Autophagy in Metabolic Age-Related Human Diseases

TFEB-dependent Induction of Thermogenesis by the Hepatocyte SLC2A Inhibitor Trehalose

(2018) Yiming Zhang et al.   Autophagy

Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis

(2018) Yusuke Osonoi et al.   Autophagy

ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1α deacetylation

(2018) Shuyi Wang et al.   INTERNATIONAL JOURNAL OF OBESITY

Nutrient excess and autophagic deficiency: explaining metabolic diseases in obesity

(2018) Gustav van Niekerk et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Targeting autophagy in obesity: from pathophysiology to management

(2018) Yingmei Zhang et al.   Nature Reviews Endocrinology

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes

(2018) Hyejin Lim et al.   Nature Communications

Upstream stimulating factor 1 suppresses autophagy and hepatic lipid droplet catabolism by activating mTOR

(2018) Jun Guo et al.   FEBS LETTERS

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation inSaccharomyces cerevisiae

(2017) Wenjie Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in the liver: functions in health and disease

(2017) Takashi Ueno et al.   Nature Reviews Gastroenterology & Hepatology

Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival

(2017) Heather L. Hayes et al.   PLoS One

Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow

(2017) Anne-Clemence Vion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

(2017) Manuel Blandino-Rosano et al.   Nature Communications

Inhibition of Miro1 disturbs mitophagy and pancreatic β-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes

(2017) Lingling Chen et al.   Oncotarget

Diet-induced obesity impairs spermatogenesis: a potential role for autophagy

(2017) Yang Mu et al.   Scientific Reports

The endoplasmic reticulum stress/autophagy pathway is involved in cholesterol-induced pancreatic β-cell injury

(2017) Fei-Juan Kong et al.   Scientific Reports

Autophagy protects pancreatic beta cell mass and function in the setting of a high-fat and high-glucose diet

(2017) Qingfeng Sheng et al.   Scientific Reports

Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis

(2016) Hae-Youn Lee et al.   Autophagy

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

(2016) Marta Pajares et al.   Autophagy

Dipeptidyl peptidase-4 inhibitor MK-626 restores insulin secretion through enhancing autophagy in high fat diet-induced mice

(2016) Limei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy is a major regulator of beta cell insulin homeostasis

(2016) Yael Riahi et al.   DIABETOLOGIA

Laminar Shear Stress Promotes Vascular Endothelial Cell Autophagy Through Upregulation with Rab4

(2016) Pingbo Yao et al.   DNA AND CELL BIOLOGY

Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis

(2016) Da Hyun Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice

(2016) Satoshi Tanaka et al.   HEPATOLOGY

The Unrelenting Challenge of Obesity

(2016) Jody W. Zylke et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity

(2016) Kyle M. Trudeau et al.   JOURNAL OF CELL BIOLOGY

Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy

(2016) Yu-Cheng Lin et al.   JOURNAL OF HEPATOLOGY

Vitamin D induces autophagy of pancreatic β-cells and enhances insulin secretion

(2016) Yubin Wang et al.   Molecular Medicine Reports

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

(2016) Hi-Jai R. Shin et al.   NATURE

Transcriptional Dysregulation of Adipose Tissue Autophagy in Obesity

(2016) Nitzan Maixner et al.   PHYSIOLOGY

Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis

(2016) Ismail Sergin et al.   Science Signaling

Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids

(2016) Audrey Swiader et al.   Oncotarget

Effect of Exendin-4 on Autophagy Clearance in Beta Cell of Rats with Tacrolimus-induced Diabetes Mellitus

(2016) Sun Woo Lim et al.   Scientific Reports

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology

(2016) Rehana Akter et al.   Journal of Diabetes Research

Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis

(2016) Ismail Sergin et al.   Science Signaling

Defective autophagy in vascular smooth muscle cells alters contractility and Ca2+ homeostasis in mice

(2015) Cédéric F. Michiels et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis

(2015) Mandy OJ Grootaert et al.   Autophagy

Autophagy: an emerging therapeutic target in vascular diseases

(2015) Cécile Vindis   BRITISH JOURNAL OF PHARMACOLOGY

Autophagy in Vascular Disease

(2015) G. R. Y. De Meyer et al.   CIRCULATION RESEARCH

High-fat diet increases autophagic flux in pancreatic beta cells in vivo and ex vivo in mice

(2015) Kwan Yi Chu et al.   DIABETOLOGIA

The small GTPase Rab7 as a central regulator of hepatocellular lipophagy

(2015) Barbara Schroeder et al.   HEPATOLOGY

Autophagy: a druggable process that is deregulated in aging and human disease

(2015) Guido Kroemer   JOURNAL OF CLINICAL INVESTIGATION

Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway

(2015) Xiaodi Fan et al.   Journal of Translational Medicine

Autophagy in adipose tissue of patients with obesity and type 2 diabetes

(2015) J. Kosacka et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Minireview: Autophagy in Pancreatic β-Cells and Its Implication in Diabetes

(2015) Hirotaka Watada et al.   MOLECULAR ENDOCRINOLOGY

Liraglutide protects pancreatic β-cells against free fatty acids in vitro and affects glucolipid metabolism in apolipoprotein E−/− mice by activating autophagy

