Medication Related Osteonecrosis of the Jaw: 2021 Position Statement of the Korean Society for Bone and Mineral Research and the Korean Association of Oral and Maxillofacial Surgeons

Is implant surgery a risk factor for osteonecrosis of the jaw in older adult patients with osteoporosis? A national cohort propensity score‐matched study

(2021) Jae‐In Ryu et al.   CLINICAL ORAL IMPLANTS RESEARCH

Oral risk factors associated with medication-related osteonecrosis of the jaw in patients with cancer

(2021) Nobuhiro Ueda et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Serum biomarkers for bisphosphonate-related osteonecrosis of the jaw: a prospective clinical study

(2021) Jung-Hyun Park et al.   OSTEOPOROSIS INTERNATIONAL

Machine Learning Approaches for Predicting Bisphosphonate-Related Osteonecrosis in Women with Osteoporosis Using VEGFA Gene Polymorphisms

(2021) Jin-Woo Kim et al.   Journal of Personalized Medicine

Alveolar bone histological necrosis observed prior to extractions in patients, who received bone‐targeting agents

(2020) Ourania Nicolatou‐Galitis et al.   ORAL DISEASES

Teriparatide Promotes Bone Healing in Medication-Related Osteonecrosis of the Jaw: A Placebo-Controlled, Randomized Trial

(2020) Ie-Wen Sim et al.   JOURNAL OF CLINICAL ONCOLOGY

Therapeutic approach and management algorithms in medication-related osteonecrosis of the jaw (MONJ): recommendations of a multidisciplinary group of experts

(2020) Monique Chalem et al.   Archives of Osteoporosis

Incidence of and risk for osteonecrosis of the jaw in Korean osteoporosis patients treated with bisphosphonates: A nationwide cohort-study

(2020) Se Hwa Kim et al.   BONE

Does inflammatory dental disease affect the development of medication-related osteonecrosis of the jaw in patients using high-dose bone-modifying agents?

(2020) Nobuhiro Ueda et al.   Clinical Oral Investigations

Teriparatide Did Not Increase Adult Osteosarcoma Incidence in a 15‐Year US Postmarketing Surveillance Study

(2020) Alicia Gilsenan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020

(2020) Giuseppina Campisi et al.   International Journal of Environmental Research and Public Health

Prevalence of medication related osteonecrosis of the jaw in patients treated with sequential antiresorptive drugs: systematic review and meta-analysis

(2020) Akanksha Srivastava et al.   SUPPORTIVE CARE IN CANCER

Medication-Related Osteonecrosis of the Jaw: MASCC/ISOO/ASCO Clinical Practice Guideline

(2019) Noam Yarom et al.   JOURNAL OF CLINICAL ONCOLOGY

Serum C-terminal cross-linking telopeptide level as a predictive biomarker of osteonecrosis after dentoalveolar surgery in patients receiving bisphosphonate therapy

(2019) Mohamed E. Awad et al.   JOURNAL OF THE AMERICAN DENTAL ASSOCIATION

Risk-reductive dental strategies for medication related osteonecrosis of the jaw among cancer patients: A systematic review with meta-analyses

(2018) Harry Karna et al.   ORAL ONCOLOGY

The effect of antiresorptive drugs on implant therapy: Systematic review and meta-analysis

(2018) Andreas Stavropoulos et al.   CLINICAL ORAL IMPLANTS RESEARCH

Evaluation of medication-related osteonecrosis of the jaw using the Japanese Adverse Drug Event Report database

(2018) Ayaka Inada et al.   Therapeutics and Clinical Risk Management

Short-Term Teriparatide and Recombinant Human Bone Morphogenetic Protein-2 for Regenerative Approach to Medication-Related Osteonecrosis of the Jaw: A Preliminary Study

(2017) Junho Jung et al.   JOURNAL OF BONE AND MINERAL RESEARCH

SIRT1/HERC4 Locus Associated With Bisphosphonate-Induced Osteonecrosis of the Jaw: An Exome-Wide Association Analysis

(2017) Guang Yang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Vertebral Fractures After Discontinuation of Denosumab: A Post Hoc Analysis of the Randomized Placebo-Controlled FREEDOM Trial and Its Extension

(2017) Steven R Cummings et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Does the Addition of Bone Morphogenetic Protein 2 to Platelet-Rich Fibrin Improve Healing After Treatment for Medication-Related Osteonecrosis of the Jaw?

(2017) Jung-Hyun Park et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Risk factors for medication-related osteonecrosis of the jaws: A systematic review

(2017) K McGowan et al.   ORAL DISEASES

10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension

(2017) Henry G Bone et al.   Lancet Diabetes & Endocrinology

Role of microcracks in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw

(2016) Jin-Woo Kim et al.   Clinical Oral Investigations

Antiresorptive agent-related osteonecrosis of the jaw: Position Paper 2017 of the Japanese Allied Committee on Osteonecrosis of the Jaw

(2016) Toshiyuki Yoneda et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Impact of Osteonecrosis of the Jaw on Osteoporosis Treatment in Japan: Results of a Questionnaire-Based Survey by the Adequate Treatment of Osteoporosis (A-TOP) Research Group

(2015) Akira Taguchi et al.   CALCIFIED TISSUE INTERNATIONAL

Biomarkers for Bisphosphonate-Related Osteonecrosis of the Jaw

(2015) Jin-Woo Kim et al.   Clinical Implant Dentistry and Related Research

Temporal Correlation Between Bisphosphonate Termination and Symptom Resolution in Osteonecrosis of the Jaw: A Pooled Case Report Analysis

(2015) Andrew M. Hinson et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Safety of long-term denosumab therapy: results from the open label extension phase of two phase 3 studies in patients with metastatic breast and prostate cancer

(2015) Alison T. Stopeck et al.   SUPPORTIVE CARE IN CANCER

Osteonecrosis of the jaw in patients with dental prostheses being treated with bisphosphonates or denosumab

(2015) Kunimichi Niibe et al.   Journal of Prosthodontic Research

Leucocyte-rich and platelet-rich fibrin for the treatment of bisphosphonate-related osteonecrosis of the jaw: a prospective feasibility study

(2014) Jin-Woo Kim et al.   BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY

Diagnosis and Management of Osteonecrosis of the Jaw: A Systematic Review and International Consensus

(2014) Aliya A Khan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

American Association of Oral and Maxillofacial Surgeons Position Paper on Medication-Related Osteonecrosis of the Jaw—2014 Update

(2014) Salvatore L. Ruggiero et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Bisphosphonate Use and the Risk of Adverse Jaw Outcomes

(2014) Vassiliki M. Cartsos et al.   JOURNAL OF THE AMERICAN DENTAL ASSOCIATION

Microbial Biofilms in Osteomyelitis of the Jaw and Osteonecrosis of the Jaw Secondary to Bisphosphonate Therapy

(2014) Parish P. Sedghizadeh et al.   JOURNAL OF THE AMERICAN DENTAL ASSOCIATION

Managing the care of patients receiving antiresorptive therapy for prevention and treatment of osteoporosis

(2014) John W. Hellstein et al.   JOURNAL OF THE AMERICAN DENTAL ASSOCIATION

Assessing the association between bisphosphonate exposure and delayed mucosal healing after tooth extraction

(2014) Cesar A. Migliorati et al.   JOURNAL OF THE AMERICAN DENTAL ASSOCIATION

Distinctive role of 6-month teriparatide treatment on intractable bisphosphonate-related osteonecrosis of the jaw

(2014) K. M. Kim et al.   OSTEOPOROSIS INTERNATIONAL

Three-year denosumab treatment in postmenopausal Japanese women and men with osteoporosis: results from a 1-year open-label extension of the Denosumab Fracture Intervention Randomized Placebo Controlled Trial (DIRECT)

