The triggering pathway to insulin secretion: Functional similarities and differences between the human and the mouse β cells and their translational relevance

Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

(2017) Koenraad Philippaert et al.   Nature Communications

Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells

(2017) Matthew T. Dickerson et al.   PLoS One

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Heterogeneity and nearest-neighbor coupling can explain small-worldness and wave properties in pancreatic islets

(2016) Giacomo Cappon et al.   CHAOS

Very Low-Calorie Diet and 6 Months of Weight Stability in Type 2 Diabetes: Pathophysiological Changes in Responders and Nonresponders

(2016) Sarah Steven et al.   DIABETES CARE

Cell polarity defines three distinct domains in pancreatic β-cells

(2016) Wan J. Gan et al.   JOURNAL OF CELL SCIENCE

Pharmacologic Therapy of Type 2 Diabetes

(2016) Jennifer J. Wright et al.   MEDICAL CLINICS OF NORTH AMERICA

The Pancreatic β-Cell: A Bioenergetic Perspective

(2016) David G. Nicholls   PHYSIOLOGICAL REVIEWS

Decreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise

(2016) Aleena M. Notary et al.   PLoS Computational Biology

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

(2015) Guy A. Rutter et al.   BIOCHEMICAL JOURNAL

The relationship between node degree and dissipation rate in networks of diffusively coupled oscillators and its significance for pancreatic beta cells

(2015) Marko Gosak et al.   CHAOS

Multilayer network representation of membrane potential and cytosolic calcium concentration dynamics in beta cells

(2015) Marko Gosak et al.   CHAOS SOLITONS & FRACTALS

Type 2 Diabetes–Associated K+Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis

(2015) Nicholas C. Vierra et al.   DIABETES

Slow potentials encode intercellular coupling and insulin demand in pancreatic beta cells

(2015) Fanny Lebreton et al.   DIABETOLOGIA

Low Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cδ

(2015) Nikki L. Farnsworth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes

(2015) Leslie S. Satin et al.   MOLECULAR ASPECTS OF MEDICINE

Membrane Potential and Calcium Dynamics in Beta Cells from Mouse Pancreas Tissue Slices: Theory, Experimentation, and Analysis

(2015) Jurij Dolenšek et al.   SENSORS

Modulation of Glucokinase Regulatory Protein: A Double-Edged Sword?

(2015) Martijn C.G.J. Brouwers et al.   TRENDS IN MOLECULAR MEDICINE

Structural similarities and differences between the human and the mouse pancreas

(2015) Jurij Dolenšek et al.   Islets

Progressive glucose stimulation of islet beta cells reveals a transition from segregated to integrated modular functional connectivity patterns

(2015) Rene Markovič et al.   Scientific Reports

Intrinsic Islet Heterogeneity and Gap Junction Coupling Determine Spatiotemporal Ca2+ Wave Dynamics

(2014) Richard K.P. Benninger et al.   BIOPHYSICAL JOURNAL

Dimensionality and Size Scaling of Coordinated Ca2+ Dynamics in MIN6 β-cell Clusters

(2014) Thomas H. Hraha et al.   BIOPHYSICAL JOURNAL

Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes

(2014) Patrick Gilon et al.   CELL CALCIUM

The elusive importance of being a mitochondrial Ca2+ uniporter

(2014) Diana Pendin et al.   CELL CALCIUM

Beta cell connectivity in pancreatic islets: a type 2 diabetes target?

(2014) Guy A. Rutter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Control of Insulin Secretion by Cholinergic Signaling in the Human Pancreatic Islet

(2014) J. Molina et al.   DIABETES

Decreasing Cx36 Gap Junction Coupling Compensates for Overactive KATPChannels to Restore Insulin Secretion and Prevent Hyperglycemia in a Mouse Model of Neonatal Diabetes

(2014) Linda M. Nguyen et al.   DIABETES

Neurotransmitter control of islet hormone pulsatility

(2014) E. Gylfe et al.   DIABETES OBESITY & METABOLISM

The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells

(2014) Oanh H. Do et al.   DIABETOLOGIA

GLUT2, glucose sensing and glucose homeostasis

(2014) Bernard Thorens   DIABETOLOGIA

Pancreatic β-Cell–specific Ablation of TASK-1 Channels Augments Glucose-stimulated Calcium Entry and Insulin Secretion, Improving Glucose Tolerance

(2014) Prasanna K. Dadi et al.   ENDOCRINOLOGY

New insights into the role of connexins in pancreatic islet function and diabetes

(2014) Nikki L. Farnsworth et al.   FEBS LETTERS

Calcium Co-regulates Oxidative Metabolism and ATP Synthase-dependent Respiration in Pancreatic Beta Cells

(2014) Umberto De Marchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotransmitters act as paracrine signals to regulate insulin secretion from the human pancreatic islet

(2014) Rayner Rodriguez-Diaz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Na+current properties in islet α- and β-cells reflect cell-specificScn3aandScn9aexpression

