'Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich’s ataxia'

Lipid peroxidation is essential for α-synuclein-induced cell death

(2015) Plamena R. Angelova et al.   JOURNAL OF NEUROCHEMISTRY

Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia

(2015) Rosella Abeti et al.   PHARMACOLOGICAL RESEARCH

Poly(ADP-ribose) polymerase-1-induced NAD+ depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation

(2013) Tiina M. Kauppinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Clinical features of Friedreich's ataxia: classical and atypical phenotypes

(2013) Michael H. Parkinson et al.   JOURNAL OF NEUROCHEMISTRY

Neurodegeneration in Friedreich’s Ataxia: From Defective Frataxin to Oxidative Stress

(2013) Cláudio M. Gomes et al.   Oxidative Medicine and Cellular Longevity

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

(2013) K. M. Holmstrom et al.   Biology Open

Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation

(2012) Shauna Hill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Friedreich's ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase

(2012) Gregory R. Wagner et al.   HUMAN MOLECULAR GENETICS

Human neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment

(2012) Kate E. C. Duberley et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The cerebellar component of Friedreich’s ataxia

(2011) Arnulf H. Koeppen et al.   ACTA NEUROPATHOLOGICA

Changes in mitochondrial glutathione levels and protein thiol oxidation in ∆yfh1 yeast cells and the lymphoblasts of patients with Friedreich's ataxia

(2011) A.L. Bulteau et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

(2011) Rosella Abeti et al.   BRAIN

Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation

(2011) Seonmin Lee et al.   CELL RESEARCH

Sulforaphane inhibits mitochondrial permeability transition and oxidative stress

(2011) Tiffany Greco et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pathology and pathogenesis of sensory neuropathy in Friedreich’s ataxia

(2010) Jennifer A. Morral et al.   ACTA NEUROPATHOLOGICA

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations

(2010) A. Y. Abramov et al.   BRAIN

The Neuropathology of Late-Onset Friedreich’s Ataxia

(2010) Arnulf H. Koeppen et al.   CEREBELLUM

Isotope-reinforced polyunsaturated fatty acids protect yeast cells from oxidative stress

(2010) Shauna Hill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Altered lipid metabolism in a Drosophila model of Friedreich's ataxia

(2010) J. A. Navarro et al.   HUMAN MOLECULAR GENETICS

Qualitative determination of superoxide release at both sides of the mitochondrial inner membrane by capillary electrophoretic analysis of the oxidation products of triphenylphosphonium hydroethidine

(2009) Xin Xu et al.   FREE RADICAL BIOLOGY AND MEDICINE

The pathogenesis of Friedreich ataxia and the structure and function of frataxin

(2009) Massimo Pandolfo et al.   JOURNAL OF NEUROLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Regulation of Mitochondrial Structure and Function by the F1Fo-ATPase Inhibitor Protein, IF1

(2008) Michelangelo Campanella et al.   Cell Metabolism

Glutathione-dependent redox status of frataxin-deficient cells in a yeast model of Friedreich's ataxia

(2008) F. Auchere et al.   HUMAN MOLECULAR GENETICS