE