Extracellular Vesicle-Based Therapy for COVID-19: Promises, Challenges and Future Prospects

SARS-CoV-2 encephalitis is a cytokine release syndrome: evidences from cerebrospinal fluid analyses

(2021) Andrea Pilotto et al.   CLINICAL INFECTIOUS DISEASES

Elucidating Methods for Isolation and Quantification of Exosomes: A Review

(2021) Talitha Keren Kurian et al.   MOLECULAR BIOTECHNOLOGY

Immunotherapies and immunomodulatory approaches in clinical trials - a mini review

(2021) Mohd. Iqbal Yatoo et al.   Human Vaccines & Immunotherapeutics

Extracellular Vesicles: Novel Roles in Neurological Disorders

(2021) Qian Jin et al.   Stem Cells International

Promising Extracellular Vesicle-Based Vaccines against Viruses, Including SARS-CoV-2

(2021) Berina Sabanovic et al.   Biology-Basel

The Magnitude of Hematological Abnormalities Among COVID-19 Patients in Addis Ababa, Ethiopia

(2021) Shambel Araya et al.   Journal of Multidisciplinary Healthcare

Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles

(2021) Mario Gimona et al.   CYTOTHERAPY

Emerging roles of extracellular vesicles in COVID‐19, a double‐edged sword?

(2021) Xiaohuan Xia et al.   IMMUNOLOGY

Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection

(2021) Bo Diao et al.   Nature Communications

Excretion of urine extracellular vesicles bearing markers of activated immune cells and calcium/phosphorus physiology differ between calcium kidney stone formers and non-stone formers

(2021) Jiqing Zhang et al.   BMC Nephrology

The Potential Role of Extracellular Vesicles in COVID-19 Treatment: Opportunity and Challenge

(2021) Yan-yan Yan et al.   Frontiers in Molecular Biosciences

Updates on clinical trials evaluating the regenerative potential of allogenic mesenchymal stem cells in COVID-19

(2021) Dhavan Sharma et al.   npj Regenerative Medicine

Immunomodulatory and Regenerative Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Renal Diseases

(2020) Kenji Tsuji et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

(2020) Hao Xu et al.   International Journal of Oral Science

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Cardiovascular complications in COVID-19

(2020) Brit Long et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

Psychological symptoms among frontline healthcare workers during COVID-19 outbreak in Wuhan

(2020) Jiang Du et al.   GENERAL HOSPITAL PSYCHIATRY

Clinical Best Practice Advice for Hepatology and Liver Transplant Providers During the COVID‐19 Pandemic: AASLD Expert Panel Consensus Statement

(2020) Oren K. Fix et al.   HEPATOLOGY

Acute Liver Injury in COVID‐19: Prevalence and Association with Clinical Outcomes in a Large US Cohort

(2020) Meaghan M. Phipps et al.   HEPATOLOGY

Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus ‐2 (SARS‐CoV‐2)

(2020) Alberto Paniz‐Mondolfi et al.   JOURNAL OF MEDICAL VIROLOGY

Kidney disease is associated with in-hospital death of patients with COVID-19

(2020) Yichun Cheng et al.   KIDNEY INTERNATIONAL

The Novel Coronavirus 2019 epidemic and kidneys

(2020) Saraladevi Naicker et al.   KIDNEY INTERNATIONAL

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19

(2020) Vikram Sengupta et al.   STEM CELLS AND DEVELOPMENT

Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019

(2020) Adeel S. Zubair et al.   JAMA Neurology

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

In vitro modeling of blood–brain barrier and interface functions in neuroimmune communication

(2020) Michelle A. Erickson et al.   Fluids and Barriers of the CNS

Hematological findings in coronavirus disease 2019: indications of progression of disease

(2020) Xiaoqing Liu et al.   ANNALS OF HEMATOLOGY

Unexpected Features of Cardiac Pathology in COVID-19 Infection

(2020) Sharon E. Fox et al.   CIRCULATION

Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series

(2020) Benjamin T Bradley et al.   LANCET

COVID‐19–associated Guillain‐Barré syndrome: The early pandemic experience

(2020) James B. Caress et al.   MUSCLE & NERVE

Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

(2020) Yanwei Li et al.   PHARMACOLOGICAL RESEARCH

Re: “Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19” by Sengupta et al.

(2020) Sai Kiang Lim et al.   STEM CELLS AND DEVELOPMENT

Severe COVID-19 infection associated with endothelial activation

(2020) Robert Escher et al.   THROMBOSIS RESEARCH

COVID-19 Vaccine: A comprehensive status report

(2020) Simran Preet Kaur et al.   VIRUS RESEARCH

Cytokine Storm in COVID-19—Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper

(2020) Sonu Bhaskar et al.   Frontiers in Immunology

Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study

(2020) Yanan Li et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Cytokine release syndrome‐associated encephalopathy in patients with COVID‐19

(2020) P. Perrin et al.   EUROPEAN JOURNAL OF NEUROLOGY

Extracellular Vesicles as Innovative Tool for Diagnosis, Regeneration and Protection against Neurological Damage

(2020) Pavle Andjus et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SARS‐CoV‐2 specific virulence factors in COVID‐19

(2020) Ashutosh Kumar et al.   JOURNAL OF MEDICAL VIROLOGY

Potential application of mesenchymal stem cells and their exosomes in lung injury: an emerging therapeutic option for COVID-19 patients

(2020) Sara Al-Khawaga et al.   Stem Cell Research & Therapy

Recent Advances in Extracellular Vesicles as Drug Delivery Systems and Their Potential in Precision Medicine

(2020) Bart de Jong et al.   Pharmaceutics

Exosome engineering: Current progress in cargo loading and targeted delivery

(2020) Shengyang Fu et al.   NanoImpact

CB2 receptor‐selective agonists as candidates for targeting infection, inflammation, and immunity in SARS‐CoV ‐2 infections

(2020) M. F. Meeran et al.   DRUG DEVELOPMENT RESEARCH

Cerebrospinal Fluid Features in Patients With Coronavirus Disease 2019 and Neurological Manifestations: Correlation with Brain Magnetic Resonance Imaging Findings in 58 Patients

(2020) François Lersy et al.   JOURNAL OF INFECTIOUS DISEASES

Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses

(2020) Jonas Nascimento Conde et al.   mBio

Early injection of human adipose tissue-derived mesenchymal stem cell after inflammation ameliorates dextran sulfate sodium-induced colitis in mice through the induction of M2 macrophages and regulatory T cells

(2019) Yuzo Kawata et al.   CELL AND TISSUE RESEARCH

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Decoy exosomes as a novel biologic reagent to antagonize inflammation

(2019) Natalie Duong et al.   International Journal of Nanomedicine

Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer

(2019) Jana Plava et al.   Molecular Cancer

Advances in therapeutic applications of extracellular vesicles

(2019) Oscar P. B. Wiklander et al.   Science Translational Medicine

Mesenchymal stromal cells-derived exosomes alleviate ischemia/reperfusion injury in mouse lung by transporting anti-apoptotic miR-21-5p

(2019) Ji wei Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A potential role of microvesicle-containing miR-223/142 in lung inflammation

(2019) Duo Zhang et al.   THORAX

Exosomes from Bone Marrow Mesenchymal Stem Cells Inhibit Neuronal Apoptosis and Promote Motor Function Recovery via the Wnt/β-catenin Signaling Pathway

(2019) Ci Li et al.   CELL TRANSPLANTATION

Human umbilical cord perivascular cells-derived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice

(2019) Esteban Fiore et al.   GENE THERAPY

The Role of Mesenchymal Stem Cells in Radiation-Induced Lung Fibrosis

(2019) Zanoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mesenchymal Stem Cell–Derived Extracellular Vesicles Decrease Lung Injury in Mice

(2019) Qi Hao et al.   JOURNAL OF IMMUNOLOGY

Tumor-derived extracellular vesicles: insights into bystander effects of exosomes after irradiation

(2019) Nasrollah Jabbari et al.   LASERS IN MEDICAL SCIENCE

Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents

(2019) Xiaohuan Xia et al.   PROGRESS IN NEUROBIOLOGY

Mesenchymal stem cells cultured under hypoxic conditions had a greater therapeutic effect on mice with liver cirrhosis compared to those cultured under normal oxygen conditions

(2019) Yuichi Kojima et al.   Regenerative Therapy

Functional Evidence of Pulmonary Extracellular Vesicles in Infectious and Noninfectious Lung Inflammation

(2018) Heedoo Lee et al.   JOURNAL OF IMMUNOLOGY

Exosome-Mediated Small RNA Delivery: A Novel Therapeutic Approach for Inflammatory Lung Responses

(2018) Duo Zhang et al.   MOLECULAR THERAPY

Neuroimmune Axes of the Blood–Brain Barriers and Blood–Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions

(2018) Michelle A. Erickson et al.   PHARMACOLOGICAL REVIEWS

Administration of mesenchymal stem cells during ECMO results in a rapid decline in oxygenator performance

(2018) Jonathan Edward Millar et al.   THORAX

Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke (Review)

(2018) Yingchen Li et al.   Experimental and Therapeutic Medicine

Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine

(2018) Somayeh Keshtkar et al.   Stem Cell Research & Therapy

Potential of Exosomes for the Treatment of Stroke

(2018) Shi-Bin Hong et al.   CELL TRANSPLANTATION

Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration

(2018) Lauren Scarfe et al.   Stem Cell Research & Therapy

Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice

(2018) Yusuke Watanabe et al.   Stem Cells Translational Medicine

Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats

(2018) Masatsugu Ohara et al.   Stem Cells International

In Vitro Macrophage Assay Predicts the In Vivo Anti-inflammatory Potential of Exosomes from Human Mesenchymal Stromal Cells

(2018) Natalia Pacienza et al.   Molecular Therapy-Methods & Clinical Development

Platelet-derived Extracellular Vesicles: An Emerging Therapeutic Approach

(2017) Shi-Cong Tao et al.   International Journal of Biological Sciences

Therapeutic application of extracellular vesicles in kidney disease: promises and challenges

(2017) Lin-Li Lv et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Attenuates Apoptosis, Inflammation, and Promotes Angiogenesis after Spinal Cord Injury in Rats

(2017) Jiang-Hu Huang et al.   JOURNAL OF NEUROTRAUMA

The pattern recognition receptor, Mincle, is essential for maintaining the M1 macrophage phenotype in acute renal inflammation

(2017) Lin L. Lv et al.   KIDNEY INTERNATIONAL

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

(2017) Emma Lefrançais et al.   NATURE

Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice

(2017) Viola Neudecker et al.   Science Translational Medicine

Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling

(2017) Qiyu Wang et al.   Nature Communications

Mesenchymal stem cell-derived extracellular vesicles for kidney repair: current status and looming challenges

(2017) Arash Aghajani Nargesi et al.   Stem Cell Research & Therapy

Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model

(2017) Shang-Chun Guo et al.   Theranostics

Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype

(2016) Ling Li et al.   CANCER RESEARCH

Liver immunology and its role in inflammation and homeostasis

(2016) Mark W Robinson et al.   Cellular & Molecular Immunology

Extracellular vesicles: masters of intercellular communication and potential clinical interventions

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

CCR2 Positive Exosome Released by Mesenchymal Stem Cells Suppresses Macrophage Functions and Alleviates Ischemia/Reperfusion-Induced Renal Injury

(2016) Bing Shen et al.   Stem Cells International

Mesenchymal Stem Cell-Derived Exosomes Improve the Microenvironment of Infarcted Myocardium Contributing to Angiogenesis and Anti-Inflammation

(2015) Xiaomei Teng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

ESCRTs are everywhere

(2015) J. H. Hurley   EMBO JOURNAL

Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection

(2015) Bin Yu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b

(2015) Dongdong Ti et al.   Journal of Translational Medicine

Role of Wnt Signaling in Central Nervous System Injury

(2015) Catherine Lambert et al.   MOLECULAR NEUROBIOLOGY

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

(2015) Sweta Rani et al.   MOLECULAR THERAPY

Chromatographically isolated CD63+CD81+extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI

(2015) Dong-ki Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Acute Myocardial Ischemic Injury

(2015) Yuanyuan Zhao et al.   Stem Cells International

Aging Mesenchymal Stem Cells Fail to Protect Because of Impaired Migration and Antiinflammatory Response

(2014) Martha L. Bustos et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Ischemic Preconditioning Potentiates the Protective Effect of Stem Cells through Secretion of Exosomes by Targeting Mecp2 via miR-22

(2014) Yuliang Feng et al.   PLoS One

Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models

(2014) Cheau Tan et al.   Stem Cell Research & Therapy

Thecis-acting signals that target proteins to exosomes and microvesicles

(2013) Jr-Ming Yang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Role of Platelets and their Microparticles in Rehabilitation of Ischemic Brain Tissue

(2013) Yael Hayon et al.   CNS & Neurological Disorders-Drug Targets

Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model

(2013) Suyan Bian et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

(2013) Fatih Arslan et al.   Stem Cell Research

Human Mesenchymal Stem Cell Microvesicles for Treatment ofEscherichia coliEndotoxin-Induced Acute Lung Injury in Mice

(2013) Ying-gang Zhu et al.   STEM CELLS

C-Reactive Protein Increases BBB Permeability: Implications for Obesity and Neuroinflammation

(2012) Hung Hsuchou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Platelet Microparticles Induce Angiogenesis and Neurogenesis after Cerebral Ischemia

(2012) Yael Hayon et al.   CURRENT NEUROVASCULAR RESEARCH

Platelet Microparticles Promote Neural Stem Cell Proliferation, Survival and Differentiation

(2012) Yael Hayon et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells

(2012) B Li et al.   ONCOGENE

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

(2012) J. F. Nabhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Are Therapeutic Human Mesenchymal Stromal Cells Compatible with Human Blood?

(2012) Guido Moll et al.   STEM CELLS

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Liver Fibrosis

(2012) Tingfen Li et al.   STEM CELLS AND DEVELOPMENT

The source of human mesenchymal stromal cells influences their TLR profile as well as their functional properties

(2011) Gordana Raicevic et al.   CELLULAR IMMUNOLOGY

The neutrophil in vascular inflammation

(2011) Mia Phillipson et al.   NATURE MEDICINE

The application of exosomes as a nanoscale cancer vaccine

(2010) Alexander Seifalian   International Journal of Nanomedicine

Exosomes/microvesicles as a mechanism of cell-to-cell communication

(2010) Giovanni Camussi et al.   KIDNEY INTERNATIONAL

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

(2010) Ruenn Chai Lai et al.   Stem Cell Research

Microparticles in endothelial cell and vascular homeostasis: are they really noxious?

(2009) O. Morel et al.   HAEMATOLOGICA

Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats

(2009) M. B. Herrera et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sepsis-induced human lymphocyte apoptosis and cytokine production in “humanized” mice

(2009) Jacqueline Unsinger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Circulating Microparticles from Patients with Septic Shock Exert Protective Role in Vascular Function

(2008) Hadj Ahmed Mostefai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE