Extracellular Vesicles as Innovative Tool for Diagnosis, Regeneration and Protection against Neurological Damage

Highlight article: Neural stem cell-derived exosomes facilitate spinal cord functional recovery after injury by promoting angiogenesis

(2020) Dong Zhong et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Time-Dependent Memory and Gait Improvement by Intranasally-Administered Extracellular Vesicles in Parkinson’s Disease Model Rats

(2020) Karīna Narbute et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mesenchymal stem cell‐derived small extracellular vesicles and bone regeneration

(2020) Xiaoqin Wang et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

The novel target：exosoms derived from M2 macrophage

(2020) Yuyang Hou et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Exosomes - Beyond Stem Cells for Cardiac Protection and Repair

(2020) Carolina Balbi et al.   STEM CELLS

The crosstalk: exosomes and lipid metabolism

(2020) Wei Wang et al.   Cell Communication and Signaling

A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option?

(2020) Karim Sidhom et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Vesicles: From Biomarkers to Therapeutic Tools

(2020) Simona Bernardi et al.   Biology-Basel

Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid

(2019) Kentaro Otake et al.   BMC Medical Genomics

On the Choice of the Extracellular Vesicles for Therapeutic Purposes

(2019) Claudia Campanella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Vesicle-Mediated Cell–Cell Communication in the Nervous System: Focus on Neurological Diseases

(2019) Celeste Caruso Bavisotto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1

(2019) Judith M. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicles can act as a potent immunomodulators of human microglial cells

(2019) Ugnė Jonavičė et al.   Journal of Tissue Engineering and Regenerative Medicine

Exosome in Cardiovascular Diseases: A Complex World Full of Hope

(2019) Gloria Bellin et al.   Cells

Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS

(2019) André Varcianna et al.   EBioMedicine

Bone Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Recovery Following Spinal Cord Injury via Improvement of the Integrity of the Blood-Spinal Cord Barrier

(2019) Yanhui Lu et al.   Frontiers in Neuroscience

Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improve Motor Symptoms and Normalize Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6-Hydroxydopamine-Treated Rats

(2019) Karīna Narbute et al.   Stem Cells Translational Medicine

Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury

(2019) Zheng Gang Zhang et al.   Nature Reviews Neurology

Golden Exosomes Selectively Target Brain Pathologies in Neurodegenerative and Neurodevelopmental Disorders

(2019) Nisim Perets et al.   NANO LETTERS

Proteomics analysis of Schwann cell-derived exosomes: a novel therapeutic strategy for central nervous system injury

(2019) Zhijian Wei et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Regulation of myelination by exosome associated retinoic acid release from NG2-positive cells

(2019) Maria B. Goncalves et al.   JOURNAL OF NEUROSCIENCE

Involvement of exosomes in dopaminergic neurodegeneration by microglial activation in midbrain slice cultures

(2019) Reiho Tsutsumi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Exosomes from human adipose‐derived stem cells promote sciatic nerve regeneration via optimizing Schwann cell function

(2019) Jing Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Advances in therapeutic applications of extracellular vesicles

(2019) Oscar P. B. Wiklander et al.   Science Translational Medicine

Exosomes from Human Gingiva-Derived Mesenchymal Stem Cells Combined with Biodegradable Chitin Conduits Promote Rat Sciatic Nerve Regeneration

(2019) Feng Rao et al.   Stem Cells International

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

(2019) Marta Lombardi et al.   ACTA NEUROPATHOLOGICA

Extracellular Vesicle-Induced Differentiation of Neural Stem Progenitor Cells

(2019) Eleonora Stronati et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer’s Disease

(2019) Ge Gao et al.   Frontiers in Cellular Neuroscience

Characterization of Dermal Stem Cells of Diabetic Patients

(2019) Letizia Ferroni et al.   Cells

Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury

(2019) Shaowei Guo et al.   ACS Nano

Exosomes released from neural progenitor cells and induced neural progenitor cells regulate neurogenesis through miR-21a

(2019) Yizhao Ma et al.   Cell Communication and Signaling

The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?

