Article
Pharmacology & Pharmacy
Peishan Qiu, Daojiang Li, Cong Xiao, Fei Xu, Xiaoyu Chen, Ying Chang, Lan Liu, Lei Zhang, Qiu Zhao, Yuhua Chen
Summary: The extent of gut inflammation depends on the gut barrier's integrity and enteric neuroimmune interactions. The role of Eph/ephrin signaling in regulating gut homeostasis, inflammation, neuroimmune interactions, and pain pathways is critical. Targeting the Eph/ephrin system provides innovative treatments for gut inflammation disorders.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Chemistry, Applied
Haidi Xu, Bradley L. Reuhs, Thaisa M. Cantu-Jungles, Yunus E. Tuncil, Amandeep Kaur, Anton Terekhov, Eric C. Martens, Bruce R. Hamaker
Summary: This study investigated the relationship between fine structure and fermentability of Corn arabinoxylan (CAX) by the human gut microbiota. The analysis revealed an organized structural feature of CAX, with complex branching patterns. Contrary to conventional views, smaller fiber structures with higher branch complexity fermented slower.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Analytical
Xiaofeng Zhu, Congcong Du, Ali Mohsin, Qian Yin, Feng Xu, Zebo Liu, Zejian Wang, Yingping Zhuang, Ju Chu, Meijin Guo, Xiwei Tian
Summary: A highly efficient, accurate, noninvasive detection method for gentamicin was developed to provide timely feedback for high-throughput screening of high-yield strains. The random forest algorithm was found to have the highest prediction accuracy. A stable genetically high-yield strain was successfully screened out and the new data sets were updated in the model database to improve the learning ability of the DBTL cycle.
ANALYTICAL CHEMISTRY
(2022)
Article
Food Science & Technology
Chloe Robert, Armelle Penhoat, Leslie Couedelo, Magali Monnoye, Dominique Rainteau, Emmanuelle Meugnier, Sofia Bary, Helene Abrous, Emmanuelle Loizon, Pranvera Krasniqi, Stephanie Chanon, Aurekie Vieille-Marchiset, Francois Caillet, Sabine Danthine, Hubert Vidal, Nicolas Guillot, Philippe Gerard, Carole Vaysse, Marie-Caroline Michalski
Summary: The study found that natural emulsifiers such as plant lecithins, including those from rapeseed and soy, do not promote obesity and inflammation induced by high-fat diet. These lecithins also have no effect on gut barrier markers and caecal bile acids, and contribute to the status of n-3 PUFA. Moreover, they can improve gut microbiota diversity and increase the abundance of beneficial bacteria.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Chemistry, Medicinal
Yang Liu, Siyuan Xu, Qiudie Cai, Dawei Li, Hongye Li, Weidong Yang
Summary: In this study, we investigated the interaction between okadaic acid (OA) and gut microbiota using an in vitro fermentation experiment. We found that OA can reshape the bacterial composition and lead to the production of various metabolites. Our findings confirmed the direct interaction between OA and gut bacteria, providing valuable evidence for understanding the metabolic process and complex toxicity of OA.
Article
Agriculture, Multidisciplinary
Yu Wang, Chao Han, Jinghe Cheng, Zhanjun Wang, Lulu Liu, Houyu Huang, Qiuxia Liang, Ruiying Liu, Beibei Ran, Weidong Li
Summary: Fermented Cerasus humilis fruit (FCHF) has higher levels of active compounds and antioxidants, and can improve liver fat accumulation. Fermentation also regulates gut microbiota and alleviates dysbacteriosis caused by hyperlipidemia.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Food Science & Technology
Yarsmin Yunus Zeebone, Brigitta Bota, Veronika Halas, Balazs Libisch, Ferenc Olasz, Peter Papp, Tibor Kereszteny, Annamaria Gerocs, Omeralfaroug Ali, Melinda Kovacs, Andras Szabo
Summary: This study investigated the effects of dietary fumonisins on the gut and faecal microbiota of weaned pigs. Results showed no effects on growth performance, but there were changes in serum enzyme activities and alterations in microbial populations in the duodenum, ileum, and faeces. The study suggests that a high dosage of fumonisins can alter the gut microbiota of pigs without affecting their growth performance.
