The Role of GDF15 as a Myomitokine

Regulation of diurnal energy balance by mitokines

(2021) Susanne Klaus et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

GFRAL-expressing neurons suppress food intake via aversive pathways

(2021) Paul V. Sabatini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

(2021) Anders B. Klein et al.   Nature Communications

DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance

(2021) Juan Zhang et al.   iScience

GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease

(2021) Dongdong Wang et al.   Nature Reviews Endocrinology

Growth differentiation factor 15 increases in both cerebrospinal fluid and serum during pregnancy

(2021) Ulrika Andersson-Hall et al.   PLoS One

Activation of the hypothalamic–pituitary–adrenal axis by exogenous and endogenous GDF15

(2021) Irene Cimino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

(2021) Mohammad Abu-Odeh et al.   Cell Reports

GDF15 Induces Anorexia through Nausea and Emesis

(2020) Tito Borner et al.   Cell Metabolism

Muscle‐derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress

(2020) Mario Ost et al.   EMBO REPORTS

GDF15: A hormone conveying somatic distress to the brain

(2020) Samuel M Lockhart et al.   ENDOCRINE REVIEWS

Muscle-organ crosstalk: the emerging roles of myokines

(2020) Mai Charlotte Krogh Severinsen et al.   ENDOCRINE REVIEWS

Associations between serum GDF15 concentrations, muscle mass and strength show sex-specific differences in older hospital patients

(2020) Catrin Herpich et al.   REJUVENATION RESEARCH

GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss

(2020) Tito Borner et al.   Cell Reports

GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness

(2020) Maria Conte et al.   Frontiers in Immunology

Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age

(2020) Adiv A. Johnson et al.   AGEING RESEARCH REVIEWS

Mitochondrial-derived peptides in energy metabolism

(2020) Troy L. Merry et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice

(2020) Rowena Suriben et al.   NATURE MEDICINE

The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling

(2020) Amy A Worth et al.   eLife

Inflammaging, hormesis and the rationale for anti-aging strategies

(2020) Aurelia Santoro et al.   AGEING RESEARCH REVIEWS

Is GLUT4 translocation the answer to exercise-stimulated muscle glucose uptake?

(2020) Erik A. Richter   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?

(2020) Samuel N. Breit et al.   Annual Review of Physiology

GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates

(2020) Danna M. Breen et al.   Cell Metabolism

Area Postrema Cell Types that Mediate Nausea-Associated Behaviors

(2020) Chuchu Zhang et al.   NEURON

Altered GDF15 and FGF21 Levels in Response to Strenuous Exercise: A Study in Marathon Runners

(2020) Laura Campderrós et al.   Frontiers in Physiology

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

(2019) Satish Patel et al.   Cell Metabolism

GDF15 acts synergistically with liraglutide but is not necessary for the weight loss induced by bariatric surgery in mice

(2019) Henriette Frikke-Schmidt et al.   Molecular Metabolism

Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases

(2019) Seung Joon Baek et al.   PHARMACOLOGY & THERAPEUTICS

Cellular circadian period length inversely correlates with HbA1c levels in individuals with type 2 diabetes

(2019) Flore Sinturel et al.   DIABETOLOGIA

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

(2019) Demine et al.   Cells

Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions

(2019) Saara Forsström et al.   Cell Metabolism

Mitochondrial uncoupling and longevity – A role for mitokines?

(2019) Susanne Klaus et al.   EXPERIMENTAL GERONTOLOGY

Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy

(2019) Nanna Scharff Poulsen et al.   MITOCHONDRION

Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice

(2019) Carla Igual Gil et al.   Scientific Reports

Human Aging and Longevity Are Characterized by High Levels of Mitokines

(2018) Maria Conte et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Exercise increases circulating GDF15 in humans

(2018) Maximilian Kleinert et al.   Molecular Metabolism

The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases

(2018) Vicky W.W. Tsai et al.   Cell Metabolism

Growth/differentiation factor 15 causes TGFβ-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension

(2018) Benjamin E Garfield et al.   THORAX

ER stress in skeletal muscle remodeling and myopathies

(2017) Dil Afroze et al.   FEBS Journal

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

(2017) Jer-Yuan Hsu et al.   NATURE

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

(2017) Linda Yang et al.   NATURE MEDICINE

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

(2017) Shannon E Mullican et al.   NATURE MEDICINE

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

(2017) Paul J Emmerson et al.   NATURE MEDICINE

First Behavioural Characterisation of a Knockout Mouse Model for the Transforming Growth Factor (TGF)-β Superfamily Cytokine, MIC-1/GDF15

(2017) Jac Kee Low et al.   PLoS One

Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity

(2017) Ryan M. Morrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Over-expression of growth differentiation factor 15 (GDF15) preventing cold ischemia reperfusion (I/R) injury in heart transplantation through Foxo3a signaling

(2017) Yixin Zhang et al.   Oncotarget

Growth Differentiation Factor 15 as a Biomarker in Cardiovascular Disease

(2016) Kai C. Wollert et al.   CLINICAL CHEMISTRY

Regulation of myokine expression: Role of exercise and cellular stress

(2016) Mario Ost et al.   FREE RADICAL BIOLOGY AND MEDICINE

Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders

(2016) Yasunori Fujita et al.   Geriatrics & Gerontology International

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

(2016) Hyo Kyun Chung et al.   JOURNAL OF CELL BIOLOGY

Growth Differentiation Factor 15 Is a Novel Diagnostic Biomarker of Mitochondrial Diseases

(2016) Xinbo Ji et al.   MOLECULAR NEUROBIOLOGY

Exercise-stimulated glucose uptake — regulation and implications for glycaemic control

(2016) Lykke Sylow et al.   Nature Reviews Endocrinology

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action

(2016) Mario Ost et al.   Molecular Metabolism

GDF-15 Is Elevated in Children with Mitochondrial Diseases and Is Induced by Mitochondrial Dysfunction

(2016) Raquel Montero et al.   PLoS One

Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders

(2015) Shuichi Yatsuga et al.   ANNALS OF NEUROLOGY

Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux

(2015) Mario Ost et al.   FASEB JOURNAL

GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases

(2015) Yasunori Fujita et al.   MITOCHONDRION

NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway

(2015) K-W Min et al.   ONCOGENE

Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wastingin vivo

(2015) Mehul S. Patel et al.   Journal of Cachexia Sarcopenia and Muscle

Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI

(2015) Vicky Wang-Wei Tsai et al.   PLoS One

Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies

(2014) Susana Kalko et al.   BMC GENOMICS

Integrative Biology of Exercise

(2014) John A. Hawley et al.   CELL

Mitohormesis

(2014) Jeanho Yun et al.   Cell Metabolism

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

(2014) Michael Ristow et al.   Dose-Response

Exercise and circulating Cortisol levels: The intensity threshold effect

(2014) E. E. Hill et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Activation of AMPKα2 Is Not Crucial for Mitochondrial Uncoupling-Induced Metabolic Effects but Required to Maintain Skeletal Muscle Integrity

(2014) Mario Ost et al.   PLoS One

Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs

(2014) S. A. A. Bloch et al.   THORAX

Profiling of circadian genes expressed in the uterus endometrial stromal cells of pregnant rats as revealed by DNA microarray coupled with RNA interference

(2014) Hirotaka Tasaki   Frontiers in Endocrinology

Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine

(2013) Susanne Keipert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

(2013) Brendan Egan et al.   Cell Metabolism

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1α/ATF6α Complex

(2011) Jun Wu et al.   Cell Metabolism

Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice

(2010) Susanne Keipert et al.   AGING CELL

Specific metabolic rates of major organs and tissues across adulthood: evaluation by mechanistic model of resting energy expenditure

(2010) ZiMian Wang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Growth-differentiation factor-15, endoglin and N-terminal pro-brain natriuretic peptide induction in athletes participating in an ultramarathon foot race

(2009) Isabelle Tchou et al.   BIOMARKERS

Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo

(2008) Susanne Neschen et al.   PHYSIOLOGICAL GENOMICS

Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1

(2007) Yvonne Katterle et al.   PHYSIOLOGICAL GENOMICS