Article
Multidisciplinary Sciences
Milad Etemadi Sh, Farnaz Shooshtarian, Golnaz Tajmiri, MohammadSoroush Sehat
Summary: The present experiment aimed to assess the preventive effects of L-PRF on osteonecrosis of the jaw in rats. The application of L-PRF resulted in a significant reduction in osteonecrosis centers and the number of osteoclast cells. Therefore, it can be inferred that possible preventive effects on the clinical occurrence of osteonecrosis could be expected from the application of L-PRF.
Article
Orthopedics
Yuta Nakanishi, Takehiko Matsushita, Kanto Nagai, Daisuke Araki, Yuichi Hoshino, Ryosuke Kuroda
Summary: This pilot study compares the release of growth factors from fibrin clot (FC) and leukocyte-rich platelet-rich fibrin (L-PRF) used in knee arthroscopic surgery for meniscal repair. The study found no significant difference in the amount and pattern of growth factor release between FC and L-PRF during the two-week observation period.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Benjie Law, Hui Yuh Soh, Syed Nabil, Rama Krsna Rajandram, Abd Jabar Nazimi, Roszalina Ramli
Summary: The study successfully treated eight cases of ORN and MRONJ with a combination of sequestrectomy and L-PRF, achieving an overall success rate of 87.5%. Using L-PRF as an adjunct allowed for predictable management of ORN and MRONJ without significant morbidity.
APPLIED SCIENCES-BASEL
(2021)
Article
Pharmacology & Pharmacy
Guang Yang, Sonal Singh, Caitrin W. McDonough, Jatinder K. Lamba, Issam Hamadeh, L. Shannon Holliday, Danxin Wang, Joseph Katz, Peter A. Lakatos, Bernadett Balla, Janos P. Kosa, Gian Andrea Pelliccioni, Douglas K. Price, Sara L. Van Driest, William D. Figg, Taimour Langaee, Jan S. Moreb, Yan Gong
Summary: The study identified a lead SNP, rs2736308 on chromosome 8, associated with an increased risk of MRONJ in patients with cancer and osteoporosis. This SNP is linked to genes regulating bone mineral density, providing insights into the potential mechanism of MRONJ.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Surgery
Aneliza de Fatima Moraes-da-Silva, Gustavo Maluf, Izabel Regina Fischer Rubira-Bullen, Paulo Sergio da Silva Santos
Summary: This case report explores the use of leukocyte and platelet-rich fibrin combined with rhBMP-2 to treat medication-related osteonecrosis of the jaw and shows promising results in complete healing of the condition.
JOURNAL OF CRANIOFACIAL SURGERY
(2023)
Article
Medicine, General & Internal
Sebastian Blatt, Maximilian Krueger, Peer W. Kaemmerer, Daniel G. E. Thiem, Philipp Matheis, Anne-Katrin Eisenbeiss, Joerg Wiltfang, Bilal Al-Nawas, Hendrik Naujokat
Summary: The study concluded that PRF as an adjunct did not significantly optimize wound healing in patients with MRONJ. There were no significant changes in downstaging, pain sensation, or oral health-related quality of life observed with the addition of PRF in surgical therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yesel Kim, Jeong-Kui Ku
Summary: This study successfully established a MRONJ rat model on the calvaria, which mimicked the characteristics of MRONJ and can be used for developing treatments for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Michele Miranda, Francesco Gianfreda, Carlo Raffone, Donato Antonacci, Valeria Pistilli, Patrizio Bollero
Summary: The study found that inserting a PRF plug after tooth extraction can effectively prevent the onset of MRONJ, especially in patients with systemic diseases. While the control group had cases of MRONJ, the study group that received PRF did not report any. Patients who developed MRONJ often had low levels of CTX. Using platelet concentrates in high-risk MRONJ patients is a cost-effective technique in oral surgery.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Kota Morishita, Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Miho Sasaki, Yukinori Takagi, Misa Sumi, Masahiro Umeda
Summary: The study found that a drug holiday of 3 months for medication-related osteonecrosis of the jaw in osteoporosis patients receiving antiresorptive agents does not promote sequestra separation or improve treatment outcomes, and early surgical therapy is recommended.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