(2015) JIA WANG et al.   Molecular Medicine Reports

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

Insulin secretory granules control autophagy in pancreatic   cells

(2015) A. Goginashvili et al.   SCIENCE

Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression

(2015) J Liu et al.   Cell Death & Disease

High intensity interval training improves liver and adipose tissue insulin sensitivity

(2015) Katarina Marcinko et al.   Molecular Metabolism

Autophagy Regulates Vascular Endothelial Cell eNOS and ET-1 Expression Induced by Laminar Shear Stress in an Ex Vivo Perfused System

(2014) Fengxia Guo et al.   ANNALS OF BIOMEDICAL ENGINEERING

Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway

(2014) Young Mi Song et al.   Autophagy

Deficient Chaperone-Mediated Autophagy in Liver Leads to Metabolic Dysregulation

(2014) Jaime L. Schneider et al.   Cell Metabolism

Pancreatic  -Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment

(2014) A. Bartolome et al.   DIABETES

Exogenous administration of spermine improves glucose utilization and decreases bodyweight in mice

(2014) Satish Kumar Sadasivan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of Autophagic Turnover in β-Cells by Fatty Acids and Glucose Leads to Apoptotic Cell Death

(2014) Shakeel U. R. Mir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes

(2014) Jinyoung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy

(2014) Nayumi Shigihara et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity

(2014) Jacqueline F. Rivera et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy—a key player in cellular and body metabolism

(2014) Kook Hwan Kim et al.   Nature Reviews Endocrinology

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

(2014) Á González-Rodríguez et al.   Cell Death & Disease

Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes

(2014) Yu-Mi Lim et al.   Nature Communications

Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers

(2014) Hwan-Woo Park et al.   Nature Communications

PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress

(2013) Joshua K. Salabei et al.   BIOCHEMICAL JOURNAL

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Nrf2 Protects Pancreatic  -Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice

(2013) Y. Yagishita et al.   DIABETES

Regulation of autophagy and apoptosis in response to ox-LDL in vascular smooth muscle cells, and the modulatory effects of the microRNA hsa-let-7g

(2013) Zufeng Ding et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Defective regulation of adipose tissue autophagy in obesity

(2013) C E Nuñez et al.   INTERNATIONAL JOURNAL OF OBESITY

Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release

(2013) Xiao-Yan Dai et al.   KIDNEY INTERNATIONAL

The PARK2 gene is involved in the maintenance of pancreatic β-cell functions related to insulin production and secretion

(2013) Hyun-Seok Jin et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor

(2013) Takehiro Torisu et al.   NATURE MEDICINE

Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet

(2013) O V Leontieva et al.   Cell Death & Disease

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

Berberine: New perspectives for old remedies

(2012) Micol Tillhon et al.   BIOCHEMICAL PHARMACOLOGY

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Autophagy Links Inflammasomes to Atherosclerotic Progression

(2012) Babak Razani et al.   Cell Metabolism

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

(2012) Xianghai Liao et al.   Cell Metabolism

Role of Hypothalamic Proopiomelanocortin Neuron Autophagy in the Control of Appetite and Leptin Response

(2012) Wenying Quan et al.   ENDOCRINOLOGY

Autophagy Activity Is Up-Regulated in Adipose Tissue of Obese Individuals and Modulates Proinflammatory Cytokine Expression

(2012) H. J. Jansen et al.   ENDOCRINOLOGY

Induction of Autophagy by Palmitic Acid via Protein Kinase C-mediated Signaling Pathway Independent of mTOR (Mammalian Target of Rapamycin)

(2012) Shi Hao Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calorie Restriction Enhances Insulin-Stimulated Glucose Uptake and Akt Phosphorylation in Both Fast-Twitch and Slow-Twitch Skeletal Muscle of 24-Month-Old Rats

(2012) D. A. Sequea et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy in Adipose Tissue

(2012) Nitzan Maixner et al.   Obesity Facts

Palmitate Activates Autophagy in INS-1E β-Cells and in Isolated Rat and Human Pancreatic Islets

(2012) Luisa Martino et al.   PLoS One

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Role of autophagy in angiogenesis in aortic endothelial cells

(2011) Jianhai Du et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Regulation of Lipid Droplet Cholesterol Efflux From Macrophage Foam Cells

(2011) Mireille Ouimet et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidized LDLs trigger endoplasmic reticulum stress and autophagy: Prevention by HDLs

(2011) Carole Muller et al.   Autophagy

TFEB regulates autophagy: An integrated coordination of cellular degradation and recycling processes

(2011) Carmine Settembre et al.   Autophagy

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

(2011) Mireille Ouimet et al.   Cell Metabolism

Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice

(2011) W. Quan et al.   DIABETOLOGIA

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway

(2010) Koji Komiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HDLs inhibit endoplasmic reticulum stress and autophagic response induced by oxidized LDLs

(2010) C Muller et al.   CELL DEATH AND DIFFERENTIATION

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

(2010) Nirmala Hariharan et al.   CIRCULATION RESEARCH

Altered lipid content inhibits autophagic vesicular fusion

(2010) Hiroshi Koga et al.   FASEB JOURNAL

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy plays a protective role in free cholesterol overload-induced death of smooth muscle cells

(2010) Kedi Xu et al.   JOURNAL OF LIPID RESEARCH

Unknown

(2010) Anita Ost et al.   MOLECULAR MEDICINE

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia

(2009) Hui-Yu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism