NLRP3 Inflammasome Pharmacological Inhibitors in Glycyrrhiza for NLRP3-Driven Diseases Treatment: Extinguishing the Fire of Inflammation

Pathomechanism Characterization and Potential Therapeutics Identification for Parkinson’s Disease Targeting Neuroinflammation

(2021) Chiung-Mei Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Isoliquiritin ameliorates depression by suppressing NLRP3-mediated pyroptosis via miRNA-27a/SYK/NF-κB axis

(2021) Yuanjie Li et al.   Journal of Neuroinflammation

Total Flavonoids of Glycyrrhiza uralensis Alleviates Irinotecan-Induced Colitis via Modification of Gut Microbiota and Fecal Metabolism

(2021) Shi-Jun Yue et al.   Frontiers in Immunology

Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity

(2021) Nan Qin et al.   Frontiers of Medicine

Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction

(2021) Qiang Li et al.   EMBO REPORTS

Autofluorescence Lifetime Reports Cartilage Damage in Osteoarthritis

(2020) João L. Lagarto et al.   Scientific Reports

Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators

(2020) Dongling Liu et al.   BIOCHEMICAL PHARMACOLOGY

Oral treatment with glycyrrhizin inhibits NLRP3 inflammasome activation and promotes microglial M2 polarization after traumatic spinal cord injury

(2020) Xiao-Qiang Su et al.   BRAIN RESEARCH BULLETIN

Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases

(2020) Wei Shi et al.   Cell Death & Disease

Icariside Ⅱ, a main compound in Epimedii Folium, induces idiosyncratic hepatotoxicity by enhancing NLRP3 inflammasome activation

(2020) Zhilei Wang et al.   Acta Pharmaceutica Sinica B

NLRP3 inflammasome-dependent pyroptosis and apoptosis in hippocampus neurons mediates depressive-like behavior in diabetic mice

(2020) Dong-Xia Li et al.   BEHAVIOURAL BRAIN RESEARCH

Minocycline alleviates NLRP3 inflammasome-dependent pyroptosis in monosodium glutamate-induced depressive rats

(2020) Feng Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Blockade of extracellular high-mobility group box 1 attenuates inflammation-mediated damage and haze grade in mice with corneal wounds

(2020) Yongying Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Focus on the Role of NLRP3 Inflammasome in Diseases

(2020) Roberta Fusco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors

(2020) Mats Dehlin et al.   Nature Reviews Rheumatology

NLRP3 Inflammasomes in Parkinson’s disease and their Regulation by Parkin

(2020) Yi-Qun Yan et al.   NEUROSCIENCE

The NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis

(2020) Jana Knorr et al.   SEMINARS IN LIVER DISEASE

Targeting the NLRP3 Inflammasome in Severe COVID-19

(2020) Tracey L. Freeman et al.   Frontiers in Immunology

Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation

(2020) Zijian Yan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The NLRP3 inflammasome: Mechanism of action, role in disease and therapies

(2020) Li Wang et al.   MOLECULAR ASPECTS OF MEDICINE

Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway

(2020) Dan-Dan Tian et al.   MOLECULAR NEUROBIOLOGY

Echinatin effectively protects against NLRP3 inflammasome–driven diseases by targeting HSP90

(2020) Guang Xu et al.   JCI Insight

Hepatoprotective effects of Huangqi decoction (Astragali Radix and Glycyrrhizae Radix et Rhizoma) on cholestatic liver injury in mice: Involvement of alleviating intestinal microbiota dysbiosis

(2020) Juan Zou et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome-mediated diseases

(2020) Hongbin Liu et al.   PHARMACOLOGICAL RESEARCH

Research Progress of Glycyrrhizic Acid on Antiviral Activity

(2019) Zhi-Gang Sun et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome

(2019) Zhilei Wang et al.   Acta Pharmaceutica Sinica B

Licochalcone B Extracted from Glycyrrhiza uralensis Fisch Induces Apoptotic Effects in Human Hepatoma Cell HepG2

(2019) Jun Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Metabolic regulation of inflammasomes in inflammation

(2019) Qiuli Yang et al.   IMMUNOLOGY

Parkinson's Disease and Parkinsonism

(2019) Michael T Hayes   AMERICAN JOURNAL OF MEDICINE

Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets

(2019) Sohaib Nizami et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glycyrrhizin administration ameliorates Streptococcus aureus-induced acute lung injury

(2019) Li Yao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A

(2019) Hongming Lv et al.   Cell Death & Disease

Carbenoxolone ameliorates insulin sensitivity in obese mice induced by high fat diet via regulating the IκB-α/NF-κB pathway and NLRP3 inflammasome

(2019) Yuning Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Resolvins: Emerging Players in Autoimmune and Inflammatory Diseases

(2019) Fereshte Abdolmaleki et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Neuroprotective effects of isoliquiritigenin against cognitive impairment via suppression of synaptic dysfunction, neuronal injury, and neuroinflammation in rats with kainic acid-induced seizures

(2019) Xiaobo Zhu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Natural products in licorice for the therapy of liver diseases: Progress and future opportunities

(2019) Xiaojiaoyang Li et al.   PHARMACOLOGICAL RESEARCH

Inflammation and Cardiovascular Diseases: The Most Recent Findings

(2019) Daniela Sorriento et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gout

(2019) Nicola Dalbeth et al.   Nature Reviews Disease Primers

DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation

(2019) Joel Zindel et al.   Annual Review of Pathology-Mechanisms of Disease

Carbamazepine promotes specific stimuli-induced NLRP3 inflammasome activation and causes idiosyncratic liver injury in mice

(2019) Zhilei Wang et al.   ARCHIVES OF TOXICOLOGY

Targeting the microglial NLRP3 inflammasome and its role in Parkinson's disease

(2019) Md. Ezazul Haque et al.   MOVEMENT DISORDERS

Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases

(2019) Xiangna Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Amelioration of Hyperglycemia-Induced Nephropathy by 3,3′-Diindolylmethane in Diabetic Mice

(2019) Kyeong-Mi Choi et al.   MOLECULES

Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption

(2019) Danli Cui et al.   PHYTOMEDICINE

Liquiritigenin attenuates high glucose-induced mesangial matrix accumulation, oxidative stress, and inflammation by suppression of the NF-κB and NLRP3 inflammasome pathways

(2018) Xiaoguang Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

Glycyrrhizin alleviates non-alcoholic steatohepatitis via modulating bile acids and meta-inflammation

(2018) Tingting Yan et al.   DRUG METABOLISM AND DISPOSITION

Nicotine Alters Estrogen Receptor-Beta-Regulated Inflammasome Activity and Exacerbates Ischemic Brain Damage in Female Rats

(2018) Nathan d’Adesky et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

NLRP3 as a potentially novel biomarker for the management of osteoarthritis

(2018) M.J. McAllister et al.   OSTEOARTHRITIS AND CARTILAGE

Isoliquiritigenin Ameliorates Indomethacin-Induced Small Intestinal Damage by Inhibiting NOD-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation

(2018) Shiro Nakamura et al.   PHARMACOLOGY

Periodontal complications with age

(2018) Goesta Rutger Persson   PERIODONTOLOGY 2000

Liquorice (Glycyrrhiza glabra ): A phytochemical and pharmacological review

(2018) Giulia Pastorino et al.   PHYTOTHERAPY RESEARCH

Activation of NLRP3 Inflammasome Promotes Foam Cell Formation in Vascular Smooth Muscle Cells and Atherogenesis Via HMGB1

(2018) Rui Wang et al.   Journal of the American Heart Association

Isoliquiritigenin (ISL) and its formulations: potential antitumor agents

(2018) Ting-ting Zhao et al.   CURRENT MEDICINAL CHEMISTRY

A Review: The Anti-inflammatory, Anticancer, Antibacterial Properties of Four Kinds of Licorice Flavonoids Isolated from Licorice

(2018) Ze-Feng Wang et al.   CURRENT MEDICINAL CHEMISTRY

Periodontal ligament fibroblasts migration injury via ROS/TXNIP/Nlrp3 inflammasome pathway with Porphyromonas gingivalis lipopolysaccharide

(2018) Dawei Lian et al.   MOLECULAR IMMUNOLOGY

Licochalcone A attenuates acne symptoms mediated by suppression of NLRP3 inflammasome

(2018) Gabsik Yang et al.   PHYTOTHERAPY RESEARCH

Current and future pharmacological therapies for NAFLD/NASH

(2017) Yoshio Sumida et al.   JOURNAL OF GASTROENTEROLOGY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway

(2017) Jun Zeng et al.   Journal of Neuroinflammation

Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review

(2017) Jakeline Rheinheimer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Traumatic Spinal Cord Injury—Repair and Regeneration

(2017) Christopher S. Ahuja et al.   NEUROSURGERY

The multistep road to ventilator-associated lung abscess: A retrospective study of S.aureus ventilator-associated pneumonia

(2017) Roman Mounier et al.   PLoS One

Isoliquiritigenin Activates Nuclear Factor Erythroid-2 Related Factor 2 to Suppress the NOD-Like Receptor Protein 3 Inflammasome and Inhibits the NF-κB Pathway in Macrophages and in Acute Lung Injury

(2017) Qinmei Liu et al.   Frontiers in Immunology

Regulation and Function of the Nucleotide Binding Domain Leucine-Rich Repeat-Containing Receptor, Pyrin Domain-Containing-3 Inflammasome in Lung Disease

(2016) Seonmin Lee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Antihyperuricemic effect of liquiritigenin in potassium oxonate-induced hyperuricemic rats

(2016) Long Hongyan et al.   BIOMEDICINE & PHARMACOTHERAPY

Mangiferin alleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

(2016) Chen-wei Pan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

(2016) Xingkai Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine

(2016) Shuai Ji et al.   JOURNAL OF NATURAL PRODUCTS

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome

(2016) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Gout

(2016) Nicola Dalbeth et al.   LANCET

The anti-inflammatory activity of licorice, a widely used Chinese herb

(2016) Rui Yang et al.   PHARMACEUTICAL BIOLOGY

The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature

(2016) André F. Carvalho et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH

(2016) Xingyong Wan et al.   Canadian Journal of Gastroenterology and Hepatology

Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury

(2015) Arash Moghaddam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma

(2015) Wei Chi et al.   Journal of Neuroinflammation

Hyperuricemia-induced inflammasome and kidney diseases

(2015) Yoshitaka Isaka et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A Review: The Pharmacology of Isoliquiritigenin

(2015) Fu Peng et al.   PHYTOTHERAPY RESEARCH

The role of the NLRP3 inflammasome in pulmonary diseases

(2015) Nima Hosseinian et al.   Therapeutic Advances in Respiratory Disease

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb

(2015) Liqiang Wang et al.   Acta Pharmaceutica Sinica B

Osteoarthritis Pathogenesis: A Review of Molecular Mechanisms

(2014) Bingjiang Xia et al.   CALCIFIED TISSUE INTERNATIONAL

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

The Pathophysiology and Treatment of Glaucoma

(2014) Robert N. Weinreb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

New Insights into Acne Pathogenesis: Propionibacterium Acnes Activates the Inflammasome

(2014) Emmanuel Contassot et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Propionibacterium acnes Activates the NLRP3 Inflammasome in Human Sebocytes

(2014) Zheng Jun Li et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation

(2014) Hiroe Honda et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice

(2013) Yu Fu et al.   FOOD CHEMISTRY

IL-1β Drives Inflammatory Responses to Propionibacterium acnes In Vitro and In Vivo

(2013) Magdalena Kistowska et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inflammation and the pathogenesis of diabetic nephropathy

(2012) Jun Wada et al.   CLINICAL SCIENCE

Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family

(2012) Cees J. Tack et al.   IMMUNOLOGICAL REVIEWS

Intracerebral haemorrhage: mechanisms of injury and therapeutic targets

(2012) Richard F Keep et al.   LANCET NEUROLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Periodontal ligament and gingival fibroblasts from periodontitis patients are more active in interaction with Porphyromonas gingivalis

(2011) N. Scheres et al.   JOURNAL OF PERIODONTAL RESEARCH

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Periodontal Ligament Fibroblasts Sustain Destructive Immune Modulators of Chronic Periodontitis

(2010) Ahmed R. El-Awady et al.   JOURNAL OF PERIODONTOLOGY

Advances in the management of intracerebral hemorrhage

(2010) Opeolu Adeoye et al.   Nature Reviews Neurology

What a vascular surgeon should know and do about atherosclerotic risk factors

(2009) Christos D. Liapis et al.   JOURNAL OF VASCULAR SURGERY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Antiviral effects ofGlycyrrhiza species

(2007) Cristina Fiore et al.   PHYTOTHERAPY RESEARCH