The neuroprotective action of 3,3′-diindolylmethane against ischemia involves an inhibition of apoptosis and autophagy that depends on HDAC and AhR/CYP1A1 but not ERα/CYP19A1 signaling

Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors

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Synergistic Association of Valproate and Resveratrol Reduces Brain Injury in Ischemic Stroke

(2018) Lara Faggi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

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Bazedoxifene and raloxifene protect neocortical neurons undergoing hypoxia via targeting ERα and PPAR-γ

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Steroid and Xenobiotic Receptor Signalling in Apoptosis and Autophagy of the Nervous System

(2017) Agnieszka Wnuk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

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Delayed Treatment with Histone Deacetylase Inhibitors Promotes Stroke Recovery

(2017) Timal S. Kannangara et al.   JOURNAL OF NEUROSCIENCE

Real-World Outcomes of Acute Ischemic Stroke Treatment with Intravenous Recombinant Tissue Plasminogen Activator

(2017) Keith A. Betts et al.   Journal of Stroke & Cerebrovascular Diseases

Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells

(2017) Agnieszka Wnuk et al.   MOLECULAR NEUROBIOLOGY

Neuropeptide Y Y2 and Y5 receptors as promising targets for neuroprotection in primary neurons exposed to oxygen-glucose deprivation and in transient focal cerebral ischemia in rats

(2017) Helena Domin et al.   NEUROSCIENCE

Neuroprotective strategies and the underlying molecular basis of cerebrovascular stroke

(2017) Michael Karsy et al.   Neurosurgical Focus

Sodium Valproate, a Histone Deacetylase Inhibitor, Is Associated With Reduced Stroke Risk After Previous Ischemic Stroke or Transient Ischemic Attack

(2017) Rebecca L. Brookes et al.   STROKE

Expression of Class I Histone Deacetylases in Ipsilateral and Contralateral Hemispheres after the Focal Photothrombotic Infarction in the Mouse Brain

(2017) Svetlana Demyanenko et al.   Translational Stroke Research

Real-World Outcomes of Acute Ischemic Stroke Treatment with Intravenous Recombinant Tissue Plasminogen Activator

(2017) Keith A. Betts et al.   Journal of Stroke & Cerebrovascular Diseases

Sodium hydrosulfide attenuates cerebral ischemia/reperfusion injury by suppressing overactivated autophagy in rats

(2017) Wen-Wu Jiang et al.   FEBS Open Bio

Potassium 2-(1-hydroxypentyl)-benzoate attenuates neuronal apoptosis in neuron–astrocyte co-culture system through neurotrophy and neuroinflammation pathway

(2017) Dongmei Liu et al.   Acta Pharmaceutica Sinica B

Oxygen-Glucose-Deprivation/Reoxygenation-Induced Autophagic Cell Death Depends on JNK-Mediated Phosphorylation of Bcl-2

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Cyclosporine A Treatment Abrogates Ischemia-Induced Neuronal Cell Death by Preserving Mitochondrial Integrity through Upregulation of the Parkinson's Disease-Associated Protein DJ-1

(2016) Naoki Tajiri et al.   CNS Neuroscience & Therapeutics

The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats

(2016) Min Jung Park et al.   Journal of Neuroinflammation

Dynamic changes in neuronal autophagy and apoptosis in the ischemic penumbra following permanent ischemic stroke

(2016) Peng-yue Zhang et al.   Neural Regeneration Research

Neuroprotective action of raloxifene against hypoxia-induced damage in mouse hippocampal cells depends on ERα but not ERβ or GPR30 signalling

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The role of p38MAPK signal pathway in the neuroprotective mechanism of limb postconditioning against rat cerebral ischemia/reperfusion injury

(2015) Hao Li et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Inhibiting histone deacetylase 6 partly protects cultured rat cortical neurons from oxygen-glucose deprivation-induced necroptosis

(2015) LIMING YUAN et al.   Molecular Medicine Reports

Selective Aryl Hydrocarbon Receptor Modulator 3,3′-Diindolylmethane Impairs AhR and ARNT Signaling and Protects Mouse Neuronal Cells Against Hypoxia

