Article
Multidisciplinary Sciences
Kyeong-Mee Park, Namkwon Lee, Jaeyeon Kim, Hyun Sil Kim, Wonse Park
Summary: This study aimed to investigate the preventive effect of teriparatide (TPD) administration on medication-related osteonecrosis of the jaw (MRONJ) before tooth extraction. The results showed that TPD reduced the occurrence of MRONJ in rats treated with zoledronic acid.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Guang Yang, Sonal Singh, Caitrin W. McDonough, Jatinder K. Lamba, Issam Hamadeh, L. Shannon Holliday, Danxin Wang, Joseph Katz, Peter A. Lakatos, Bernadett Balla, Janos P. Kosa, Gian Andrea Pelliccioni, Douglas K. Price, Sara L. Van Driest, William D. Figg, Taimour Langaee, Jan S. Moreb, Yan Gong
Summary: The study identified a lead SNP, rs2736308 on chromosome 8, associated with an increased risk of MRONJ in patients with cancer and osteoporosis. This SNP is linked to genes regulating bone mineral density, providing insights into the potential mechanism of MRONJ.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Min-Jeong Kwoen, Jung-Hyun Park, Keun-Suh Kim, Jae-Ryun Lee, Jin-Woo Kim, HyeJin Lee, Hyo-Jung Lee
Summary: The presence of periodontal disease significantly increases the risk of medication-related osteonecrosis of the jaw (MRONJ) in patients, even without tooth extraction. Therefore, patients taking bisphosphonates should actively manage and treat periodontal diseases.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Ran Yan, Ruixue Jiang, Longwei Hu, Yuwei Deng, Jin Wen, Xinquan Jiang
Summary: This review provides an overview of medication-related osteonecrosis of the jaw (MRONJ), emphasizing the significance of animal models and discussing classical and modified rodent models for studying MRONJ. It also highlights the lack of a unified assessment system for these models and presents different approaches for evaluating MRONJ-like lesions in rodents.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Takuma Watanabe, Keita Asai, Shizuko Fukuhara, Ryuji Uozumi, Kazuhisa Bessho
Summary: This study evaluated the variables associated with treatment outcomes in patients with ARONJ at a single center, finding that surgery and HBO therapy were effective treatment approaches for both stage 2 and 3 ARONJ. Extensive surgery was more effective in healing than conservative surgery for stage 2 ARONJ, while >= 46 sessions of HBO therapy was less associated with healing in the same stage.
Article
Endocrinology & Metabolism
Ruxandra Coropciuc, Renaat Coopman, Melisa Garip, Evelien Gielen, Constantinus Politis, Tim Van den Wyngaert, Benoit Beuselinck
Summary: This study found that the incidence of medication-related osteonecrosis of the jaw (MRONJ) after dental extractions is 2.7% per person-year in patients with osteoporosis and 26.4% per person-year in patients with bone metastases. Dental infection as the reason for extraction increases the risk of osteonecrosis in both patient groups. The use of leukocyte and platelet-rich fibrin and antibiotics can significantly reduce the risk, and a longer interval since last administration of antiresorptive agents also reduces the risk.
Article
Medicine, General & Internal
Yesel Kim, Jeong-Kui Ku
Summary: This study successfully established a MRONJ rat model on the calvaria, which mimicked the characteristics of MRONJ and can be used for developing treatments for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Koma Sanda, Yasunori Ayukawa, Noriyuki Yasunami, Naomi Adachi, Akihiro Furuhashi, Mikio Imai, Ken Matsunaka, Kiyoshi Koyano
Summary: The study found that injecting fluvastatin after tooth extraction can promote the healing of medication-related osteonecrosis of the jaw-like lesions, reducing the risk of necrotic bone formation.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Chemistry, Medicinal
Ken Matsunaka, Mikio Imai, Koma Sanda, Noriyuki Yasunami, Akihiro Furuhashi, Ikiru Atsuta, Hiroko Wada, Yasunori Ayukawa
Summary: This study found that a single injection of benidipine near MRONJ-like lesions can promote healing of osteonecrotic extraction socket, reducing the area of necrotic bone and recovering soft tissue continuity.
Review
Medicine, General & Internal
Natalie H. Beth-Tasdogan, Benjamin Mayer, Heba Hussein, Oliver Zolk, Jens-Uwe Peter
Summary: Interventions for the prophylaxis or treatment of MRONJ have shown mixed results with varying levels of certainty due to the diversity of included studies. Preventive measures such as regular dental examinations and specific treatment protocols for dentoalveolar surgery may lower the risk of developing MRONJ. For established MRONJ, different treatments including hyperbaric oxygen therapy and growth factors have been tested, but more research is needed to confirm their effectiveness.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Multidisciplinary Sciences
Milad Etemadi Sh, Farnaz Shooshtarian, Golnaz Tajmiri, MohammadSoroush Sehat
Summary: The present experiment aimed to assess the preventive effects of L-PRF on osteonecrosis of the jaw in rats. The application of L-PRF resulted in a significant reduction in osteonecrosis centers and the number of osteoclast cells. Therefore, it can be inferred that possible preventive effects on the clinical occurrence of osteonecrosis could be expected from the application of L-PRF.
Article
Multidisciplinary Sciences
Kota Morishita, Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Miho Sasaki, Yukinori Takagi, Misa Sumi, Masahiro Umeda
Summary: The study found that a drug holiday of 3 months for medication-related osteonecrosis of the jaw in osteoporosis patients receiving antiresorptive agents does not promote sequestra separation or improve treatment outcomes, and early surgical therapy is recommended.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Gul Merve Yalcin-Ulker, Murat Gunbatan, Gonca Duygu, Merva Soluk-Tekkesin, Ceyda Ozcakir-Tomruk
Summary: This study examines the preventive effect of deferoxamine (DFO) on medication-related osteonecrosis of the jaw (MRONJ). Female Sprague Dawley rats were treated with zoledronic acid (ZA) to create an osteonecrosis model, and DFO was applied locally to prevent MRONJ. The results showed no significant difference in new bone formation between the treatment groups, although HIF-1 alpha levels were higher in the DFO-treated group. Further large-scale studies are needed to understand the preventive effects of DFO on MRONJ.
Review
Biotechnology & Applied Microbiology
Nobuyuki Kaibuchi, Takanori Iwata, Yoko Kawase Koga, Toshihiro Okamoto
Summary: The optimal treatment and prevention methods for medication-related osteonecrosis of the jaw (MRONJ) are unclear. Novel therapies, including cell therapies using mesenchymal stromal cell (MSC) sheets, have shown potential effectiveness in treating MRONJ. However, more clinical trials are needed to confirm their efficacy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
George Adrian Ciobanu, Adrian Camen, Mihaela Ionescu, Daniel Vlad, Cristina Maria Munteanu, Mircea Ionut Gheorghita, Cristian Virgil Lungulescu, Ionela Elisabeta Staicu, Elena Claudia Sin, Luminita Chivu, Razvan Mercut, Sanda Mihaela Popescu
Summary: This study aimed to establish the importance of risk factors in the development of MRONJ in cancer patients receiving zoledronic acid therapy. The analysis of 174 cancer patients revealed that treatment duration, chemotherapy, and hypertension were risk factors, while endocrine therapy and obesity were protective factors for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Medicinal
Parish P. Sedghizadeh, Shuting Sun, Adam F. Junka, Eric Richard, Keivan Sadrerafi, Susan Mahabady, Neema Bakhshalian, Natalia Tjokro, Marzenna Bartoszewicz, Monika Oleksy, Patrycja Szymczyk, Mark W. Lundy, Jeffrey D. Neighbors, R. Graham G. Russell, Charles E. McKenna, Frank H. Ebetino
JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Review
Dentistry, Oral Surgery & Medicine
Alvin Cardona, Amir Balouch, Moiz Mohammed Abdul, Parish P. Sedghizadeh, Reyes Enciso
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2017)
Article
Chemistry, Analytical
Adam Junka, Wojciech Wojtowicz, Adam Zabek, Grzegorz Krasowski, Danuta Smutnicka, Barbara Bakalorz, Agnieszka Boruta, Mariusz Dziadas, Piotr Mlynarz, Parish Paymon Sedghizadeh, Marzenna Bartoszewicz
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2017)
Article
Dentistry, Oral Surgery & Medicine
S. Mahabady, N. Tjokro, S. Aharonian, H. H. Zadeh, C. Chen, H. Allayee, P. P. Sedghizadeh
MOLECULAR ORAL MICROBIOLOGY
(2017)
Article
Chemistry, Applied
Anna Zywicka, Adam F. Junka, Patrycja Szymczyk, Grzegorz Chodaczek, Jakub Grzesiak, Parish Paymon Sedghizadeh, Karol Fijalkowski
CARBOHYDRATE POLYMERS
(2018)
Article
Multidisciplinary Sciences
A. F. Junka, R. Rakoczy, P. Szymczyk, M. Bartoszewicz, P. P. Sedghizadeh, K. Fijalkowski
SCIENTIFIC REPORTS
(2018)
Article
Oncology
Atlas Khan, Qian Liu, Xuelian Chen, Andres Stucky, Parish P. Sedghizadeh, Daniel Adelpour, Xi Zhang, Kai Wang, Jiang F. Zhong
MOLECULAR ONCOLOGY
(2019)
Letter
Dentistry, Oral Surgery & Medicine
Allan C. Jones, Parish P. Sedghizadeh
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2020)
Article
Biochemistry & Molecular Biology
Parish P. P. Sedghizadeh, Philip Cherian, Sahar Roshandel, Natalia Tjokro, Casey Chen, Adam E. F. Junka, Eric Hu, Jeffrey Neighbors, Jacek Pawlak, R. Graham G. Russell, Charles E. E. McKenna, Frank H. H. Ebetino, Shuting Sun, Esmat Sodagar
Summary: Osteomyelitis is a severe orthopedic infection caused by Staphylococcus aureus biofilms. Novel antibiotic conjugates comprising bone-binding bisphosphonates were designed and tested for their effectiveness against biofilm growth in this study. The conjugates demonstrated dose-dependent antimicrobial activity and retained bone-binding properties as well as the antimicrobial activity of the parent antibiotic, although at lower levels due to chemical modification. These findings are important for the development of new drugs for osteomyelitis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Endocrinology & Metabolism
Parish Sedghizadeh, Esmat Sodagar, Raffle Garabedian, Jasveen Wadia, Frank Ebetino, Philip Cherian, Shuting Sun, Neema Bakhshalian, Jeffrey Neighbors, R. Graham Russell, Charles McKenna
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Article
Acoustics
Colman Moore, Yuting Bai, Ali Hariri, Joan B. Sanchez, Ching-Yu Lin, Sreenivas Koka, Parish Sedghizadeh, Casey Chen, Jesse Jokerst
Meeting Abstract
Endocrinology & Metabolism
Jayesh Shah, Frank H. Ebetino, Lianping Xing, Robert Boeckman, Shuting Sun, Parish Sedghizadeh, Michael T. Yin, Suzanne Lentzsch, Graham Russell, Serge Cremers
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Meeting Abstract
Endocrinology & Metabolism
Parish Sedghizadeh, Frank Ebetino, Shuting Sun, Keivan Sadrerafi, Adam Junka, Susan Mahabady, Jeffrey Neighbors, Graham Russell, Charles E. McKenna
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Article
Chemistry, Applied
Adam Junka, Karol Fijalkowski, Adam Zabek, Katarzyna Mikolajewicz, Grzegorz Chodaczek, Patrycja Szymczyk, Danuta Smutnicka, Anna Zywicka, Parish Paymon Sedghizadeh, Mariusz Dziadas, Piotr Mlynarz, Marzenna Bartoszewicz
CARBOHYDRATE POLYMERS
(2017)
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.