Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells

Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells

(2013) L. Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breast Cancer Cell Uptake of the Inflammatory Mediator Neutrophil Elastase Triggers an Anticancer Adaptive Immune Response

(2012) E. A. Mittendorf et al.   CANCER RESEARCH

Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological types

(2012) Francisco Ferro de Beça et al.   JOURNAL OF CLINICAL PATHOLOGY

CD44+/CD24- phenotype contributes to malignant relapse following surgical resection and chemotherapy in patients with invasive ductal carcinoma

(2012) Yan Lin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Indole-3-Carbinol disrupts Estrogen Receptor-alpha dependent expression of Insulin-like Growth Factor-1 Receptor and Insulin Receptor Substrate-1 and proliferation of human breast cancer cells

(2012) Crystal N. Marconett et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Role of Cancer Stem Cells in Breast Cancer Initiation and Progression: Potential Cancer Stem Cell-Directed Therapies

(2012) Panagiota Economopoulou et al.   ONCOLOGIST

Antiproliferative effects of artemisinin on human breast cancer cells requires the downregulated expression of the E2F1 transcription factor and loss of E2F1-target cell cycle genes

(2011) Antony S. Tin et al.   ANTI-CANCER DRUGS

Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells

(2011) C. N. Marconett et al.   CARCINOGENESIS

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

(2011) Piyush B. Gupta et al.   CELL

A positive cross-regulation of HER2 and ER-α36 controls ALDH1 positive breast cancer cells

(2011) Lianguo Kang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling

(2011) Ida Aronchik et al.   MOLECULAR CARCINOGENESIS

Maintenance of tumor initiating cells of defined genetic composition by nucleostemin

(2011) N. Okamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Side-population cells in luminal-type breast cancer have tumour-initiating cell properties and are regulated by HER2 expression and signalling

(2010) T Nakanishi et al.   BRITISH JOURNAL OF CANCER

Molecular cytogenetic characterization of stem-like cancer cells isolated from established cell lines

(2010) Patrizia Gasparini et al.   CANCER LETTERS

Activation of Murine Double Minute 2 by Akt in Mammary Epithelium Delays Mammary Involution and Accelerates Mammary Tumorigenesis

(2010) X. Cheng et al.   CANCER RESEARCH

Tumor-Initiating Function of Nucleostemin-Enriched Mammary Tumor Cells

(2010) T. Lin et al.   CANCER RESEARCH

Direct Inhibition of Elastase Activity by Indole-3-Carbinol Triggers a CD40-TRAF Regulatory Cascade That Disrupts NF-κB Transcriptional Activity in Human Breast Cancer Cells

(2010) Ida Aronchik et al.   CANCER RESEARCH

1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells

(2010) Hanh H. Nguyen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Anticancer Properties of Indole Compounds: Mechanism of Apoptosis Induction and Role in Chemotherapy

(2010) Aamir Ahmad et al.   CURRENT DRUG TARGETS

Indole-3-Carbinol Triggers Aryl Hydrocarbon Receptor-dependent Estrogen Receptor (ER)α Protein Degradation in Breast Cancer Cells Disrupting an ERα-GATA3 Transcriptional Cross-Regulatory Loop

(2010) Crystal N. Marconett et al.   MOLECULAR BIOLOGY OF THE CELL

GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest

(2010) L Meng et al.   ONCOGENE

Breast cancer stem cells: tools and models to rely on

(2009) Emmanuelle Charafe-Jauffret et al.   BMC CANCER

HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells

(2009) Yi Zhang et al.   BMC CELL BIOLOGY

Cancer stem cells in breast cancer and metastasis

(2009) Jessica C. Lawson et al.   BREAST CANCER RESEARCH AND TREATMENT

Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics

(2009) Fazlul H. Sarkar et al.   CANCER TREATMENT REVIEWS

HER-2, Notch, and Breast Cancer Stem Cells: Targeting an Axis of Evil

(2009) H. Korkaya et al.   CLINICAL CANCER RESEARCH

The role of HER2 in early breast cancer metastasis and the origins of resistance to HER2-targeted therapies

(2009) Jaclyn A. Freudenberg et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Resistance to Endocrine Therapy: Are Breast Cancer Stem Cells the Culprits?

(2009) Ciara S. O’Brien et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Minireview: Modulation of Hormone Receptor Signaling by Dietary Anticancer Indoles

(2009) Gary L. Firestone et al.   MOLECULAR ENDOCRINOLOGY

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

(2009) Bin-Bing S. Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Breast cancer stem cells

(2009) Kazuharu Kai et al.   Breast Cancer

Tumor Suppressive Functions of p53

(2009) J. T. Zilfou et al.   Cold Spring Harbor Perspectives in Biology

Cancer stem cells: markers or biomarkers?

(2008) Wendy A. Woodward et al.   CANCER AND METASTASIS REVIEWS

Indole-3-carbinol as a chemopreventive and anti-cancer agent

(2008) Jing-Ru Weng et al.   CANCER LETTERS

Cancer chemotherapy with indole-3-carbinol, bis(3′-indolyl)methane and synthetic analogs

(2008) Stephen Safe et al.   CANCER LETTERS

Aldehyde dehydrogenase activity as a functional marker for lung cancer

(2008) Deniz Ucar et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity

(2008) Christine T. Brew et al.   INTERNATIONAL JOURNAL OF CANCER

Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy

(2008) X. Li et al.   JNCI-Journal of the National Cancer Institute

Aberrant Expression of Nucleostemin Activates p53 and Induces Cell Cycle Arrest via Inhibition of MDM2

(2008) M.-S. Dai et al.   MOLECULAR AND CELLULAR BIOLOGY

Cell Line Data Base: structure and recent improvements towards molecular authentication of human cell lines

(2008) P. Romano et al.   NUCLEIC ACIDS RESEARCH

HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion

(2008) H Korkaya et al.   ONCOGENE

The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing

(2008) H. H. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Executioner caspase-3 and caspase-7 are functionally distinct proteases

(2008) J. G. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALDH1 as a Functional Marker of Cancer Stem and Progenitor Cells

(2008) Julie Douville et al.   STEM CELLS AND DEVELOPMENT