Review
Surgery
Owen Tsung Wen Ho, Winston Cheng Ann Ng, Zachariah Gene Wing Ow, Yeung Jek Ho, Wen Hui Lim, Jie Ning Yong, Renaeta Shiqi Wang, Keng Lin Wong, Cheng Han Ng, Mark D. Muthiah, Claire Min-Li Teo
Summary: Both oral and IV bisphosphonates are effective in reducing fracture incidence post-OLT compared to calcium and vitamin D. Oral formulations may also have an advantage over IV in reducing bone loss and fracture incidence post-OLT.
TRANSPLANT INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
Kaleen N. Hayes, Ulrike Baschant, Barbara Hauser, Andrea M. Burden, Elizabeth M. Winter
Summary: GIOP, caused by chronic GC therapy, can lead to fractures in up to 40% of patients if untreated. Low awareness among clinicians and lack of clear guidelines on when to start and stop anti-osteoporosis treatment are major barriers to preventing fractures in patients with GC use. This review summarizes current evidence and provides considerations for the duration of anti-osteoporosis treatment in GC patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Hematology
Toby A. Eyre, Paw Jensen, Stephen Booth, Tarec Christoffer El-Galaly
Summary: With the improvement of survival outcomes for lymphoma patients, the focus on reducing long-term complications of therapy, such as glucocorticoid-induced osteoporosis (GIO), has increased. This review summarizes the pathophysiology of GIO, the risk of GIO in observational studies, and the efficacy of prophylactic measures from clinical trials, providing recommendations for GIO risk assessment and management in lymphoma based on current literature.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Review
Oncology
Jinyoung Kim, Chaiho Jeong, Jeongmin Lee, Jeonghoon Ha, Ki-Hyun Baek, Seohyun Kim, Tai Joon An, Chan Kwon Park, Hyoung Kyu Yoon, Jeong Uk Lim
Summary: This study discusses the common complications associated with bone metastases in lung cancer patients and the efficacy of bone-modifying agents in reducing skeletal-related events and improving outcomes. It also explores the combined effects of bone-modifying agents with radiotherapy or immunotherapy.
SEMINARS IN ONCOLOGY
(2023)
Article
Geriatrics & Gerontology
Mary E. Walsh, Mari Nerdrum, Tom Fahey, Frank Moriarty
Summary: Initiation of bone-health medication in older patients is associated with factors such as female sex, older age, state-funded health cover, and osteoporosis. High fracture risk for hip and all fractures, previous fracture, rheumatoid arthritis, corticosteroid use, and certain comorbidities are also associated with medication initiation. Undertreatment remains a concern, particularly in older patients with multiple conditions.
Article
Endocrinology & Metabolism
Mary E. Walsh, Tom Fahey, Frank Moriarty
Summary: The study found suboptimal persistence rates for oral bisphosphonates and denosumab in older primary care patients, with less than half of patients continuing treatment at 2 years. Factors associated with discontinuation included age, number of medications, and health coverage. Few patients switched to alternative therapy, which could increase fracture risk.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Rheumatology
Koshiro Sonomoto, Shingo Nakayamada, Yoshihisa Fujino, Hiroko Miyata, Satoshi Kubo, Yuya Fujita, Yoshino Inoue, Satsuki Matsunaga, Shigeru Iwata, Kentaro Hanami, Yasuyuki Todoroki, Hiroko Yoshinari-Korekoda, Akio Kawabe, Ayako Yamaguchi, Masanobu Ueno, Yurie Satoh-Kanda, Ryuichiro Kanda, Masashi Funada, Naoaki Ohkubo, Katsuhide Kusaka, Shumpei Kosaka, Atsushi Nagayasu, Shunsuke Fukuyo, Masao Nawata, Yusuke Miyazaki, Mikiko Tokunaga, Kenichi Tanaka, Yosuke Okada, Yoshiya Tanaka
Summary: This study aimed to investigate the effects of biological/target synthesized DMARDs (b/tsDMARDs) on bone metabolism in patients with rheumatoid arthritis (RA). The results showed that without anti-osteoporotic treatment, b/tsDMARDs treatment could lead to the progression of osteoporosis in RA patients. Bone turnover markers (BTMs) may not be able to reflect changes in bone mineral density (BMD). Therefore, regular monitoring of BMD in RA patients is recommended for early management of osteoporosis.
Article
Materials Science, Characterization & Testing
Chunlan Jing, Shenmao Chen, Sehajdev Singh Bhatia, Bowen Li, Hongze Liang, Chaozong Liu, Zhenjiang Liang, Junying Liu, Haiyan Li, Ziyu Liu, Hui Tan, Lingling Zhao
Summary: Bone-targeted polymeric nanoparticles for alendronate delivery were fabricated and shown to have sustained release and good cytocompatibility, with high affinity to bone cells.
Article
Endocrinology & Metabolism
Shan Shan Qi, Meng Li Shao, Ze Sun, Si Min Chen, Ying Jun Hu, Xin Sheng Li, De Jing Chen, Hong Xing Zheng, Tian Li Yue
Summary: Chondroitin sulfate can prevent diabetic osteoporosis by reducing blood glucose, improving bone density and microstructure, alleviating inflammation and oxidative stress, and regulating bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Ji Hyun Lee, JooYong Park, Jung Hee Kim, Ji-Yeob Choi, Hyung Jin Choi, Eu Jeong Ku, A. Ram Hong, Chan Soo Shin, Nam H. Cho
Summary: This Korean prospective cohort study found that decreasing waist circumference and lean muscle mass loss were significant risk factors for hip bone loss in both men and women. Other factors may have sex-specific or age-specific effects on hip bone loss. None of the genetic factors tested were associated with hip bone loss after multiple testing adjustments, indicating that modifiable factors may play a larger role in determining bone health.
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: Bone mineral density (BMD) loss shows greater variability at shorter testing intervals, but this variability diminishes over longer intervals. Using reports of rapid BMD loss as an indication for antifracture medication initiation may not be accurate.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: This study examined medication adherence in women with osteoporosis before and after a fracture. The results show that many women experience a decline in medication adherence after a fracture, which is paradoxical to expectations. Fracture on therapy represents an important opportunity for clinicians to emphasize treatment adherence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Tai-Li Chen, Kai-Hung Chang, Kuei-Ying Su
Summary: This article provides a review of the association between inflammatory arthritis, such as RA and SpA, and the development of osteoporosis. It discusses the mechanisms, pathophysiology, and treatment options related to bone destruction in patients with RA and SpA. Inflammatory cytokines, autoantibodies, and multiple signaling pathways play essential roles in bone destruction in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Yosuke Uchino, Takayuki Higashi, Naomi Kobayashi, Tetsuhiko Inoue, Yuichi Mochida, Yutaka Inaba
Summary: Cervical lesions were found in 57% of patients with rheumatoid arthritis, with prednisolone usage, biological agent usage, and higher RA stage identified as significant risk factors. The presence of osteoporosis may contribute to the development of vertical subluxation.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Engineering, Biomedical
Yongzhi Cui, Yuanyuan Guo, Li Kong, Jingyu Shi, Ping Liu, Rui Li, Yongtao Geng, Weihang Gao, Zhiping Zhang, Dehao Fu
Summary: The complex pathogenesis of osteoporosis makes it difficult to treat with conventional therapies. Researchers have developed an exosome delivery system based on exosomes secreted by mesenchymal stem cells derived from induced pluripotent stem cells. By modifying a bone-targeting peptide, the system can specifically deliver siRNA to osteoblasts and enhance therapeutic effects.
