Iron Overload, Oxidative Stress, and Ferroptosis in the Failing Heart and Liver

Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum

(2021) Tasuku Konno et al.   Cells

Mitoferrin 2 deficiency prevents mitochondrial iron overload-induced endothelial injury and alleviates atherosclerosis

(2021) Dongchen Wang et al.   EXPERIMENTAL CELL RESEARCH

Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis

(2021) Gai Gao et al.   Journal of Natural Medicines

Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling

(2021) Li-Fei Luo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

On Iron Metabolism and Its Regulation

(2021) Anne-Cathrine S. Vogt et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ferroptosis in infection, inflammation, and immunity

(2021) Xin Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms of Neurodegeneration in Various Forms of Parkinsonism—Similarities and Differences

(2021) Dariusz Koziorowski et al.   Cells

Role of Oxidative Stress in the Pathogenesis of Amyotrophic Lateral Sclerosis: Antioxidant Metalloenzymes and Therapeutic Strategies

(2021) Pavlína Hemerková et al.   Biomolecules

Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

(2021) Kai Hou et al.   EBioMedicine

Targeting Ferroptosis to Treat Cardiovascular Diseases: A New Continent to Be Explored

(2021) Fangze Huang et al.   Frontiers in Cell and Developmental Biology

Histochrome Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death

(2021) Ji-Won Hwang et al.   Antioxidants

Iron overload as a risk factor for hepatic ischemia‐reperfusion injury in liver transplantation: Potential role of ferroptosis

(2020) Naoya Yamada et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

(2020) Naoya Yamada et al.   Cell Death & Disease

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Ferroptosis is involved in alcohol-induced cell death in vivo and in vitro

(2020) Chun-Yu Liu et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Iron chaperone PCBP1 protects murine liver from lipid peroxidation and steatosis

(2020) Olga Protchenko et al.   HEPATOLOGY

TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells

(2020) Do Hyung Kim et al.   Cell Death & Disease

ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma

(2020) Ji Feng et al.   ACTA PHARMACOLOGICA SINICA

Emerging roles of ferroptosis in liver pathophysiology

(2020) Kyu Min Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Acyl-CoA thioesterase 1 prevents cardiomyocytes from Doxorubicin-induced ferroptosis via shaping the lipid composition

(2020) Yunchang Liu et al.   Cell Death & Disease

NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration

(2019) Maria Quiles del Rey et al.   Frontiers in Neuroscience

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Death and Liver Disease

(2019) Satoka Aizawa et al.   Gut and Liver

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation

(2019) Wenjun Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Biallelic HEPHL1 variants impair ferroxidase activity and cause an abnormal hair phenotype

(2019) Prashant Sharma et al.   PLoS Genetics

Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases

(2019) Toshitaka Nakamura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Relevance of the iron-responsive element (IRE) pseudotriloop structure for IRP1/2 binding and validation of IRE-like structures using the yeast three-hybrid system

(2019) Shih-Cheng Chen et al.   GENE

Mechanism of glycyrrhizin on ferroptosis during acute liver failure by inhibiting oxidative stress

(2019) Yao Wang et al.   Molecular Medicine Reports

Emerging and established modes of cell death during acetaminophen-induced liver injury

(2019) Hartmut Jaeschke et al.   ARCHIVES OF TOXICOLOGY

Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis

(2019) Zhou Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation–Mediated Cell Death in Mice

(2019) Jing Qi et al.   AMERICAN JOURNAL OF PATHOLOGY

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

(2019) Caitlin W. Brown et al.   DEVELOPMENTAL CELL

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

(2018) Yuichi Baba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis

(2018) Bei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT

(2018) Zongqi Wang et al.   CANCER LETTERS

Canonical and non-canonical mechanisms of Nrf2 activation

(2018) Carlos Alfredo Silva-Islas et al.   PHARMACOLOGICAL RESEARCH

Beneficial effects of intravenous iron therapy in a rat model of heart failure with preserved systemic iron status but depleted intracellular cardiac stores

(2018) Aleksandra Paterek et al.   Scientific Reports

New drugs in preclinical and early stage clinical development in the treatment of heart failure

(2018) Juan Tamargo et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The role of oxidative stress in Friedreich's ataxia

(2017) Federica Lupoli et al.   FEBS LETTERS

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Systemic iron homeostasis and erythropoiesis

(2017) George Papanikolaou et al.   IUBMB LIFE

Effect of Oral Iron Repletion on Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction and Iron Deficiency

(2017) Gregory D. Lewis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

An Overview of the Advantages of KEAP1-NRF2 System Activation During Inflammatory Disease Treatment

(2017) Nadine Keleku-Lukwete et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidant Mechanisms in Renal Injury and Disease

(2016) Brian B. Ratliff et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis

(2016) Xiaofang Sun et al.   HEPATOLOGY

The mutual control of iron and erythropoiesis

(2016) C. Camaschella et al.   International Journal of Laboratory Hematology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

'Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich’s ataxia'

(2016) R Abeti et al.   Cell Death & Disease

Mitochondria and Iron: current questions

(2016) Bibbin T. Paul et al.   Expert Review of Hematology

Transferrin Receptor 2 Dependent Alterations of Brain Iron Metabolism Affect Anxiety Circuits in the Mouse

(2016) Rosa Maria Pellegrino et al.   Scientific Reports

NCOA4 Deficiency Impairs Systemic Iron Homeostasis

(2016) Roberto Bellelli et al.   Cell Reports

An essential cell-autonomous role for hepcidin in cardiac iron homeostasis

(2016) Samira Lakhal-Littleton et al.   eLife

Iron –sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery

(2015) Nunziata Maio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications

(2015) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

HSPB1 as a novel regulator of ferroptotic cancer cell death

(2015) X Sun et al.   ONCOGENE

Iron-Induced Damage in Cardiomyopathy: Oxidative-Dependent and Independent Mechanisms

(2015) Elena Gammella et al.   Oxidative Medicine and Cellular Longevity

The Pathogenesis of Cardiomyopathy in Friedreich Ataxia

(2015) Arnulf H. Koeppen et al.   PLoS One

Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function

(2015) Samira Lakhal-Littleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart

(2015) Wenjing Xu et al.   Cell Reports

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

(2015) Joseph D Mancias et al.   eLife

Cardiac Mitochondria and Reactive Oxygen Species Generation

(2014) Yeong-Renn Chen et al.   CIRCULATION RESEARCH

mRNA regulation of cardiac iron transporters and ferritin subunits in a mouse model of iron overload

(2014) Casey J. Brewer et al.   EXPERIMENTAL HEMATOLOGY

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

(2014) Deborah Chiabrando et al.   Frontiers in Pharmacology

Labile iron in cells and body fluids: physiology, pathology, and pharmacology

(2014) Zvi Ioav Cabantchik   Frontiers in Pharmacology

The regulation of iron transport

(2013) David M. Frazer et al.   BIOFACTORS

Cardiovascular Function and Treatment in β-Thalassemia Major

(2013) Dudley J. Pennell et al.   CIRCULATION

Cardiomyopathy of Friedreich Ataxia

(2013) Frank Weidemann et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial calcium uniporter blocker effectively prevents brain mitochondrial dysfunction caused by iron overload

(2013) Jirapas Sripetchwandee et al.   LIFE SCIENCES

Systemic Iron Homeostasis

(2013) Tomas Ganz   PHYSIOLOGICAL REVIEWS

Toward clinical application of the Keap1–Nrf2 pathway

(2013) Takafumi Suzuki et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Multi-Copper Oxidases and Human Iron Metabolism

(2013) Ganna Vashchenko et al.   Nutrients

Prooxidant Mechanisms in Iron Overload Cardiomyopathy

(2013) Ching-Feng Cheng et al.   Biomed Research International

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Regulation of iron transport and the role of transferrin

(2011) Konstantinos Gkouvatsos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria

(2011) M.-B. Troadec et al.   BLOOD

Iron Overload Decreases Ca V 1.3-Dependent L-Type Ca 2+ Currents Leading to Bradycardia, Altered Electrical Conduction, and Atrial Fibrillation

(2011) Robert A. Rose et al.   Circulation-Arrhythmia and Electrophysiology

Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease

(2011) Kris V. Kowdley et al.   HEPATOLOGY

Lipocalin-2 Induces Cardiomyocyte Apoptosis by Increasing Intracellular Iron Accumulation

(2011) Guoxiong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage

(2010) Paolo Arosio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

The mitochondrial protein frataxin is essential for heme biosynthesis in plants

(2010) María V. Maliandi et al.   FEBS Journal

Iron-Overload Cardiomyopathy: Pathophysiology, Diagnosis, and Treatment

(2010) Colm J. Murphy et al.   JOURNAL OF CARDIAC FAILURE

Impaired expression of duodenal iron transporters in Dahl salt-sensitive heart failure rats

(2010) Yoshiro Naito et al.   JOURNAL OF HYPERTENSION

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

(2010) D. R. Richardson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardioprotection: A radical view

(2009) Claudia Penna et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network

(2008) Martina U. Muckenthaler et al.   Annual Review of Nutrition

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Adipokines, Myokines and Cardiovascular Disease

(2008) Kenneth Walsh   CIRCULATION JOURNAL

Mitochondrial DNA Damage in Iron Overload

(2008) Xueshan Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The paradigm of postconditioning to protect the heart

(2008) C. Penna et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Heart protection by ischemic preconditioning: A novel pathway initiated by iron and mediated by ferritin

(2008) Mordechai Chevion et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Regulation of Mitochondrial Iron Import through Differential Turnover of Mitoferrin 1 and Mitoferrin 2

(2008) P. N. Paradkar et al.   MOLECULAR AND CELLULAR BIOLOGY

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE

Iron-Overload–Related Disease inHFEHereditary Hemochromatosis

(2008) Katrina J. Allen et al.   NEW ENGLAND JOURNAL OF MEDICINE