Recent Advances in Reactions Using Enaminone in Water or Aqueous Medium

Synthesis of 6,7-Dihydro-1H,5H-pyrazolo[1,2-a]pyrazoles by Azomethine Imine-Alkyne Cycloadditions Using Immobilized Cu(II)-Catalysts

(2021) Urša Štanfel et al.   MOLECULES

Enaminones as building blocks in drug development: Recent advances in their chemistry, synthesis, and biological properties

(2021) Isis J. Amaye et al.   TETRAHEDRON

Preparation of Thiazole-2-thiones through TBPB-Promoted Oxidative Cascade Cyclization of Enaminones with Elemental Sulfur

(2021) Biao Zhang et al.   ORGANIC LETTERS

Transition‐Metal‐Free C( sp 2 )‐H Dithiocarbamation and Chromone Annulation Cascade for 3‐Dithiocarbamyl Chromone Synthesis

(2021) Tao Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper(II)‐Mediated Intermolecular Radical [3+2]‐Annulation of N , N ‐Dimethyl Enaminones: Direct Access to 5‐Acyl‐3‐Furancarboxaldehydes

(2021) Biao Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Amine-catalyzed synthesis of N2-sulfonyl 1,2,3-triazole in water and the tunable N2-H 1,2,3-triazole synthesis in DMSO via metal-free enamine annulation

(2021) Yanhui Guo et al.   CHINESE CHEMICAL LETTERS

Base‐Promoted Synthesis of 3‐Alkenyl ‐2‐pyridones from N ‐Propargyl ‐β‐enaminones and Aryl Aldehydes

(2021) Qingyu Tian et al.   CHINESE JOURNAL OF CHEMISTRY

Electrochemical C-H Halogenations of Enaminones and Electron-Rich Arenes with Sodium Halide (NaX) as Halogen Source for the Synthesis of 3-Halochromones and Haloarenes

(2021) Yan Lin et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Enaminone C(sp2)–N Bond Phosphonation for Stereoselective Synthesis of Alkenylphosphonates

(2021) Ting Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Tunable Trifunctionalization of Tertiary Enaminones for the Regioselective and Metal-Free Synthesis of Discrete and Proximal Phosphoryl Nitriles

(2021) Zhongrong Xu et al.   ORGANIC LETTERS

Pd-Catalyzed Triple-Fold C(sp2)–H Activation with Enaminones and Alkenes for Pyrrole Synthesis via Hydrogen Evolution

(2021) Leiqing Fu et al.   ORGANIC LETTERS

Synthesis of 3,3-Dihalogenated 2-Aminochromanones via Tandem Dihalogenation and Cyclization of o-Hydroxyarylenaminones with NXS (X = Cl or Br)

(2021) Tian Luo et al.   JOURNAL OF ORGANIC CHEMISTRY

Transition Metal‐free C‐H Sulfonylation and Pyrazole Annulation Cascade for the Synthesis of 4‐Sulfonyl Pyrazoles

(2020) Lihong Tian et al.   ChemCatChem

IBX-Promoted Oxidative Cyclization of N-Hydroxyalkyl Enamines: A Metal-free Approach towards 2,3-Disubstituted Pyrroles and Pyridines

(2020) Peng Gao et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalyst‐Free Synthesis of α‐Diazoketones in Water by Microwave Promoted Enaminone C=C Double Bond Cleavage

(2020) Lu Gan et al.   ChemistrySelect

Synthesis of 2,3-Dihydro-4-pyridones and 4-Pyridones by the Cyclization Reaction of Ester-Tethered Enaminones

(2020) Milovan Stojanović et al.   JOURNAL OF ORGANIC CHEMISTRY

Microwave-Assisted Synthesis of Fluorescent Pyrido[2,3-b]indolizines from Alkylpyridinium Salts and Enaminones

(2020) Ekaterina A. Sokolova et al.   MOLECULES

Scissoring Enaminone C═C Double Bond by Free Radical Process for the Synthesis of α-Trifluoromethyl Ketones with CF3SO2Na

(2020) Lu Gan et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of N-Aryl-4-arylhexahydroquinoline Derivatives by Reaction of Cyclic Enaminones with Arylidenemalononitriles in DMSO

(2020) Takeshi Oriyama et al.   SYNTHESIS-STUTTGART

CAN‐mediated Oxidative Coupling‐Reaction of Xanthenes with Enaminones

(2020) Changyuan Zhang et al.   Asian Journal of Organic Chemistry

Visible Light-Induced Thiocyanation of Enaminone C-H Bond to Access Polyfunctionalized Alkenes and Thiocyano Chromones

(2019) Yong Gao et al.   JOURNAL OF ORGANIC CHEMISTRY

Domino C-H Sulfonylation and Pyrazole Annulation for Fully Substituted Pyrazole Synthesis in Water Using Hydrophilic Enaminones

(2019) Yanhui Guo et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Functionalized α-Vinyl Aldehydes from Enaminones

(2019) Jie Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Brønsted acid-promoted ‘on–water’ C(sp3)-H functionalization for the synthesis of isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine derivatives targeting the SKP2-CKS1 interaction

(2019) Shuo Yuan et al.   CHINESE CHEMICAL LETTERS

Thermo‐Induced Free‐Radical Cleavage of Enaminone C=C Double Bond for α‐Acyloxyl Ketone Synthesis

(2019) Lihong Tian et al.   Asian Journal of Organic Chemistry

Aqueous Synthesis of 3,4‐Dihydropyridinones from Acryloyl Chloride and Enaminones by Domino Amidation and Intramolecular Michael Addition

(2019) Tian Luo et al.   ChemistrySelect

The C=C Bond Decomposition Initiated by Enamine‐Azide Cycloaddition for Catalyst‐ and Additive‐Free Synthesis of N ‐Sulfonyl Amidines

(2019) Xixi Zheng et al.   ADVANCED SYNTHESIS & CATALYSIS

In-Water Synthesis of 5-Thiolated 1,2,3-Triazoles from β-Thioenaminones by Diazo Transfer Reaction

(2019) Leiling Deng et al.   JOURNAL OF ORGANIC CHEMISTRY

Switchable Synthesis of α,α‐Dihalomethyl and α,α,α‐Trihalomethyl Ketones by Metal‐Free Decomposition of Enaminone C=C Double Bond

(2019) Yunyun Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of Enaminone‐Pd(II) Complexes and Their Application in Catalysing Aqueous Suzuki‐Miyaura Cross Coupling Reaction

(2019) Leiqing Fu et al.   CHINESE JOURNAL OF CHEMISTRY

Redox neutral [4+2] benzannulation of dienals and tertiary enaminones for benzaldehyde synthesis

(2018) Lu Yang et al.   CHEMICAL COMMUNICATIONS

The Hydrophobic Effect Applied to Organic Synthesis: Recent Synthetic Chemistry “in Water”

(2018) Bruce H. Lipshutz et al.   CHEMISTRY-A EUROPEAN JOURNAL

Visible-Light-Induced External Radical-Triggered Annulation To Access CF2-Containing Benzoxepine Derivatives

(2018) Haoyue Xiang et al.   ORGANIC LETTERS

Catalyst-free synthesis of 4-acyl-NH-1,2,3-triazoles by water-mediated cycloaddition reactions of enaminones and tosyl azide

(2018) Lu Yang et al.   Beilstein Journal of Organic Chemistry

Rh(iii)-Catalyzed regioselective C–H [4 + 2] C-annulation of vinyl enaminones with alkynes to form polysubstituted salicylaldehydes

(2018) Yinsong Zhao et al.   Organic Chemistry Frontiers

Straightforward Synthesis of Novel Difluorinated 2-Hydroxyl-Substituted Dihydroquinolones Through Selectfluor-triggered Annulation of 2-Aminoarylenaminones

(2018) Qing-Lan Zhao et al.   ChemistrySelect

Synthesis of Polyaromatic Rings: Rh(III)-Catalyzed [5 + 1] Annulation of Enaminones with Vinyl Esters through C–H Bond Functionalization

(2018) Gaohui Liang et al.   ORGANIC LETTERS

Catalyst-free synthesis of 3-substituted-3-hydroxy-2-oxindoles by reaction of isatin and cyclic enaminone in water

(2018) Keshri Nath Tiwari et al.   SYNTHETIC COMMUNICATIONS

A base-free, ultrasound accelerated one-pot synthesis of 2-sulfonylquinolines in water

(2017) Long-Yong Xie et al.   GREEN CHEMISTRY

Selectfluor-Triggered Tandem Cyclization of o-Hydroxyarylenaminones To Access Difluorinated 2-Amino-Substituted Chromanones

(2017) Qinglan Zhao et al.   JOURNAL OF ORGANIC CHEMISTRY

TBHP/TBAI-Mediated Oxidative Cascade Reaction Consisting of Dimerization, Cyclization, and 1,2-Aryl Migration: Metal-Free Synthesis of Pyrrolin-4-ones and Highly Substituted Pyrroles

(2017) Xiaoyuan Zhao et al.   JOURNAL OF ORGANIC CHEMISTRY

Mn(OAc)3-Promoted Oxidative Csp3–P Bond Formation through Csp2–Csp2 and P–H Bond Cleavage: Access to β-Ketophosphonates

(2017) Pan Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY

Iodine-Catalyzed Cross Dehydrogenative Coupling Reaction: Sulfenylation of Enaminones Using Dimethyl Sulfoxide as an Oxidant

(2017) Yogesh Siddaraju et al.   JOURNAL OF ORGANIC CHEMISTRY

Regioselective three-component synthesis of 2,3-disubstituted quinolines via the enaminone modified Povarov reaction

(2017) Yi Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Chemoselective Synthesis of N-Arylenaminones and 3-Aroylquinolines by Synergistic Control of Temperature and Amount of Catalyst

(2017) Fuchao Yu et al.   SYNLETT

Water-acetic acid mediated chemoselective synthesis of pyrazolines via multimolecular domino reactions of enaminones and sulfonyl hydrazines

(2017) Yi Li et al.   TETRAHEDRON

Recent developments in chemical reactivity of N,N-dimethylenamino ketones as synthons for various heterocycles

(2017) Hatem M. Gaber et al.   RSC Advances

Catalytic Fehling's Reaction: An Efficient Aerobic Oxidation of Aldehyde Catalyzed by Copper in Water

(2016) Mingxin Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enaminones as Synthons for a Directed C−H Functionalization: RhIII -Catalyzed Synthesis of Naphthalenes

(2016) Shuguang Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Domino Reactions Based on Combinatorial Bond Transformations in Electron-Deficient Tertiary Enamines

(2016) Jie-Ping Wan et al.   CHEMICAL RECORD

Synthesis of β,β-diaryl propiophenones via palladium-catalyzed domino arylboronation, elimination and enone hydroarylation of enaminones

(2016) Shanshan Zhong et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

KIO3-Catalyzed Aerobic Cross-Coupling Reactions of Enaminones and Thiophenols: Synthesis of Polyfunctionalized Alkenes by Metal-Free C–H Sulfenylation

(2016) Jie-Ping Wan et al.   ORGANIC LETTERS

Metal/Benzoyl Peroxide (BPO)-Controlled Chemoselective Cycloisomerization of (o-Alkynyl)phenyl Enaminones: Synthesis of α-Naphthylamines and Indeno[1,2-c]pyrrolones

(2016) Fangfang Zhang et al.   ORGANIC LETTERS

Visible-Light-Induced CC Bond Cleavage of Enaminones for the Synthesis of 1,2-Diketones and Quinoxalines in Sustainable Medium

(2015) Shuo Cao et al.   ChemCatChem

Cyclic enaminones. Part II: applications as versatile intermediates in alkaloid synthesis

(2015) Amit Kumar Chattopadhyay et al.   CHEMICAL COMMUNICATIONS

An Environmentally Benign Catalytic Method for Versatile Synthesis of 1,4-Dihydropyridines via Multicomponent Reactions

(2015) Shuo Cao et al.   CHINESE JOURNAL OF CHEMISTRY

A Metal- and Azide-Free Multicomponent Assembly toward Regioselective Construction of 1,5-Disubstituted 1,2,3-Triazoles

(2015) Jie-Ping Wan et al.   JOURNAL OF ORGANIC CHEMISTRY

Enaminone-Based Three-Component Reactions for the Diastereoselective Synthesis of Fused Tetrahydropyridines

(2015) Jie-Ping Wan et al.   SYNTHESIS-STUTTGART

Recent Advances on Multicomponent Reactions Based on the Transamination Process of Electron Deficient Enamines

(2015) Shuo Cao et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

Mesoporous alumina sulphuric acid: A novel and efficient catalyst for on-water synthesis of functionalized 1,4-dihydropyridine derivatives via β-enaminones

(2014) Nayeem Ahmed et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

Diastereoselective Construction of Tetrahydropyridine Fused Bicyclic Structures via Three-Component Domino Reaction

(2014) Jie-Ping Wan et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct Oxidative Coupling of Enamines and Electron-Deficient Amines: TBAI/TBHP-Mediated Synthesis of Substituted Diaminoalkenes under Metal-Free Conditions

(2014) Yucheng Yuan et al.   ORGANIC LETTERS

Metal-free synthesis of 1,3,5-trisubstituted benzenes by the cyclotrimerization of enaminones or alkynes in water

(2014) Jie-Ping Wan et al.   RSC Advances

Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis

(2013) Manoj B. Gawande et al.   CHEMICAL SOCIETY REVIEWS

Copper-Catalyzed Selective Single Arylsulfanylation of Aryl Diiodides with Aryl Thiols

(2013) Jie-Ping Wan et al.   SYNTHESIS-STUTTGART

Water-Promoted Synthesis of Enaminones: Mechanism Investigation and Application in Multicomponent Reactions

(2013) Yunyun Liu et al.   SYNTHETIC COMMUNICATIONS

Chemo-selective copper-catalyzed C-O coupling reactions of phenols with aryl/vinyl halides using enaminone as efficient ligand

(2012) Jie-Ping Wan et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Magnetic copper–iron nanoparticles as simple heterogeneous catalysts for the azide–alkyne click reaction in water

(2012) Reuben Hudson et al.   GREEN CHEMISTRY

Green chemistry oriented organic synthesis in water

(2011) Marc-Olivier Simon et al.   CHEMICAL SOCIETY REVIEWS

Water: Nature’s Reaction Enforcer—Comparative Effects for Organic Synthesis “In-Water” and “On-Water”

(2010) Richard N. Butler et al.   CHEMICAL REVIEWS

Facile Synthesis of 2-(Phenylthio)phenols by Copper(I)-Catalyzed Tandem Transformation of C−S Coupling/C−H Functionalization

(2010) Runsheng Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY