The epigenome as a potential mediator of cancer and disease prevention in prenatal development

Prenatal Exposure to Polycyclic Aromatic Hydrocarbons, Benzo[ a ]pyrene–DNA Adducts, and Genomic DNA Methylation in Cord Blood

(2012) Julie B. Herbstman et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Maternal intake of quercetin during gestation alters ex vivo benzo[a]pyrene metabolism and DNA adduct formation in adult offspring

(2012) K. Vanhees et al.   MUTAGENESIS

Transgenerational Actions of Environmental Compounds on Reproductive Disease and Identification of Epigenetic Biomarkers of Ancestral Exposures

(2012) Mohan Manikkam et al.   PLoS One

Caffeine-Induced Activated Glucocorticoid Metabolism in the Hippocampus Causes Hypothalamic-Pituitary-Adrenal Axis Inhibition in Fetal Rats

(2012) Dan Xu et al.   PLoS One

Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo

(2011) Seung Joon Lee et al.   BMC CANCER

Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells

(2011) Barbara Stefanska et al.   BRITISH JOURNAL OF NUTRITION

Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): Timing of maternal exposures determines target tissue response in offspring

(2011) Lyndsey E. Shorey et al.   CANCER LETTERS

(-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells

(2011) V. Nandakumar et al.   CARCINOGENESIS

Gestational low protein diet in the rat mediatesIgf2gene expression in male offspring via altered hepatic DNA methylation

(2011) Li Gong et al.   Epigenetics

Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer

(2011) K Ted Thurn et al.   Future Oncology

Effects of Vitamin A or Beta Carotene Supplementation on Pregnancy-Related Mortality and Infant Mortality in Rural Bangladesh

(2011) Keith P. West et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical significance of aberrant DNA methylation in childhood acute lymphoblastic leukemia

(2011) Seisho Takeuchi et al.   LEUKEMIA RESEARCH

Acetaldehyde-Mediated Neurotoxicity: Relevance to Fetal Alcohol Spectrum Disorders

(2011) Ming Tong et al.   Oxidative Medicine and Cellular Longevity

Alcohol Exposure Decreases CREB Binding Protein Expression and Histone Acetylation in the Developing Cerebellum

(2011) Weixiang Guo et al.   PLoS One

Prenatal environmental exposures, epigenetics, and disease

(2011) Frederica Perera et al.   REPRODUCTIVE TOXICOLOGY

DNA methylation and soy phytoestrogens: quantitative study in DU-145 and PC-3 human prostate cancer cell lines

(2011) Mawussi Adjakly et al.   Epigenomics

Progress in Nanotechnology Based Approaches to Enhance the Potential of Chemopreventive Agents

(2011) Irfana Muqbil et al.   Cancers

Maternal caffeine intake from coffee and tea, fetal growth, and the risks of adverse birth outcomes: the Generation R Study

(2010) Rachel Bakker et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Nutrition, Epigenetics, and Developmental Plasticity: Implications for Understanding Human Disease

(2010) Graham C. Burdge et al.   Annual Review of Nutrition

Perinatal Exposure to Oestradiol and Bisphenol A Alters the Prostate Epigenome and Increases Susceptibility to Carcinogenesis

(2010) Gail S. Prins et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Cancer chemoprevention by dietary polyphenols: Promising role for epigenetics

(2010) Alexander Link et al.   BIOCHEMICAL PHARMACOLOGY

Chemopreventive Agent 3,3'-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases

(2010) Y. Li et al.   CANCER RESEARCH

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells

(2010) Y. Li et al.   CLINICAL CANCER RESEARCH

Epigenetic analysis of childhood acute lymphoblastic leukemia

(2010) Thomas L. Dunwell et al.   Epigenetics

5-azacytidine treatment reorganizes genomic histone modification patterns

(2010) Vitalina M. Komashko et al.   Epigenetics

Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response

(2010) Jason G. Bromer et al.   FASEB JOURNAL

Epigenetics: prenatal exposure to genistein leaves a permanent signature on the hematopoietic lineage

(2010) Kimberly Vanhees et al.   FASEB JOURNAL

Vorinostat (NSC# 701852) in Patients with Relapsed Non-small Cell Lung Cancer: A Wisconsin Oncology Network Phase II Study

(2010) Anne M. Traynor et al.   Journal of Thoracic Oncology

CADPE Inhibits PMA-Stimulated Gastric Carcinoma Cell Invasion and Matrix Metalloproteinase-9 Expression by FAK/MEK/ERK-Mediated AP-1 Activation

(2010) H. Han et al.   MOLECULAR CANCER RESEARCH

Daidzein Effect on Hormone Refractory Prostate Cancer In Vitro and In Vivo Compared to Genistein and Soy Extract: Potentiation of Radiotherapy

