Peroxisome proliferator-activated receptor α activation attenuates the inflammatory response to protect the liver from acute failure by promoting the autophagy pathway

Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy

(2014) You-Tong Wu et al.   Autophagy

Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol mediated liver fibrosis in mice

(2013) Yue-Min Nan et al.   Lipids in Health and Disease

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

MicroRNA-141 Represses HBV Replication by Targeting PPARA

(2012) Wei Hu et al.   PLoS One

Inhibition of Glycogen Synthase Kinase 3β Ameliorates D-GalN/LPS-Induced Liver Injury by Reducing Endoplasmic Reticulum Stress-Triggered Apoptosis

(2012) Liyan Chen et al.   PLoS One

Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism

(2011) Feng Ren et al.   HEPATOLOGY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Reduced Peroxisome Proliferator-Activated Receptor α Expression Is Associated With Decreased Survival and Increased Tissue Bacterial Load in Sepsis

(2011) Stephen W. Standage et al.   SHOCK

Lack of PPARα exacerbates lipopolysaccharide-induced liver toxicity through STAT1 inflammatory signaling and increased oxidative/nitrosative stress

(2011) Seong Ho Yoo et al.   TOXICOLOGY LETTERS

Autophagy Shapes Inflammation

(2010) László Fésüs et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

PPARγ activation induces autophagy in breast cancer cells

(2009) Jie Zhou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Toll-like receptors control autophagy

(2008) Mónica A Delgado et al.   EMBO JOURNAL

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE