Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 45, Pages 9585-9589Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob02411h
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Funding
- National Natural Science Foundation of China [21562025]
- Science Fund for Distinguished Young Scholars in Jiangxi Province [20162BCB23023]
- Natural Science Foundation of Jiangxi Province [20161ACB21010]
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The regioselective construction of functionalized quinolines by the three-component reactions of enaminones, aldehydes and anilines is accomplished. Unlike conventional Povarov reactions employing terminal alkynes or alkenes as C3-C4 fragment sources which provide 2,4-disubstituted quinolines, the present method allows fast and regioselective formation of 2,3-disubstituted quinolines as a modified new version of the Povarov reaction.
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