BIOACTIVE MATERIALS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Faustino Mercado, Stephen Hamlet, Saso Ivanovski
JOURNAL OF PERIODONTOLOGY
(2020)
Article
Biochemical Research Methods
F. Blaudez, S. Ivanovski, S. Hamlet, C. Vaquette
Article
Chemistry, Physical
Abdalla Abdal-hay, Karan Gulati, Tulio Fernandez-Medina, Ma Qian, Saso Ivanovski
APPLIED SURFACE SCIENCE
(2020)
Article
Dentistry, Oral Surgery & Medicine
B. Fu, K. McGowan, J. H. Sun, M. Batstone
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Michal Bartnikowski, Cedryck Vaquette, Saso Ivanovski
CLINICAL ORAL IMPLANTS RESEARCH
(2020)
Article
Dentistry, Oral Surgery & Medicine
Michael Payer, Wah Ching Tan, Jie Han, Saso Ivanovski, Nikos Mattheos, Bjarni E. Pjetursson, Longfei Zhuang, George Fokas, May C. M. Wong, Stephan Acham, Niklaus P. Lang
CLINICAL ORAL IMPLANTS RESEARCH
(2020)
Article
Dentistry, Oral Surgery & Medicine
Faustino Mercado, Stephen Hamlet, Saso Ivanovski
JOURNAL OF PERIODONTAL RESEARCH
(2020)
Review
Materials Science, Biomaterials
Hasham S. Sofi, Abdalla Abdal-hay, Saso Ivanovski, Yu Shrike Zhang, Faheem A. Sheikh
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Emma K. Bartle, Kelly M. McGowan
Summary: The study aimed to understand clinical supervisors' views overseeing final year dental students and investigate their role, support, and training. Results showed low levels of formal training and the need for further development. The driving motivator for supervisors was a desire to teach, but challenges like lack of recognition and defined career pathways were reported.
EUROPEAN JOURNAL OF DENTAL EDUCATION
(2021)
Article
Dentistry, Oral Surgery & Medicine
K. McGowan, T. Phillips, E. Gielis, T. Dover, G. Mitchell, A. Mutch, C. Sexton, P. M. Sowa, S. Ivanovski
Summary: This study found that the majority of diabetes patients had not visited a dentist in the previous year, with a high percentage requiring periodontal assessment and having multiple carious lesions. Both patients and staff showed strong support for integration of dental care at diabetes clinics, with similar unmet treatment needs and access rates for private and public dental patients.
AUSTRALIAN DENTAL JOURNAL
(2021)
Article
Public, Environmental & Occupational Health
Nicole Stormon, Christopher Sexton, Cecilia Chen, Elizabeth Hsu, Pei-Chen Chen, Kelly McGowan
Summary: The study shows that implementing SMS reminders in public dental services can improve attendance rates, but for the Children and Adolescent Oral Health Service (CAOHS), attendance rates decreased and unable to attend (UTA) rates increased, while for adult services, attendance rates increased. Overall, SMS reminders had mixed effects on CAOHS and adult services.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2022)
Article
Dentistry, Oral Surgery & Medicine
P. Marcin Sowa, Jonas Fooken, Kelly McGowan, Stephen Birch
Summary: Choosing between reusable instruments and disposable instruments for dental care provision requires a careful consideration of costs, procedure type, and environmental impact. This study found that reusable instruments are generally more cost-effective than disposable instruments, but the best choice still depends on the specific procedure. The current practice of using a mix of instruments can offer the lowest cost alternative in certain cases.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Joel Tuckett, Gary Ian Brierly, Jason Tong, Kelly McGowan, Lakshmi Ramalingam, Martin Druce Batstone
Summary: The use of postinjury prophylactic antibiotics for midfacial fractures to prevent infection is often questioned. This retrospective multicenter cohort study found that there was no significant difference in infection rates between patients who received postinjury prophylactic antibiotics and those who did not. Therefore, the practice of using antibiotics for midfacial fractures should be reconsidered.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
K. Davies, K. McGowan, T. Dover, T. McGowan, S. K. Tadakamadla
Summary: This study aimed to understand the barriers to and enablers of dental referrals for patients with diabetes. The results showed that time constraints, lack of awareness and knowledge regarding dental referrals were significant barriers, while online referral pathways, more education, and availability of resources were identified as key enablers for dental referrals.
AUSTRALIAN DENTAL JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Hollie Bendotti, Kelly McGowan, Sheleigh Lawler
Summary: This study highlighted the important role of dental practitioners in promoting smoking cessation. Although a significant number of smokers visited the oral health service, not all of them received smoking cessation support. Addressing barriers to smoking cessation promotion in oral health care settings may improve overall and oral health outcomes for patients.
HEALTH PROMOTION JOURNAL OF AUSTRALIA
(2021)
