Role of Wnt Signaling in Central Nervous System Injury

Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice

(2015) Felipe G Serrano et al.   Molecular Neurodegeneration

How are you really feeling? A prospective evaluation of cognitive function following trauma

(2014) Erin C. Hall et al.   Journal of Trauma and Acute Care Surgery

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

IL-17A contributes to brain ischemia reperfusion injury through calpain-TRPC6 pathway in mice

(2014) Jiancheng Zhang et al.   NEUROSCIENCE

Thrombin Enhances NGF-Mediated Neurite Extension via Increased and Sustained Activation of p44/42 MAPK and p38 MAPK

(2014) Rania E. Mufti et al.   PLoS One

Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum

(2014) Juvenal A. Ríos et al.   PROGRESS IN NEUROBIOLOGY

The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration

(2014) Charlotte E J Clark et al.   Science China-Life Sciences

The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity

(2014) Cendrine Tourette et al.   PLOS BIOLOGY

Traumatic Brain Injury: Oxidative Stress and Neuroprotection

(2013) Carolin Cornelius et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of Wnt1 and Fzd1 in the spinal cord pathogenesis of amyotrophic lateral sclerosis-transgenic mice

(2013) Shanshan Wang et al.   BIOTECHNOLOGY LETTERS

WNT signaling underlies the pathogenesis of neuropathic pain in rodents

(2013) Yan-Kai Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Overexpression of Wnt3a facilitates the proliferation and neural differentiation of neural stem cells in vitro and after transplantation into an injured rat retina

(2013) Xi-Tao Yang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Posttrauma cotreatment with lithium and valproate: reduction of lesion volume, attenuation of blood-brain barrier disruption, and improvement in motor coordination in mice with traumatic brain injury

(2013) Fengshan Yu et al.   JOURNAL OF NEUROSURGERY

Wnts Are Expressed in the Spinal Cord of Adult Mice and Are Differentially Induced after Injury

(2013) Carlos González-Fernández et al.   JOURNAL OF NEUROTRAUMA

Wnt Signaling in Skeletal Muscle Dynamics: Myogenesis, Neuromuscular Synapse and Fibrosis

(2013) Pedro Cisternas et al.   MOLECULAR NEUROBIOLOGY

Neurothrombectomy in the treatment of acute ischaemic stroke

(2013) Olav Jansen et al.   Nature Reviews Neurology

Animal models of traumatic brain injury

(2013) Ye Xiong et al.   NATURE REVIEWS NEUROSCIENCE

Glucocorticoid receptor β regulates injury-mediated astrocyte activation and contributes to glioma pathogenesis via modulation of β-catenin/TCF transcriptional activity

(2013) Ying Yin et al.   NEUROBIOLOGY OF DISEASE

microRNAs Involved in Regulating Spontaneous Recovery in Embolic Stroke Model

(2013) Fu Jia Liu et al.   PLoS One

The Role and Dynamics of β-Catenin in Precondition Induced Neuroprotection after Traumatic Brain Injury

(2013) Gali Umschweif et al.   PLoS One

A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro

(2013) S. J. Habib et al.   SCIENCE

Wnt your brain be inflamed? Yes, it Wnt!

(2013) Bianca Marchetti et al.   TRENDS IN MOLECULAR MEDICINE

Characterization of Wnt/β-catenin and BMP/Smad signaling pathways in an in vitro model of amyotrophic lateral sclerosis

(2013) Cristina Pinto et al.   Frontiers in Cellular Neuroscience

Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca2+ in mitochondrial dynamics

(2013) Carmen Silva-Alvarez et al.   Frontiers in Cellular Neuroscience

Wnt signaling in the regulation of adult hippocampal neurogenesis

(2013) Lorena Varela-Nallar et al.   Frontiers in Cellular Neuroscience

WNT signaling in neuronal maturation and synaptogenesis

(2013) Silvana B. Rosso et al.   Frontiers in Cellular Neuroscience

Estrogen regulation of Dkk1 and Wnt/β-Catenin signaling in neurodegenerative disease

(2012) Erin L. Scott et al.   BRAIN RESEARCH

Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies

(2012) Gang Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

The Pro-Survival Function of Akt Kinase can be Overridden or Altered to Contribute to Induction of Apoptosis

(2012) D. M. Benbrook et al.   CURRENT CANCER DRUG TARGETS

Three decades of Wnts: a personal perspective on how a scientific field developed

(2012) Roel Nusse et al.   EMBO JOURNAL

Different Functions of HIPK2 and CtBP2 in Traumatic Brain Injury

(2012) Feihui Zou et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Wnt Signaling: Role in Alzheimer Disease and Schizophrenia

(2012) Nibaldo C. Inestrosa et al.   Journal of Neuroimmune Pharmacology

The immunology of traumatic brain injury: a prime target for Alzheimer’s disease prevention

(2012) Brian Giunta et al.   Journal of Neuroinflammation

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reducing canonical Wingless/Wnt signaling pathway confers protection against mutant Huntingtin toxicity in Drosophila

(2012) Pascale Dupont et al.   NEUROBIOLOGY OF DISEASE

Wnt signaling pathway is involved in the pathogenesis of amyotrophic lateral sclerosis in adult transgenic mice

(2012) Yanchun Chen et al.   NEUROLOGICAL RESEARCH

Activation of Akt/GSK-3beta/beta-catenin signaling pathway is involved in survival of neurons after traumatic brain injury in rats

(2012) Shangfeng Zhao et al.   NEUROLOGICAL RESEARCH

Suppression of Frizzled-2-mediated Wnt/Ca2+ signaling significantly attenuates intracellular calcium accumulation in vitro and in a rat model of traumatic brain injury

(2012) L.-J. Niu et al.   NEUROSCIENCE

Spatio-Temporal Expression Pattern of Frizzled Receptors after Contusive Spinal Cord Injury in Adult Rats

(2012) Pau Gonzalez et al.   PLoS One

The Vasculome of the Mouse Brain

(2012) Shuzhen Guo et al.   PLoS One

Understanding Secondary Injury

(2012) Richard Ben Borgens et al.   QUARTERLY REVIEW OF BIOLOGY

Epidemiology of traumatic spinal cord injury: trends and future implications

(2012) M J DeVivo   SPINAL CORD

Targeting Wnt Pathways in Disease

(2012) Z. F. Zimmerman et al.   Cold Spring Harbor Perspectives in Biology

Wnt Signaling

(2012) R. Nusse   Cold Spring Harbor Perspectives in Biology

An update on spinal cord injury research

(2012) He-Qi Cao et al.   Neuroscience Bulletin

Canonical Wnt Signalling Requires the BMP Pathway to Inhibit Oligodendrocyte Maturation

(2011) Keith Feigenson et al.   ASN Neuro

Circulating Dickkopf-1 in acute ischemic stroke and clinically stable cerebrovascular disease

(2011) Thomas Seifert-Held et al.   ATHEROSCLEROSIS

Vascular plasticity in cerebrovascular disorders

(2011) Lars IH Edvinsson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effects of Gender on Gene Expression in the Blood of Ischemic Stroke Patients

(2011) Yingfang Tian et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lithium Ameliorates Neurodegeneration, Suppresses Neuroinflammation, and Improves Behavioral Performance in a Mouse Model of Traumatic Brain Injury

(2011) Fengshan Yu et al.   JOURNAL OF NEUROTRAUMA

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination

(2011) Stephen P J Fancy et al.   NATURE NEUROSCIENCE

Involvement of the Glycogen Synthase Kinase-3 Signaling Pathway in TBI Pathology and Neurocognitive Outcome

(2011) Pramod K. Dash et al.   PLoS One

Differential Expression of Wnts after Spinal Cord Contusion Injury in Adult Rats

(2011) Carmen María Fernández-Martos et al.   PLoS One

Gene Expression Profiling of Blood in Brain Arteriovenous Malformation Patients

(2011) Shantel M. Weinsheimer et al.   Translational Stroke Research

Genome-wide identification of new Wnt/β-catenin target genes in the human genome using CART method

(2010) Christian Hödar et al.   BMC GENOMICS

Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury

(2010) Teuntje M. J. C. Andriessen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Wnt-3a and Wnt-3 differently stimulate proliferation and neurogenesis of spinal neural precursors and promote neurite outgrowth by canonical signaling

(2010) Monica D. David et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study

(2010) Martin J O'Donnell et al.   LANCET

Reactive astrocytes as therapeutic targets for CNS disorders

(2010) Mary E. Hamby et al.   Neurotherapeutics

Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses

(2010) L. Varela-Nallar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt Signaling Regulates Symmetry of Division of Neural Stem Cells in the Adult Brain and in Response to Injury

(2010) David Piccin et al.   STEM CELLS

Review of Lithium Effects on Brain and Blood

(2009) Wise Young   CELL TRANSPLANTATION

Wnt-5a/JNK Signaling Promotes the Clustering of PSD-95 in Hippocampal Neurons

(2009) Ginny G. Farías et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/β-catenin signaling pathway

(2009) Macarena S. Arrázola et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Wnt-Ryk Signaling Mediates Axon Growth Inhibition and Limits Functional Recovery after Spinal Cord Injury

(2009) Tomohiro Miyashita et al.   JOURNAL OF NEUROTRAUMA

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model of Alzheimer's disease

(2009) E M Toledo et al.   MOLECULAR PSYCHIATRY

Emerging roles of Wnts in the adult nervous system

(2009) Nibaldo C. Inestrosa et al.   NATURE REVIEWS NEUROSCIENCE

SDF-1  stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration

(2009) X. Pi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt Signaling in Neural Circuit Assembly

(2008) Patricia C. Salinas et al.   Annual Review of Neuroscience

Heart Disease and Stroke Statistics—2009 Update

(2008) et al.   CIRCULATION

Wnt/β-catenin signaling controls development of the blood–brain barrier

(2008) Stefan Liebner et al.   JOURNAL OF CELL BIOLOGY

Induction of the Wnt Antagonist, Dickkopf-1, Contributes to the Development of Neuronal Death in Models of Brain Focal Ischemia

(2008) Federica Mastroiacovo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Role of Dickkopf-1, an Antagonist of the Wnt/ -Catenin Signaling Pathway, in Estrogen-Induced Neuroprotection and Attenuation of Tau Phosphorylation

(2008) Q.-G. Zhang et al.   JOURNAL OF NEUROSCIENCE

Repulsive Wnt Signaling Inhibits Axon Regeneration after CNS Injury

(2008) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes

(2008) Mathew J Reeves et al.   LANCET NEUROLOGY

Moderate and severe traumatic brain injury in adults

(2008) Andrew IR Maas et al.   LANCET NEUROLOGY

Wnt-mediated self-renewal of neural stem/progenitor cells

(2008) M. Y. S. Kalani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature

(2008) J. M. Stenman et al.   SCIENCE