Article
Endocrinology & Metabolism
Stefano Ciardullo, Emanuele Muraca, Francesca Zerbini, Giuseppina Manzoni, Gianluca Perseghin
Summary: The study investigated the association between liver steatosis and fibrosis with reduced bone mineral density in the US population aged 50 and above. Results showed a high prevalence of steatosis and significant fibrosis in the study population, but after adjustment, liver steatosis and fibrosis were not found to be associated with reduced BMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Microbiology
Antonio Mazzotti, Laura Langone, Alberto Arceri, Elena Artioli, Simone Ottavio Zielli, Simone Bonelli, Pejman Abdi, Cesare Faldini
Summary: Probiotics have become an attractive therapeutic strategy for several diseases, including osteoporosis, osteoarthritis, muscle loss-related disease, wound and ulcer issues, and prevention of surgical antibiotic prophylaxis side effects. Although probiotics are not included in guidelines for these conditions, several studies have reported theoretical benefits of their administration. Further high-level clinical trials are necessary to convert research into solid clinical practice. However, probiotics represent a cost-effective future perspective and may play a role in association with traditional orthopedic therapies.
Article
Endocrinology & Metabolism
Yi-Hsiu Fu, Wei-Ju Liu, Chia-Lin Lee, Jun-Sing Wang
Summary: This study investigated the relationship between insulin resistance, beta-cell secretion, and bone mineral density (BMD) and osteoporosis. The results showed that insulin resistance was positively associated with osteoporosis in individuals with high beta-cell secretion, while beta-cell secretion was negatively associated with osteoporosis in individuals with low insulin resistance. These findings suggest that the relationship between beta-cell secretion and BMD/osteoporosis changes as insulin resistance increases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Hiroyuki Takase, Yuki Takeuchi, Tomotada Fujita, Tsuyoshi Ohishi
Summary: This study investigated the effects of dietary salt intake on bone density in the general female population, and found a significant negative association between salt intake and bone density. The study suggests that excessive salt intake independently reduces bone density in females. Therefore, osteoporosis can be prevented by reducing salt intake.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
He Tong, Miaomiao Wang, Jingjing Liu, Chuangen Guo, Zhongqiu Wang, Jianhua Wang, Xiao Chen
Summary: This study investigated the prevalence and associated factors of bone loss in patients with pancreatic neuroendocrine tumors (PNETs). The results showed a high prevalence of osteoporosis and low bone mass in PNET patients, with age and diabetes being associated factors for bone loss.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ji Hyun Lee, JooYong Park, Jung Hee Kim, Ji-Yeob Choi, Hyung Jin Choi, Eu Jeong Ku, A. Ram Hong, Chan Soo Shin, Nam H. Cho
Summary: This Korean prospective cohort study found that decreasing waist circumference and lean muscle mass loss were significant risk factors for hip bone loss in both men and women. Other factors may have sex-specific or age-specific effects on hip bone loss. None of the genetic factors tested were associated with hip bone loss after multiple testing adjustments, indicating that modifiable factors may play a larger role in determining bone health.
Article
Orthopedics
Huawei Han, Shuai Chen, Xinzhe Wang, Jie Jin, Xianghui Li, Zhiwei Li
Summary: This study examined the impact of lower extremity muscle strength and mass on bone mineral density (BMD). The results showed a positive correlation between muscle strength and mass with BMD. These findings have important implications for the prevention, early diagnosis, and treatment of osteopenia and osteoporosis.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Francesca Di Marcello, Giulia Di Donato, Debora Mariarita d'Angelo, Luciana Breda, Francesco Chiarelli
Summary: Bone health is influenced by various factors, including genetic factors, inflammation, and chronic diseases. Optimal nutrition and physical activity contribute to bone mass accumulation in youth. Juvenile arthritis patients are at higher risk of osteoporosis and fractures due to multiple contributing factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
M. L. Wilczek, L. Bhatta, B. M. Brumpton, B. Freyschuss, T. B. Brismar
Summary: The study showed a negative correlation between DXR T-score and fracture risk, indicating the potential use of DXR in population-based screening for osteoporosis.
Article
Medicine, General & Internal
Johanna Schoenau, Axel Wester, Joern M. Schattenberg, Hannes Hagstrom
Summary: People with PBC have a higher risk of osteoporosis-related fractures and higher postfracture mortality compared to the general population.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, Eugene McCloskey, Helena Johansson, Nicholas C. Harvey, John A. Kanis, William D. Leslie
Summary: This study found that medical comorbidity is associated with fracture risk and can increase the risk of fractures independently of FRAX. By using complex and simple measures of medical comorbidity, FRAX-based risk estimates can be modified to capture the increased fracture risk associated with multiple comorbid conditions in older patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Sara De Salvo, Vito Pavone, Sebastiano Coco, Eleonora Dell'Agli, Chiara Blatti, Gianluca Testa
Summary: This review provides a comprehensive overview of the common characteristics and diagnostic methods of nonmalignant bone tumors, aiming to help clinicians gain a better understanding of these tumors in their everyday work.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: This study examined medication adherence in women with osteoporosis before and after a fracture. The results show that many women experience a decline in medication adherence after a fracture, which is paradoxical to expectations. Fracture on therapy represents an important opportunity for clinicians to emphasize treatment adherence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Ghada El-Hajj Fuleihan, Marlene Chakhtoura, Cristiana Cipriani, Richard Eastell, Tatiana Karonova, Jian-Min Liu, Salvatore Minisola, Ambrish Mithal, Carolina A. Moreira, Munro Peacock, Marian Schini, Barbara Silva, Marcella Walker, Ola El Zein, Claudio Marcocci
Summary: This narrative review summarizes data on classical and nonclassical manifestations of primary hyperparathyroidism (PHPT). The presentation of PHPT has shifted from predominantly symptomatic to asymptomatic, posing challenges in diagnosis and treatment. Limited knowledge exists regarding the natural history and response to interventions of asymptomatic PHPT.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Sonia Gera, Sunitha Sampathi, Sravya Maddukuri, Sujatha Dodoala, Vijayabhaskarreddy Junnuthula, Sathish Dyawanapelly
Summary: Naringenin nanosuspension (NRG-NS) demonstrated anti-osteoporotic activity by upregulating osteocalcin levels in MG-63 cells and normalized bone density and biochemical parameters in an osteoporotic rat model. The results suggest that oral administration of NRG-NS could be a potential therapeutic formulation for osteoporosis treatment.
Article
Endocrinology & Metabolism
Lin Li, Elizabeth B. Andrews, Xinyu Li, Zoran Doder, Evgeny Zalmover, Kristen Sharma, Juliana H. Oliveira, Juhaeri Juhaeri, Chuntao Wu
Summary: The study found that the incidence of DKA in US commercially insured patients with T1DM decreased at an average annual rate of 6.1% in 2018-2019, after a steady increase since 2011.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Pharmacology & Pharmacy
Laurie Zografos, Dan Wolin, Elizabeth Andrews, Brian Calingaert, Yanina Balabanova, Andrea Horvat-Broecker, Christine Tarenz, Kiliana Suzart-Woischnik
Summary: The study found that patients and physicians generally had high levels of awareness and understanding of key safety information in the educational materials, particularly in regards to bleeding risk, indications, and other important information.
EXPERT OPINION ON DRUG SAFETY
(2022)
Review
Oncology
Edith A. Perez, Chau Dang, Caleb Lee, Jasmeet Singh, Kongming Wang, J. Bradley Layton, Alicia Gilsenan, Michelle D. Hackshaw, Javier Cortes
Summary: HER2-targeted therapies have shown good efficacy in breast cancer patients, but there are also risks of adverse events, including hematologic, cardiopulmonary, and gastro-hepatobiliary events.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Public, Environmental & Occupational Health
Catherine B. Johannes, Catherine W. Saltus, James A. Kaye, Brian Calingaert, Sigal Kaplan, Mark Forrest Gordon, Elizabeth B. Andrews
Summary: This study found a slight increased risk of melanoma in users of rasagiline compared to other antiparkinsonian drugs. Although this increase was consistent with dose and duration, the higher frequency of skin cancer surveillance among rasagiline users may have influenced the observed results.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Article
Clinical Neurology
Joan Forns, Elena Dudukina, David Hagg, Peter Szentkuti, Karin Gembert, Estel Plana, Alicia Gilsenan, Erzsebet Horvath-Puho, Vera Ehrenstein, Johan Reutfors, Cristina Rebordosa
Summary: This study compared the risks of cardiovascular and cerebrovascular events in patients treated with lisdexamfetamine dimesylate (LDX) and patients previously treated with other attention-deficit/hyperactivity disorder (ADHD) medications using data from Danish and Swedish national registers. The results showed that there was little to no increased risk of cardiovascular and cerebrovascular events in patients treated with LDX compared to patients previously treated with other ADHD medications.
NEUROLOGY AND THERAPY
(2022)
Article
Public, Environmental & Occupational Health
Heather E. Danysh, Catherine B. Johannes, Daniel C. Beachler, J. Bradley Layton, Ryan Ziemiecki, Alejandro Arana, Jade Dinh, Ling Li, Brian Calingaert, Manel Pladevall-Vila, Phillip R. Hunt, Hungta Chen, Cecilia Karlsson, Kristina Johnsson, Alicia Gilsenan
Summary: This study compared the incidence rates of acute liver injury and urinary tract infection among patients using dapagliflozin and other glucose-lowering drugs. The results showed that patients initiating dapagliflozin had lower rates of acute liver injury and urinary tract infection compared to those using other drugs.
Article
Public, Environmental & Occupational Health
Catherine B. Johannes, Daniel C. Beachler, J. Bradley Layton, Heather E. Danysh, Ryan Ziemiecki, Alejandro Arana, Jade Dinh, Ling Li, Brian Calingaert, Manel Pladevall-Vila, Phillip R. Hunt, Hungta Chen, Cecilia Karlsson, Kristina Johnsson, Alicia Gilsenan
Summary: This study evaluated the risk of hospitalization for acute kidney injury (hAKI) in patients with type 2 diabetes mellitus (T2DM) initiating dapagliflozin compared to other glucose-lowering drugs (GLDs). The results showed that patients using dapagliflozin had a lower risk of hAKI hospitalization compared to patients using other GLDs.
Meeting Abstract
Public, Environmental & Occupational Health
Candace C. Fuller, Alison Tse Kawai, Kevin Haynes, Kevin Coughlin, Juliane Reynolds, Rebecca Hawrusik, Casie Horgan, Brian Calingaert, Catherine B. Johannes, J. Bradley Layton, Aliza Peterson, Nicolas Praet, Corinne Willame, Emily Yost, Carla Brannan, Cheryl N. McMahill-Walraven, Maria Guzman, Aziza Jamal-allial, Vinit Nair, Ryan Seals, Florence Wang, Mano Selvan, Qianli Ma, Richard Platt, Alicia W. Gilsenan, Jeffrey Brown
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
Alicia W. Gilsenan, Alison Tse Kawai, Candace C. Fuller, Cynthia De Luise, J. Bradley Layton, Catherine B. Johannes, Jeffrey Brown, Richard Platt
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Review
Endocrinology & Metabolism
John H. Krege, Alicia W. Gilsenan, John L. Komacko, Nicole Kellier-Steele
Summary: The phase 3 trials of teriparatide were terminated early due to the discovery of osteosarcoma in rats treated with high doses of the drug. However, subsequent clinical trials and investigations showed that teriparatide is effective and well-tolerated. Based on these findings, teriparatide was approved for the treatment of osteoporosis in high-risk patients, with a warning about potential osteosarcoma risk.
Meeting Abstract
Public, Environmental & Occupational Health
Catherine W. Saltus, Sigal Kaplan, Mark F. Gordon, Brian Calingaert, Elizabeth B. Andrews, James A. Kaye, Catherine B. Johannes
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2021)
Meeting Abstract
Public, Environmental & Occupational Health
Heather E. Danysh, Alicia Gilsenan, Alejandro Arana, Manel Pladevall-Vila, J. Bradley Layton, Ryan Ziemiecki, Hungta Chen, Phillip Hunt, Catherine B. Johannes
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2021)
Article
Endocrinology & Metabolism
A. Gilsenan, D. Harris, M. Reynolds, D. McSorley, K. Midkiff, L. Jackson, B. Muldavin, N. Kellier-Steele, E. Andrews
Summary: The Forteo Patient Registry was established to estimate the incidence of osteosarcoma in US patients treated with teriparatide between 2009 and 2019. No incident cases of osteosarcoma were identified among registered patients, indicating that the risk of osteosarcoma in this population is very low.
OSTEOPOROSIS INTERNATIONAL
(2021)