Mitochondria as intracellular signaling platforms in health and disease

Glycosphingolipid Biosynthesis Pathway in the Spinal Cord and Dorsal Root Ganglia During Inflammatory Pain: Early and Late Changes in Expression Patterns of Glycosyltransferase Genes

(2020) Motoki Morita et al.   NEUROSCIENCE

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

(2020) Jeonghan Kim et al.   SCIENCE

Coming together to define membrane contact sites

(2019) Luca Scorrano et al.   Nature Communications

Activation of innate immunity by mitochondrial dsRNA in mouse cells lacking p53 protein.

(2019) Dagmara M. Wiatrek et al.   RNA

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

MAVS polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling

(2019) Ming‐Shih Hwang et al.   FEBS Journal

Ceramides bind VDAC2 to trigger mitochondrial apoptosis

(2019) Shashank Dadsena et al.   Nature Communications

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

(2019) Weina Zhang et al.   CELL

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

(2019) Lodoe Lama et al.   Nature Communications

Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin

(2019) Angelique Camilleri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipid signalling drives proteolytic rewiring of mitochondria by YME1L

(2019) Thomas MacVicar et al.   NATURE

Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury

(2019) Hiroshi Maekawa et al.   Cell Reports

Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

(2019) Chun-Cheih Chao et al.   CELL

Cardiolipin is essential for early embryonic viability and mitochondrial integrity of neurons in mammals

(2019) Takaoki Kasahara et al.   FASEB JOURNAL

Developmental ROS individualizes organismal stress resistance and lifespan

(2019) Daphne Bazopoulou et al.   NATURE

Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults

(2018) Ameya S Kulkarni et al.   AGING CELL

The role of cardiolipin in promoting the membrane pore-forming activity of BAX oligomers

(2018) Yei-Chen Lai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress

(2018) Kyung Hwa Kim et al.   Cell Metabolism

Phospholipid transport protein function at organelle contact sites

(2018) Shamshad Cockcroft et al.   CURRENT OPINION IN CELL BIOLOGY

Lowered iPLA 2 γ activity causes increased mitochondrial lipid peroxidation and mitochondrial dysfunction in a rotenone-induced model of Parkinson's disease

(2018) Honglu Chao et al.   EXPERIMENTAL NEUROLOGY

Human Aging and Longevity Are Characterized by High Levels of Mitokines

(2018) Maria Conte et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy

(2018) Amel Karaa et al.   NEUROLOGY

Ethanolamine Utilization in Bacteria

(2018) Karan Gautam Kaval et al.   mBio

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

(2018) Dannielle DeWaal et al.   Nature Communications

Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein

(2018) Tammy Ryan et al.   Nature Communications

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling

(2018) Qian Zhang et al.   CELL

Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs

(2018) Manoj Kumar Jaiswal   MEDICINAL RESEARCH REVIEWS

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

(2018) Ashish Dhir et al.   NATURE

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation

(2018) Chengchuan Ma et al.   NATURE CELL BIOLOGY

The phospholipase iPLA2γ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling

(2017) Gao-Yuan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

(2017) Tomer Shpilka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay

(2017) Justin Hall et al.   PLoS One

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

(2016) Carsten Merkwirth et al.   CELL

Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR mt

(2016) Ye Tian et al.   CELL

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

(2016) Andrea J. Wolf et al.   CELL

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response

(2016) Hyun-Eui Kim et al.   CELL

NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy

(2016) V E Kagan et al.   CELL DEATH AND DIFFERENTIATION

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction

(2016) Danya Ben-Hail et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus

(2016) Iwona A. Buskiewicz et al.   Science Signaling

Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress

(2016) T. Kelly Rainbolt et al.   Cell Reports

Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation

(2016) Bianca Hartmann et al.   eLife

Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus

(2016) Iwona A. Buskiewicz et al.   Science Signaling

HnRNPA2 is a novel histone acetyltransferase that mediates mitochondrial stress-induced nuclear gene expression

(2016) Manti Guha et al.   Cell Discovery

Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy

(2015) Paul Hsu et al.   Autophagy

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

(2015) Changhan Lee et al.   Cell Metabolism

MyxococcusCsgA,DrosophilaSniffer, and human HSD10 are cardiolipin phospholipases

(2015) Tye O'Hara Boynton et al.   GENES & DEVELOPMENT

Cytosolic phospholipase A2: physiological function and role in disease

(2015) Christina C. Leslie   JOURNAL OF LIPID RESEARCH

Measuring In Vivo Mitophagy

(2015) Nuo Sun et al.   MOLECULAR CELL

Repeated intraperitoneal injections of liposomes containing phosphatidic acid and cardiolipin reduce amyloid-β levels in APP/PS1 transgenic mice

(2015) Lara Ordóñez-Gutiérrez et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Role of membrane contact sites in protein import into mitochondria

(2015) Susanne E. Horvath et al.   PROTEIN SCIENCE

Mitochondrial Proteins Moonlighting in the Nucleus

(2015) Richard M. Monaghan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Correction: Structural basis for the prion-like MAVS filaments in antiviral innate immunity

(2015) Hui Xu et al.   eLife

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

(2014) D J Roberts et al.   CELL DEATH AND DIFFERENTIATION

Alpha-Synuclein Binds to the Inner Membrane of Mitochondria in an α-Helical Conformation

(2014) Marta Robotta et al.   CHEMBIOCHEM

Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics

(2014) M. J. Baker et al.   EMBO JOURNAL

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

(2014) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

A mitochondrial pathway for biosynthesis of lipid mediators

(2014) Yulia Y. Tyurina et al.   Nature Chemistry

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

(2014) Lior Mayo et al.   NATURE MEDICINE

Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols

(2013) Angelique Camilleri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

(2013) Elizabeth A. Schroeder et al.   Cell Metabolism

Lactosylceramide Interacts with and Activates Cytosolic Phospholipase A2α

(2013) Hiroyuki Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

(2013) A. V. Birk et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

Lipids of mitochondria

(2013) Susanne E. Horvath et al.   PROGRESS IN LIPID RESEARCH

Mitochondrial lipid trafficking

(2013) Takashi Tatsuta et al.   TRENDS IN CELL BIOLOGY

MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

(2013) Siqi Liu et al.   eLife

Binding of β-Amyloid (1–42) Peptide to Negatively Charged Phospholipid Membranes in the Liquid-Ordered State: Modeling and Experimental Studies

(2012) Hasna Ahyayauch et al.   BIOPHYSICAL JOURNAL

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

Dual Function of Mitochondrial Nm23-H4 Protein in Phosphotransfer and Intermembrane Lipid Transfer

(2012) Uwe Schlattner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation

(2012) Lukas Stiburek et al.   MOLECULAR BIOLOGY OF THE CELL

The Membrane Stress Response Buffers Lethal Effects of Lipid Disequilibrium by Reprogramming the Protein Homeostasis Network

(2012) Guillaume Thibault et al.   MOLECULAR CELL

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

(2012) Yuan Zhang et al.   eLife

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients

(2011) Julien Pothlichet et al.   EMBO Molecular Medicine

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus

(2011) S. M. Horner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane

(2010) Vidyaramanan Ganesan et al.   APOPTOSIS

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Removal or masking of phosphatidylinositol(4,5)bisphosphate from the outer mitochondrial membrane causes mitochondrial fragmentation

(2010) Erika Rosivatz et al.   CELLULAR SIGNALLING

(R)-α-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria

(2010) Jeffrey S. Monette et al.   PHARMACOLOGICAL RESEARCH

Mitochondrial Cardiolipin Involved in Outer-Membrane Protein Biogenesis: Implications for Barth Syndrome

(2009) Natalia Gebert et al.   CURRENT BIOLOGY

Phosphatidylserine decarboxylases, key enzymes of lipid metabolism

(2009) Irmgard Schuiki et al.   IUBMB LIFE

Enhanced levels of mitochondrial enzyme 17β-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosis

(2009) Zdena Krištofiková et al.   Molecular BioSystems

MAVS-Mediated Apoptosis and Its Inhibition by Viral Proteins

(2009) Yu Lei et al.   PLoS One

Role of Phospholipid Scramblase 3 in the Regulation of Tumor Necrosis Factor-α-Induced Apoptosis†

(2008) Jihua Liu et al.   BIOCHEMISTRY

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

(2008) Shih-Ching Lo et al.   EXPERIMENTAL CELL RESEARCH

Cardiolipin provides an essential activating platform for caspase-8 on mitochondria

(2008) Francois Gonzalvez et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial dysfunction in rat brain with agingInvolvement of complex I, reactive oxygen species and cardiolipin

(2008) G PETROSILLO et al.   NEUROCHEMISTRY INTERNATIONAL