Transcriptional Regulation of Hepatic Autophagy by Nuclear Receptors

The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer

(2021) Lulu Sun et al.   Nature Reviews Gastroenterology & Hepatology

Prenatal dexamethasone exposure caused fetal rats liver dysplasia by inhibiting autophagy-mediated cell proliferation

(2021) Dingmei Zhang et al.   TOXICOLOGY

Prevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation

(2021) Shouyan Wu et al.   Cell Death & Disease

FXR in liver physiology: Multiple faces to regulate liver metabolism

(2021) Katrin Panzitt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Autophagy in major human diseases

(2021) Daniel J Klionsky et al.   EMBO JOURNAL

The protection of selenium against cadmium-induced mitophagy via modulating nuclear xenobiotic receptors response and oxidative stress in the liver of rabbits

(2021) Linwei Zhang et al.   ENVIRONMENTAL POLLUTION

Farnesoid X Receptor as Target for Therapies to Treat Cholestasis-Induced Liver Injury

(2021) Anca D. Petrescu et al.   Cells

Bile Acid Receptors and the Gut–Liver Axis in Nonalcoholic Fatty Liver Disease

(2021) Rui Xue et al.   Cells

The Nuclear Receptor PXR in Chronic Liver Disease

(2021) Katia Sayaf et al.   Cells

FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis

(2020) Katrin Panzitt et al.   JOURNAL OF HEPATOLOGY

Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

(2020) Sangwon Byun et al.   Nature Communications

Estrogen and estrogen receptors chauffeur the sex-biased autophagic action in liver

(2020) Sipra Mohapatra et al.   CELL DEATH AND DIFFERENTIATION

Transcriptional Control of Circadian Rhythms and Metabolism: A Matter of Time and Space

(2020) Yong Hoon Kim et al.   ENDOCRINE REVIEWS

Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk

(2020) Rohit A. Sinha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LXRα activation inhibits autophagy and lipophagy in hepatocytes by dysregulating ATG4B and Rab‐8B, reducing mitochondrial fuel oxidation

(2020) Yun Seok Kim et al.   HEPATOLOGY

The small heterodimer partner inhibits activation of hepatic stellate cells via autophagy

(2020) Wei Ma et al.   Advances in Clinical and Experimental Medicine

Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease

(2020) Anne Fougerat et al.   Cells

Mir214-3p and Hnf4a/Hnf4α reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis

(2020) Da-Hye Lee et al.   Autophagy

Nuclear Receptors as Autophagy-Based Antimicrobial Therapeutics

(2020) Prashanta Silwal et al.   Cells

Calcitriol alleviates ethanol-induced hepatotoxicity via AMPK/mTOR-mediated autophagy

(2020) Fang Yuan et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Regulation of autophagy by bile acids and in cholestasis - CholestoPHAGY or CholeSTOPagy

(2020) Katrin Panzitt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Taurine protected As2O3-induced the activation of hepatic stellate cells through inhibiting PPARα-autophagy pathway

(2019) Zhidong Wang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Relevance of Autophagy in Parenchymal and Non-Parenchymal Liver Cells for Health and Disease

(2019) Ralf Weiskirchen et al.   Cells

Autophagy: Dual Response in the Development of Hepatocellular Carcinoma

(2019) Hamza Yazdani et al.   Cells

PPARδ attenuates hepatic steatosis through autophagy-mediated fatty acid oxidation

(2019) Lei Tong et al.   Cell Death & Disease

ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and Disease

(2019) Hui Xia et al.   Frontiers in Endocrinology

The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα

(2019) Anton Iershov et al.   Nature Communications

Autophagy regulates lipid metabolism through selective turnover of NCoR1

(2019) Tetsuya Saito et al.   Nature Communications

Transcriptional Regulation of Autophagy: Mechanisms and Diseases

(2019) Chiara Di Malta et al.   Frontiers in Cell and Developmental Biology

Ligand-dependent transcriptional induction of lethal autophagy: A new perspective for cancer treatment

(2018) Sandrine Silvente-Poirot et al.   Autophagy

FGF21 mediates the protective effect of fenofibrate against acetaminophen -induced hepatotoxicity via activating autophagy in mice

(2018) Yi Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Farnesoid X receptor: A “homeostat” for hepatic nutrient metabolism