(2014) T. Sugimoto et al.   OSTEOPOROSIS INTERNATIONAL

Prospective biomarker evaluation in patients with osteonecrosis of the jaw who received bisphosphonates

(2013) Jin-Woo Kim et al.   BONE

Combination of Zoledronic Acid and Targeted Therapy Is Active But May Induce Osteonecrosis of the Jaw in Patients With Metastatic Renal Cell Carcinoma

(2013) Torben Smidt-Hansen et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Oral Health Risk Factors for Bisphosphonate-Associated Jaw Osteonecrosis

(2013) Claudine Tsao et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Early Inhibitory Effects of Zoledronic Acid in Tooth Extraction Sockets in Dogs Are Negated by Recombinant Human Bone Morphogenetic Protein

(2013) David A. Gerard et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Osteonecrosis of the Jaw in Sweden Associated With the Oral Use of Bisphosphonate

(2013) Mattias Ulmner et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Efficacy and safety of 12-weekly versus 4-weekly zoledronic acid for prolonged treatment of patients with bone metastases from breast cancer (ZOOM): a phase 3, open-label, randomised, non-inferiority trial

(2013) Dino Amadori et al.   LANCET ONCOLOGY

Osteonecrosis of the jaw – Prevention and treatment strategies for oral health professionals

(2013) Nicole V. Hinchy et al.   ORAL ONCOLOGY

Comparison of nonexposed and exposed bisphosphonate-induced osteonecrosis of the jaws: a retrospective analysis from the Copenhagen cohort and a proposal for an updated classification system

(2013) Morten Schiodt et al.   Oral Surgery Oral Medicine Oral Pathology Oral Radiology

The effects of osteoclast modifiers on the oral cavity

(2013) Matthew S. Epstein et al.   Current Opinion in Supportive and Palliative Care

Intravenous Bisphosphonates for Postmenopausal Osteoporosis: Safety Profiles of Zoledronic Acid and Ibandronate in Clinical Practice

(2012) Patricia Sieber et al.   CLINICAL DRUG INVESTIGATION

Osteonecrosis associated with dental implants in patients undergoing bisphosphonate treatment

(2012) Tae-Geon Kwon et al.   CLINICAL ORAL IMPLANTS RESEARCH

Osteopathology induced by bisphosphonates and dental implants: clinical observations

(2012) Christine Jacobsen et al.   Clinical Oral Investigations

Increased incidence of osteonecrosis of the jaw after tooth extraction in patients treated with bisphosphonates: a cohort study

(2012) T. Yamazaki et al.   INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis

(2012) Robinder S Dhillon et al.   JOURNAL OF BONE AND MINERAL RESEARCH

What Is the Role of Hyperbaric Oxygen in the Management of Bisphosphonate-Related Osteonecrosis of the Jaw: A Randomized Controlled Trial of Hyperbaric Oxygen as an Adjunct to Surgery and Antibiotics

(2012) John J. Freiberger et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Osteonecrosis and atypical fractures—common origins?

(2012) G. Subramanian et al.   OSTEOPOROSIS INTERNATIONAL

Short-term teriparatide therapy as an adjunctive modality for bisphosphonate-related osteonecrosis of the jaws

(2012) Y.-D. Kwon et al.   OSTEOPOROSIS INTERNATIONAL

Incidence of osteonecrosis of the jaw among users of bisphosphonates with selected cancers or osteoporosis

(2012) Patricia Tennis et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Incidence of serious side effects with intravenous bisphosphonate: a clinical audit

(2012) D. Powell et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Antiresorptives and Osteonecrosis of the Jaw

(2012) Junro Yamashita et al.   Journal of Evidence-Based Dental Practice

A Retrospective Study Evaluating Frequency and Risk Factors of Osteonecrosis of the Jaw in 576 Cancer Patients Receiving Intravenous Bisphosphonates

(2011) Vivek Thumbigere-Math et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases

(2011) F. Saad et al.   ANNALS OF ONCOLOGY

Potential pathophysiological mechanisms in osteonecrosis of the jaw

(2011) Regina Landesberg et al.   Annals of the New York Academy of Sciences

Treatment of bisphosphonate-related osteonecrosis of the jaws: presentation of a protocol and an observational longitudinal study of an Italian series of cases

(2011) Sebastiano Ferlito et al.   BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY

An epidemiological study of alendronate-related osteonecrosis of the jaws. A case series from the south-east of Scotland with attention given to case definition and prevalence

(2011) Nick Malden et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Effects of Denosumab Treatment and Discontinuation on Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women with Low Bone Mass

(2011) Henry G. Bone et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

ONJ in Two Dental Practice-Based Research Network Regions

(2011) J.L. Fellows et al.   JOURNAL OF DENTAL RESEARCH

Nationwide Survey for Bisphosphonate-Related Osteonecrosis of the Jaws in Japan

(2011) Masahiro Urade et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Bisphosphonates-related osteonecrosis of the jaws: a concise review of the literature and a report of a single-centre experience with 151 patients

(2011) Paolo Vescovi et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Bisphosphonate-associated Osteonecrosis of the Jaw in Ontario: A Survey of Oral and Maxillofacial Surgeons

(2011) A. A. KHAN et al.   JOURNAL OF RHEUMATOLOGY

Epidemiology and pathogenesis of osteonecrosis of the jaw

(2011) Ian R. Reid et al.   Nature Reviews Rheumatology

The effects of bisphosphonates on jaw bone remodeling, tissue properties, and extraction healing

(2011) Matthew R. Allen   Odontology

Pathophysiology of atypical femoral fractures and osteonecrosis of the jaw

(2011) J. Compston   OSTEOPOROSIS INTERNATIONAL

Nonexposed Variant of Bisphosphonate-associated Osteonecrosis of the Jaw: A Case Series

(2010) Stefano Fedele et al.   AMERICAN JOURNAL OF MEDICINE

Bevacizumab and osteonecrosis of the jaw: incidence and association with bisphosphonate therapy in three large prospective trials in advanced breast cancer

(2010) Valentina Guarneri et al.   BREAST CANCER RESEARCH AND TREATMENT

Effect of Zoledronate on Oral Wound Healing in Rats

(2010) Junro Yamashita et al.   CLINICAL CANCER RESEARCH

Retrospective study of two biochemical markers for the risk assessment of oral bisphosphonate-related osteonecrosis of the jaws: can they be utilized as risk markers?

(2010) Yong-Dae Kwon et al.   CLINICAL ORAL IMPLANTS RESEARCH

Successful treatment of advanced bisphosphonate-related osteonecrosis of the mandible with adjunctive teriparatide therapy

(2010) Jang-Jaer Lee et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology, and Japanese Society of Oral and Maxillofacial Surgeons

(2010) Toshiyuki Yoneda et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Bisphosphonate-Related Osteonecrosis of the Jaw Associated With Dental Implants

(2010) Towy Sorel Lazarovici et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Inhibition of Necrotic Actions of Nitrogen-Containing Bisphosphonates (NBPs) and Their Elimination From Bone by Etidronate (a Non-NBP): A Proposal for Possible Utilization of Etidronate as a Substitution Drug for NBPs

(2010) Takefumi Oizumi et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Osteonecrosis of the Jaw in a Patient on Denosumab

(2010) Tara L. Aghaloo et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Teriparatide and Osseous Regeneration in the Oral Cavity

(2010) Jill D. Bashutski et al.   NEW ENGLAND JOURNAL OF MEDICINE

Teriparatide Therapy for Alendronate-Associated Osteonecrosis of the Jaw

(2010) Ada Cheung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Predicting risk for bisphosphonate-related osteonecrosis of the jaws: CTX versus radiographic markers

(2010) Kenneth E. Fleisher et al.   ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS

Sunitinib may raise the risk of bisphosphonate-related osteonecrosis of the jaw: presentation of three cases

(2010) Sebastian Hoefert et al.   ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS

Treatment outcomes in patients with bisphosphonate-related osteonecrosis of the jaws: a prospective study

(2010) Matteo Scoletta et al.   ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS

A SNP in CYP2C8 is not associated with the development of bisphosphonate-related osteonecrosis of the jaw in men with castrate-resistant prostate cancer

(2010) Sissung et al.   Therapeutics and Clinical Risk Management

Bisphosphonate-associated osteonecrosis of the jaw: A key role of inflammation?

(2009) Philippe Lesclous et al.   BONE

Osteonecrosis of the jaws induced by anti-RANK ligand therapy

(2009) K.H. Taylor et al.   BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY

Importance of microcracks in etiology of bisphosphonate-related osteonecrosis of the jaw: a possible pathogenetic model of symptomatic and non-symptomatic osteonecrosis of the jaw based on scanning electron microscopy findings

(2009) Sebastian Hoefert et al.   Clinical Oral Investigations

Cancer treatment dosing regimens of zoledronic acid result in near-complete suppression of mandible intracortical bone remodeling in beagle dogs

(2009) Matthew R Allen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Teriparatide for acceleration of fracture repair in humans: A prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures

(2009) Per Aspenberg et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Intravenous Bisphosphonate-Related Osteonecrosis of the Jaw: Bone Scintigraphy as an Early Indicator

(2009) Felice S. O'Ryan et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

The Role of Surgical Resection in the Management of Bisphosphonate-Related Osteonecrosis of the Jaws

(2009) Eric R. Carlson et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

The Pathogenesis of Bisphosphonate-Related Osteonecrosis of the Jaw: So Many Hypotheses, So Few Data

(2009) Matthew R. Allen et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Correlation Between Serum C-Terminal Cross-Linking Telopeptide of Type I Collagen and Staging of Oral Bisphosphonate-Related Osteonecrosis of the Jaws

(2009) Yong-Dae Kwon et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Prevalence of Osteonecrosis of the Jaw in Patients With Oral Bisphosphonate Exposure

(2009) Joan C. Lo et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis

(2009) Steven R. Cummings et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral bisphosphonate-related osteonecrosis of the jaw: the first report in Asia

(2009) J. W. Hong et al.   OSTEOPOROSIS INTERNATIONAL

Osteonecrosis of the jaw induced by oral administration of bisphosphonates in Asian population: five cases

(2009) W. Park et al.   OSTEOPOROSIS INTERNATIONAL

Reduction of osteonecrosis of the jaw (ONJ) after implementation of preventive measures in patients with multiple myeloma treated with zoledronic acid

(2008) M. A. Dimopoulos et al.   ANNALS OF ONCOLOGY

Decreased occurrence of osteonecrosis of the jaw after implementation of dental preventive measures in solid tumour patients with bone metastases treated with bisphosphonates. The experience of the National Cancer Institute of Milan

(2008) C. I. Ripamonti et al.   ANNALS OF ONCOLOGY

Osteonecrosis of the jaw — Who gets it, and why?

(2008) Ian R. Reid   BONE

Bisphosphonates and Osteonecrosis of the Jaw: Moving from the Bedside to the Bench

(2008) Matthew R. Allen   CELLS TISSUES ORGANS

A probable case of oral bisphosphonate-associated osteonecrosis of the jaw and recovery with parathyroid hormone treatment

(2008) Kyung-Eun Song et al.   CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL

Teriparatide

(2008) Stephanie K A Blick et al.   DRUGS

Frequency and Risk Factors Associated With Osteonecrosis of the Jaw in Cancer Patients Treated With Intravenous Bisphosphonates

(2008) Ana O Hoff et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Collagen telopeptide (serum CTX) and its relationship with the size and number of lesions in osteonecrosis of the jaws in cancer patients on intravenous bisphosphonates

(2008) Jose V. Bagan et al.   ORAL ONCOLOGY

Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy

(2008) R. G. G. Russell et al.   OSTEOPOROSIS INTERNATIONAL