FXR in liver physiology: Multiple faces to regulate liver metabolism

FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis

(2020) Katrin Panzitt et al.   JOURNAL OF HEPATOLOGY

SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis

(2020) Jiyu Zhou et al.   Nature Communications

Promotion of lipogenesis by PPARγ-activated FXR expression in adipocytes

(2020) Saki Shinohara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FXR Isoforms Control Different Metabolic Functions in Liver Cells via Binding to Specific DNA Motifs

(2020) Jose Miguel Ramos Pittol et al.   GASTROENTEROLOGY

Molecular Physiology of Bile Acid Signaling in Health, Disease and Aging

(2020) Alessia Perino et al.   PHYSIOLOGICAL REVIEWS

Regulation of autophagy by bile acids and in cholestasis - CholestoPHAGY or CholeSTOPagy

(2020) Katrin Panzitt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The farnesoid X receptor agonist EDP-305 reduces interstitial renal fibrosis in a mouse model of unilateral ureteral obstruction

(2019) Shen Li et al.   FASEB JOURNAL

Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling-activated Src maintains cholesterol levels and protects from atherosclerosis

(2019) Sangwon Byun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Src-mediated crosstalk between FXR and YAP protects against renal fibrosis

(2019) Dong-Hyun Kim et al.   FASEB JOURNAL

Obeticholic acid may increase the risk of gallstone formation in susceptible patients

(2019) Samer Al-Dury et al.   JOURNAL OF HEPATOLOGY

Farnesoid X Receptor alters adipose tissue architecture in mice and limits storage capacity leading to metabolic derangements

(2019) Tim van Zutphen et al.   JOURNAL OF LIPID RESEARCH

Drug Therapies for Chronic Cholestatic Liver Diseases

(2019) Martin Wagner et al.   Annual Review of Pharmacology and Toxicology

A Human-like Bile Acid Pool Induced by Deletion of Cyp2c70 Modulates Effects of Farnesoid X Receptor Activation in Mice

(2019) Jan Freark de Boer et al.   JOURNAL OF LIPID RESEARCH

Steroidogenic control of liver metabolism through a nuclear receptor-network

(2019) Alexandra Milona et al.   Molecular Metabolism

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

(2019) Zobair M Younossi et al.   LANCET

Bile acid receptors and the kidney

(2018) Michal Herman-Edelstein et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Colesevelam attenuates cholestatic liver and bile duct injury inMdr2−/−mice by modulating composition, signalling and excretion of faecal bile acids

(2018) Claudia Daniela Fuchs et al.   GUT

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

(2018) Preeti Pathak et al.   HEPATOLOGY

The Nuclear Bile Acid Receptor FXR is a PKA- and FOXA2-Sensitive Activator of Fasting Hepatic Gluconeogenesis

(2018) Maheul Ploton et al.   JOURNAL OF HEPATOLOGY

Asynchronous rhythms of circulating conjugated and unconjugated bile acids in the modulation of human metabolism

(2018) Amani Al-Khaifi et al.   JOURNAL OF INTERNAL MEDICINE

FXR activation by obeticholic acid or nonsteroidal agonists induces a human-like lipoprotein cholesterol change in mice with humanized chimeric liver

(2018) Romeo Papazyan et al.   JOURNAL OF LIPID RESEARCH

Farnesoid X receptor antagonist exacerbates dyslipidemia in mice

(2018) Yuichiro Amano et al.   Pharmacological Reports

Progress and challenges of selective Farnesoid X Receptor modulation

(2018) Vittoria Massafra et al.   PHARMACOLOGY & THERAPEUTICS

Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis

(2018) Sangwon Byun et al.   Nature Communications

Fibroblast Growth Factor 15/19 – From Basic Functions to Therapeutic Perspectives

(2018) Emmanuel Somm et al.   ENDOCRINE REVIEWS

Sex differences in lipid metabolism are affected by presence of the gut microbiota

(2018) Annemarie Baars et al.   Scientific Reports

Small Heterodimer Partner and Fibroblast Growth Factor 19 Inhibit Expression of NPC1L1 in Mouse Intestine and Cholesterol Absorption

(2018) Young-Chae Kim et al.   GASTROENTEROLOGY

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

(2018) Lulu Sun et al.   NATURE MEDICINE

Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice

(2017) Jan Freark de Boer et al.   GASTROENTEROLOGY

Farnesoid X Receptor Activation Promotes Hepatic Amino Acid Catabolism and Ammonium Clearance in Mice

(2017) Vittoria Massafra et al.   GASTROENTEROLOGY

Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice

(2017) Kang Ho Kim et al.   HEPATOLOGY

Small heterodimer partner deletion prevents hepatic steatosis and when combined with farnesoid X receptor loss protects against type 2 diabetes in mice

(2017) Oludemilade Akinrotimi et al.   HEPATOLOGY

Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism

(2017) Preeti Pathak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism

(2017) Elizabeth J. Tarling et al.   JOURNAL OF CLINICAL INVESTIGATION

Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance

(2017) Geoffrey A. Preidis et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct but complementary contributions of PPAR isotypes to energy homeostasis

(2017) Vanessa Dubois et al.   JOURNAL OF CLINICAL INVESTIGATION

Biliary bile acids in hepatobiliary injury – What is the link?

(2017) Peter Fickert et al.   JOURNAL OF HEPATOLOGY

Treatment with the natural FXR agonist chenodeoxycholic acid reduces clearance of plasma LDL whilst decreasing circulating PCSK9, lipoprotein(a) and apolipoprotein C-III

(2017) M. Ghosh Laskar et al.   JOURNAL OF INTERNAL MEDICINE

Bile acids and bariatric surgery

(2017) Vance L. Albaugh et al.   MOLECULAR ASPECTS OF MEDICINE

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

(2017) Bérengère Benoit et al.   NATURE MEDICINE

Targeting nuclear receptors for the treatment of fatty liver disease

(2017) Naoki Tanaka et al.   PHARMACOLOGY & THERAPEUTICS

A CK2–RNF4 interplay coordinates non-canonical SUMOylation and degradation of nuclear receptor FXR

(2017) Stéphanie Bilodeau et al.   Journal of Molecular Cell Biology

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

(2016) Nicole M. Kettner et al.   CANCER CELL

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

An Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice

(2016) Cen Xie et al.   DIABETES

Effects of obeticholic acid on lipoprotein metabolism in healthy volunteers

(2016) R. Pencek et al.   DIABETES OBESITY & METABOLISM

An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease

(2016) Frank J. Gonzalez et al.   GASTROENTEROLOGY

Microbiota-induced obesity requires farnesoid X receptor

(2016) Ava Parséus et al.   GUT

Mechanistic target of rapamycin complex 1 is an essential mediator of metabolic and mitogenic effects of fibroblast growth factor 19 in hepatoma cells

(2016) Zhi Yi Wan et al.   HEPATOLOGY

Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice

(2016) Yang Xu et al.   HEPATOLOGY

Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid

(2016) Noortje Ijssennagger et al.   JOURNAL OF HEPATOLOGY

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans

(2016) Shogo Takahashi et al.   JOURNAL OF LIPID RESEARCH

FXR Primes the Liver for Intestinal FGF15 Signaling by Transient Induction of β-Klotho

(2016) Ting Fu et al.   MOLECULAR ENDOCRINOLOGY

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

(2016) Frederik Nevens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nuclear Receptor Modulation for the Treatment of Nonalcoholic Fatty Liver Disease

(2016) Claudia Fuchs et al.   SEMINARS IN LIVER DISEASE

Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis

(2016) Natalia Gomez-Ospina et al.   Nature Communications

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

(2016) Len Verbeke et al.   Scientific Reports

MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism

(2015) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23

(2015) Chiara Degirolamo et al.   NATURE REVIEWS DRUG DISCOVERY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

(2015) Bryn M. Owen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

(2015) Changtao Jiang et al.   Nature Communications

Association of FXR gene variants with cholelithiasis

(2015) Satoko Hirobe-Jahn et al.   Clinics and Research in Hepatology and Gastroenterology

The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression

(2015) Ingrid T. G. W. Bijsmans et al.   Scientific Reports

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

(2015) Jorge C. Correia et al.   Molecular Metabolism

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

Nuclear bile acid signaling through the farnesoid X receptor

(2014) Claire Mazuy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

(2014) D.-H. Kim et al.   EMBO JOURNAL

The critical role of myeloid-derived suppressor cells and FXR activation in immune-mediated liver injury

(2014) Haiyan Zhang et al.   JOURNAL OF AUTOIMMUNITY

Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk

(2014) Fleur Lien et al.   JOURNAL OF CLINICAL INVESTIGATION

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal

(2014) Johannes Schmitt et al.   LIVER INTERNATIONAL

Transcriptional regulation of autophagy by an FXR–CREB axis

(2014) Sunmi Seok et al.   NATURE

Nutrient-sensing nuclear receptors coordinate autophagy

(2014) Jae Man Lee et al.   NATURE

FXR is a molecular target for the effects of vertical sleeve gastrectomy

(2014) Karen K. Ryan et al.   NATURE

FXR: the key to benefits in bariatric surgery?

(2014) Folkert Kuipers et al.   NATURE MEDICINE

Farnesoid X receptor (FXR) gene deficiency impairs urine concentration in mice

(2014) Xiaoyan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose-lowering effects of intestinal bile acid sequestration through enhancement of splanchnic glucose utilization

(2014) Janne Prawitt et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition

(2013) Javier Vaquero et al.   BIOCHEMICAL PHARMACOLOGY

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?