(2018) Vittoria Massafra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1

(2018) Miriam Toledo et al.   Cell Metabolism

Zinc reduces hepatic lipid deposition and activates lipophagy via Zn2+/MTF-1/PPARα and Ca2+/CaMKKβ/AMPK pathways

(2018) Chuan-Chuan Wei et al.   FASEB JOURNAL

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

(2018) Brijesh K. Singh et al.   Science Signaling

Inhibitory effect of PXR on ammonia-induced hepatocyte autophagy via P53

(2018) Linlin Yan et al.   TOXICOLOGY LETTERS

Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

(2018) Brijesh K. Singh et al.   Science Signaling

Autophagy in Metabolic Age-Related Human Diseases

(2018) Manon Moulis et al.   Cells

Autophagy: An Essential Degradation Program for Cellular Homeostasis and Life

(2018) Yoomi Chun et al.   Cells

Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice

(2017) Kang Ho Kim et al.   HEPATOLOGY

MiR-19a Affects Hepatocyte Autophagy via Regulating lncRNA NBR2 and AMPK/PPARα in D-GalN/Lipopolysaccharide-Stimulated Hepatocytes

(2017) Yan-Min Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance

(2017) Geoffrey A. Preidis et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetic Control of Autophagy: Nuclear Events Gain More Attention

(2017) Sung Hee Baek et al.   MOLECULAR CELL

1,25(OH)2 D3 attenuates hepatic steatosis by inducing autophagy in mice

(2017) Renlong Li et al.   Obesity

ERRγ: a Junior Orphan with a Senior Role in Metabolism

(2017) Jagannath Misra et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pioglitazone Enhances Cytosolic Lipolysis, β-oxidation and Autophagy to Ameliorate Hepatic Steatosis

(2017) Pi-Jung Hsiao et al.   Scientific Reports

The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbα and indirectly via Cebpb/(C/ebpβ) in zebrafish

(2016) Guodong Huang et al.   Autophagy

Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy

(2016) Hsiang-Cheng Chi et al.   Autophagy

Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response

(2016) Ido Goldstein et al.   GENOME RESEARCH

Transcriptional regulation of mammalian autophagy at a glance

(2016) Jens Füllgrabe et al.   JOURNAL OF CELL SCIENCE

Inhibition of glycogen synthase kinase 3β promotes autophagy to protect mice from acute liver failure mediated by peroxisome proliferator-activated receptor α

(2016) F Ren et al.   Cell Death & Disease

Taurine protects against As2O3-induced autophagy in livers of rat offsprings through PPARγ pathway

(2016) Jie Bai et al.   Scientific Reports

Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling

(2015) Rohit A Sinha et al.   Autophagy

Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity

(2015) Michaela Mueller et al.   JOURNAL OF HEPATOLOGY

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

(2015) Keisuke Mochida et al.   NATURE

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Discrete functions of nuclear receptor Rev-erb  couple metabolism to the clock

(2015) Y. Zhang et al.   SCIENCE

Binding Rubicon to cross the Rubicon

(2014) Kohichi Matsunaga et al.   Autophagy

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

Impaired Restoration of Plasmacytoid Dendritic Cells in HIV-1-Infected Patients with Poor CD4 T Cell Reconstitution Is Associated with Decrease in Capacity to Produce IFN-  but Not Proinflammatory Cytokines

(2014) N. Sachdeva et al.   JOURNAL OF IMMUNOLOGY

Cell metabolism: Autophagy transcribed

(2014) Carmine Settembre et al.   NATURE

Transcriptional regulation of autophagy by an FXR–CREB axis

(2014) Sunmi Seok et al.   NATURE

Nutrient-sensing nuclear receptors coordinate autophagy

(2014) Jae Man Lee et al.   NATURE

FXR is a molecular target for the effects of vertical sleeve gastrectomy

(2014) Karen K. Ryan et al.   NATURE

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bile acids are nutrient signaling hormones

(2014) Huiping Zhou et al.   STEROIDS

Peroxisome proliferator-activated receptor α activation attenuates the inflammatory response to protect the liver from acute failure by promoting the autophagy pathway

(2014) M Jiao et al.   Cell Death & Disease

Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity

(2014) Sharon Manley et al.   Redox Biology

Chromosome 19 open reading frame 80 is upregulated by thyroid hormone and modulates autophagy and lipid metabolism

