Article
Biochemistry & Molecular Biology
Alexander M. M. Efremov, Olga V. V. Beznos, Roman O. O. Eremeev, Natalia B. B. Chesnokova, Elena R. R. Milaeva, Elena F. F. Shevtsova, Natalia A. A. Lozinskaya
Summary: This article presents an efficient method for synthesizing novel 2-oxindole derivatives using microwave-assisted decarboxylative condensation. The compounds were found to regulate intraocular pressure and show potential antiglaucomic activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Roman O. Eremeev, Olga V. Beznos, Alexander M. Efremov, Natalia B. Chesnokova, Natalia A. Lozinskaya
Summary: Compounds with a 2-oxindole scaffold are important in organic synthesis and the synthesis of bioactive organic compounds. Developing new methods to modify this scaffold is an interesting and urgent task. In this study, a rational approach to the synthesis of 5-amino-substituted derivatives of 2-oxindole has been created, characterized by high total yield and few steps. The one-stage modification of the obtained 5-amino-2-oxindoles leads to compounds with promising antiglaucomic activity, with the most active compound 7a reducing intraocular pressure by 24% in normotensive rabbits (18% for the reference drug timolol).
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Physical
Selvam Ramasamy
Summary: Controlling the morphology of sensitizer on a TiO2 nanocrystalline surface is crucial for enhancing electron injection and suppressing charge recombination, ultimately leading to improved performance of dye-sensitized solar cells.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Chemistry, Medicinal
Kristin M. Reiland, Todd J. Eckroat
Summary: Polymethylene-linked isatin dimers and 3-indolyl-3-hydroxy-2-oxindole dimers were synthesized as selective BChE inhibitors, with the best compounds showing significant inhibitory activity and moderate blood-brain barrier permeability. These compounds exhibited selectivity towards BChE and demonstrated potential as lead compounds for further exploration.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Physical
Priyanka P. Bavdane, Sooraj Sreenath, Devendra Y. Nikumbe, Chetan M. Pawar, Muhsin Chalil Kuzhiyil, Rajaram K. Nagarale
Summary: In this study, N-sulfonated poly-(arylene-oxindole) was synthesized using metal-free superacid. The resulting polymers exhibited high decomposition temperatures, good mechanical and oxidative stability, and showed potential for use in VRFB applications.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Chemistry, Organic
Ziying Xiao, Fengshun Xu, Jing Sun, Chao-Guo Yan
Summary: A convenient method for constructing novel dispirooxindole motifs was developed through a base-promoted three-component reaction of ammonium acetate, isatins, and in situ-generated 3-isatyl-1,4-dicarbonyl compounds. The reaction of dimedone adducts of 3-ethoxy-carbonylmethyleneoxindoles with ammonium acetate and isatins, promoted by pi-peridine, produced multifunctionalized dispiro[indoline-3,2'-quinoline-3',3-indoline] derivatives with good yields and high diastereoselectivity. A similar reaction of dimedone adducts of 3-phenacylideneoxindoles yielded unique dispiro[indoline-3,2'-pyrrole-3',3-indoline] derivatives with a cyclohexanedione substituent. A plausible reaction mechanism is proposed to explain the formation of the different spirooxindoles.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Pedro Brandao, Oscar Lopez, Luisa Leitzbach, Holger Stark, Jose G. Fernandez-Bolanos, Anthony J. Burke, Marta Pineiro
Summary: The study successfully synthesized oxindole-lactam hybrids using molecular hybridization and multicomponent reactions. The compounds showed potential in inhibiting central nervous system targets, suggesting them as new potential agents for the treatment of Alzheimer's disease.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Zahra Sadeghian, Mohammad Bayat
Summary: This review focuses on the recent reactions of isatin, especially in water and aqueous media, from 2018 to 2021, with an emphasis on green chemistry. It provides valuable insights and new ideas for further research.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Chemistry, Organic
Pedro Brandao, Adrian Puerta, Jose M. Padron, Maxim L. Kuznetsov, Anthony J. Burke, Marta Pineiro
Summary: Multicomponent reactions (MCRs) are valuable tools for synthesizing new molecules in a fast, effective, and environmentally friendly manner. This study introduces the first library of isatin-based Ugi 4 component reaction (U4CR) derivatives, showing promising antiproliferative activity in biological screening against tumor cell lines.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Hua Zhao, Yufen Zhao
Summary: Multicomponent reactions (MCRs) have become indispensable tools for organic chemists worldwide, finding extensive utility in the synthesis of complex natural products, heterocyclic molecules with significant bioactivity, and pharmaceutical agents. The multicomponent one-pot 1,3-dipolar cycloaddition reaction is highly favored in terms of green synthesis due to its high step- and atom-economies, remarkable product diversity, as well as excellent efficiency and diastereoselectivity.
Article
Chemistry, Organic
Mohammad Bayat, Vosough Saeni, Milad Masoumi, Fahimeh Sadat Hosseini
Summary: A series of potentially bioactive compounds with indole or indene frameworks were successfully synthesized through a multi-component reaction, offering advantages such as mild conditions, simple operation, and purification process without the need for chromatographic techniques.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Multidisciplinary
Robabeh Baharfar, Mohadeseh Verdian, Saadieh Mohajer
Summary: A novel method for the diastereoselective synthesis of spiro [indoline-3,2'-pyrrole] derivatives has been developed. The reaction involves a three-component reaction of isatin-based ketimines, pyridinium salts, and alkynes under low power microwave, leading to high yields in a short reaction time. This method offers environmentally friendly conditions and excellent yields.
Article
Chemistry, Multidisciplinary
Subramaniam Muthusamy, Nandarapu Kumarswamyreddy, Venkitasamy Kesavan
Summary: In this study, the organocatalytic Friedel-Crafts aminoalkylation reaction was demonstrated for the synthesis of biologically important hybrid molecular architectures. The reaction showed excellent yields and enantioselectivities of the desired products under mild reaction conditions.
Article
Chemistry, Organic
Suresh Kumar Maury, Sundaram Singh
Summary: A simple, efficient, and green method has been developed for the synthesis of spiro[indoline-3,4'-quinoline] derivatives. The method uses isatin, ethyl cyanoacetate/malononitrile, dimedone, and aniline as starting materials, with the green catalyst DABCO and green solvent ethanol. The method provides good to exceptional yields in a short reaction time and has a broad substrate scope, including gram scale reactions.
SYNTHESIS-STUTTGART
(2023)
Article
Medicine, Research & Experimental
Seyedmousa Motavallihaghi, Amir Hossein Maghsood, Davood Nematollahi, Nastaran Barati, Sara Soleimani Asl, Abbas Farmani, Faeze Foroughi-Parvar, Mohammad Fallah
Summary: This study investigated the potential protective role of DIM nanoparticles in a toxoplasmosis animal model, and found that nano-DIM can reduce the proliferation of intracellular parasites, reduce liver cell pathology, and alleviate oxidative stress.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Chemistry, Organic
Keshri Nath Tiwari, Darshana Bora, Garima Chauhan, Deepika Yadav, Kavita Sharma, Ashima Thakur, Lachhman Singh, Vishwadeep Tripathi
SYNTHETIC COMMUNICATIONS
(2016)
Article
Chemistry, Organic
Keshri Nath Tiwari, Taur Prakash Pandurang, Suyash Pant, Rahul Kumar
TETRAHEDRON LETTERS
(2016)
Article
Chemistry, Organic
Keshri Nath Tiwari, Mane Rajendra Uttam, Puja Kumari, Piyush Vatsa, S. M. Prabhakaran
SYNTHETIC COMMUNICATIONS
(2017)
Article
Chemistry, Organic
Keshri Nath Tiwari, Taur Prakash Pandurang, Suyash Pant, P. Sreelekha
SYNTHETIC COMMUNICATIONS
(2018)
Article
Chemistry, Organic
Keshri Nath Tiwari, S. M. Prabhakaran, Vaneet Kumar, Thakar Snehal Rajendra, Shintu Mathew
Article
Chemistry, Medicinal
Jean-Philippe Monserrat, Rasha I. Al-Safi, Keshri Nath Tiwari, Lionel Quentin, Guy G. Chabot, Anne Vessieres, Gerard Jaouen, Nouri Neamati, Elizabeth A. Hillard
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2011)
Article
Chemistry, Inorganic & Nuclear
Keshri Nath Tiwari, Jean-Philippe Monserrat, Arnaud Hequet, Carine Ganem-Elbaz, Thierry Cresteil, Gerard Jaouen, Anne Vessieres, Elizabeth A. Hillard, Claude Jolivalt
DALTON TRANSACTIONS
(2012)
Article
Chemistry, Inorganic & Nuclear
Jean-Philippe Monserrat, Keshri Nath Tiwari, Lionel Quentin, Pascal Pigeon, Gerard Jaouen, Anne Vessieres, Guy G. Chabot, Elizabeth A. Hillard
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2013)
Article
Chemistry, Inorganic & Nuclear
Keshri Nath Tiwari, Jean-Philippe Monserrat, Frederic de Montigny, Gerard Jaouen, Marie-Noelle Rager, Elizabeth Hillard
Article
