Recent Advances in Reactions Using Enaminone in Water or Aqueous Medium

Enaminones have in the past decade received renewed interest in organic synthesis by acting as highly versatile building blocks. Particularly, the featured amino and carbonyl group in the enaminone structure endow them with the ability of tolerating water via hydrogen bonding effect. Thus, designing synthetic methods in aqueous medium with enaminones as the main building blocks has received extensive attention and notable success. Based on our longstanding efforts and interests in enaminone chemistry, we review herein the research advances in enaminone participated organic synthesis in aqueous medium.

Automated summary

Enaminones have attracted renewed interest in organic synthesis for their versatility, especially their ability to tolerate water. Designing synthetic methods in aqueous medium using enaminones as building blocks has received extensive attention and notable success.