Article
Biology
Stephen R. Stockdale, Lorraine A. Draper, Sarah M. O'Donovan, Wiley Barton, Orla O'Sullivan, Laura A. Volpicelli-Daley, Aideen M. Sullivan, Cora O'Neill, Colin Hill
Summary: Stockdale et al. assess longitudinal faecal virome changes in a rat model of Parkinson's Disease (PD) in which either monomeric or preformed fibrils (PFF) of alpha-synuclein were administered directly into their enteric nervous system. They demonstrate that virome alterations are potentially reactive to host alpha-synuclein changes that are associated with PD development.
COMMUNICATIONS BIOLOGY
(2021)
Article
Chemistry, Analytical
Lei Feng, Ying Deng, Shufan Song, Yanqiu Sun, Jingnan Cui, Xiaochi Ma, Lingling Jin, Yan Wang, Tony D. James, Chao Wang
Summary: This study developed a fluorescence visualization tool to investigate the functional role of gut microbiota associated with obesity and disorders of lipid metabolism.
ANALYTICAL CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Chu Wan, Kaizhang Wu, Xingyu Lu, Fang Fang, Yaqian Li, Yumin Zhao, Shubo Li, Jie Gao
Summary: The study found that different culture media have varying effects on the bacterial community structure and metabolites, with the AMB medium being the most effective in maintaining a stable bacterial community structure and producing fewer metabolites and short-chain fatty acids. Culturing with AMB medium for 48 hours is considered the most suitable in vitro model for human gut microbiota fermentation, providing an alternative approach for diet and health research.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Nidhi Sori, Nafee Chundanga Poyil, Mahejibin Khan
Summary: This study investigated the effects of Kodo millet (KOM) and Kutki millet (KUM) on gut microbiota and metabolites in human fecal samples. The results showed that different millet groups had varying effects on gut microbiota and metabolites, with different abundances of specific metabolites. The study also identified correlations between beneficial metabolites and specific bacterial genera, and confirmed the upregulation of various metabolic pathways in millet groups.
Article
Microbiology
Austin Campbell, Kristi Gdanetz, Alexander W. W. Schmidt, Thomas M. M. Schmidt
Summary: Hydrogen gas (H-2) produced during carbohydrate fermentation in the human gut microbiome can modulate fermentation and may differentiate individual microbiomes and metabolites. High concentrations of H-2 stimulate the production of anti-inflammatory butyrate, while gut methanogenesis decreases butyrate production and impacts the competitive fitness of butyrate producers.
Article
Food Science & Technology
Ville M. Koistinen, Maria Hedberg, Lin Shi, Anders Johansson, Otto Savolainen, Marko Lehtonen, Anna-Marja Aura, Kati Hanhineva, Rikard Landberg
Summary: This study used metabolomics to identify seven microbial metabolites commonly produced during fermentation and found that a mixture of these metabolites exhibited stronger inhibition against bacteria compared to individual compounds. The results suggest that metabolites produced by LAB may modulate local microbial ecology through synergistic effects.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Oncology
Karolina Kazmierczak-Siedlecka, Karolina Skonieczna-Zydecka, Jaroslaw Bilinski, Giandomenico Roviello, Luigi Francesco Iannone, Alessandro Atzeni, Bartosz Kamil Sobocki, Karol Polom
Summary: Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a recommended curative therapy for hematologic malignancies, but complications such as graft-versus-host disease, mucositis, and infections can disrupt gut microbiota balance and barrier integrity. Fecal microbiota transplantation (FMT) may be effective in restoring gut microbiota diversity, although caution is needed with the use of fungal probiotics due to the risk of fungemia/septicemia.
Article
Chemistry, Applied
Shiyi Lu, Bernadine M. Flanagan, Deirdre Mikkelsen, Barbara A. Williams, Michael J. Gidley
Summary: The study found that the primary cell walls of plants provide a main dietary source of fermentable carbohydrates. The individual components like xyloglucan, pectin, and cellulose found in these cell walls were fermented differently by the gut microbiota, leading to varied fermentation outcomes and shifts in microbial communities.
FOOD HYDROCOLLOIDS
(2022)
Article
Biotechnology & Applied Microbiology
Marco Rusnati, Giulia Paiardi, Chiara Tobia, Chiara Urbinati, Alessio Lodola, Pasqualina D'Ursi, Miriam Corrado, Riccardo Castelli, Rebecca C. Wade, Massimiliano Tognolini, Paola Chiodelli
Summary: UniPR1331, a derivative of 3 beta-hydroxy-Delta(5)-cholenic acid, has been shown to inhibit Eph-ephrin interaction and VEGFR2 activation, leading to the suppression of tumor cell-driven angiogenesis. These findings highlight the potential of Delta(5)-cholenic acid as a promising molecular scaffold for the development of multitarget antiangiogenic compounds.
CANCER GENE THERAPY
(2022)
Correction
Biotechnology & Applied Microbiology
Marco Rusnati, Giulia Paiardi, Chiara Tobia, Chiara Urbinati, Alessio Lodola, Pasqualina D'Ursi, Miriam Corrado, Riccardo Castelli, Rebecca C. Wade, Massimiliano Tognolini, Paola Chiodelli
CANCER GENE THERAPY
(2022)
Article
Chemistry, Medicinal
Francesca Ferlenghi, Carmine Giorgio, Matteo Incerti, Lorenzo Guidetti, Paola Chiodelli, Marco Rusnati, Massimiliano Tognolini, Federica Vacondio, Marco Mor, Alessio Lodola
Summary: This study improved the oral bioavailability of UniPR129 by functionalizing the 3α-hydroxyl group on the LCA steroidal ring to 3-hydroxyimine, and successfully synthesized the 3-hydroxyimine derivative UniPR500. UniPR500 demonstrated higher stability and improved pharmacological profile, serving as an EphA2 receptor antagonist.
Review
Chemistry, Medicinal
Lorenzo Guidetti, Riccardo Castelli, Laura Scalvini, Francesca Ferlenghi, Miriam Corrado, Carmine Giorgio, Massimiliano Tognolini, Alessio Lodola
Summary: This review summarizes the role of the Eph-ephrin system in pathological conditions and discusses the progress in developing therapeutic compounds targeting this signaling system.
Review
Pharmacology & Pharmacy
Gian Marco Elisi, Laura Scalvini, Alessio Lodola, Annalida Bedini, Gilberto Spadoni, Silvia Rivara
Summary: This review describes the design strategies used in the discovery of melatonin receptor ligands, guided by in silico approaches and molecular modeling techniques. Different types of ligands with various activity profiles have been developed, including agonist/antagonist and subtype-selective compounds. In silico drug discovery has played a crucial role in the design of novel ligands targeting melatonin receptors, providing insights into pharmacological characterization and therapeutic perspectives.
EXPERT OPINION ON DRUG DISCOVERY
(2022)
Article
Chemistry, Medicinal
Francesca Galvani, Laura Scalvini, Silvia Rivara, Alessio Lodola, Marco Mor
Summary: The mechanism of action of three different types of monoglyceride lipase (MGL) inhibitors on the enzyme was investigated, and it was found that the expulsion of the leaving group has a significant impact on MGL carbamoylation. Simulation results showed that changes in the electronic structure of the leaving group affect reaction energetics, and different types of inhibitors follow different carbamoylation pathways. These findings contribute to understanding structure-activity relationships and provide insights for the design of covalent inhibitors.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Pharmacology & Pharmacy
Mariarosaria Cammarota, Francesca Ferlenghi, Federica Vacondio, Fabrizio Vincenzi, Katia Varani, Annalida Bedini, Silvia Rivara, Marco Mor, Francesca Boscia
Summary: Inhibiting FAAH or stimulating melatonin receptors can enhance endocannabinoid and melatoninergic signaling, which may be beneficial for treating neuroinflammation and neurodegenerative diseases.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Alessandro Papa, Silvia Pasquini, Francesca Galvani, Mariarosaria Cammarota, Chiara Contri, Gabriele Carullo, Sandra Gemma, Anna Ramunno, Stefania Lamponi, Beatrice Gorelli, Simona Saponara, Katia Varani, Marco Mor, Giuseppe Campiani, Francesca Boscia, Fabrizio Vincenzi, Alessio Lodola, Stefania Butini
Summary: The neuroprotective performance of the endocannabinoid system (ECS) against neuroinflammation can be significantly enhanced by inhibiting the key ECS enzyme FAAH. In this study, a series of carbamate-based FAAH inhibitors were developed with improved drug properties compared to previous analogues. These inhibitors showed nanomolar potency, good water solubility, and chemical stability. They exhibited excellent selectivity against monoacylglycerol lipase and cannabinoid receptors, and demonstrated reversible mechanisms of action without toxicity or cardiac effects. Selected analogues displayed notable neuroprotective effects against oxidative stress and neuroinflammation.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Miriam Girardini, Francesca Ferlenghi, Giannamaria Annunziato, Giulia Degiacomi, Bianca Papotti, Cinzia Marchi, Jose Camilla Sammartino, Sari S. Rasheed, Anna Contini, Maria Rosalia Pasca, Federica Vacondio, Joanna C. Evans, Thomas Dick, Rolf Mueller, Gabriele Costantino, Marco Pieroni
Summary: Tuberculosis is a deadly infectious disease and the increase in drug-resistant strains is concerning. Previous studies have identified compounds with inhibitory activity against Mycobacterium tuberculosis strains. In this study, researchers aimed to determine the metabolic fate of these compounds and explore structural modifications to improve activity and avoid rapid clearance. Novel antitubercular chemotypes were also investigated. The findings led to the design of improved compounds with good activity against drug-susceptible and drug-resistant strains.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Francesca Romana Ferrari, Carmine Giorgio, Alfonso Zappia, Vigilio Ballabeni, Simona Bertoni, Elisabetta Barocelli, Laura Scalvini, Francesca Galvani, Marco Mor, Alessio Lodola, Massimiliano Tognolini
Summary: It has been demonstrated that the Eph-ephrin system, particularly the EphA2 receptor, plays a key role in supporting tumor growth, invasion, metastasis, and neovascularization. In this study, new commercially available FXR agonists, including Cilofexor, Nidufexor, Tropifexor, Turofexorate isopropyl, and Vonafexor, were characterized as potential Eph ligands. Molecular modeling investigations and binding assays showed that Cilofexor specifically and reversibly binds to the EphA2 receptor with a ki value in the low micromolar range.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Kemel Arafet, Laura Scalvini, Francesca Galvani, Sergio Marti, Vicent Moliner, Marco Mor, Alessio Lodola
Summary: Targeted covalent inhibitors show potential for drug discovery, specifically for kinases. Targeting the catalytic lysine of EGFR has gained attention for overcoming resistance caused by the C797S mutation. Sulfonyl fluoride derivatives have been reported as inhibitors of EGFRL858R/T790M/C797S through sulfonylation of Lys745. However, the mechanism behind this process is poorly understood.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Medicinal
Francesca Galvani, Daniele Pala, Alberto Cuzzolin, Laura Scalvini, Alessio Lodola, Marco Mor, Andrea Rizzi
Summary: In this study, two metadynamics protocols were used to estimate the residence times of muscarinic M3 receptor antagonists. The results showed that both computational methods were able to accurately rank compounds according to their experimental residence times.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Medicinal
Claudio Festuccia, Miriam Corrado, Alessandra Rossetti, Riccardo Castelli, Alessio Lodola, Giovanni Luca Gravina, Massimiliano Tognolini, Carmine Giorgio
Summary: This study demonstrated the inhibitory effects of Eph antagonism on prostate cancer both in vitro and in vivo. The Eph antagonist UniPR1331 inhibited PC3 cell growth, induced apoptosis, and downregulated epithelial mesenchymal transition markers. Furthermore, UniPR1331 reduced PC3 cell migration, invasion, and vasculomimicry capabilities.
Article
Chemistry, Physical
Sergio Marti, Kemel Arafet, Alessio Lodola, Adrian J. Mulholland, Katarzyna Swiderek, Vicent Moliner
Summary: This study simulated the inhibition mechanism of the main protease of the novel coronavirus, revealing a two-step mechanism for two proposed peptidyl covalent inhibitors.
Article
Chemistry, Analytical
Bingbing Liu, Jie Cao, Lu Liu, Min Zeng, Hongli Yu, Hao Wu
Summary: This study investigated the effect of processing with Chebulae Fructus on the chemical composition of Euphorbia pekinensis (EP) and found that it could alter the composition and reduce toxicity, providing a scientific basis for optimizing processing technology and handling other ethnomedicines with toxic properties.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Renuka P. Rathnasekara, Abu M. Rustum
Summary: A simple and robust HPLC method was developed for simultaneous determination of four active pharmaceutical ingredients and their degradation products. The method successfully separated the peaks of interest and demonstrated stability-indicating capability by separating the degradation products in stressed samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Bryan Lee, Gita Kharal, Benjamin Sreenan, Claire Lin, Ruosheng Zeng, Colin A. Fox, Patricia Ellison, Robert O. Ryan, Paul J. Brett, David Aucoin, Xiaoshan Zhu
Summary: In this study, a new type of Mn-doped nanocrystals was developed for detecting a biomarker of a fatal disease. The sensitivity of the detection was enhanced by surface treatment and time-resolved reading, achieving a detection limit comparable to enzyme-based immunoassay.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xiaoling Liu, Ting Yang, Lu Chen, Lili Lan, Guoxiang Sun, Ping Guo
Summary: In this study, the quality of Yiqing tablet was comprehensively evaluated using multi-component quantification, multi-dimensional fingerprint construction, and antioxidant activity analysis. The results showed that the sample had 25 components with antioxidant activity according to the HPLC fingerprint and most bands of FTIR also showed antioxidant activity. Based on the evaluation results of HPLC and FTIR fingerprint, all samples were classified as first level, demonstrating the consistency of sample quality. This study provides a new idea for achieving comprehensive quality evaluation of traditional Chinese medicines.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Siqi Li, Hao Guo, Yan Gao, Wen Tian, Shan Wang, Chen Shen, Lili Xu, Hailong Liu, Jinliang Zhang, Yingwu Wang
Summary: Using competitive ELISA to detect free cytokines is limited in accurately determining their real state and quantity. In this study, a novel cytokine immunoassay was developed using Rosetta molecular docking prediction technique to establish a method that can detect the true concentration of free cytokines without disrupting the dynamic equilibrium.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Changqing Yu, Tiantian Xie, Haiyan Liu, Ligai Bai
Summary: A phenyl-hybrid monolithic adsorbent with porous structure and multiple functional groups was prepared. It was used for the online extraction and quantification of coumarins in mouse plasma, showing good removal ability and selectivity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Joao B. Pereira Jr, Vanessa S. Carvalho, William Q. Ferreira, Rennan G. O. Araujo, Sergio L. C. Ferreira
Summary: This work presents a simple, cost-effective, and environmentally friendly method for determining the content of multiple elements in medicinal herbs using ICP OES. The optimized experimental parameters result in low dissolved organic carbon content and residual acidity concentration. The accuracy of the method is confirmed through the analysis of certified reference materials, and its environmental friendliness is validated using the AGREE metric. Principal component analysis is used to classify the medicinal herbs based on their inorganic constituent concentrations.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Orwa Siddig, Chenxi Liu, Mohamed Abdulbagi, Min Song, Yu-ting Lu, Tai-jun Hang