(2013) Yi-Hsin Tseng et al.   Autophagy

SnapShot: Selective Autophagy

(2013) Meiyan Jin et al.   CELL

A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

(2013) Ning Ding et al.   CELL

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Distinct Properties of Cell-Type-Specific and Shared Transcription Factor Binding Sites

(2013) Jason Gertz et al.   MOLECULAR CELL

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The return of the nucleus: transcriptional and epigenetic control of autophagy

(2013) Jens Füllgrabe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hepatocyte Nuclear Factor 4 Alpha and Farnesoid X Receptor Co-regulates Gene Transcription in Mouse Livers on a Genome-Wide Scale

(2013) Ann M. Thomas et al.   PHARMACEUTICAL RESEARCH

Suppression of Autophagic Flux by Bile Acids in Hepatocytes

(2013) Sharon Manley et al.   TOXICOLOGICAL SCIENCES

Involvement of PPARγ in the antitumoral action of cannabinoids on hepatocellular carcinoma

(2013) D Vara et al.   Cell Death & Disease

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

(2013) Fei Li et al.   Nature Communications

Foxa1 and Foxa2 Are Essential for Sexual Dimorphism in Liver Cancer

(2012) Zhaoyu Li et al.   CELL

Regulation of lipid stores and metabolism by lipophagy

(2012) K Liu et al.   CELL DEATH AND DIFFERENTIATION

HNF4α Antagonists Discovered by a High-Throughput Screen for Modulators of the Human Insulin Promoter

(2012) Alice Kiselyuk et al.   CHEMISTRY & BIOLOGY

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice

(2012) Yuan Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy

(2012) Rohit Anthony Sinha et al.   JOURNAL OF CLINICAL INVESTIGATION

Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes

(2012) Mark B. Meyer et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Tissue Specific Induction of p62/Sqstm1 by Farnesoid X Receptor

(2012) Jessica A. Williams et al.   PLoS One

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

TFEB regulates autophagy: An integrated coordination of cellular degradation and recycling processes

(2011) Carmine Settembre et al.   Autophagy

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor

(2011) Milan Surjit et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nuclear receptors in liver disease

(2011) Martin Wagner et al.   HEPATOLOGY

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

(2011) Eugenia Morselli et al.   JOURNAL OF CELL BIOLOGY

Genome-Wide Profiling of Liver X Receptor, Retinoid X Receptor, and Peroxisome Proliferator-Activated Receptor   in Mouse Liver Reveals Extensive Sharing of Binding Sites

(2011) M. Boergesen et al.   MOLECULAR AND CELLULAR BIOLOGY

A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism

(2011) D. Feng et al.   SCIENCE

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

(2011) S. Kir et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Hepatic Hepatocyte Nuclear Factor 4α Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis

(2010) Liya Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of nuclear receptor SHP in metabolism and cancer

(2010) Yuxia Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats

(2010) Toshiaki Nakano et al.   JOURNAL OF HEPATOLOGY

ChIPing the cistrome of PXR in mouse liver

(2010) Julia Yue Cui et al.   NUCLEIC ACIDS RESEARCH

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Fibroblast growth factor 21: from pharmacology to physiology

(2009) Steven A Kliewer et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

FGF21 induces PGC-1  and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

(2009) M. J. Potthoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Hepatic regulation of fatty acid synthase by insulin and T3: evidence for T3 genomic and nongenomic actions

(2008) Anne Radenne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription

(2008) Mathieu Lupien et al.   CELL

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

FXR: a metabolic regulator and cell protector

(2008) Yan-Dong Wang et al.   CELL RESEARCH

The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism

(2008) Hélène Duez et al.   Diabetes & Vascular Disease Research

Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors

(2008) Vincent Giguère   ENDOCRINE REVIEWS

Thyroid hormone (T3) and TRβ agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats

(2008) Andrea Perra et al.   FASEB JOURNAL

Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist

(2008) Edward E. Cable et al.   HEPATOLOGY

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Genome-Wide Identification of Estrogen Receptor α-Binding Sites in Mouse Liver

(2007) Hui Gao et al.   MOLECULAR ENDOCRINOLOGY