(2010) Vinita Singh-Gupta et al.   PHARMACEUTICAL RESEARCH

Sulforaphane Causes Epigenetic Repression of hTERT Expression in Human Breast Cancer Cell Lines

(2010) Syed M. Meeran et al.   PLoS One

Sex- and Diet-Specific Changes of Imprinted Gene Expression and DNA Methylation in Mouse Placenta under a High-Fat Diet

(2010) Catherine Gallou-Kabani et al.   PLoS One

Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth

(2010) Jianqing Lin et al.   PROSTATE

The Genetic Landscape of the Childhood Cancer Medulloblastoma

(2010) D. W. Parsons et al.   SCIENCE

Prenatal Exposure to Flavonoids: Implication for Cancer Risk

(2010) Kimberly Vanhees et al.   TOXICOLOGICAL SCIENCES

Effect of cadmium on cortisol production and 11β-hydroxysteroid dehydrogenase 2 expression by cultured human choriocarcinoma cells (JEG-3)

(2010) Ana Maria Ronco et al.   TOXICOLOGY IN VITRO

Effects of arsenic exposure on DNA methylation and epigenetic gene regulation

(2010) John F Reichard et al.   Epigenomics

Maternal Ethanol Consumption Alters the Epigenotype and the Phenotype of Offspring in a Mouse Model

(2010) Nina Kaminen-Ahola et al.   PLoS Genetics

Epigenetic targets of bioactive dietary components for cancer prevention and therapy

(2010) Syed M. Meeran et al.   Clinical Epigenetics

Perspectives on the soy–breast cancer relation

(2009) Mark Messina et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies

(2009) Gamze Bora-Tatar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Influence of Prenatal Lead Exposure on Genomic Methylation of Cord Blood DNA

(2009) J. Richard Pilsner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Effects of Mixtures of Polychlorinated Biphenyls, Methylmercury, and Organochlorine Pesticides on Hepatic DNA Methylation in Prepubertal Female Sprague-Dawley Rats

(2009) Daniel Desaulniers et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Histone deacetylase inhibitors: Potential in cancer therapy

(2009) P.A. Marks et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Impairment in protein expression profile of testicular steroid receptor coregulators in male rat offspring perinatally exposed to Bisphenol A

(2009) Smita Salian et al.   LIFE SCIENCES

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias

(2009) Luke B Hesson et al.   Molecular Cancer

Relation of DNA Methylation of 5′-CpG Island of ACSL3 to Transplacental Exposure to Airborne Polycyclic Aromatic Hydrocarbons and Childhood Asthma

(2009) Frederica Perera et al.   PLoS One

Transgenerational effects of the endocrine disruptor vinclozolin on the methylation pattern of imprinted genes in the mouse sperm

(2009) Christelle Stouder et al.   REPRODUCTION

Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis

(2009) Qiang Zhang et al.   TOXICOLOGY IN VITRO

Environmental Epigenetics and Asthma

(2008) Rachel L. Miller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Quercetin augments TRAIL-induced apoptotic death: Involvement of the ERK signal transduction pathway

(2008) Young-Ho Kim et al.   BIOCHEMICAL PHARMACOLOGY

Curcumin is a potent DNA hypomethylation agent

(2008) Zhongfa Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Arsenic Exposure In utero Exacerbates Skin Cancer Response in Adulthood with Contemporaneous Distortion of Tumor Stem Cell Dynamics

(2008) M. P. Waalkes et al.   CANCER RESEARCH

Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine

(2008) D. J. Castro et al.   CARCINOGENESIS

Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression

(2008) N. J. Kang et al.   CARCINOGENESIS

Quercetin Is Able to Demethylate the p16INK4a Gene Promoter

(2008) Sainan Tan et al.   CHEMOTHERAPY

Modulation of gene methylation by genistein or lycopene in breast cancer cells

(2008) Audrey King-Batoon et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

A phase I clinical trial of the histone deacetylase inhibitor belinostat in patients with advanced hematological neoplasia

(2008) Peter Gimsing et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression

(2008) Jae-Hoon Jeong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD

(2008) J. Wu et al.   JOURNAL OF NEUROSCIENCE

Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon

(2008) Markus Waldecker et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells

(2008) M. Sun et al.   MOLECULAR CANCER THERAPEUTICS

Green tea extract increases cyclophosphamide-induced teratogenesis by modulating the expression of cytochrome P-450 mRNA

(2008) Dongsun Park et al.   REPRODUCTIVE TOXICOLOGY

Exposure of the U.S. Population to Bisphenol A and 4- tertiary -Octylphenol: 2003–2004

(2007) Antonia M. Calafat et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG

(2007) Joel B. Berletch et al.   JOURNAL OF CELLULAR BIOCHEMISTRY