(2019) James W. Fawcett   NEUROCHEMICAL RESEARCH

Muscle-Derived Extracellular Vesicles Influence Motor Neuron Regeneration Accuracy

(2019) Roger D. Madison et al.   NEUROSCIENCE

Stem Cell-Derived Exosomes Protect Astrocyte Cultures From in vitro Ischemia and Decrease Injury as Post-stroke Intravenous Therapy

(2019) Xiaoyun Sun et al.   Frontiers in Cellular Neuroscience

The functions and clinical application potential of exosomes derived from adipose mesenchymal stem cells: a comprehensive review

(2019) Pengyu Hong et al.   Stem Cell Research & Therapy

MSC-Derived Exosomes-Based Therapy for Peripheral Nerve Injury: A Novel Therapeutic Strategy

(2019) Ruiqi Dong et al.   Biomed Research International

A proteolytic C-terminal fragment of Nogo-A (reticulon-4A) is released in exosomes and potently inhibits axon regeneration

(2019) Yuichi Sekine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes Derived from miR-126-modified MSCs Promote Angiogenesis and Neurogenesis and Attenuate Apoptosis after Spinal Cord Injury in Rats

(2019) Jiang-Hu Huang et al.   NEUROSCIENCE

The exosome-mediated autocrine and paracrine actions of plasma gelsolin in ovarian cancer chemoresistance

(2019) Meshach Asare-Werehene et al.   ONCOGENE

Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury

(2019) Chuanliang Zhao et al.   Drug Design Development and Therapy

ASCs-Exosomes Recover Coupling Efficiency and Mitochondrial Membrane Potential in an in vitro Model of ALS

(2019) Elisa Calabria et al.   Frontiers in Neuroscience

Extracellular Vesicles Can Deliver Anti-inflammatory and Anti-scarring Activities of Mesenchymal Stromal Cells After Spinal Cord Injury

(2019) Pasquale Romanelli et al.   Frontiers in Neurology

Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop

(2019) Ashley E. Russell et al.   Journal of Extracellular Vesicles

Insulin-like growth factor-1 enhances neuroprotective effects of neural stem cell exosomes after spinal cord injury via an miR-219a-2-3p/YY1 mechanism

(2019) Ke Ma et al.   Aging-US

Engineering of Exosomes to Target Cancer Metastasis

(2019) Zhenjiang Zhang et al.   Cellular and Molecular Bioengineering

Changes in the Morphology, Number, and Pathological Protein Levels of Plasma Exosomes May Help Diagnose Alzheimer’s Disease

(2019) Ruihua Sun et al.   JOURNAL OF ALZHEIMERS DISEASE

The influence of environment and origin on brain resident macrophages and implications for therapy

(2019) Mariko L. Bennett et al.   NATURE NEUROSCIENCE

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations

(2018) Ilaria Prada et al.   ACTA NEUROPATHOLOGICA

Extracellular Vesicles: Mechanisms in Human Health and Disease

(2018) Marine Malloci et al.   ANTIOXIDANTS & REDOX SIGNALING

The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier

(2018) Junichi Matsumoto et al.   CURRENT PHARMACEUTICAL DESIGN

Neuroplasticity in stroke recovery. The role of microglia in engaging and modifying synapses and networks

(2018) Ioanna Sandvig et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons

(2018) Shan Huang et al.   FASEB JOURNAL

Inflammation leads to distinct populations of extracellular vesicles from microglia

(2018) Yiyi Yang et al.   Journal of Neuroinflammation

In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation

(2018) Jing Jing Li et al.   Journal of Neuroinflammation

Exosomes derived from bone mesenchymal stem cells repair traumatic spinal cord injury via suppressing the activation of A1 neurotoxic reactive astrocytes

(2018) Wei Liu et al.   JOURNAL OF NEUROTRAUMA

hucMSC derived exosomes promote functional recovery in spinal cord injury mice via attenuating inflammation

