Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells

Toward Connecting Metabolism to the Exocytotic Site

(2017) Mourad Ferdaoussi et al.   TRENDS IN CELL BIOLOGY

Metabolomics applied to the pancreatic islet

(2016) Jessica R. Gooding et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The Pancreatic β-Cell: A Bioenergetic Perspective

(2016) David G. Nicholls   PHYSIOLOGICAL REVIEWS

Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes

(2016) Yves Mugabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

(2016) Melissa F. Brereton et al.   Nature Communications

A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens

(2016) Gemma L. Pearson et al.   Molecular Metabolism

Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression

(2016) Émilie Pepin et al.   PLoS One

Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes

(2015) Christopher J. Nolan et al.   DIABETES

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells

(2015) Mourad Ferdaoussi et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors

(2015) Paola Llanos et al.   PLoS One

α/β-Hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli

(2015) Shangang Zhao et al.   Molecular Metabolism

α/β-Hydrolase Domain-6-Accessible Monoacylglycerol Controls Glucose-Stimulated Insulin Secretion

(2014) Shangang Zhao et al.   Cell Metabolism

A Fresh View of Glycolysis and Glucokinase Regulation: History and Current Status

(2014) Sigurd Lenzen   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Signaling in Fuel-Induced Insulin Secretion

(2013) Marc Prentki et al.   Cell Metabolism

Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high-fat diet obese mice

(2013) C. Rancoule et al.   DIABETOLOGIA

Metabolome Response to Glucose in the β-Cell Line INS-1 832/13

(2013) Matthew A. Lorenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Cytosolic Isocitrate Dehydrogenase as a Negative Regulator of Glucose Signaling for Insulin Secretion in Pancreatic ß-Cells

(2013) Claudiane Guay et al.   PLoS One

Intensive insulin for type 2 diabetes: the risk of causing harm

(2013) Christopher J Nolan et al.   Lancet Diabetes & Endocrinology

Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired  -Cell Function

(2012) J. K. Kruit et al.   DIABETES

The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions

(2012) Mohammed Bensellam et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A Novel High-Throughput Assay for Islet Respiration Reveals Uncoupling of Rodent and Human Islets

(2012) Jakob D. Wikstrom et al.   PLoS One

Metabolomic analysis of pancreatic β-cell insulin release in response to glucose

(2012) Mei Huang et al.   Islets

Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines

(2011) Peter Spégel et al.   BIOCHEMICAL JOURNAL

Cholesterol induces pancreatic β cell apoptosis through oxidative stress pathway

(2011) Xiuli Lu et al.   CELL STRESS & CHAPERONES

The dual control of insulin secretion by glucose involves triggering and amplifying pathways in β-cells

(2011) Jean-Claude Henquin   DIABETES RESEARCH AND CLINICAL PRACTICE

Reactive oxygen species are produced at low glucose and contribute to the activation of AMPK in insulin-secreting cells

(2011) Alexandre Sarre et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glycerolipid/free fatty acid cycle and islet β-cell function in health, obesity and diabetes

(2011) Marc Prentki et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: Knockdown of SCOT inhibits insulin release in rat insulinoma cells

(2010) Noaman M. Hasan et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

 -Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced  -Cell Mass

(2010) M.-L. Peyot et al.   DIABETES

Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β-cells

(2010) W. Gehrmann et al.   DIABETES OBESITY & METABOLISM

Regulation of insulin secretion: role of mitochondrial signalling

(2010) S. Jitrapakdee et al.   DIABETOLOGIA

Activation of the KATPchannel by Mg-nucleotide interaction with SUR1

(2010) Peter Proks et al.   JOURNAL OF GENERAL PHYSIOLOGY

Glucolipotoxicity of the pancreatic beta cell

(2009) Vincent Poitout et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

High glucose promotes intracellular lipid accumulation in vascular smooth muscle cells by impairing cholesterol influx and efflux balance

(2009) Jia-hong Xue et al.   CARDIOVASCULAR RESEARCH

Shortcomings of current models of glucose-induced insulin secretion

(2009) J. C. Henquin et al.   DIABETES OBESITY & METABOLISM

Pioglitazone Acutely Reduces Insulin Secretion and Causes Metabolic Deceleration of the Pancreatic β-Cell at Submaximal Glucose Concentrations

(2009) Julien Lamontagne et al.   ENDOCRINOLOGY

The Deletion Variant of Nicotinamide Nucleotide Transhydrogenase (Nnt) Does Not Affect Insulin Secretion or Glucose Tolerance

(2009) Nicole Wong et al.   ENDOCRINOLOGY

Adipose Triglyceride Lipase Is Implicated in Fuel- and Non-fuel-stimulated Insulin Secretion

(2009) Marie-Line Peyot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutaredoxin-1 Mediates NADPH-Dependent Stimulation of Calcium-Dependent Insulin Secretion

(2009) Thomas M. Reinbothe et al.   MOLECULAR ENDOCRINOLOGY

Metabolic cycling in control of glucose-stimulated insulin secretion

(2008) Mette V. Jensen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion

(2008) C. Leloup et al.   DIABETES

Glycerolipid Metabolism and Signaling in Health and Disease

(2008) Marc Prentki et al.   ENDOCRINE REVIEWS

Metabolomic and Mass Isotopomer Analysis of Liver Gluconeogenesis and Citric Acid Cycle

(2008) Lili Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol in islet dysfunction and type 2 diabetes

(2008) Liam R. Brunham et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The islet β-cell: fuel responsive and vulnerable

(2008) Christopher J. Nolan et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells

(2007) Michael J. MacDonald et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS