Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3′-diindolylmethane and chemotherapy drugs

Overcoming Endocrine Resistance in Breast Cancer

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Tumorigenic and Metastatic Role of CD44−/low/CD24−/low Cells in Luminal Breast Cancer

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The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics

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The role and mechanisms of action of microRNAs in cancer drug resistance

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Genomic characterization of metastatic breast cancers

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An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

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Epigenetics in cancer therapy and nanomedicine

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Are 90% of deaths from cancer caused by metastases?

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Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

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The timeline of epigenetic drug discovery: from reality to dreams

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Explorative Analysis of Low-Dose Metronomic Chemotherapy with Cyclophosphamide and Methotrexate in a Cohort of Metastatic Breast Cancer Patients

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A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

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RNA-Targeted Therapeutics

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The biology and role of CD44 in cancer progression: therapeutic implications

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Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Recent Advances in the Treatment of Breast Cancer

(2018) Christy W. S. Tong et al.   Frontiers in Oncology

3,3′-Diindolylmethane suppresses ovarian cancer cell viability and metastasis and enhances chemotherapy sensitivity via STAT3 and Akt signaling in vitro and in vivo

(2018) Minghua Zou et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A new promising way of maintenance therapy in advanced ovarian cancer: a comparative clinical study

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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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Organoid technology and applications in cancer research

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MicroRNAs as biomarkers for clinical studies

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Different miR-21-3p isoforms and their different features in colorectal cancer

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Drug Resistance Driven by Cancer Stem Cells and Their Niche

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RNA Therapeutics in Oncology: Advances, Challenges, and Future Directions

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Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

(2017) Sydney M. Shaffer et al.   NATURE

Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression

(2016) Rémy Denzler et al.   MOLECULAR CELL

Epigenetic Determinants of Cancer

(2016) Stephen B. Baylin et al.   Cold Spring Harbor Perspectives in Biology

Targeting miR-21-3p inhibits proliferation and invasion of ovarian cancer cells

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Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog

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Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Antiproliferative and anti-inflammatory properties of diindolylmethane and lupeol against N-butyl-N-(4-hydroxybutyl) nitrosamine induced bladder carcinogenesis in experimental rats

(2015) B Prabhu et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

MicroRNA-21, up-regulated by arsenite, directs the epithelial–mesenchymal transition and enhances the invasive potential of transformed human bronchial epithelial cells by targeting PDCD4

(2015) Fei Luo et al.   TOXICOLOGY LETTERS

3,3′-diindolylmethane potentiates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of gastric cancer cells

(2015) YANG YE et al.   Oncology Letters

Polarized cell migration induces cancer type-specific CD133/integrin/Src/Akt/GSK3β/β-catenin signaling required for maintenance of cancer stem cell properties

(2015) Ying-Jhen Su et al.   Oncotarget

MiR-21 Enhances Melanoma Invasiveness via Inhibition of Tissue Inhibitor of Metalloproteinases 3 Expression: In Vivo Effects of MiR-21 Inhibitor

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miR-21-3p is a positive regulator of L1CAM in several human carcinomas

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Past, Present, and Future Challenges in Breast Cancer Treatment

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Myofibroblastoma of the breast with smooth muscle differentiation showing deletion of 13q14 region: Report of a case

(2014) Anne-Laure Trépant et al.   PATHOLOGY RESEARCH AND PRACTICE

miR-21 regulates N-methyl-N-nitro-N′-nitrosoguanidine-induced gastric tumorigenesis by targeting FASLG and BTG2

(2014) Qiaoyuan Yang et al.   TOXICOLOGY LETTERS

3,3′-Diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in vitro and in vivo by regulation of epithelial mesenchymal transition

(2014) TINGTING WU et al.   Experimental and Therapeutic Medicine

3,3′-Diindolylmethane ameliorates experimental hepatic fibrosis via inhibiting miR-21 expression

(2013) Zhengping Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Comparative preclinical pharmacokinetics study of 3,3′-diindolylmethane formulations: is personalized treatment and targeted chemoprevention in the horizon?

(2013) Mikhail Paltsev et al.   EPMA Journal

Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3)

(2012) Prabodh K Kandala et al.   BMC Medicine

Mesenchymal traits are selected along with stem features in breast cancer cells grown as mammospheres

(2012) Silvia Borgna et al.   CELL CYCLE

Mammary and vaginal myofibroblastomas are genetically related lesions: fluorescence in situ hybridization analysis shows deletion of 13q14 region

(2012) Gaetano Magro et al.   HUMAN PATHOLOGY

Clinically Used Breast Cancer Markers Such As Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2 Are Unstable Throughout Tumor Progression

(2012) Linda Sofie Lindström et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular Alterations Associated with Breast Cancer Mortality

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Epigenetics and chemoresistance in colorectal cancer: An opportunity for treatment tailoring and novel therapeutic strategies

(2011) Francesco Crea et al.   DRUG RESISTANCE UPDATES

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

3,3′-Diindolylmethane inhibits breast cancer cell growth via miR-21-mediated Cdc25A degradation

(2011) Yucui Jin   MOLECULAR AND CELLULAR BIOCHEMISTRY

Understanding the Dual Nature of CD44 in Breast Cancer Progression

(2011) J. M. V. Louderbough et al.   MOLECULAR CANCER RESEARCH

3,3′-Diindolylmethane Modulates Estrogen Metabolism in Patients with Thyroid Proliferative Disease: A Pilot Study

(2011) Shilpi Rajoria et al.   THYROID

Chemopreventive Agent 3,3'-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases

(2010) Y. Li et al.   CANCER RESEARCH

A New Class of Estrogen Receptor Beta-Selective Activators

(2010) R. Lo et al.   MOLECULAR INTERVENTIONS

Cytogenomics of cancers: From chromosome to sequence

(2010) Alain Bernheim   Molecular Oncology

Overcoming Drug Resistance in Patients with Metastatic Breast Cancer

(2009) Serena T Wong et al.   PHARMACOTHERAPY

High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability

(2008) Alysha K. Croker et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE