Article
Cell Biology
Tiancheng Li, Han Wang, Chunxiao Lv, Li Huang, Cheng Zhang, Chenchen Zhou, Shujuan Zou, Peipei Duan
Summary: Intermittent PTH promotes periodontal repair by accelerating the regeneration of root resorption through ephrinB2-EPHB4 forward signaling pathway, as evidenced by in vivo and in vitro experiments.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mark von Zastrow, Alexander Sorkin
Summary: This review outlines the intricate relationships between endocytosis and cellular signaling, particularly focusing on tyrosine kinase and G protein-coupled receptors. The examples provided offer an insight into the current consensus, uncertainties, and controversies in this rapidly advancing field of cell biology.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 90, 2021
(2021)
Article
Oncology
Jennifer R. Bourn, Sasha J. Ruiz-Torres, Brian G. Hunt, Nancy M. Benight, Susan E. Waltz
Summary: This study provides evidence for the novel role of RON signaling in regulating breast cancer initiation, progression, and metastasis by modulating tumor cell intrinsic processes and the tumor microenvironment. Activation of RON signaling promotes tumor cell intrinsic growth and immune evasion, supporting breast cancer progression, and targeting RON signaling may be a potential therapeutic strategy against breast cancer.
Review
Biochemistry & Molecular Biology
Claudia Lee, Gayathri Viswanathan, Issac Choi, Chanpreet Jassal, Taylor Kohlmann, Sudarshan Rajagopal
Summary: Beta-arrestins, multifunctional adapter proteins, play a key role in regulating signaling pathways important for endothelial function and could potentially lead to the development of novel therapies for the treatment of vascular disease.
Review
Biochemistry & Molecular Biology
Amita R. Sahoo, Matthias Buck
Summary: This review focuses on the interaction between Eph receptors and ephrin ligands in regulating various processes from embryonic development to tissue homeostasis. It also highlights the importance of the transmembrane domain of Eph receptors in signal transduction and introduces techniques such as NMR and molecular modeling used to study them. Additionally, the use of transmembrane peptides to manipulate Eph receptor signaling is discussed, along with future directions for research in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sinan Sen, Ralf Erber
Summary: During orthodontic tooth movement, neuronal guidance molecules (NGMs), particularly Semaphorins, ephrins, and Eph receptors, have been identified to play important roles in bone remodeling. However, research on the functions of NGMs during orthodontic tooth movement is currently limited, and further studies are needed to fully understand their significance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Beiyuan Hu, Tiantian Zou, Wei Qin, Xiaotian Shen, Yinghan Su, Jianhua Li, Yang Chen, Ze Zhang, Haoting Sun, Yan Zheng, Chao-Qun Wang, Zhengxin Wang, Tian-En Li, Shun Wang, Le Zhu, Xufeng Wang, Yan Fu, Xudong Ren, Qiongzhu Dong, Lun-Xiu Qin
Summary: Lenvatinib, a first-line treatment for hepatocellular carcinoma (HCC), has limited clinical benefits. This study reveals that HCC cells develop resistance to Lenvatinib by activating the EGFR-STAT3-ABCB1 pathway. Combined treatment with erlotinib, an EGFR inhibitor, may overcome acquired resistance and improve the clinical benefit of Lenvatinib.
Article
Multidisciplinary Sciences
Bihui Cao, Manting Liu, Lu Wang, Kangshun Zhu, Mingyue Cai, Xiaopei Chen, Yunfei Feng, Shuo Yang, Shengyu Fu, Cheng Zhi, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Xin Yang, Ming Zhao, Qingde Wu, Linfeng Xu, Lili Yang, Hui Lian, Qi Zhao, Zhenfeng Zhang
Summary: The complex immunosuppressive tumor microenvironment and lack of tumor-specific targets hinder the application of CAR T cell therapy in solid tumors. AXL, highly expressed in NSCLC but not in normal tissues, might be a target for CAR T cell therapy. Combining microwave ablation and AXL-CAR T cells shows superior antitumor efficacy.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Hui Chen, Mindy Smith, Jasmin Herz, Tong Li, Rebecca Hasley, Cecile Le Saout, Ziang Zhu, Jie Cheng, Andres Gronda, Jose A. Martina, Pablo M. Irusta, Tatiana Karpova, Dorian B. McGavern, Marta Catalfamo
Summary: PAR1 activation in CD8 T cells accelerates calcium mobilization, facilitates granule trafficking through actin polymerization, and repositions the microtubule organizing center toward the immunological synapse. Mice lacking PAR1 exhibit reduced cytokine-producing T cells in response to viral infection, and specific deletion of PAR1 in LCMV GP33-specific CD8 T cells results in diminished expansion and effector function. These findings suggest that PAR1 plays a crucial role in T cell activation and function, offering a new therapeutic strategy to modulate CD8 T cell effector function.
Article
Medicine, Research & Experimental
Alberto Bartolome, Nina Suda, Junjie Yu, Changyu Zhu, Jinsook Son, Hongxu Ding, Andrea Califano, Domenico Accili, Utpal B. Pajvani
Summary: This study suggests that Notch/Ephrin signaling can permanently alter islet architecture during a morphogenetic window in early life, leading to beta cell dysfunction and progression of type 2 diabetes (T2D).
Article
Pharmacology & Pharmacy
Maria Krchniakova, Silvia Paukovcekova, Petr Chlapek, Jakub Neradil, Jan Skoda, Renata Veselska
Summary: This study analyzed the effects of combining three TKIs and two iron-chelating agents in the treatment of pediatric solid tumors. The results showed that the combination of these drugs had synergistic and/or additive effects, inhibiting cell signaling and inducing apoptosis. The combination of lapatinib with the iron-chelating agents had the most significant effects. These findings provide a rationale for the novel strategy of combining iron-chelating agents with TKIs in the therapy of pediatric solid tumors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Javier Garcia-Ceca, Sara Montero-Herradon, Ana Gonzalez, Rosa Plaza, Agustin G. Zapata
Summary: The lack of EphA4 alters T-cell differentiation and the histological organization of the thymus, impacting various T cell subsets as well as the proportions of thymocytes selected positively and negatively.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Thomas Neill, Aastha Kapoor, Christopher Xie, Simone Buraschi, Renato Iozzo
Summary: Proteoglycans and selected extracellular matrix constituents are emerging as critical regulators of autophagy, influencing various cell types by activating a dynamic signaling network. These matrix constituents, both proautophagic and anti-angiogenic, engage specific cell surface receptors and contribute to proper tissue homeostasis independently of nutrient availability. Their role in matrix-regulated autophagy can potentially be leveraged for therapeutic purposes in combating diseases.
Review
Cell Biology
Peiyuan Huang, Zhihao Zhao, Liting Duan
Summary: Dynamic protein-protein interactions are crucial for cell functioning, and homo-interactions are widely used to activate intracellular signaling pathways. Optogenetic tools based on light-sensitive proteins offer unprecedented specificity and spatiotemporal precision in dissecting complex signaling networks. This review focuses on recent progress in developing optogenetic tools for light-inducible protein-protein homo-interactions and their applications in optical activation of signaling pathways.
NEURAL REGENERATION RESEARCH
(2022)
Review
Chemistry, Analytical
Juan Gao, Jingyi Jian, Zhengjin Jiang, Ann Van Schepdael
Summary: Tyrosine kinases have been extensively studied as drug targets due to their regulation of cellular processes. The deregulation of tyrosine kinases plays a key role in the pathophysiology of various diseases. Several techniques, including traditional binding assays and high-throughput screening methods, have been developed to discover new tyrosine kinase inhibitors. This review provides insights into the different assay methods for the exploration of novel tyrosine kinase inhibitors.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)