Protein-Protein Interaction Inhibitors Targeting the Eph-Ephrin System with a Focus on Amino Acid Conjugates of Bile Acids
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Protein-Protein Interaction Inhibitors Targeting the Eph-Ephrin System with a Focus on Amino Acid Conjugates of Bile Acids
Authors
Keywords
-
Journal
Pharmaceuticals
Volume 15, Issue 2, Pages 137
Publisher
MDPI AG
Online
2022-01-26
DOI
10.3390/ph15020137
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin
- (2021) Marco Rusnati et al. CANCER GENE THERAPY
- Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties
- (2020) Matteo Incerti et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Radiopharmacologist’s and Radiochemist’s View on Targeting the Eph/Ephrin Receptor Tyrosine Kinase System
- (2020) Christin Neuber et al. ACS Omega
- Safety, tolerability, pharmacokinetics, and pharmacodynamics of the afucosylated, humanized anti-EPHA2 antibody DS-8895a: a first-in-human phase I dose escalation and dose expansion study in patients with advanced solid tumors
- (2019) Kohei Shitara et al. Journal for ImmunoTherapy of Cancer
- ATIM-23. PRELIMINARY FINDINGS OF A PHASE I SAFETY AND BIOIMAGING TRIAL OF KB004 (IFABOTUZUMAB) IN PATIENTS WITH GLIOBLASTOMA
- (2019) Hui Gan et al. NEURO-ONCOLOGY
- Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice
- (2019) Francesca Ferlenghi et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- EphrinB2/EphB4 signaling regulates non‐sprouting angiogenesis by VEGF
- (2018) Elena Groppa et al. EMBO REPORTS
- UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice
- (2018) Claudio Festuccia et al. Oncotarget
- Structure-Based Design of Novel EphA2 Agonistic Agents with Nanomolar Affinity in Vitro and in Cell
- (2018) Luca Gambini et al. ACS Chemical Biology
- Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein–Protein Interaction Inhibitors Targeting the EphA2 Receptor
- (2017) Matteo Incerti et al. JOURNAL OF MEDICINAL CHEMISTRY
- Comment on “KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study”
- (2017) Amy Hughes et al. LEUKEMIA RESEARCH
- Eph-ephrin signaling modulated by polymerization and condensation of receptors
- (2017) Samuel Ojosnegros et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of EBV LMP1-triggered EphA4 downregulation in EBV-associated B lymphoma and its impact on patients survival
- (2016) Y.-C. Huang et al. BLOOD
- Three stories on Eph kinase inhibitors: From in silico discovery to in vivo validation
- (2016) Andrea Unzue et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study
- (2016) Ronan T. Swords et al. LEUKEMIA RESEARCH
- Mechanisms of ephrin–Eph signalling in development, physiology and disease
- (2016) Artur Kania et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Eph Receptors and Ephrins: Therapeutic Opportunities
- (2015) Antonio Barquilla et al. Annual Review of Pharmacology and Toxicology
- Design and Characterization of Novel EphA2 Agonists for Targeted Delivery of Chemotherapy to Cancer Cells
- (2015) Bainan Wu et al. CHEMISTRY & BIOLOGY
- Targeting the Eph-ephrin System with Protein-Protein Interaction (PPI) Inhibitors
- (2015) Massimiliano Tognolini et al. CURRENT DRUG TARGETS
- Targeting the Eph System with Peptides and Peptide Conjugates
- (2015) Stefan Riedl et al. CURRENT DRUG TARGETS
- Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph–ephrin system
- (2015) Riccardo Castelli et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Malaria parasites target the hepatocyte receptor EphA2 for successful host infection
- (2015) A. Kaushansky et al. SCIENCE
- Are We Using the Right Pharmacological Tools to Target EphA4?
- (2014) Massimiliano Tognolini et al. ACS Chemical Neuroscience
- UniPR129 is a competitive small molecule Eph-ephrin antagonist blockingin vitroangiogenesis at low micromolar concentrations
- (2014) I Hassan-Mohamed et al. BRITISH JOURNAL OF PHARMACOLOGY
- NMR-Based Approaches for the Identification and Optimization of Inhibitors of Protein–Protein Interactions
- (2014) Elisa Barile et al. CHEMICAL REVIEWS
- Ephs and Ephrins in malignant gliomas
- (2014) Sara Ferluga et al. GROWTH FACTORS
- Combining Ligand- and Structure-Based Approaches for the Discovery of New Inhibitors of the EPHA2–ephrin-A1 Interaction
- (2014) Daniele Pala et al. Journal of Chemical Information and Modeling
- On the Use of 2,5-Dimethyl-Pyrrol-1-yl-Benzoic Acid Derivatives as EPH-Ephrin Antagonists
- (2014) A. Lodola et al. JOURNAL OF VIROLOGY
- Homotypic receptor-receptor interactions regulating Eph signaling
- (2014) Dimitar B Nikolov et al. Cell Adhesion & Migration
- Specific tumor delivery of paclitaxel using glycolipid-like polymer micelles containing gold nanospheres
- (2013) Jian You et al. BIOMATERIALS
- EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme
- (2013) Bryan W. Day et al. CANCER CELL
- Amino Acid Conjugates of Lithocholic Acid As Antagonists of the EphA2 Receptor
- (2013) Matteo Incerti et al. JOURNAL OF MEDICINAL CHEMISTRY
- The EphA2 Receptor Drives Self-Renewal and Tumorigenicity in Stem-like Tumor-Propagating Cells from Human Glioblastomas
- (2012) Elena Binda et al. CANCER CELL
- Structure-Activity Relationships and Mechanism of Action of Eph-ephrin Antagonists: Interaction of Cholanic Acid with the EphA2 Receptor
- (2012) Massimiliano Tognolini et al. ChemMedChem
- Expression of EphrinB2 and EphB4 in glioma tissues correlated to the progression of glioma and the prognosis of glioblastoma patients
- (2012) Yanyang Tu et al. Clinical & Translational Oncology
- Phase 1, open-label study of MEDI-547 in patients with relapsed or refractory solid tumors
- (2012) Christina M. Annunziata et al. INVESTIGATIONAL NEW DRUGS
- Structural and Functional Characterization of Monomeric EphrinA1 Binding Site to EphA2 Receptor
- (2012) Carla M. Lema Tomé et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Concepts and consequences of Eph receptor clustering
- (2012) Peter W. Janes et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Structural and Functional Characterization of an Agonistic Anti-Human EphA2 Monoclonal Antibody
- (2011) Li Peng et al. JOURNAL OF MOLECULAR BIOLOGY
- Comprehensive analysis of kinase inhibitor selectivity
- (2011) Mindy I Davis et al. NATURE BIOTECHNOLOGY
- Lithocholic Acid Is an Eph-ephrin Ligand Interfering with Eph-kinase Activation
- (2011) Carmine Giorgio et al. PLoS One
- PEGylation Potentiates the Effectiveness of an Antagonistic Peptide That Targets the EphB4 Receptor with Nanomolar Affinity
- (2011) Roberta Noberini et al. PLoS One
- Proteomic profiling of secretome and adherent plasma membranes from distinct mammary epithelial cell subpopulations
- (2011) Hong Ji et al. PROTEOMICS
- EphA2 Targeted Chemotherapy Using an Antibody Drug Conjugate in Endometrial Carcinoma
- (2010) J. W. Lee et al. CLINICAL CANCER RESEARCH
- Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle
- (2010) Maria Genander et al. STEM CELLS
- Eph Receptors and Ephrin Ligands: Important Players in Angiogenesis and Tumor Angiogenesis
- (2010) Birgit Mosch et al. Journal of Oncology
- EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop with Akt
- (2009) Hui Miao et al. CANCER CELL
- Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex
- (2009) Juha P Himanen et al. EMBO REPORTS
- Eph-Ephrin Bidirectional Signaling in Physiology and Disease
- (2008) Elena B. Pasquale CELL
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started