GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates
Published 2020 View Full Article
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Title
GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates
Authors
Keywords
growth differentiation factor 15, cisplatin, chemotherapy, weight loss, survival, emesis
Journal
Cell Metabolism
Volume 32, Issue 6, Pages 938-950.e6
Publisher
Elsevier BV
Online
2020-11-17
DOI
10.1016/j.cmet.2020.10.023
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Note: Only part of the references are listed.- GDF15 Induces Anorexia through Nausea and Emesis
- (2020) Tito Borner et al. Cell Metabolism
- Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies
- (2020) Elena Conte et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss
- (2020) Tito Borner et al. Cell Reports
- Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice
- (2020) Rowena Suriben et al. NATURE MEDICINE
- The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling
- (2020) Amy A Worth et al. eLife
- Characterization of cachexia in the human fibrosarcoma HT-1080 mouse tumour model
- (2020) Barbara Bernardo et al. Journal of Cachexia Sarcopenia and Muscle
- GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans
- (2019) Satish Patel et al. Cell Metabolism
- One shot NEPA plus dexamethasone to prevent multiple-day chemotherapy in sarcoma patients
- (2019) Giuseppe Badalamenti et al. SUPPORTIVE CARE IN CANCER
- Chemotherapy‐induced cachexia dysregulates hypothalamic and systemic lipoamines and is attenuated by cannabigerol
- (2019) Daniel I. Brierley et al. Journal of Cachexia Sarcopenia and Muscle
- GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS
- (2019) Vicky Wang-Wei Tsai et al. INTERNATIONAL JOURNAL OF OBESITY
- Effects of ondansetron and [6]-gingerol on pica and gut microbiota in rats treated with cisplatin
- (2019) Xiaodi Feng et al. Drug Design Development and Therapy
- The society for immunotherapy of cancer consensus statement on immunotherapy for the treatment of advanced renal cell carcinoma (RCC)
- (2019) Brian I. Rini et al. Journal for ImmunoTherapy of Cancer
- GDF15 promotes the proliferation of cervical cancer cells by phosphorylating AKT1 and Erk1/2 through the receptor ErbB2
- (2018) Shan Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Fenofibrate prevents skeletal muscle loss in mice with lung cancer
- (2018) Marcus D. Goncalves et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm
- (2018) Richard D. Palmiter TRENDS IN NEUROSCIENCES
- Growth differentiation factor 15 in a community-based sample: age-dependent reference limits and prognostic impact
- (2018) Steven Doerstling et al. UPSALA JOURNAL OF MEDICAL SCIENCES
- Vomiting in pregnancy is associated with a higher risk of low birth weight: a cohort study
- (2018) Clive J. Petry et al. BMC Pregnancy and Childbirth
- Cancer-associated cachexia
- (2018) Vickie E. Baracos et al. Nature Reviews Disease Primers
- Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum
- (2018) Marlena Fejzo et al. GEBURTSHILFE UND FRAUENHEILKUNDE
- GDF15 and Growth Control
- (2018) Paul J. Emmerson et al. Frontiers in Physiology
- Butyrylcholinesterase regulates central ghrelin signaling and has an impact on food intake and glucose homeostasis
- (2017) V P Chen et al. INTERNATIONAL JOURNAL OF OBESITY
- NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development
- (2017) Nivedita M. Ratnam et al. JOURNAL OF CLINICAL INVESTIGATION
- Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update
- (2017) Paul J. Hesketh et al. JOURNAL OF CLINICAL ONCOLOGY
- Growth Differentiation Factor–15 and Risk of CKD Progression
- (2017) Viji Nair et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- NCCN Guidelines Insights: Antiemesis, Version 2.2017
- (2017) Michael J. Berger et al. Journal of the National Comprehensive Cancer Network
- Oxaliplatin induces muscle loss and muscle-specific molecular changes in Mice
