Isoliquiritin ameliorates depression by suppressing NLRP3-mediated pyroptosis via miRNA-27a/SYK/NF-κB axis

Inflammasomes in neuroinflammatory and neurodegenerative diseases

(2019) Sofie Voet et al.   EMBO Molecular Medicine

Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway

(2019) Li-Ting Guo et al.   Journal of Neuroinflammation

Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model

(2019) Bo Zhang et al.   MOLECULES

Suppressing the Na+/H+ exchanger 1: a new sight to treat depression

(2019) Xueyang Deng et al.   Cell Death & Disease

Silencing of microRNA‐27a facilitates autophagy and apoptosis of melanoma cells through the activation of the SYK‐dependent mTOR signaling pathway

(2019) Hua Tang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke

(2019) Pengfei Xu et al.   Cell Death & Disease

Antidepressant-Like Activity of Myelophil via Attenuation of Microglial-Mediated Neuroinflammation in Mice Undergoing Unpredictable Chronic Mild Stress

(2019) Jin-Seok Lee et al.   Frontiers in Pharmacology

Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

(2019) Burak I. Arioz et al.   Frontiers in Immunology

MicroRNA-27a alleviates IL-1β-induced inflammatory response and articular cartilage degradation via TLR4/NF-κB signaling pathway in articular chondrocytes

(2019) Wen-Jun Qiu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Activating newborn neurons suppresses depression and anxiety-like behaviors

(2019) Elif Tunc-Ozcan et al.   Nature Communications

Renoprotective Effects Of Isoliquiritin Against Cationic Bovine Serum Albumin-Induced Membranous Glomerulonephritis In Experimental Rat Model Through Its Anti-Oxidative And Anti-Inflammatory Properties

(2019) Yingying Liu et al.   Drug Design Development and Therapy

lncRNA GAS5/miR-452-5p Reduces Oxidative Stress and Pyroptosis of High-Glucose-Stimulated Renal Tubular Cells

(2019) Cuisong Xie et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Principles of inflammasome priming and inhibition: Implications for psychiatric disorders

(2018) Francis J. Herman et al.   BRAIN BEHAVIOR AND IMMUNITY

Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis

(2018) Chen Qu et al.   HEPATOLOGY

Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice

(2018) Adam K. Walker et al.   MOLECULAR PSYCHIATRY

Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling

(2018) Geoffroy Laumet et al.   NEUROPSYCHOPHARMACOLOGY

Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke

(2018) Saifudeen Ismael et al.   Scientific Reports

MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting inflammation and apoptosis through modulating TLR4/MyD88/NF-κB pathway

(2018) MinJie Ju et al.   CELL CYCLE

Social defeat stress before pregnancy induces depressive-like behaviours and cognitive deficits in adult male offspring: correlation with neurobiological changes

(2018) Sheng Wei et al.   BMC NEUROSCIENCE

Down-Regulation Of Mir-107 Worsen Spatial Memory By Suppressing SYK Expression And Inactivating NF-ΚB Signaling Pathway

(2018) Wenjie Hu et al.   Current Alzheimer Research

Abnormal protein and mRNA expression of inflammatory cytokines in the prefrontal cortex of depressed individuals who died by suicide

(2018) Ghanshyam N. Pandey et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Lavandula angustifolia Essential Oil and Linalool Counteract Social Aversion Induced by Social Defeat

(2018) Lucia Caputo et al.   MOLECULES

Effect of Ketamine on LTP and NMDAR EPSC in Hippocampus of the Chronic Social Defeat Stress Mice Model of Depression

(2018) Yu Yang et al.   Frontiers in Behavioral Neuroscience

Protective effect of isoliquiritin against corticosterone-induced neurotoxicity in PC12 cells

(2017) Yu-zhi Zhou et al.   Food & Function

The Major Chromoblastomycosis Etiologic Agent Fonsecaea pedrosoi Activates the NLRP3 Inflammasome

(2017) Raffael Júnio Araújo de Castro et al.   Frontiers in Immunology

Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats

(2017) Yi-Yun Liu et al.   PLoS One

miR-23∼27∼24 clusters control effector T cell differentiation and function

(2016) Sunglim Cho et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

(2016) Yan Zhou et al.   Molecular Neurodegeneration

Antidepressant therapies inhibit inflammation and microglial M1-polarization

(2016) Hans O. Kalkman et al.   PHARMACOLOGY & THERAPEUTICS

Predicting relapse after antidepressant withdrawal – a systematic review

(2016) I. M. Berwian et al.   PSYCHOLOGICAL MEDICINE

Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice

(2015) Juanjuan Tang et al.   Scientific Reports

Studies On The Identification Of Constituents In Ethanol Extract Of Radix Glycyrrhizae And Their Anticancer Activity

(2014) X Shi et al.   African Journal of Traditional Complementary and Alternative Medicines

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1Areceptors without diminishing nervous system function or chemotherapy efficacy

(2013) Sara Jane Ward et al.   BRITISH JOURNAL OF PHARMACOLOGY

Stress-Induced Recruitment of Bone Marrow-Derived Monocytes to the Brain Promotes Anxiety-Like Behavior

(2013) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

MicroRNA Expression Is Down-Regulated and Reorganized in Prefrontal Cortex of Depressed Suicide Subjects

(2012) Neil R. Smalheiser et al.   PLoS One

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice

(2008) Weixing Wang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY