UniPR129 is a competitive small molecule Eph-ephrin antagonist blockingin vitroangiogenesis at low micromolar concentrations

The Concise Guide to PHARMACOLOGY 2013/14: Catalytic Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

HTS by NMR of Combinatorial Libraries: A Fragment-Based Approach to Ligand Discovery

(2013) Bainan Wu et al.   CHEMISTRY & BIOLOGY

Target Hopping as a Useful Tool for the Identification of Novel EphA2 Protein-Protein Antagonists

(2013) Massimiliano Tognolini et al.   ChemMedChem

Amino Acid Conjugates of Lithocholic Acid As Antagonists of the EphA2 Receptor

(2013) Matteo Incerti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Blocking ephrinB2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis, and tumor growth

(2012) M. A. Abengozar et al.   BLOOD

Regulation of apoptosis in HL-1 cardiomyocytes by phosphorylation of the receptor tyrosine kinase EphA2 and protection by lithocholic acid

(2012) J Jehle et al.   BRITISH JOURNAL OF PHARMACOLOGY

The EphA2 Receptor Drives Self-Renewal and Tumorigenicity in Stem-like Tumor-Propagating Cells from Human Glioblastomas

(2012) Elena Binda et al.   CANCER CELL

Structure-Activity Relationships and Mechanism of Action of Eph-ephrin Antagonists: Interaction of Cholanic Acid with the EphA2 Receptor

(2012) Massimiliano Tognolini et al.   ChemMedChem

Perturbation of the EphA2–EphrinA1 System in Human Prostate Cancer Cells by Colonic (Poly)phenol Catabolites

(2012) Massimiliano Tognolini et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

(2012) Annelies Van Hoecke et al.   NATURE MEDICINE

Inhibition of Eph receptor–ephrin ligand interaction by tea polyphenols

(2012) Roberta Noberini et al.   PHARMACOLOGICAL RESEARCH

A Small Molecule Agonist of EphA2 Receptor Tyrosine Kinase Inhibits Tumor Cell Migration In Vitro and Prostate Cancer Metastasis In Vivo

(2012) Aaron Petty et al.   PLoS One

A Disalicylic Acid-Furanyl Derivative Inhibits Ephrin Binding to a Subset of Eph Receptors

(2011) Roberta Noberini et al.   Chemical Biology & Drug Design

Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase

(2011) Oscar P.J. van Linden et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Polyphenol rich botanicals used as food supplements interfere with EphA2–ephrinA1 system

(2011) Iftiin Hassan Mohamed et al.   PHARMACOLOGICAL RESEARCH

Lithocholic Acid Is an Eph-ephrin Ligand Interfering with Eph-kinase Activation

(2011) Carmine Giorgio et al.   PLoS One

Targeting Eph receptors with peptides and small molecules: Progress and challenges

(2011) Roberta Noberini et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis

(2010) Georg Martiny-Baron et al.   ANGIOGENESIS

EphB Signaling Directs Peripheral Nerve Regeneration through Sox2-Dependent Schwann Cell Sorting

(2010) Simona Parrinello et al.   CELL

Emerging strategies for EphA2 receptor targeting for cancer therapeutics

(2010) Manish Tandon et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biomarkers to predict the clinical efficacy of bevacizumab in cancer

(2010) Adrian M Jubb et al.   LANCET ONCOLOGY

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

(2010) Suphansa Sawamiphak et al.   NATURE

Architecture of Eph receptor clusters

(2010) J. P. Himanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex

(2009) Juha P Himanen et al.   EMBO REPORTS

Structure-Based Optimization of Potent and Selective Inhibitors of the Tyrosine Kinase Erythropoietin Producing Human Hepatocellular Carcinoma Receptor B4 (EphB4)

(2009) Karine Lafleur et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors

(2008) Roberta Noberini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of cell retraction by the combined actions of Abl–CrkII and Rho–ROCK1 signaling

(2008) XiaoDong Huang et al.   JOURNAL OF CELL BIOLOGY

MM-GB/SA Rescoring of Docking Poses in Structure-Based Lead Optimization

(2008) Cristiano R. W. Guimarães et al.   Journal of Chemical Information and Modeling