Chemistry, Multidisciplinary
R. Chandran, S. M. Prabhakaran, Vaneet Kumar, Snehal Rajendra Thakar, Keshri Nath Tiwari
Article
Chemistry, Organic
Keshri Nath Tiwari, Rinku Choubey, Saumya Shukla, Parul Gautam
Article
Chemistry, Organic
Dilek Isik Tasgin, Irem Bayraktar
Summary: We present a synthetic method for pyrrolizine-3-one derivatives and investigate their photophysical properties. These compounds are prepared through a series of reactions involving substituted pyrroles in one-pot, two-step oxidation, and intramolecular cyclization processes. The photophysical properties of the synthesized compounds are studied using UV-Vis and fluorescence spectroscopy in various solvents. The introduction of pyrrolyl substituents has a significant impact on Stokes shifts and quantum yield values.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Satish Kumar Burra, Vaikunta Rao Lakinani, Raghunadh Akula, Chiranjeevi Yankkanti
Summary: A novel and green strategy for the construction of biologically relevant substituted indolyl-4H-chromenes scaffolds is reported, using L-proline as a catalyst and water as a promoter solvent. This catalytic system offers wider applicability, shorter reaction times, and high yields, making it an ideal condition for green chemistry.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Abouelhaoul El Alami, Amine El Maraghi, Fatima Youssoufi, Assiya Atif, Hamid Sdassi
Summary: Nitrobenzimidazoles have become increasingly important in the design of new compounds in medicinal, therapeutic and chemical fields. This review provides an overview of the synthesis strategies and biological activities of nitrobenzimidazole derivatives.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Nilesh Raghunath Khedkar, Alex Joseph, Milind Sindkhedkar
Summary: In this study, a new library of 3-(2-(pyrimidin-5-yl)thiazol-4-yl)-1,2,4-oxadiazole compounds was designed and synthesized as potential anticancer agents using in silico fragment-based drug design. The compounds were tested for their anticancer activity in vitro, and one compound exhibited excellent activity against multiple cancer cell lines.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Terungwa H. Iorkula, Bryce A. Tolman, Scott R. Burt, Matt A. Peterson
Summary: A new method for synthesizing C-6 substituted products has been discovered in this study, which utilizes lower doses of fluoride and CsF as a catalyst, with high reaction yields and cost-effectiveness under suitable conditions.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Ranjana Aggarwal, Swati Sharma
Summary: This review article mainly focuses on the synthesis of 3(5)-trifluoromethylpyrazoles via condensation reaction of trifluoromethyl-beta-diketones with hydrazines. It emphasizes the importance of fluorine-containing compounds and pyrazoles in the field of biology. The literature reported condensation reactions of trifluoromethyl-beta-diketones with hydrazines are covered.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
F. M. Alshareef, Sami A. Al-Harbi, Esam S. Allehyani, Omeima Abdullah, Magdy A. Ibrahim
Summary: This study aimed to construct a novel category of linear annulated chromeno[3',2':5,6]pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidines. The chemical reactivity of the synthesized compounds was investigated, and they showed significant antimicrobial activity against various strains.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Preethi Dhanapal, S. L. Manju
Summary: Thiazole based Schiff base scaffolds have become an integral part of drug development in recent years, playing a versatile role as building blocks for lead drug molecules. This study presents a facile one pot synthetic method for producing novel 4-aryl thiazoles with high yield, shorter reaction time, and milder conditions, without the need for catalysts or purification techniques.
SYNTHETIC COMMUNICATIONS
(2024)