- (2017) Claire E. Feather et al. MUSCLE & NERVE
- Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
- (2017) Jer-Yuan Hsu et al. NATURE
- GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
- (2017) Linda Yang et al. NATURE MEDICINE
- GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
- (2017) Shannon E Mullican et al. NATURE MEDICINE
- The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
- (2017) Paul J Emmerson et al. NATURE MEDICINE
- Preventing chemotherapy-induced nausea and vomiting in patients with lung cancer: efficacy of NEPA (netupitant-palonosetron), the first combination antiemetic
- (2017) Paul J. Hesketh et al. SUPPORTIVE CARE IN CANCER
- Refining the role of pegfilgrastim (a long-acting G-CSF) for prevention of chemotherapy-induced febrile neutropenia: consensus guidance recommendations
- (2017) Matti Aapro et al. SUPPORTIVE CARE IN CANCER
- A novel preventive therapy for paclitaxel-induced cognitive deficits: preclinical evidence from C57BL/6 mice
- (2017) P Huehnchen et al. Translational Psychiatry
- BGP-15 Protects against Oxaliplatin-Induced Skeletal Myopathy and Mitochondrial Reactive Oxygen Species Production in Mice
- (2017) James C. Sorensen et al. Frontiers in Pharmacology
- Overall Survival Following Neoadjuvant Chemotherapy vs Primary Cytoreductive Surgery in Women With Epithelial Ovarian Cancer
- (2017) J. Alejandro Rauh-Hain et al. JAMA Oncology
- ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass
- (2017) Rafael Barreto et al. Scientific Reports
- Found in Translation: Maximizing the Clinical Relevance of Nonclinical Oncology Studies
- (2016) Mary E. Spilker et al. CLINICAL CANCER RESEARCH
- Excitatory Hindbrain–Forebrain Communication Is Required for Cisplatin-Induced Anorexia and Weight Loss
- (2016) Amber L. Alhadeff et al. JOURNAL OF NEUROSCIENCE
- 2016 updated MASCC/ESMO consensus recommendations: prevention of nausea and vomiting following multiple-day chemotherapy, high-dose chemotherapy, and breakthrough nausea and vomiting
- (2016) Lawrence H. Einhorn et al. SUPPORTIVE CARE IN CANCER
- ActRII blockade protects mice from cancer cachexia and prolongs survival in the presence of anti-cancer treatments
- (2016) Shinji Hatakeyama et al. Skeletal Muscle
- Risk Model–Guided Antiemetic Prophylaxis vs Physician’s Choice in Patients Receiving Chemotherapy for Early-Stage Breast Cancer
- (2016) Mark Clemons et al. JAMA Oncology
- Longitudinal Changes in Multiple Biomarkers Are Associated with Cardiotoxicity in Breast Cancer Patients Treated with Doxorubicin, Taxanes, and Trastuzumab
- (2015) M. Putt et al. CLINICAL CHEMISTRY
- Growth differentiation factor 15 in heart failure with preserved vs. reduced ejection fraction
- (2015) Michelle M.Y. Chan et al. EUROPEAN JOURNAL OF HEART FAILURE
- Alkylating Agent Melphalan Augments the Efficacy of Adoptive Immunotherapy Using Tumor-Specific CD4+T Cells
- (2015) Xiaoyun Lu et al. JOURNAL OF IMMUNOLOGY
- Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) Gene Deletion Promotes Cancer Growth in TRAMP Prostate Cancer Prone Mice
- (2015) Yasmin Husaini et al. PLoS One
- Growth Differentiation Factor 15 (GDF-15) Plasma Levels Increase during Bleomycin- and Cisplatin-Based Treatment of Testicular Cancer Patients and Relate to Endothelial Damage
- (2015) Renske Altena et al. PLoS One
- GDF15 promotes EMT and metastasis in colorectal cancer
- (2015) Chen Li et al. Oncotarget
- MAP3K11/GDF15 axis is a critical driver of cancer cachexia
- (2015) Lorena Lerner et al. Journal of Cachexia Sarcopenia and Muscle
- Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients
- (2015) Lorena Lerner et al. Journal of Cachexia Sarcopenia and Muscle
- Ghrelin prevents tumour- and cisplatin-induced muscle wasting: characterization of multiple mechanisms involved
- (2015) Ji-an Chen et al. Journal of Cachexia Sarcopenia and Muscle
- Association of Serum Level of Growth Differentiation Factor 15 with Liver Cirrhosis and Hepatocellular Carcinoma
