Article
Endocrinology & Metabolism
Judith Everts-Graber, Daniel Lehmann, John-Patrik Burkard, Benoit Schaller, Brigitta Gahl, HansJoerg Haeuselmann, Ueli Studer, Hans-Rudolf Ziswiler, Stephan Reichenbach, Thomas Lehmann
Summary: This study aimed to determine the risk of ONJ in a real-world population, showing a higher incidence rate in patients receiving denosumab therapy compared to those receiving BPs, with previous BP therapy potentially being an additional risk factor for ONJ development.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Athanasios D. Anastasilakis, Jessica Pepe, Nicola Napoli, Andrea Palermo, Christos Magopoulos, Aliya A. Khan, M. Carola Zillikens, Jean-Jacques Body
Summary: This study evaluates the differences of MRONJ among different patient categories and provides recommendations on how to mitigate the risk and optimally manage MRONJ. The results indicate that patients with advanced malignancies are at a higher risk for MRONJ compared to those with benign bone diseases, but the overall risk is considerably lower than the benefits of treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Immunology
Weidong Zhang, Ling Gao, Wenhao Ren, Shaoming Li, Jingjing Zheng, Shasha Li, Chunmiao Jiang, Shuying Yang, Keqian Zhi
Summary: Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse drug effect, with hypotheses involving reduced bone remodeling, infection, inflammation, and bisphosphonates-induced immune dysfunction. Treatment with bisphosphonates disrupts mucosal and osteo immune homeostasis, impairing the body's ability to resist infection and repair from injury, contributing to the development of MRONJ.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Wen Pan, Jianyu Gu, Shihan Xu, Chunmei Zhang, Jinsong Wang, Songlin Wang, Junji Xu
Summary: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication in patients with osteoporosis or metastatic bone cancer. The study found that dietary nitrate, abundant in green vegetables, can protect against BRONJ-like lesions in mice. Nitrate intake increased plasma nitric oxide levels, reducing monocyte necrosis and inflammatory cytokine production. The findings suggest that dietary nitrate can inhibit monocyte necroptosis in BRONJ and promote bone remodeling after injury.
CELL PROLIFERATION
(2023)
Article
Medicine, General & Internal
Gabor Kammerhofer, Daniel Vegh, Dorottya Banyai, Adam Vegh, Arpad Joob-Fancsaly, Peter Hermann, Zoltan Geczi, Tamas Hegedus, Kata Sara Somogyi, Bulcsu Bencze, Zita Biczo, Donat Huba Juhasz, Peter Zaborszky, Marta Ujpal, Mihaly Tamas Vaszilko, Zsolt Nemeth
Summary: This study aimed to evaluate the association between hyperglycemia and medication-related osteonecrosis of the jaw (MRONJ). The results showed a significant association between hyperglycemia and MRONJ, suggesting that hyperglycemia may lead to vascular anomaly and immune dysfunction, resulting in necrosis after tooth extraction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Krzysztof Wrobel, Maciej Sikora, Maciej Checinski, Maria Jas, Dariusz Chlubek
Summary: MRONJ is a condition that is becoming more common in dental and maxillofacial practice, requiring comprehensive, accessible, and up-to-date data. Besides bisphosphonates, angiogenesis inhibitors and anti-RANKL monoclonal antibodies can also increase the risk of the disease. Thorough physical examination, periodic correction of dental prostheses, and adequate preparation for oral procedures can prevent or minimize the risk of MRONJ.
APPLIED SCIENCES-BASEL
(2021)
Article
Multidisciplinary Sciences
Fatima Regina Nunes de Sousa, Vanessa Costa de Sousa Ferreira, Conceicao da Silva Martins, Hugo Victor Dantas, Frederico Barbosa de Sousa, Virginia Claudia Carneiro Girao-Carmona, Paula Goes, Gerly Anne de Castro Brito, Renata Ferreira de Carvalho Leitao
Summary: The study evaluated the effect of Zoledronic acid on orthodontic tooth movement and root and bone resorption, finding that it can reduce tooth movement and exhibit anti-resorptive effects.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Hironobu Hata, Kenji Imamachi, Michihiro Ueda, Masashi Matsuzaka, Hiroaki Hiraga, Toshihisa Osanai, Toru Harabayashi, Katsuya Fujimoto, Satoshi Oizumi, Masato Takahashi, Kazuhito Yoshikawa, Jun Sato, Yutaka Yamazaki, Yoshimasa Kitagawa
Summary: The study aimed to clarify the incidence of MRONJ and the corresponding survival rate of patients treated with zoledronic acid for different types of cancer. The results showed that patients with shorter survival times did not develop MRONJ, and dentists need to be aware of prognosis-related factors to predict MRONJ risk for effective dental management planning.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Toxicology
Bhumrapee Srivichit, Chanisa Thonusin, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Bisphosphonates are commonly used in the treatment of bone and joint diseases, but long-term use can lead to osteonecrosis. Osteonecrosis is characterized by cell death and impaired cell functions, with medication-related osteonecrosis of the jaw being the most concerning condition. In addition to surgical treatment, non-surgical interventions have been explored to mitigate bisphosphonate-induced osteonecrosis.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Marcelo Vitale, Monica Grazieli Correa, Edilson Ervolino, Fabiano Ribeiro Cirano, Fernanda Vieira Ribeiro, Mabelle Freitas Monteiro, Marcio Zaffalon Casati, Suzana Peres Pimentel
Summary: This study evaluated the effect of resveratrol (RES) on the prevention of medication-related osteonecrosis of the jaws (MRONJ) in ovariectomized (OVX) rats treated with zoledronate (ZOL). The results showed that RES reduced tissue impairment caused by ZOL, but it could not prevent the occurrence of MRONJ.
Review
Geriatrics & Gerontology
Bridget Boston, Deepak Ipe, Bogdan Capitanescu, Andrei Gresita, Stephen Hamlet, Robert Love, Michael Hadjiargyrou, Chien-Ling Huang, Iulian Nusem, Rodica Ileana Miroiu, Aurel Popa-Wagner, Patrick Hans-Heinrich Warnke, Eugen Bogdan Petcu
Summary: Medication-related osteonecrosis of the jaw (MRONJ) refers to the non-healing jawbone ulcerative-necrotic lesion appearing after dental therapy or minor trauma in patients treated previously with certain medications. Studies have been conducted to explore MRONJ's classification, clinical features, and pathophysiology, as well as its management and new trends in treatment. Conservative therapy may not be effective for severe cases of MRONJ, but new methods that promote local angiogenesis and vascularization show promise in limited trials.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jie Liu, Nikos Mattheos, Chuanxi Deng, Cheng Su, Zekun Wang, Nanyu Luo, Hua Tang
Summary: Icariin benefits MRONJ by improving soft tissue wound area and empty bone lacuna ratio, while teriparatide activates RANKL expression and reduces bone necrosis area and empty lacuna ratio. These findings suggest potential therapeutic benefits for patients with MRONJ.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Medicine, General & Internal
Xiao-Hong Wu, Shi-Wei Chen
Summary: This report presents a case of multiple myeloma (MM) identified in a surgical specimen previously diagnosed as medication-related osteonecrosis of the jaw (MRONJ) in a patient with MM. The patient exhibited symptoms of both MRONJ and MM, suggesting that MM and MRONJ can occur simultaneously at the same site.