Summary: In this study, a reliable LC-QTOF-MS method was developed to separate and characterize process-related substances and degradation products of Lurasidone hydrochloride. The results showed that Lurasidone hydrochloride exhibited instability under certain stress conditions, and several previously unidentified compounds were discovered. The study emphasizes the importance of monitoring and controlling related substances in the manufacturing processes to optimize the process and ensure quality control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Jiaxi Fang, Luping Wang, Di Zhang, Yan Liang, Shouxin Li, Jingkui Tian, Qiang He, Juan Jin, Wei Zhu
Summary: This study reports that a novel compound called CPS-A exhibits therapeutic effects on cisplatin-induced acute kidney injury (AKI) and explores its potential mechanisms through transcriptomics and metabolomics. CPS-A improves cell viability, reduces inflammatory markers, and attenuates cisplatin-induced kidney injury. The study also identifies potential targets related to amino acid metabolism.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ricardo Conde, Nadia Oliveira, Elisabete Morais, Ana Paula Amaral, Adriana Sousa, Goncalo Graca, Ignacio Verde
Summary: Decreased levels of tyrosine, glutamate, valine, leucine, and isoleucine are associated with worsening pathological cognitive decline. Decreased levels of isobutyrate, histidine, acetone, and unknown-1 metabolite are potential biomarkers with neuroprotective and antioxidant actions for cognitive decline.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
A. L. Santunione, F. Palazzoli, P. Verri, D. Vandelli, V. Castagnetti, C. Profeta, E. Silingardi
Summary: This study describes two fatal suicide cases involving four cardiovascular drugs, and presents the concentrations and distribution of these drugs in different post-mortem specimens. The study developed a fast, sensitive, and simple method for drug detection suitable for forensic purposes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Meiyun Shi, Xinyue Zheng, Yuncheng Ge, Ning Zhang, Luyao Yu, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin
Summary: This study investigated the cellular uptake of low, medium and high molecular weight polyethylene glycol (PEG) in MCF-7 cells using UPLC-MS/MS and CID techniques. The results showed that PEG600, PEG2K, PEG4K and PEG10K exhibited low toxicity and had limited cellular entry at concentrations of 5-1200 μg/mL. Additionally, the environmental friendliness of the developed analytical methods was evaluated.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ruijin Geng, Mengjie Yu, Jinbiao Xu, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie
Summary: This study validated serum methionine as a potential biomarker for Kawasaki disease (KD), and found that its alteration is associated with the activation of DNMT1 in KD patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Eman Shawky, Rasha A. Nassra, Aliaa M. T. El-Alkamy, Shaimaa M. Sallam, Samah M. El Sohafy
Summary: This study employed network pharmacology-based analysis and reverse molecular docking to investigate the molecular targets and pathways associated with gynecological disorders and the potential therapeutic effects of fenugreek constituents. The results highlighted the potential of steroidal saponins, isoflavones, and flavones as active constituents of fenugreek with implications for lactation, reproductive processes, and estrogenic activity. Animal model study further supported the presence of these bioactive compounds and their effects on body weight, serum prolactin levels, serum estradiol levels, and ovarian histological structure.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xuelong Zhao, Ruixue Dai, Jing Wang, Liangliang Cao, Peidong Chen, Weifeng Yao, Fangfang Cheng, Beihua Bao, Li Zhang
Summary: This study identified the skin-permeable and skin-retainable components of Cayratia japonica ointment and found that flavonoids are the main active components that play a crucial role in the inflammatory and proliferative phases of wound healing.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