(2013) Marine Baptissart et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Glucose sensing O-GlcNAcylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR)

(2013) Wahiba Berrabah et al.   HEPATOLOGY

Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis

(2013) Jiesi Xu et al.   HEPATOLOGY

Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats

(2013) Len Verbeke et al.   HEPATOLOGY

SUMOylation of the Farnesoid X Receptor (FXR) Regulates the Expression of FXR Target Genes

(2013) Natarajan Balasubramaniyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TGR5 receptor mediates bile acid–induced itch and analgesia

(2013) Farzad Alemi et al.   JOURNAL OF CLINICAL INVESTIGATION

Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice

(2013) Thomas Gautier et al.   JOURNAL OF LIPID RESEARCH

Farnesoid X Receptor Inhibits the Transcriptional Activity of Carbohydrate Response Element Binding Protein in Human Hepatocytes

(2013) S. Caron et al.   MOLECULAR AND CELLULAR BIOLOGY

Bile acids and gut peptide secretion after bariatric surgery: A 1-year prospective randomized pilot trial

(2013) Robert E. Steinert et al.   Obesity

Hepatocyte Nuclear Factor 4 Alpha and Farnesoid X Receptor Co-regulates Gene Transcription in Mouse Livers on a Genome-Wide Scale

(2013) Ann M. Thomas et al.   PHARMACEUTICAL RESEARCH

Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes

(2012) Natarajan Balasubramaniyan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice

(2012) Matthew J. Potthoff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR

(2012) Hansook Chong et al.   BMC GENOMICS

General Molecular Biology and Architecture of Nuclear Receptors

(2012) Michal Pawlak et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis

(2012) Luciano Adorini et al.   DRUG DISCOVERY TODAY

Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition

(2012) Barbara Renga et al.   FASEB JOURNAL

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

(2012) M. J. Potthoff et al.   GENES & DEVELOPMENT

Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice

(2012) Jiyoung Lee et al.   HEPATOLOGY

Loss of FXR Protects against Diet-Induced Obesity and Accelerates Liver Carcinogenesis inob/obMice

(2012) Yanqiao Zhang et al.   MOLECULAR ENDOCRINOLOGY

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

(2012) Anna C. Calkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure

(2012) Mitsuhiro Watanabe et al.   PLoS One

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

(2012) Taoufiq Harach et al.   Scientific Reports

Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine

(2011) Raffaella M. Gadaleta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

(2011) Matthew J. Potthoff et al.   Cell Metabolism

Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity

(2011) J. Prawitt et al.   DIABETES

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure

(2011) Mitsuhiro Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma Bile Acids Are Associated with Energy Expenditure and Thyroid Function in Humans

(2011) Johann Ockenga et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Farnesoid X receptor represses hepatic human APOA gene expression

(2011) Indumathi Chennamsetty et al.   JOURNAL OF CLINICAL INVESTIGATION

Studies in mice, hamsters, and rats demonstrate that repression of hepatic apoA-I expression by taurocholic acid in mice is not mediated by the farnesoid-X-receptor

(2011) Christophe Gardès et al.   JOURNAL OF LIPID RESEARCH

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

(2011) S. Kir et al.   SCIENCE

Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications

(2010) Jongsook Kim Kemper   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease

(2010) Zhao-Xia Yang et al.   Hepatology International

Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis

(2010) Sayeepriyadarshini Anakk et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

O-GlcNAc signaling: a metabolic link between diabetes and cancer?

(2010) C. Slawson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Farnesoid X Receptor Critically Determines the Fibrotic Response in Mice but Is Expressed to a Low Extent in Human Hepatic Stellate Cells and Periductal Myofibroblasts

(2009) Peter Fickert et al.   AMERICAN JOURNAL OF PATHOLOGY

A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia

(2009) Mark J. Evans et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ablation of ARNT/HIF1β in Liver Alters Gluconeogenesis, Lipogenic Gene Expression, and Serum Ketones

(2009) Xiaohui L. Wang et al.   Cell Metabolism

FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States

(2009) Jongsook Kim Kemper et al.   Cell Metabolism

Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine

(2009) Ann M. Thomas et al.   HEPATOLOGY

Fibroblast Growth Factor-19, a Novel Factor That Inhibits Hepatic Fatty Acid Synthesis

(2009) Sushant Bhatnagar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Increased Flux through the Glucose 6-Phosphate Pool in Enterocytes Delays Glucose Absorption inFxr–/–Mice

(2009) Theo H. van Dijk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR−/−and apoE−/−mice

(2009) Helen B. Hartman et al.   JOURNAL OF LIPID RESEARCH

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

(2009) Philippe Lefebvre et al.   PHYSIOLOGICAL REVIEWS

Circadian Dysregulation Disrupts Bile Acid Homeostasis

(2009) Ke Ma et al.   PLoS One

FGF21 induces PGC-1  and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

(2009) M. J. Potthoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes

(2008) Cédric Langhi et al.   FEBS LETTERS

The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor

(2008) Tamara Frankenberg et al.   HEPATOLOGY

Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

(2008) Yan-Dong Wang et al.   HEPATOLOGY

Phosphorylation of Farnesoid X Receptor by Protein Kinase C Promotes Its Transcriptional Activity

(2008) Romain Gineste et al.   MOLECULAR ENDOCRINOLOGY