(2018) Guodong Sun et al.   Materials Science & Engineering C-Materials for Biological Applications

Effect of Exosomes from Rat Adipose-Derived Mesenchymal Stem Cells on Neurite Outgrowth and Sciatic Nerve Regeneration After Crush Injury

(2018) Vesna Bucan et al.   MOLECULAR NEUROBIOLOGY

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

(2018) Arnau Hervera et al.   NATURE CELL BIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth

(2018) Maria B. Goncalves et al.   NEUROBIOLOGY OF DISEASE

Cell-to-cell Communication by Extracellular Vesicles: Focus on Microglia

(2018) Rosa C. Paolicelli et al.   NEUROSCIENCE

Fetoplacental endothelial exosomes modulate high d -glucose-induced endothelial dysfunction

(2018) Tamara Sáez et al.   PLACENTA

Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - Liquid biopsies to monitoring fetal growth

(2018) Jezid Miranda et al.   PLACENTA

Biogenesis and function of ESCRT-dependent extracellular vesicles

(2018) Thomas Juan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Human Neural Stem Cell Extracellular Vesicles Improve Recovery in a Porcine Model of Ischemic Stroke

(2018) Robin L. Webb et al.   STROKE

Role of Extracellular Vesicles in Viral and Bacterial Infections: Pathogenesis, Diagnostics, and Therapeutics

(2018) Meryl Rodrigues et al.   Theranostics

Neonatal Subventricular Zone Neural Stem Cells Release Extracellular Vesicles that Act as a Microglial Morphogen

(2018) Mary C. Morton et al.   Cell Reports

Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients

(2018) Daisy Sproviero et al.   Frontiers in Neuroscience

Axon Regeneration in the Central Nervous System: Facing the Challenges from the Inside

(2018) Michele Curcio et al.   Annual Review of Cell and Developmental Biology

Mesenchymal Stem Cell Exosomes as a Cell-Free Therapy for Nerve Injury-Induced Pain in Rats

(2018) Sheng-Jie Shiue et al.   PAIN

Extracellular Vesicles, Ageing, and Therapeutic Interventions

(2018) Nikolaos Panagiotou et al.   Cells

Promoting axonal regeneration through exosomes: An update of recent findings on exosomal PTEN and mTOR modifiers

(2018) Bor Luen Tang   BRAIN RESEARCH BULLETIN

Understanding extracellular vesicle diversity – current status

(2018) David W. Greening et al.   Expert Review of Proteomics

Extracellular vesicle mediated embryo-endometrial cross talk during implantation and in pregnancy

(2018) Noble K. Kurian et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Schwann cell-like differentiated adipose stem cells promote neurite outgrowth via secreted exosomes and RNA transfer

(2018) Rosanna C Ching et al.   Stem Cell Research & Therapy

Exosomes Derived From miR-133b-Modified Mesenchymal Stem Cells Promote Recovery After Spinal Cord Injury

(2018) Dong Li et al.   Frontiers in Neuroscience

Extracellular vesicles in food: Experimental evidence of their secretion in grape fruits

(2017) Pedro Pérez-Bermúdez et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Surgical repair in humans after traumatic nerve injury provides limited functional neural regeneration in adults

(2017) Winnie A. Palispis et al.   EXPERIMENTAL NEUROLOGY

Small Interfering RNA in Milk Exosomes Is Resistant to Digestion and Crosses the Intestinal Barrier In Vitro

(2017) Shruti Shandilya et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Paracrine Maturation and Migration of SH-SY5Y Cells by Dental Pulp Stem Cells

(2017) P. Gervois et al.   JOURNAL OF DENTAL RESEARCH

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Attenuates Apoptosis, Inflammation, and Promotes Angiogenesis after Spinal Cord Injury in Rats

(2017) Jiang-Hu Huang et al.   JOURNAL OF NEUROTRAUMA

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Hypothalamic stem cells control ageing speed partly through exosomal miRNAs

(2017) Yalin Zhang et al.   NATURE

Influence of maternal BMI on the exosomal profile during gestation and their role on maternal systemic inflammation

(2017) Omar Elfeky et al.   PLACENTA

Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus

(2017) Qianfa Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms

(2017) Connor Stonesifer et al.   PROGRESS IN NEUROBIOLOGY

Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin

(2017) Kimberly A. Krautkramer et al.   Translational Research

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

(2017) Sybren L.N. Maas et al.   TRENDS IN CELL BIOLOGY

Prion Properties of SOD1 in Amyotrophic Lateral Sclerosis and Potential Therapy

(2017) Caroline Sibilla et al.   Cold Spring Harbor Perspectives in Biology

Non-genomic transmission of longevity between generations: potential mechanisms and evidence across species

(2017) Alexander M. Vaiserman et al.   Epigenetics & Chromatin

Exosomes secreted by stem cells from human exfoliated deciduous teeth contribute to functional recovery after traumatic brain injury by shifting microglia M1/M2 polarization in rats

(2017) Ye Li et al.   Stem Cell Research & Therapy

Exosomes Mediate Mobilization of Autocrine Wnt10b to Promote Axonal Regeneration in the Injured CNS

(2017) Nardos G. Tassew et al.   Cell Reports

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype

(2017) Sara Pinto et al.   Frontiers in Neuroscience

Extracellular vesicle mediated intercellular communication at the porcine maternal-fetal interface: A new paradigm for conceptus-endometrial cross-talk

(2017) Mallikarjun Bidarimath et al.   Scientific Reports

Neurons Export Extracellular Vesicles Enriched in Cysteine String Protein and Misfolded Protein Cargo

(2017) Jingti Deng et al.   Scientific Reports

Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

(2016) Stefano Fais et al.   ACS Nano

Exosome secretion is a key pathway for clearance of pathological TDP-43

(2016) Yohei Iguchi et al.   BRAIN

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

(2016) Claire C. Chen et al.   Cellular and Molecular Bioengineering

Exosomes: mobile platforms for targeted and synergistic signaling across cell boundaries

(2016) Neha Vyas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Schwann Cell Exosomes Mediate Neuron–Glia Communication and Enhance Axonal Regeneration

(2016) Rodrigo Lopez-Leal et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The multicellular complexity of peripheral nerve regeneration

(2016) Anne-Laure Cattin et al.   CURRENT OPINION IN NEUROBIOLOGY

Origin of axonal proteins: Is the axon-schwann cell unit a functional syncytium?

(2016) Rodrigo López-Leal et al.   Cytoskeleton

Exosomes in developmental signalling

(2016) Ian John McGough et al.   DEVELOPMENT

Darwin's Pangenesis as a molecular theory of inherited diseases

(2016) Yongsheng Liu et al.   GENE

Impaired activation of ALS monocytes by exosomes

(2016) Lisa Zondler et al.   IMMUNOLOGY AND CELL BIOLOGY

Stimulating the Release of Exosomes Increases the Intercellular Transfer of Prions

(2016) Belinda B. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis

(2016) Chiaki Shimojima et al.   JOURNAL OF IMMUNOLOGY

Biological Activities of Extracellular Vesicles and Their Cargos from Bovine and Human Milk in Humans and Implications for Infants

(2016) Janos Zempleni et al.   JOURNAL OF NUTRITION

Neural stem cells from mouse strain Thy1 YFP-16 are a valuable tool to monitor and evaluate neuronal differentiation and morphology

(2016) Ivan Alić et al.   NEUROSCIENCE LETTERS

Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity

(2016) Yingshi Ouyang et al.   PLACENTA

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-141 is upregulated in preeclamptic placentae and regulates trophoblast invasion and intercellular communication

(2016) Stephanie Ospina-Prieto et al.   Translational Research

Barriers to horizontal cell transformation by extracellular vesicles containing oncogenic H-ras

