Mitophagy mechanisms in neuronal physiology and pathology during ageing

Molecular mechanisms and physiological functions of mitophagy

(2021) Mashun Onishi et al.   EMBO JOURNAL

microRNA-204 Silencing Reduces Mitochondrial Autophagy and Reactive Oxygen Species Production in a murine Alzheimer's Disease model via the TRPML1-Activated STAT3 Pathway

(2021) Lu Zhang et al.   Molecular Therapy-Nucleic Acids

Dietary spermidine improves cognitive function

(2021) Sabrina Schroeder et al.   Cell Reports

The role of SQSTM1 (p62) in mitochondrial function and clearance in human cortical neurons

(2021) Anna Poon et al.   Stem Cell Reports

Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response

(2021) Guillermo López‐Doménech et al.   EMBO JOURNAL

Altered insulin pathway compromises mitochondrial function and quality control both in in vitro and in vivo model systems

(2021) Giacoma Galizzi et al.   MITOCHONDRION

Metabolism and Innate Immunity Meet at the Mitochondria

(2021) Amir Bahat et al.   Frontiers in Cell and Developmental Biology

Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination

(2020) Su Jin Ham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons

(2020) Chantell S Evans et al.   eLife

Mitochondria as intracellular signaling platforms in health and disease

(2020) Jay X. Tan et al.   JOURNAL OF CELL BIOLOGY

Mdm2 enhances ligase activity of parkin and facilitates mitophagy

(2020) Seunghyi Kook et al.   Scientific Reports

Mitophagy coordination with retrograde transport ensures the integrity of synaptic mitochondria

(2020) Sinsuk Han et al.   Autophagy

Quality control of the mitochondrial proteome

(2020) Jiyao Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dietary Mitophagy Enhancer: A Strategy for Healthy Brain Aging?

(2020) Nimmy Varghese et al.   Antioxidants

Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection

(2020) Mingmei Wang et al.   NEUROPHARMACOLOGY

LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson’s disease

(2019) Fiona Bonello et al.   HUMAN MOLECULAR GENETICS

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Mitochondrial transport serves as a mitochondrial quality control strategy in axons: Implications for central nervous system disorders

(2019) Yan‐Rong Zheng et al.   CNS Neuroscience & Therapeutics

Sigma-1 receptor ablation impairs autophagosome clearance

(2019) Huan Yang et al.   Autophagy

Quality Control in Neurons: Mitophagy and Other Selective Autophagy Mechanisms

(2019) Chantell S. Evans et al.   JOURNAL OF MOLECULAR BIOLOGY

USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy

(2019) Kaifeng Niu et al.   Autophagy

Many makes of mitochondria

(2019) Natasha Bray   NATURE REVIEWS NEUROSCIENCE

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

(2019) Evandro F. Fang et al.   Nature Communications

Orchestrating mitochondria in neurons: Cytoskeleton as the conductor

(2019) Carlos Cardanho‐Ramos et al.   Cytoskeleton

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

(2018) Thomas G. McWilliams et al.   Cell Metabolism

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

(2018) Andrew Melber et al.   CELL RESEARCH

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila

(2018) Tom Cornelissen et al.   eLife

Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions

(2017) Mei-Yao Lin et al.   NEURON

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Heterozygous PINK1 p.G411S increases risk of Parkinson’s disease via a dominant-negative mechanism

(2016) Andreas Puschmann et al.   BRAIN

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease

(2016) Chung-Han Hsieh et al.   Cell Stem Cell

Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system

(2016) Gian-Luca McLelland et al.   JOURNAL OF CELL BIOLOGY

PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy

(2016) Kenneth R. Pryde et al.   JOURNAL OF CELL BIOLOGY

Compartmentalized Regulation of Parkin-Mediated Mitochondrial Quality Control in the Drosophila Nervous System In Vivo

(2016) H. Sung et al.   JOURNAL OF NEUROSCIENCE

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

(2016) Thanh N. Nguyen et al.   TRENDS IN CELL BIOLOGY

Deubiquitinating enzymes regulate PARK2-mediated mitophagy

(2015) Yuqing Wang et al.   Autophagy

Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains

(2015) Xuan Ye et al.   HUMAN MOLECULAR GENETICS

The Organization of Mitochondrial Quality Control and Life Cycle in the Nervous System In Vivo in the Absence of PINK1

(2015) S. Devireddy et al.   JOURNAL OF NEUROSCIENCE

Measuring In Vivo Mitophagy

(2015) Nuo Sun et al.   MOLECULAR CELL

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

(2015) Jin-Mi Heo et al.   MOLECULAR CELL

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

(2015) Christian N. Cunningham et al.   NATURE CELL BIOLOGY

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

PINK1-induced mitophagy promotes neuroprotection in Huntington’s disease

(2015) B Khalil et al.   Cell Death & Disease

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

(2014) Gian-Luca McLelland et al.   EMBO JOURNAL

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

(2014) Tom Cornelissen et al.   HUMAN MOLECULAR GENETICS

Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin

(2014) Ghazaleh Ashrafi et al.   JOURNAL OF CELL BIOLOGY

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

(2014) Alban Ordureau et al.   MOLECULAR CELL

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

(2014) Baris Bingol et al.   NATURE

Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson’s-like movement disorder

(2014) Wei Lu et al.   Nature Communications

MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin

(2014) Jina Yun et al.   eLife

PINK1 is degraded through the N-end rule pathway

(2013) Koji Yamano et al.   Autophagy

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

(2013) A. Rana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

(2013) Atsushi Hoshino et al.   Nature Communications

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical Neurons

(2012) Qian Cai et al.   CURRENT BIOLOGY

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons

(2012) Alvin P. Joselin et al.   HUMAN MOLECULAR GENETICS

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria

(2012) Song Liu et al.   PLoS Genetics

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY