Journal
STEM CELLS
Volume 28, Issue 7, Pages 1196-1205Publisher
WILEY
DOI: 10.1002/stem.442
Keywords
Adult stem cells; Epidermis; Tissue-specific stem cells; Cellular proliferation
Categories
Funding
- Swedish Cancer Society
- Swedish Research Council
- Karolinska Institute
- Tobias Stiftelsen
- Knut och Alice Wallenbergs Stiftelse
Ask authors/readers for more resources
Ephrins and their Eph tyrosine kinase receptors control many processes during embryonic development. They have more recently also been identified as important regulators of proliferation of stem/progenitor cells in the adult brain and intestine and have been implicated in tumorigenesis in a large number of tissues. We here describe the expression of a large number of ephrins and Eph receptors in the adult mouse skin. Disruption of the ephrin-Eph interaction in vivo with antagonists against the A or B class resulted in an approximate doubling of cell proliferation in the hair follicle and epidermis of adult mice. We conclude that ephrins are negative regulators of proliferation in the skin and that blocking the ephrin-Eph interaction may be an attractive strategy for regenerative therapies. STEM CELLS 2010,28 1196-1205
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available