Flavin-containing monooxygenase 3 (FMO3): genetic variants and their consequences for drug metabolism and disease

Association of FMO3 Variants with Blood Pressure in the Atherosclerosis Risk in Communities Study

(2019) Tyler S. Bryant et al.   International Journal of Hypertension

Minor diplotypes of FMO3 might protect children and adolescents from obesity and insulin resistance

(2018) Anita Morandi et al.   INTERNATIONAL JOURNAL OF OBESITY

Trimethylamine N -oxide: A harmful, protective or diagnostic marker in lifestyle diseases?

(2018) Artur Nowiński et al.   NUTRITION

Nicotine-N'-oxidation by flavin monooxygenase enzymes

(2018) Yadira X Perez-Paramo et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain

(2017) A M Teitelbaum et al.   PHARMACOGENOMICS JOURNAL

Trimethylamine- N -Oxide: Friend, Foe, or Simply Caught in the Cross-Fire?

(2017) Clara E. Cho et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

(2017) Rebecca C. Schugar et al.   Cell Reports

Characterization and Expression Profiling Analysis of Calmodulin Genes in Response to Salt and Osmotic Stresses in Pear (Pyrus bretschneideri Rehd.) and in Comparison with Arabidopsis

(2017) Jun Tang et al.   Biomed Research International

Plasma trimethylamine N-oxide concentration is associated with choline, phospholipids, and methyl metabolism

(2016) Rima Obeid et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE−/− transgenic mice expressing CETP

(2016) Heidi L. Collins et al.   ATHEROSCLEROSIS

Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels

(2016) M. Dambrova et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Drug metabolism by flavin-containing monooxygenases of human and mouse

(2016) Ian R. Phillips et al.   Expert Opinion on Drug Metabolism & Toxicology

Human flavin-containing monooxygenase 3: Structural mapping of gene polymorphisms and insights into molecular basis of drug binding

(2016) Chongliang Gao et al.   GENE

Individual differences inin vitroandin vivometabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3

(2016) Maho Okubo et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

What is the contribution of human FMO3 in the N -oxygenation of selected therapeutic drugs and drugs of abuse?

(2016) Lea Wagmann et al.   TOXICOLOGY LETTERS

Association of FMO3 Variants and Trimethylamine N-Oxide Concentration, Disease Progression, and Mortality in CKD Patients

(2016) Cassianne Robinson-Cohen et al.   PLoS One

The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing

(2015) Sandra G. Gonzalez Malagon et al.   BIOCHEMICAL PHARMACOLOGY

In vitrometabolism of an estrogen-related receptor γ modulator, GSK5182, by human liver microsomes and recombinant cytochrome P450s

(2015) Jeongmin Joo et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

A genome-wide systems analysis reveals strong link between colorectal cancer and trimethylamine N-oxide (TMAO), a gut microbial metabolite of dietary meat and fat

(2015) Rong Xu et al.   BMC GENOMICS

Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease

(2015) Aze Wilson et al.   DIGESTIVE DISEASES AND SCIENCES

Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers

(2015) Makiko Shimizu et al.   Drug Metabolism and Pharmacokinetics

Metabolomic analysis of prostate cancer risk in a prospective cohort: The alpha-tocopherol, beta-carotene cancer prevention (ATBC) study

(2015) Alison M. Mondul et al.   INTERNATIONAL JOURNAL OF CANCER

Oral L-Carnitine Supplementation Increases Trimethylamine-N-oxide but Reduces Markers of Vascular Injury in Hemodialysis Patients

(2015) Kei Fukami et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

TMAO: A small molecule of great expectations

(2015) Marcin Ufnal et al.   NUTRITION

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

(2015) Ji Miao et al.   Nature Communications

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance

(2015) Manya Warrier et al.   Cell Reports

Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study

(2014) Carolyn A Miller et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance

(2014) Sunil Veeravalli et al.   BIOCHEMICAL PHARMACOLOGY

Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide

(2014) Lisbeth K. Siddens et al.   BIOCHEMICAL PHARMACOLOGY

Effect of two-linked mutations of the FMO3 gene on itopride metabolism in Chinese healthy volunteers

(2014) Li-Ping Zhou et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Clinical utility gene card for: Trimethylaminuria – update 2014

(2014) Elizabeth A Shephard et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet

(2014) Xiang Gao et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis

(2014) Diana M. Shih et al.   JOURNAL OF LIPID RESEARCH

The Flavin-Containing Monooxygenase 3 Gene and Essential Hypertension: The Joint Effect of Polymorphism E158K and Cigarette Smoking on Disease Susceptibility

(2014) Olga Bushueva et al.   International Journal of Hypertension

Fish Intake and Risks of Total and Cause-specific Mortality in 2 Population-based Cohort Studies of 134,296 Men and Women

(2013) Yumie Takata et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Gut microbiota metabolism of l-carnitine and cardiovascular risk

(2013) John R. Ussher et al.   ATHEROSCLEROSIS

Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities

(2013) Hiroshi Yamazaki et al.   BIOCHEMICAL PHARMACOLOGY

Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque

(2013) Yasuhiro Uno et al.   BIOCHEMICAL PHARMACOLOGY

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

(2013) Brian J. Bennett et al.   Cell Metabolism

An LC–MS based study of the metabolic profile of primaquine, an 8-aminoquinoline antiparasitic drug, with an in vitro primary human hepatocyte culture model

(2013) X. Jin et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Flavin containing monooxygenase 3 genetic polymorphisms Glu158Lys and Glu308Gly and their relation to ischemic stroke

(2013) Aysun Türkanoğlu Özçelik et al.   GENE

Effect of Human Flavin-Containing Monooxygenase 3 Polymorphism on the Metabolism of Aurora Kinase Inhibitors

(2013) Gianluca Catucci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

L-Carnitine in the Secondary Prevention of Cardiovascular Disease: Systematic Review and Meta-analysis

(2013) James J. DiNicolantonio et al.   MAYO CLINIC PROCEEDINGS

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metabolomics reveals the metabolic map of procainamide in humans and mice

(2012) Fei Li et al.   BIOCHEMICAL PHARMACOLOGY

Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects

(2012) Derrek P. Hibar et al.   Brain Imaging and Behavior

Regioselective oxidation of phospho-NSAIDs by human cytochrome P450 and flavin monooxygenase isoforms: implications for their pharmacokinetic properties and safety

(2012) Gang Xie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Expression of recombinant human flavin monooxygenase and moclobemide-N-oxide synthesis on multi-mg scale

(2012) Steven P. Hanlon et al.   CHEMICAL COMMUNICATIONS

Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption

(2012) A. Joseph Bloom et al.   Pharmacogenetics and Genomics

Influence of FMO1 and 3 polymorphisms on serum olanzapine and its N-oxide metabolite in psychiatric patients

(2012) M M Söderberg et al.   PHARMACOGENOMICS JOURNAL

In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine

(2011) Jiang Ping Luo et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s

(2011) A. Potega et al.   DRUG METABOLISM AND DISPOSITION

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Understanding the contribution of synonymous mutations to human disease

(2011) Zuben E. Sauna et al.   NATURE REVIEWS GENETICS

In Vitro Metabolism Studies of Nomifensine Monooxygenation Pathways: Metabolite Identification, Reaction Phenotyping, and Bioactivation Mechanism

(2010) J. Yu et al.   DRUG METABOLISM AND DISPOSITION

A rapid and sensitive CE method with field-enhanced sample injection and in-capillary derivatization for selenomethionine metabolism catalyzed by flavin-containing monooxygenases

(2010) Xin Hai et al.   ELECTROPHORESIS

A common FMO3 polymorphism may amplify the effect of nicotine exposure in sudden infant death syndrome (SIDS)

(2010) Micaela Poetsch et al.   INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Role of carnitine in disease

(2010) Judith L Flanagan et al.   Nutrition & Metabolism

Inter-individual Variation in Flavin-containing Monooxygenase 3 in Livers from Japanese: Correlation with Hepatic Transcription Factors

(2009) Satomi Nagashima et al.   Drug Metabolism and Pharmacokinetics

Enantioselective in-line and off-line CE methods for the kinetic study on cimetidine and its chiral metabolites with reference to flavin-containing monooxygenase genetic isoforms

(2009) Xin Hai et al.   ELECTROPHORESIS

Novel variants of the human flavin-containing monooxygenase 3 (FMO3) gene associated with trimethylaminuria

(2009) Meike S. Motika et al.   MOLECULAR GENETICS AND METABOLISM

Flavin-containing monooxygenase 3 polymorphisms in 13 ethnic populations from Europe, East Asia and sub-Saharan Africa: frequency and linkage analysis

(2009) Mao Mao et al.   PHARMACOGENOMICS

Human Flavin-Containing Monooxygenase 2.1 Catalyzes Oxygenation of the Antitubercular Drugs Thiacetazone and Ethionamide

(2008) A. A. Francois et al.   DRUG METABOLISM AND DISPOSITION

Identification of the Human Enzymes Involved in the Oxidative Metabolism of Dasatinib: An Effective Approach for Determining Metabolite Formation Kinetics

(2008) L. Wang et al.   DRUG METABOLISM AND DISPOSITION

Role of Flavin-Containing Monooxygenase in Oxidative Metabolism of Voriconazole by Human Liver Microsomes

(2008) S. B. Yanni et al.   DRUG METABOLISM AND DISPOSITION

Role of flavin-containing monooxgenase in drug development

(2008) John R Cashman   Expert Opinion on Drug Metabolism & Toxicology

The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa

(2008) Krishna R. Veeramah et al.   Pharmacogenetics and Genomics

Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes

(2008) Marilyn C. Henderson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Flavin-containing monooxygenases: mutations, disease and drug response

(2008) I PHILLIPS et al.   TRENDS IN PHARMACOLOGICAL SCIENCES