Roles of Sphingolipid Metabolism in Pancreatic β Cell Dysfunction Induced by Lipotoxicity

Sphingosine kinase 1 regulates adipose proinflammatory responses and insulin resistance

(2014) Jing Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ceramide and the mitochondrial respiratory chain

(2013) Aviram Kogot-Levin et al.   BIOCHIMIE

Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic β-cell death in diet-induced obese mice

(2013) Yanfei Qi et al.   FASEB JOURNAL

Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic β-Cells

(2013) Ebru Boslem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival

(2012) Julien Véret et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

L-threo-C6-pyridinium-ceramide Bromide, a Novel Cationic Ceramide, Induces NADPH Oxidase Activation, Mitochondrial Dysfunction and Loss in Cell Viability in INS 832/13 �-cells

(2012) Ismail Syed et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes

(2012) Joo-Won Park et al.   HEPATOLOGY

Sphingosine 1-Phosphate (S1P) Regulates Glucose-stimulated Insulin Secretion in Pancreatic Beta Cells

(2012) Jamie Cantrell Stanford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction

(2012) Ebru Boslem et al.   Islets

Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6

(2011) Christopher D. Green et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ceramide synthase 4 andde novoproduction of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells

(2011) Julien Véret et al.   BIOCHEMICAL JOURNAL

Ceramide formation as a target in beta-cell survival and function

(2011) Florian Lang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic β-cells

(2010) Toshiyuki Imasawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Palmitate-Induced Inhibition of Insulin Gene Expression in Rat Islet β-Cells Involves the Ceramide Transport Protein

(2010) Jun Guo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Glucolipotoxicity Alters Lipid Partitioning and Causes Mitochondrial Dysfunction, Cholesterol, and Ceramide Deposition and Reactive Oxygen Species Production in INS832/13 ß-Cells

(2010) Wissal El-Assaad et al.   ENDOCRINOLOGY

Mitochondrial Dysfunction and Increased Reactive Oxygen Species Impair Insulin Secretion in Sphingomyelin Synthase 1-null Mice

(2010) Masato Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP-independent glucose stimulation of sphingosine kinase in rat pancreatic islets

(2010) L. D. Mastrandrea et al.   JOURNAL OF LIPID RESEARCH

Blockage of ceramide metabolism exacerbates palmitate inhibition of pro-insulin gene expression in pancreatic β-cells

(2010) Jun Guo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Plasma Membrane Subdomain Compartmentalization Contributes to Distinct Mechanisms of Ceramide Action on Insulin Signaling

(2009) C. M. Blouin et al.   DIABETES

Involvement of Per-Arnt-Sim Kinase and Extracellular-Regulated Kinases-1/2 in Palmitate Inhibition of Insulin Gene Expression in Pancreatic  -Cells

(2009) G. Fontes et al.   DIABETES

Myocardium of type 2 diabetic and obese patients is characterized by alterations in sphingolipid metabolic enzymes but not by accumulation of ceramide

(2009) Marcin Baranowski et al.   JOURNAL OF LIPID RESEARCH

Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity

(2009) Wei Hu et al.   JOURNAL OF LIPID RESEARCH

Comparison of Lipid and Fatty Acid Composition of the Liver, Subcutaneous and Intra-abdominal Adipose Tissue, and Serum

(2009) Anna Kotronen et al.   Obesity

The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice

(2009) Hervé Guillou et al.   PROGRESS IN LIPID RESEARCH

Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3

(2008) Angela M. Whetzel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

(2008) J. M. Haus et al.   DIABETES

FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice

(2008)   DIABETES OBESITY & METABOLISM

From a glucocentric to a lipocentric approach towards metabolic syndrome

(2008) Shivani Mittra et al.   DRUG DISCOVERY TODAY

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS

Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction

(2008) Vincent Poitout et al.   ENDOCRINE REVIEWS

Ceramide is a cardiotoxin in lipotoxic cardiomyopathy

(2008) Tae-Sik Park et al.   JOURNAL OF LIPID RESEARCH

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipid accumulation in non-adipose tissue and lipotoxicity

(2007) N.A. van Herpen et al.   PHYSIOLOGY & BEHAVIOR