Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): Timing of maternal exposures determines target tissue response in offspring

Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg: gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received four smaller doses of DBC (3.75 mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver. However, there was a marked increase in ovarian tumors (females) and hyperplastic testes (males). [C-14]-DBC (GD 17) dosing revealed transplacental distribution to fetal tissues at 10-fold lower concentrations than in paired maternal tissue and residual [C-14] 3 weeks post-dose. This study highlights the importance of developmental stage in susceptibility to environmental carcinogens. (C) 2011 Elsevier Ireland Ltd. All rights reserved.