(2015) J. Rzemieniec et al.   MOLECULAR NEUROBIOLOGY

Hippocampus and cerebral cortex present a different autophagic response after oxygen and glucose deprivation in anex vivorat brain slice model

(2015) Diego Pérez-Rodríguez et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The Crucial Involvement of Retinoid X Receptors in DDE Neurotoxicity

(2015) A. Wnuk et al.   NEUROTOXICITY RESEARCH

Hsp20 Protects against Oxygen-Glucose Deprivation/Reperfusion-Induced Golgi Fragmentation and Apoptosis through Fas/FasL Pathway

(2015) Bingwu Zhong et al.   Oxidative Medicine and Cellular Longevity

Low levels of 3,3′-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol

(2014) Maud Marques et al.   BMC CANCER

L-Kynurenine/Aryl Hydrocarbon Receptor Pathway Mediates Brain Damage After Experimental Stroke

(2014) María I. Cuartero et al.   CIRCULATION

Isomer-nonspecific action of dichlorodiphenyltrichloroethane on aryl hydrocarbon receptor and G-protein-coupled receptor 30 intracellular signaling in apoptotic neuronal cells

(2014) M. Kajta et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Resveratrol protects primary cortical neuron cultures from transient oxygen-glucose deprivation by inhibiting MMP-9

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Novel Para-Phenyl Substituted Diindolylmethanes Protect Against MPTP Neurotoxicity and Suppress Glial Activation in a Mouse Model of Parkinson’s Disease

(2014) Briana R. De Miranda et al.   TOXICOLOGICAL SCIENCES

Phosphorylation of p38 MAPK mediates hypoxic preconditioning-induced neuroprotection against cerebral ischemic injury via mitochondria translocation of Bcl-xL in mice

(2013) Li Zhao et al.   BRAIN RESEARCH

3,3'-Diindolylmethane Inhibits Lipopolysaccharide-Induced Microglial Hyperactivation and Attenuates Brain Inflammation

(2013) H. W. Kim et al.   TOXICOLOGICAL SCIENCES

Expression patterns of histone deacetylases in experimental stroke and potential targets for neuroprotection

(2012) Yan-Ting Chen et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Excessive Autophagy Contributes to Neuron Death in Cerebral Ischemia

(2012) Ruoyang Shi et al.   CNS Neuroscience & Therapeutics

Caspase Inhibitors

(2012) Nsikan Akpan et al.   NEUROSCIENTIST

3,3′-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells

(2012) Laura M. Beaver et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Increased p38 mitogen-activated protein kinase signaling is involved in the oxidative stress associated with oxygen and glucose deprivation in neonatal hippocampal slice cultures

(2011) Qing Lu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage

(2011) Bing Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Expression of Histone Deacetylases in Cellular Compartments of the Mouse Brain and the Effects of Ischemia

(2011) Selva Baltan et al.   Translational Stroke Research

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Chemopreventive Agent 3,3'-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases

(2010) Y. Li et al.   CANCER RESEARCH

Valproic Acid Attenuates Blood–Brain Barrier Disruption in a Rat Model of Transient Focal Cerebral Ischemia: The Roles of HDAC and MMP-9 Inhibition

(2010) Zhifei Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Low Concentrations of Diindolylmethane, a Metabolite of Indole-3-Carbinol, Protect against Oxidative Stress in a BRCA1-Dependent Manner

(2009) S. Fan et al.   CANCER RESEARCH

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

Single-Dose Pharmacokinetics and Tolerability of Absorption-Enhanced 3,3'-Diindolylmethane in Healthy Subjects

(2008) G. A. Reed et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

(2008) Dohoon Kim et al.   NEURON

Aryl hydrocarbon receptor-mediated apoptosis of neuronal cells: A possible interaction with estrogen receptor signaling

(2008) M. Kajta et al.   NEUROSCIENCE

Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death

(2007) A. Rami et al.   NEUROBIOLOGY OF DISEASE