(2016) Tae Hoon Lee et al.   Oncotarget

Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72 -ALS/FTD

(2016) Thomas Westergard et al.   Cell Reports

A Comprehensive Review on Exosomes and Microvesicles as Epigenetic Factors

(2016) Behnaz Bakhshandeh et al.   Current Stem Cell Research & Therapy

Extracellular Vesicles: Evolving Factors in Stem Cell Biology

(2016) Muhammad Nawaz et al.   Stem Cells International

Feto-Maternal Trafficking of Exosomes in Murine Pregnancy Models

(2016) Samantha Sheller-Miller et al.   Frontiers in Pharmacology

Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer’s disease

(2015) Tsuneyuki Mita et al.   BEHAVIOURAL BRAIN RESEARCH

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies

(2015) Anne Stuendl et al.   BRAIN

Extracellular vesicles shuffling intercellular messages: for good or for bad

(2015) Alessandra Lo Cicero et al.   CURRENT OPINION IN CELL BIOLOGY

Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine–induced apoptosis

(2015) Akvilė Jarmalavičiūtė et al.   CYTOTHERAPY

Gestational Diabetes Mellitus Is Associated With Changes in the Concentration and Bioactivity of Placenta-Derived Exosomes in Maternal Circulation Across Gestation

(2015) Carlos Salomon et al.   DIABETES

TDP-43 is intercellularly transmitted across axon terminals

(2015) Marisa S. Feiler et al.   JOURNAL OF CELL BIOLOGY

Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

(2015) Heikki Saari et al.   JOURNAL OF CONTROLLED RELEASE

Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration

(2015) Maria B. Goncalves et al.   JOURNAL OF NEUROSCIENCE

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

The role of exosomes in peripheral nerve regeneration

(2015) PaulJ Kingham et al.   Neural Regeneration Research

Chromatographically isolated CD63+CD81+extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI

(2015) Dong-ki Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

(2015) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems

(2015) Ari Waisman et al.   TRENDS IN IMMUNOLOGY

Roll over Weismann: extracellular vesicles in the transgenerational transmission of environmental effects

(2015) Sally A Eaton et al.   Epigenomics

Early diagnostic value of survivin and its alternative splice variants in breast cancer

(2014) Salma Khan et al.   BMC CANCER

Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor

(2014) Hu Zhao et al.   Cell Stem Cell

Extracellular vesicles and reproduction–promotion of successful pregnancy

(2014) Dionne Tannetta et al.   Cellular & Molecular Immunology

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking

(2014) Manal A. Farg et al.   HUMAN MOLECULAR GENETICS

The History and Reception of Charles Darwin’s Hypothesis of Pangenesis

(2014) Kate Holterhoff   JOURNAL OF THE HISTORY OF BIOLOGY

Murine neural crest stem cells and embryonic stem cell-derived neuron precursors survive and differentiate after transplantation in a model of dorsal root avulsion

(2014) Niclas Konig et al.   Journal of Tissue Engineering and Regenerative Medicine

Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy

(2014) Suchismita Sarker et al.   Journal of Translational Medicine

MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease

(2014) L Kordelas et al.   LEUKEMIA

Glial origin of mesenchymal stem cells in a tooth model system

(2014) Nina Kaukua et al.   NATURE

A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool

(2014) Lorea Manterola et al.   NEURO-ONCOLOGY

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

(2014) Leslie I. Grad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sorting it out: Regulation of exosome loading

(2014) Carolina Villarroya-Beltri et al.   SEMINARS IN CANCER BIOLOGY

Inherited small RNAs: new insights into Darwin's cell theory

(2014) Xiuju Li et al.   TRENDS IN CELL BIOLOGY

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

(2014) Rania Ghossoub et al.   Nature Communications

Limited role of free TDP-43 as a diagnostic tool in neurodegenerative diseases

(2014) Emily Feneberg et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

The Role of Extracellular Vesicles in Modulating the Host Immune Response during Parasitic Infections

(2014) Sergio Montaner et al.   Frontiers in Immunology

Molecular mechanisms for the inheritance of acquired characteristics—exosomes, microRNA shuttling, fear and stress: Lamarck resurrected?

(2014) John Smythies et al.   Frontiers in Genetics

Small-size circulating microparticles in acute coronary syndromes: Relevance to fibrinolytic status, reparative markers and outcomes

(2013) Silvia Montoro-García et al.   ATHEROSCLEROSIS

Multicomponent Meningococcal Serogroup B Vaccine (4CMenB; Bexsero®): A Review of its Use in Primary and Booster Vaccination

(2013) Natalie J. Carter   BIODRUGS

Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

(2013) P Joshi et al.   CELL DEATH AND DIFFERENTIATION

Schwann cell-derived exosomes enhance axonal regeneration in the peripheral nervous system

(2013) María Alejandra Lopez-Verrilli et al.   GLIA

Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes

(2013) Manuela Basso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes

(2013) Daniel Perez-Hernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

(2013) Yuki Takahashi et al.   JOURNAL OF BIOTECHNOLOGY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Exosomes Secreted by Human Placenta Carry Functional Fas Ligand and TRAIL Molecules and Convey Apoptosis in Activated Immune Cells, Suggesting Exosome-Mediated Immune Privilege of the Fetus

(2013) A.-C. Stenqvist et al.   JOURNAL OF IMMUNOLOGY

microRNAs Derived from Circulating Exosomes as Noninvasive Biomarkers for Screening and Diagnosing Lung Cancer

(2013) Riccardo Cazzoli et al.   Journal of Thoracic Oncology

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

Exosomes of BV-2 cells induced by alpha-synuclein: Important mediator of neurodegeneration in PD

(2013) Chongwang Chang et al.   NEUROSCIENCE LETTERS

Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

(2013) Taketoshi Kajimoto et al.   Nature Communications

Exosomes for targeted siRNA delivery across biological barriers

(2012) Samir EL Andaloussi et al.   ADVANCED DRUG DELIVERY REVIEWS

Myeloid microvesicles are a marker and therapeutic target for neuroinflammation

(2012) Claudia Verderio et al.   ANNALS OF NEUROLOGY

Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism

(2012) Flavia Antonucci et al.   EMBO JOURNAL

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

(2012) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

(2012) J. F. Nabhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transfer of Vesicles From Schwann Cells to Axons: a Novel Mechanism of Communication in the Peripheral Nervous System

(2012) M. Alejandra Lopez-Verrilli et al.   Frontiers in Physiology

Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms

(2011) Kiyoshi Sakai et al.   JOURNAL OF CLINICAL INVESTIGATION

Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages

(2011) Cecilia Lässer et al.   Journal of Translational Medicine

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

The Immunomodulatory Role of Syncytiotrophoblast Microvesicles

(2011) Jennifer Southcombe et al.   PLoS One

Exosomes from Plasmodium yoelii-Infected Reticulocytes Protect Mice from Lethal Infections

(2011) Lorena Martin-Jaular et al.   PLoS One

Trophoblast-Derived Exosomes Mediate Monocyte Recruitment and Differentiation

(2010) Safinur Atay et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein

(2010) Keiichi Tamai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Updated Technology to Produce Highly Immunogenic Dendritic Cell-derived Exosomes of Clinical Grade

(2010) Sophie Viaud et al.   JOURNAL OF IMMUNOTHERAPY

Exosomes: immune properties and potential clinical implementations

(2010) Nathalie Chaput et al.   Seminars in Immunopathology

TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways

(2009) Claudio Marcelo Fader et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Human Villous Trophoblasts Express and Secrete Placenta-Specific MicroRNAs into Maternal Circulation via Exosomes1

(2009) Shan-Shun Luo et al.   BIOLOGY OF REPRODUCTION

Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine

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Human Placenta Expresses and Secretes NKG2D Ligands via Exosomes that Down-Modulate the Cognate Receptor Expression: Evidence for Immunosuppressive Function

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Rab27a and Rab27b control different steps of the exosome secretion pathway

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