George Adrian Ciobanu, Adrian Camen, Mihaela Ionescu, Daniel Vlad, Cristina Maria Munteanu, Mircea Ionut Gheorghita, Cristian Virgil Lungulescu, Ionela Elisabeta Staicu, Elena Claudia Sin, Luminita Chivu, Razvan Mercut, Sanda Mihaela Popescu
Summary: This study aimed to establish the importance of risk factors in the development of MRONJ in cancer patients receiving zoledronic acid therapy. The analysis of 174 cancer patients revealed that treatment duration, chemotherapy, and hypertension were risk factors, while endocrine therapy and obesity were protective factors for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Xian Dong, Linhai He, Xiaolong Zang, Yang He, Jingang An, Baoping Wu, Xinhua Liu, Hongsen Bi, Yi Zhang, E. Xiao
Summary: This study found that local transplantation of ADSCs can effectively promote bone healing in BRONJ. The mechanism involves ADSCs promoting bone coupling through TGF-beta 1 activation, significantly rescuing necrotic jawbones in BRONJ and animal model jawbone samples.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Xin Chen, Weiwen Zhu, Rongyao Xu, Xin Shen, Yu Fu, Jie Cheng, Laikui Liu, Hongbing Jiang
Summary: This study revealed that long-term use of bisphosphonates such as Zoledronic Acid (ZA) may lead to Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) by inhibiting macrophage efferocytosis and promoting osteocytic apoptosis. Additionally, supplementing with geranylgeraniol (GGOH) can restore Rac1 homeostasis and rescue macrophage efferocytosis, potentially providing a new treatment approach for BRONJ.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kyeong-Mee Park, Namkwon Lee, Jaeyeon Kim, Hyun Sil Kim, Wonse Park
Summary: This study aimed to investigate the preventive effect of teriparatide (TPD) administration on medication-related osteonecrosis of the jaw (MRONJ) before tooth extraction. The results showed that TPD reduced the occurrence of MRONJ in rats treated with zoledronic acid.
SCIENTIFIC REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
C. G. J. Monteiro, E. M. Vieira, C. Emerick, R. S. Azevedo, V. A. B. Pascoal, N. Homsi, R. X. Lins
Summary: The study aimed to evaluate the preventive effect of ozonated oil on the development of MRONJ-like lesions at tooth extraction sites in rats receiving zoledronic acid treatment. While there was no statistically significant difference in the average area of vital and necrotic bone between the groups, ozonated oil appeared to reduce osteonecrosis development. Further research is needed to confirm these findings.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Chemistry, Medicinal
Jung Sun Kim, Jin Woo Kim, Jeong Yee, Sun Jong Kim, Jee Eun Chung, Hye Sun Gwak
Summary: This study aimed to investigate the relationship between PPARγ and PPARGC1A polymorphisms and the development of BRONJ in female osteoporosis patients undergoing bisphosphonate treatment. The results showed that PPARGC1A rs2946385 and rs10020457 polymorphisms were significantly associated with BRONJ. Patients with the combined genotypes of GG in both PPARγ rs1151999 and PPARGC1A rs2946385 had a higher risk of BRONJ. Old age (≥70 years) and long duration of bisphosphonate use (≥60 months) also increased the risk of BRONJ.
Article
Dentistry, Oral Surgery & Medicine
H. J. Yu, S. R. Cho, M. J. Kim, W. H. Kim, J. W. Kim, J. Choi
JOURNAL OF DENTAL RESEARCH
(2020)
Article
Dentistry, Oral Surgery & Medicine
Jeong-Hoon Lee, Hee-Jin Yu, Min-ji Kim, Jin-Woo Kim, Jongeun Choi
Article
Clinical Neurology
Hyo-Jung Kim, JaeHan Park, Ji-Soo Kim
Summary: This review discusses recent advances in the diagnosis and management of Benign Paroxysmal Positional Vertigo (BPPV), including the use of web-based technology and artificial intelligence, as well as the evidence supporting the use of vitamin D supplements for patients with BPPV and subnormal serum vitamin D levels.
JOURNAL OF NEUROLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Young Long Park, Sura Cho, Jin-Woo Kim
Summary: This case involves a 71-year-old male with mucormycosis-induced maxillary osteonecrosis extending to the cranial base. After confirmation through biopsy, the patient underwent surgical intervention and showed full recovery at the 4-week follow-up. Proper diagnosis, timely treatment, and combination therapy are crucial in managing such cases.
Article
Endocrinology & Metabolism
Jung-Hyun Park, Sura Cho, Sun-Jong Kim, Tae-Dong Jeong, Yeung-Chul Mun, Jin-Woo Kim
Summary: This prospective study identified specific biomarkers (TRACP 5b and DKK1) with abnormal serum levels in patients at risk of ONJ, before and after dentoalveolar surgery. These biomarkers could be used for close monitoring to prevent and diagnose ONJ early.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Health Care Sciences & Services
Jin-Woo Kim, Jeong Yee, Sang-Hyeon Oh, Sun-Hyun Kim, Sun-Jong Kim, Jee-Eun Chung, Hye-Sun Gwak
Summary: The study identified a significant association between VEGFA polymorphisms and BRONJ occurrence, with age and duration of bisphosphonate exposure as important risk factors. Machine learning algorithms showed high predictive performance for assessing BRONJ risk.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ji-Hoi Kim, Jung-Hyun Park, Jin-Woo Kim, Sun-Jong Kim
Summary: Ultrasonography can be used to assess the capsular width in painful TMJs, which were found to be wider compared to painless TMJs. Capsular width is a risk factor for TMJ pain and is significantly correlated with pain scores, suggesting a potential link between pain intensity and widened capsular width.
Article
Environmental Sciences
Yoonkyung Chang, Jimin Jeon, Jin-Woo Kim, Tae-Jin Song, Jinkwon Kim
Summary: Oral diseases like periodontitis and dental caries can lead to systemic inflammation and obesity. The presence of periodontitis, dental caries, and tooth loss are associated with higher BMI, while frequent tooth brushing may be related to lower BMI. Further research is needed to explore the relationship between oral health behavior, dental disease, and obesity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Health Care Sciences & Services
Minji Kim, Jingwen Li, Sehyang Kim, Wonho Kim, Sun-Hyun Kim, Sung-Min Lee, Young Long Park, Sook Yang, Jin-Woo Kim
Summary: This study utilized preoperative simulation and 3D titanium printing to fabricate and place customized BAMP devices precisely for treating skeletal Class III malocclusion. The growth modification effect was successful, with decreased ANB difference and Wits appraisal after 2 years, indicating accurate placement of the devices at planned locations.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Kang-Min Kim, Sehyang Kim, Hyun Hwang, Hey-Yun Kim, Dohyun Kim, Jung-Hyun Park, HyeRan Choo, Jin-Woo Kim
Summary: This case-control study examined the therapeutic effects of daily or weekly administration of teriparatide in the management of medication-related osteonecrosis of the jaw (MRONJ). The results showed that both daily and weekly injection groups had significantly faster healing compared to the control groups. Complete resolution of MRONJ was more likely in participants who received teriparatide injections.
Review
Cell Biology
Hyung-Jin Won, Jin-Woo Kim, Hyung-Sun Won, Jeong-Oh Shin
Summary: Palatogenesis is a complex process involving various morphogenetic events that form the palate. Disruptions in these processes often result in cleft palate, a congenital abnormality. Recent investigations have identified transcription factors and signaling pathways that regulate palatogenesis, providing insights into gene regulatory networks and facilitating the development of better treatments for cleft palate.
Article
Chemistry, Medicinal
Jung Sun Kim, Jin Woo Kim, Jeong Yee, Sun Jong Kim, Jee Eun Chung, Hye Sun Gwak
Summary: This study aimed to investigate the relationship between PPARγ and PPARGC1A polymorphisms and the development of BRONJ in female osteoporosis patients undergoing bisphosphonate treatment. The results showed that PPARGC1A rs2946385 and rs10020457 polymorphisms were significantly associated with BRONJ. Patients with the combined genotypes of GG in both PPARγ rs1151999 and PPARGC1A rs2946385 had a higher risk of BRONJ. Old age (≥70 years) and long duration of bisphosphonate use (≥60 months) also increased the risk of BRONJ.
Article
Dentistry, Oral Surgery & Medicine
Kang-min Kim, Soo-young Choi, Jung-Hyun Park, Heon-Young Kim, Sun-Jong Kim, Jin-Woo Kim
Summary: The study aimed to determine the increase and retention rate of bone height or width in patients who received extensive bone augmentation and analyze factors affecting its prognosis and stability. The results showed that extensive bone augmentation achieved a significant increase in bone height or width, and the retention rate after 6 months was high. Moreover, surgery in the maxillary region was more successful than in the mandible, with a higher maintenance rate and fewer cases of dehiscence.
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jiyeon Kim, Heon-Young Kim, Won-Ho Kim, Jin-Woo Kim, Min-Ji Kim
Article
Dentistry, Oral Surgery & Medicine
Jung-Hyun Park, Michidgerel Odkhuu, Sura Cho, Jingwen Li, Bo-Young Park, Jin-Woo Kim
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY
(2020)