- (2015) Xiuying Liu et al. PLoS One
- Squalene Selectively Protects Mouse Bone Marrow Progenitors Against Cisplatin and Carboplatin-Induced Cytotoxicity In Vivo Without Protecting Tumor Growth
- (2015) Bikul Das et al. NEOPLASIA
- Knockdown of platinum-induced growth differentiation factor 15 abrogates p27-mediated tumor growth delay in the chemoresistant ovarian cancer model A2780cis
- (2014) Julia C. Meier et al. Cancer Medicine
- Quantitative determination of platinum derived from cisplatin in human plasma ultrafiltrate using derivatization with diethyldithiocarbamate and liquid chromatography coupled with electrospray ionization tandem mass spectrometry
- (2013) Caiming Tang et al. Analytical Methods
- Platinum compounds in children with cancer
- (2013) Antonio Ruggiero et al. ANTI-CANCER DRUGS
- Growth-differentiation factor-15 and tissue doppler ımaging in detection of asymptomatic anthracycline cardiomyopathy in childhood cancer survivors
- (2013) Derya Arslan et al. CLINICAL BIOCHEMISTRY
- TNF-alpha and melphalan modulate a specific group of early expressed genes in a murine melanoma model
- (2013) Vladmir Cláudio Cordeiro de Lima et al. CYTOKINE
- Inhibition of Cisplatin-Induced Lipid Catabolism and Weight Loss by Ghrelin in Male Mice
- (2013) Jose M. Garcia et al. ENDOCRINOLOGY
- Determination of cisplatin in blood plasma by liquid chromatography with mass spectrometry detection
- (2013) D. V. Yaroshenko et al. JOURNAL OF ANALYTICAL CHEMISTRY
- Early Increases in Multiple Biomarkers Predict Subsequent Cardiotoxicity in Patients With Breast Cancer Treated With Doxorubicin, Taxanes, and Trastuzumab
- (2013) Bonnie Ky et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator
- (2013) Vicky Wang-Wei Tsai et al. PLoS One
- Prospective validation of risk prediction indexes for acute and delayed chemotherapy-induced nausea and vomiting
- (2012) N. Bouganim et al. Current Oncology
- Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) Slows Cancer Development but Increases Metastases in TRAMP Prostate Cancer Prone Mice
- (2012) Yasmin Husaini et al. PLoS One
- Development of doxorubicin-induced chronic cardiotoxicity in the B6C3F1 mouse model
- (2012) Varsha G. Desai et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- GDF-15: a novel serum marker for metastases in uveal melanoma patients
- (2011) Daniela Suesskind et al. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
- Definition and classification of cancer cachexia: an international consensus
- (2011) Kenneth Fearon et al. LANCET ONCOLOGY
- Effects of multiple doses of cyclophosphamide on mouse testes: Accessing the germ cells lost, and the functional damage of stem cells
- (2011) Ana Luiza Drumond et al. REPRODUCTIVE TOXICOLOGY
- GDF-15 Contributes to Proliferation and Immune Escape of Malignant Gliomas
- (2010) P. Roth et al. CLINICAL CANCER RESEARCH
- Evaluation of new antiemetic agents and definition of antineoplastic agent emetogenicity—state of the art
- (2010) Steven M. Grunberg et al. SUPPORTIVE CARE IN CANCER
- Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers
- (2009) E. Izbicka et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Effective Treatment of Advanced Human Melanoma Metastasis in Immunodeficient Mice Using Combination Metronomic Chemotherapy Regimens
- (2009) W. Cruz-Munoz et al. CLINICAL CANCER RESEARCH
- Expression of macrophage inhibitory cytokine-1 in prostate cancer bone metastases induces osteoclast activation and weight loss
- (2009) Savita Wakchoure et al. PROSTATE
- Skeletal Muscle Diseases, Inflammation, and NF-κB Signaling: Insights and Opportunities for Therapeutic Intervention
- (2008) Jennifer M. Peterson et al. INTERNATIONAL REVIEWS OF IMMUNOLOGY
- Oxaliplatin doublets in non-small cell lung cancer: A literature review
- (2008) Diego Cortinovis et al. LUNG CANCER
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