(2014) Quan Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Incretin-Modulated Beta Cell Energetics in Intact Islets of Langerhans

(2014) David J. Hodson et al.   MOLECULAR ENDOCRINOLOGY

Opening of an alternative ion permeation pathway in a nociceptor TRP channel

(2014) Joris Vriens et al.   Nature Chemical Biology

Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics

(2014) Richard K.P. Benninger et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents

(2014) Jantje M. Gerdes et al.   Nature Communications

Mathematical models of electrical activity of the pancreatic β-cell: A physiological review

(2014) Gerardo J Félix-Martínez et al.   Islets

Mathematical Modeling of Heterogeneous Electrophysiological Responses in Human β-Cells

(2014) Michela Riz et al.   PLoS Computational Biology

Connexin 30.2 is expressed in mouse pancreatic beta cells

(2013) C. Coronel-Cruz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Direct Autocrine Action of Insulin on  -Cells: Does It Make Physiological Sense?

(2013) C. J. Rhodes et al.   DIABETES

Circulating Levels of IL-1B+IL-6 Cause ER Stress and Dysfunction in Islets From Prediabetic Male Mice

(2013) Christina M. O'Neill et al.   ENDOCRINOLOGY

The anti-diabetic drug glibenclamide is an agonist of the transient receptor potential Ankyrin 1 (TRPA1) ion channel

(2013) Alexandru Babes et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome

(2013) A. C. Nica et al.   GENOME RESEARCH

Lipotoxicity disrupts incretin-regulated human β cell connectivity

(2013) David J. Hodson et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1γ

(2013) Jacques-Antoine Haefliger et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Mitochondrial function and insulin secretion

(2013) Pierre Maechler   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The SLC2 (GLUT) family of membrane transporters

(2013) Mike Mueckler et al.   MOLECULAR ASPECTS OF MEDICINE

Minireview: Dopaminergic Regulation of Insulin Secretion from the Pancreatic Islet

(2013) Alessandro Ustione et al.   MOLECULAR ENDOCRINOLOGY

Minireview: Intraislet Regulation of Insulin Secretion in Humans

(2013) Guy A. Rutter et al.   MOLECULAR ENDOCRINOLOGY

Glucose-Stimulated Calcium Dynamics in Islets of Langerhans in Acute Mouse Pancreas Tissue Slices

(2013) Andraž Stožer et al.   PLoS One

The Relationship between Membrane Potential and Calcium Dynamics in Glucose-Stimulated Beta Cell Syncytium in Acute Mouse Pancreas Tissue Slices

(2013) Jurij Dolenšek et al.   PLoS One

Ion channels and regulation of insulin secretion in human β-cells

(2013) Leonid E. Fridlyand et al.   Islets

Functional Connectivity in Islets of Langerhans from Mouse Pancreas Tissue Slices

(2013) Andraž Stožer et al.   PLoS Computational Biology

Impaired β-cell-β-cell coupling mediated by Cx36 gap junctions in prediabetic mice

(2012) C. P. F. Carvalho et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of Insulin Secretion in Human Pancreatic Islets

(2012) Patrik Rorsman et al.   Annual Review of Physiology

Regulation of ATP production by mitochondrial Ca2+

(2012) Andrei I. Tarasov et al.   CELL CALCIUM

Connexin-36 Gap Junctions Regulate In Vivo First- and Second-Phase Insulin Secretion Dynamics and Glucose Tolerance in the Conscious Mouse

(2012) W. S. Head et al.   DIABETES

Maintenance of  -Cell Maturity and Plasticity in the Adult Pancreas: Developmental Biology Concepts in Adult Physiology

(2012) M. Szabat et al.   DIABETES

Connexins and β-cell functions

(2012) Valentina Cigliola et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes

(2012) J. Taneera et al.   DIABETOLOGIA

SLC2A2 mutations can cause neonatal diabetes, suggesting GLUT2 may have a role in human insulin secretion

(2012) F. H. Sansbury et al.   DIABETOLOGIA

Distinctions Between the Islets of Mice and Men: Implications for New Therapies for Type 1 and 2 Diabetes

(2012) Claresa Levetan et al.   Endocrine Practice

Association of an Intensive Lifestyle Intervention With Remission of Type 2 Diabetes

(2012) Edward W. Gregg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cx36 Is a Target of Beta2/NeuroD1, Which Associates with Prenatal Differentiation of Insulin-producing β Cells

(2012) Rachel Nlend Nlend et al.   JOURNAL OF MEMBRANE BIOLOGY

Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretionin Vitro

(2012) Norman Simpson et al.   MOLECULAR ENDOCRINOLOGY

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

(2012) Barak Blum et al.   NATURE BIOTECHNOLOGY

Frequency-dependent mitochondrial Ca2+ accumulation regulates ATP synthesis in pancreatic β cells

(2012) Andrei I. Tarasov et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The Mitochondrial Ca2+ Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells

(2012) Andrei I. Tarasov et al.   PLoS One

The Mitochondrial Na+/Ca2+ Exchanger Upregulates Glucose Dependent Ca2+ Signalling Linked to Insulin Secretion

(2012) Iulia I. Nita et al.   PLoS One

Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function

(2012) R. Rodriguez-Diaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics

(2011) Nicolai M. Doliba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon

(2011) Bo Hellman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of calcium in pancreatic α- and β-cells in health and disease

(2011) Patrik Rorsman et al.   CELL CALCIUM

Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet

(2011) R. K. P. Benninger et al.   JOURNAL OF PHYSIOLOGY-LONDON

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

(2011) Goodarz Danaei et al.   LANCET

Mitochondrial signals drive insulin secretion in the pancreatic β-cell

(2011) Andreas Wiederkehr et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: Implications for understanding genetic association signals at this locus

(2011) Laura J. McCulloch et al.   MOLECULAR GENETICS AND METABOLISM

Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport

(2011) Kazuaki Ohtsubo et al.   NATURE MEDICINE

The Neurotransmitter ATP Triggers Ca2+ Responses Promoting Coordination of Pancreatic Islet Oscillations

(2011) Erik Gylfe et al.   PANCREAS

Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans

(2011) Patrik Rorsman et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

A Biophysical Model of Electrical Activity in Human β -Cells

(2010) Morten Gram Pedersen   BIOPHYSICAL JOURNAL

 -Aminobutyric Acid (GABA) Is an Autocrine Excitatory Transmitter in Human Pancreatic  -Cells

(2010) M. Braun et al.   DIABETES

Unique Arrangement of  - and  -Cells in Human Islets of Langerhans

(2010) D. Bosco et al.   DIABETES

Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses

(2010) David A. Jacobson et al.   JOURNAL OF PHYSIOLOGY-LONDON

ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic   cell

(2010) M. C. Jacques-Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice

(2010) B. Colsoul et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NALCN ion channel is a new actor in pancreatic β-cell physiology

(2010) Leigh Anne Swayne et al.   Islets

Exocytotic Properties of Human Pancreatic β-cells

(2009) Matthias Braun et al.   Annals of the New York Academy of Sciences

Enhanced Glucose Tolerance by SK4 Channel Inhibition in Pancreatic  -Cells

(2009) M. Dufer et al.   DIABETES

Shortcomings of current models of glucose-induced insulin secretion

(2009) J. C. Henquin et al.   DIABETES OBESITY & METABOLISM

Impaired Insulin Exocytosis in Neural Cell Adhesion Molecule−/−Mice Due to Defective Reorganization of the Submembrane F-Actin Network

(2009) Charlotta S. Olofsson et al.   ENDOCRINOLOGY

Glucose Generates Coincident Insulin and Somatostatin Pulses and Antisynchronous Glucagon Pulses from Human Pancreatic Islets

(2009) Bo Hellman et al.   ENDOCRINOLOGY

P2 purinergic signalling in the pancreatic β-cell: Control of insulin secretion and pharmacology

(2009) Pierre Petit et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Characterization of Erg K+Channels in α- and β-Cells of Mouse and Human Islets

(2009) Alexandre B. Hardy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assessing the potential of glucokinase activators in diabetes therapy

(2009) Franz M. Matschinsky   NATURE REVIEWS DRUG DISCOVERY

Electrophysiological and Immunocytochemical Evidence for P2X Purinergic Receptors in Pancreatic β Cells

(2009) Amélia M. Silva et al.   PANCREAS

Gap Junction Coupling and Calcium Waves in the Pancreatic Islet

(2008) Richard K.P. Benninger et al.   BIOPHYSICAL JOURNAL

Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic β-cell

(2008) A WIEDERKEHR et al.   CELL CALCIUM

Molecular Physiology of Mammalian Glucokinase

(2008) P. B. Iynedjian   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic  -Cells

(2008) E. Hisanaga et al.   DIABETES

Voltage-Gated Ion Channels in Human Pancreatic  -Cells: Electrophysiological Characterization and Role in Insulin Secretion

(2008) M. Braun et al.   DIABETES

Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4

(2008) S. Casas et al.   DIABETOLOGIA

Neonatal Diabetes Mellitus

(2008) Lydia Aguilar-Bryan et al.   ENDOCRINE REVIEWS

Cx36 makes channels coupling human pancreatic β-cells, and correlates with insulin expression

(2008) Véronique Serre-Beinier et al.   HUMAN MOLECULAR GENETICS

Oscillatory control of insulin secretion

(2008) A TENGHOLM et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Control of KCa Channels by Calcium Nano/Microdomains

(2008) Bernd Fakler et al.   NEURON

Cell coupling in mouse pancreatic  -cells measured in intact islets of Langerhans

(2008) Q. Zhang et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Glucose induces synchronous mitochondrial calcium oscillations in intact pancreatic islets

(2007) Ivan Quesada et al.   CELL CALCIUM