Article
Environmental Sciences
Guillermo Pardo-Zamora, Yanet Martinez, Jose Antonio Moreno, Antonio J. Ortiz-Ruiz
Summary: MRONJ is a rare and severe disease with unclear exact cause and potential multifactorial origins. A case series of three stage 2 MRONJ patients showed complete healing within 12 months of therapeutic protocol application, with radiography demonstrating slow but progressive healing with normal bone structure. Conservative treatment and minimally invasive surgical intervention are effective for stage 2 MRONJ, while application of PRF-L in refractory cases can improve outcomes in soft tissue healing and bone regeneration, though further research is needed to confirm effectiveness.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biotechnology & Applied Microbiology
Stephane Odet, Christophe Meyer, Camille Gaudet, Elise Weber, Julie Quenot, Stephane Derruau, Sebastien Laurence, Lisa Bompy, Marine Girodon, Brice Chatelain, Cedric Mauprivez, Esteban Brenet, Halima Kerdjoudj, Narcisse Zwetyenga, Philippe Marchetti, Anne-Sophie Hatzfeld, David Toubeau, Fabienne Pouthier, Xavier Lafarge, Heinz Redl, Mathilde Fenelon, Jean-Christophe Fricain, Roberta Di Pietro, Charlotte Ledouble, Thomas Gualdi, Anne-Laure Parmentier, Aurelien Louvrier, Florelle Gindraux
Summary: The use of human amniotic membrane (hAM) can promote tissue regeneration and healing in patients with medication-related osteonecrosis of the jaw (MRONJ). By using cryopreserved hAM, MRONJ can be effectively treated, leading to improved quality of life for patients.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
H. -S. Jung, S. Jang, H. -Y. Chung, S. Y. Park, H. -Y. Kim, Y. -C. Ha, Y. -K. Lee, J. -H. Nho
Summary: A better understanding of the features of subsequent fractures after distal radius fracture (DRF) is important for the prevention of further osteoporotic fractures. This study in South Korea found that the cumulative incidence of subsequent osteoporotic fractures increased over time and that the mortality rates of subsequent DRFs were lower than those of first-time DRFs, with women having higher risk of subsequent fractures.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Health Care Sciences & Services
Jun-Il Yoo, Yong-Chan Ha, Miji Kim, Sung-Hyo Seo, Mi-Ji Kim, Gyeong-Ye Lee, Young-Mi Seo, Changsu Sung, Ki-Soo Park
Summary: This study translated and validated the SarQoL(R) questionnaire into Korean language and setting, demonstrating its reliability and validity. It also showed that individuals with sarcopenia-associated symptoms have a lower quality of life.
QUALITY OF LIFE RESEARCH
(2021)
Article
Orthopedics
Ji-Hoon Baek, Chang Hyun Nam, Su Chan Lee, Hye Sun Ahn, Yong-Chan Ha
Summary: The study aimed to compare the outcomes of total knee arthroplasty (TKA) in patients with Parkinson's disease (PD) with a control group over a ten year follow-up period. Results showed that PD patients had worse functional outcomes and higher mortality rates after TKA. Therefore, the necessity of surgery should be carefully considered based on individual patient needs and conditions.
INTERNATIONAL ORTHOPAEDICS
(2021)
Review
Endocrinology & Metabolism
A. M. Burden, Y. Tanaka, L. Xu, Y-C Ha, E. McCloskey, S. R. Cummings, C. C. Glueer
Summary: There are regional differences in case-finding strategies for osteoporosis, particularly among patients without a fracture, with varying combinations of risk factors and bone density measurements used. Standardized case-finding strategies may improve treatment rates.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Medicine, General & Internal
Jun-Il Yoo, Yonghan Cha, Young-Kyun Lee, Yong-Chan Ha, Kyung-Hoi Koo
Summary: This study conducted a systematic review and meta-analysis to determine whether short tapered stems reduce the rate of thigh pain in hip arthroplasty. The analysis included retrospective studies and randomized controlled trials comparing short tapered stems and standard-length tapered stems. The overall results showed no significant difference in the incidence of thigh pain between the two stem designs.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Jung-Wee Park, Hong-Seok Kim, Young-Kyun Lee, Jun-Il Yoo, Yangseon Choi, Yong-Chan Ha, Kyung-Hoi Koo
Summary: After hip fracture, osteoporosis appeared to be well managed, but there was a decrease in skeletal muscle mass and an increase in the prevalence of sarcopenia. Lower BMI and preexisting sarcopenia were identified as risk factors for postoperative decrease in skeletal muscle mass.
JOURNAL OF BONE AND MINERAL METABOLISM
(2022)
Article
Orthopedics
Jung -Wee Park, Young-Kyun Lee, Hong Seok Kim, Jin-Kak Kim, Yong-Chan Ha, Kyung-Hoi Koo
Summary: This study investigated the incidence and associated factors of small axial length of the proximal femur (ALPF < 80 mm) in femoral neck fracture patients. The results showed that 8.6% of patients had ALPF < 80 mm, making them ineligible for surgery using Femoral Neck System (FNS). We recommend measuring the ALPF using reconstructed oblique coronal CT images or scaled hip radiographs before surgery in patients with short stature and/or low body weight, and using alternative fixation devices if ALPF is < 80 mm.
CLINICS IN ORTHOPEDIC SURGERY
(2023)
Article
Orthopedics
Young-Kyun Lee, Yong-Chan Ha, Samuel Jaeyoon Won, Jin-Hak Kim, Jung-Wee Park, Kyung-Hoi Koo
Summary: The study aimed to report the complications, radiological changes, clinical results, and survivorship of revision total hip arthroplasty (THA) using Delta ceramic-on-ceramic (CoC) articulation. The results showed that Delta ceramic bearing is a reliable option for revision THA, with encouraging mid-term results, acceptable survivorship, and a low complication rate.
CLINICS IN ORTHOPEDIC SURGERY
(2023)
Article
Orthopedics
Jung -Wee Park, Young-Kyun Lee, Hong-Seok Kim, Jung-Taek Kim, Yong -Chan Ha, Kyung-Hoi Koo
Summary: This study investigated the preoperative concerns and postoperative problems of patients undergoing total hip arthroplasty (THA). The most common preoperative concern was the severity of postoperative pain, followed by the need for transfusion and postoperative rehabilitation. Problems during and after the operation included shoulder pain, annoying hammering sound, nausea, back pain, and knee pain. The highest pain score was on the first postoperative day. These findings provide valuable information for problem-solving and improving patient satisfaction.
CLINICS IN ORTHOPEDIC SURGERY
(2023)
Article
Orthopedics
Jung-Wee Park, Young-Seung Ko, Young-Kyun Lee, Yong-Chan Ha, Kyung-Hoi Koo
Summary: This study evaluated the long-term clinical and radiographic outcomes of total hip arthroplasty using Delta ceramic-on-ceramic bearings. The results showed that the ceramic bearings did not fracture, but the incidence of squeaking increased. Some complications were observed after surgery, but the overall survivorship was good.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Orthopedics
Yong -Gum Park, Boo Seop Kim, Kyu-Tae Kang, Yong -Chan Ha
Summary: This prospective randomized controlled study aimed to determine the effects of abdominal massage on constipation management in elderly patients with hip fractures. The study found that patients in the massage group had significantly fewer constipation remedies and fewer defecation failures compared to the control group on postoperative day 5 and at discharge. Therefore, abdominal massage may be considered as an independent nursing initiative for constipation management.
CLINICS IN ORTHOPEDIC SURGERY
(2023)
Article
Orthopedics
Jung-Mo Hwang, Cheol-Won Lee, Pil-Sung Kim, Yong-Chan Ha
Summary: This study aimed to evaluate the efficacy of arthroscopic reduction and internal fixation with screws in the treatment of posterior wall fractures of the acetabulum. The results showed that this treatment method achieved good radiographic and clinical outcomes, with low complication rates.
CLINICS IN ORTHOPEDIC SURGERY
(2023)
Article
Medicine, General & Internal
Min Heui Yu, Namki Hong, Seunghyun Lee, Ha -Young Kim, Hye-Sun Park, Sang -Min Park, Young-Kyun Lee, Tae -Young Kim, Yong -Chan Ha, Yumie Rhee, Kyung-Hoi Koo
Summary: The study analyzed ICD-10 diagnostic codes, procedure codes, and radiographic image codes to establish an operational definition for identifying patients with osteoporotic vertebral fractures. By evaluating medical records and images, the operational definition was shown to be effective in identifying vertebral fractures.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Orthopedics
Hong Seok Kim, Jung-Wee Park, Young-Kyun Lee, Alessandro Alan Porporati, Yong-Chan Ha, Kyung-Hoi Koo
Summary: A survey found that most surgeons were aware of the technique for inserting ceramic liners, but only a few understood the minimum impaction force required for a firm fit between the metal shell and ceramic liner. Therefore, education is needed for surgeons performing ceramic-on-ceramic total hip arthroplasty.
CLINICS IN ORTHOPEDIC SURGERY
(2022)
Article
Medicine, General & Internal
Yong-Chan Ha, Yonghan Cha, Jun-Il Yoo, Jiyoon Lee, Young-Kyun Lee, Kyung-Hoi Koo
Summary: In elderly hip fracture patients, dementia was an independent risk factor for mortality at a minimum of 1 year of follow-up, and the severity of dementia in hip fracture patients was a risk factor for mortality within 6 months and 1 year, postoperatively.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.
