The Role of Glucocorticoids in Inflammatory Diseases

Sialic Acid Conjugate–Modified Liposomal Dexamethasone Palmitate Targeting Neutrophils for Rheumatoid Arthritis Therapy: Influence of Particle Size

(2021) Shuo Wang et al.   AAPS PHARMSCITECH

Glucocorticoids and the brain after critical illness

(2021) Alice R Hill et al.   ENDOCRINOLOGY

Hyaluronan-Loaded Liposomal Dexamethasone–Diclofenac Nanoparticles for Local Osteoarthritis Treatment

(2021) Ming-Cheng Chang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glucocorticoids: Dr. Jekyll and Mr. Hyde of Hippocampal Neuroinflammation

(2021) Alexey P. Bolshakov et al.   BIOCHEMISTRY-MOSCOW

How we can mitigate the side effects associated with systemic glucocorticoid after allogeneic hematopoietic cell transplantation

(2021) Shigeo Fuji et al.   BONE MARROW TRANSPLANTATION

Corticosteroid enhances epithelial barrier function in intestinal organoids derived from patients with Crohn’s disease

(2021) Pan Xu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Early efficacy and safety data with fixed‐dose combination calcipotriol/betamethasone dipropionate foam attributed to mechanism of absorption and steroid potency

(2021) Y. Tada et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Microbiota and Drug Response in Inflammatory Bowel Disease

(2021) Martina Franzin et al.   Pathogens

A flow cytometric approach to study glucocorticoid receptor expression in immune cell subpopulations of genetically engineered mice

(2021) Sybille D. Reichardt et al.   IMMUNOLOGY LETTERS

11β-hydroxysteroid dehydrogenases: A growing multi-tasking family

(2021) Elise P. Gomez-Sanchez et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms

(2021) Thomas A. Johnson et al.   Nature Communications

Glucocorticoids as Regulators of Macrophage-Mediated Tissue Homeostasis

(2021) David Diaz-Jimenez et al.   Frontiers in Immunology

A guide to changing paradigms of glucocorticoid receptor function—a model system for genome regulation and physiology

(2021) Sabine Vettorazzi et al.   FEBS Journal

Microglia in Neurodegenerative Events—An Initiator or a Significant Other?

(2021) Gaylia Jean Harry   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enduring glucocorticoid-evoked exacerbation of synaptic plasticity disruption in male rats modelling early Alzheimer’s disease amyloidosis

(2021) Yingjie Qi et al.   NEUROPSYCHOPHARMACOLOGY

Protection of Antigen-Primed Effector T Cells From Glucocorticoid-Induced Apoptosis in Cell Culture and in a Mouse Model of Multiple Sclerosis

(2021) Jasmina Bier et al.   Frontiers in Immunology

A Dry Powder Platform for Nose-to-Brain Delivery of Dexamethasone: Formulation Development and Nasal Deposition Studies

(2021) Laura Nižić Nodilo et al.   Pharmaceutics

Biomedical Applications of Supramolecular Materials in the Controllable Delivery of Steroids

(2021) Yun Hao et al.   Frontiers in Molecular Biosciences

Evaluation of Budesonide–Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Thermoreversible Gels for Ulcerative Colitis

(2020) Carolina Martins Lázaro et al.   DIGESTIVE DISEASES AND SCIENCES

Glucocorticoids delivered by inorganic‐organic hybrid nanoparticles mitigate acute graft‐versus‐host disease and sustain graft‐versus‐leukemia activity

(2020) Tina K. Kaiser et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Highly selective organ distribution and cellular uptake of inorganic-organic hybrid nanoparticles customized for the targeted delivery of glucocorticoids

(2020) Tina K. Kaiser et al.   JOURNAL OF CONTROLLED RELEASE

Ternary nanocomposite carriers based on organic clay-lipid vesicles as an effective colon-targeted drug delivery system: preparation and in vitro/in vivo characterization

(2020) Hyeon Young Kim et al.   JOURNAL OF NANOBIOTECHNOLOGY

Impaired Glucocorticoid Receptor Dimerization Aggravates LPS-Induced Circulatory and Pulmonary Dysfunction

(2020) Martin Wepler et al.   Frontiers in Immunology

Emerging treatments for inflammatory bowel disease

(2020) Karl Hazel et al.   Therapeutic Advances in Chronic Disease

Nanoparticles Derived from the Natural Antioxidant Rosmarinic Acid Ameliorate Acute Inflammatory Bowel Disease

(2020) Chan Ho Chung et al.   ACS Nano

Respiratory microbiome and epithelial interactions shape immunity in the lungs

(2020) Rachele Invernizzi et al.   IMMUNOLOGY

Modular Acid-Activatable Acetone-Based Ketal-Linked Nanomedicine by Dexamethasone Prodrugs for Enhanced Anti-Rheumatoid Arthritis with Low Side Effects

(2020) Yang Xu et al.   NANO LETTERS

The combination of acyclovir and dexamethasone protects against Alzheimer’s disease-related cognitive impairments in mice

(2020) Zhang Hui et al.   PSYCHOPHARMACOLOGY

Glucocorticoids Promote the Onset of Acute Experimental Colitis and Cancer by Upregulating mTOR Signaling in Intestinal Epithelial Cells

(2020) Zhengguo Zhang et al.   Cancers

Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study

(2020) Sofia Ramiro et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism

(2020) Dongkyun Kim et al.   IMMUNITY

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Anti-inflammatory functions of the glucocorticoid receptor require DNA binding

(2020) Laura Escoter-Torres et al.   NUCLEIC ACIDS RESEARCH

T cell optimization for graft-versus-leukemia responses

(2020) Melinda A. Biernacki et al.   JCI Insight

Promising Nanotechnology Approaches in Treatment of Autoimmune Diseases of Central Nervous System

(2020) Maria Chountoulesi et al.   Brain Sciences

Large-scale GMP-compliant CRISPR-Cas9–mediated deletion of the glucocorticoid receptor in multivirus-specific T cells

(2020) Rafet Basar et al.   Blood Advances

Intravenous methylprednisolone pulse as a treatment for hospitalised severe COVID-19 patients: results from a randomised controlled clinical trial

(2020) Maryam Edalatifard et al.   EUROPEAN RESPIRATORY JOURNAL

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19

(2020) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dexamethasone Sodium Phosphate Loaded Modified Cyclodextrin Based Nanoparticles: An Efficient Treatment for Rheumatoid Arthritis

(2020) Dhananjay Jadhav et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A living WHO guideline on drugs for covid-19

(2020) François Lamontagne et al.   BMJ-British Medical Journal

Exosome-based biomimetic nanoparticles targeted to inflamed joints for enhanced treatment of rheumatoid arthritis

(2020) Feili Yan et al.   JOURNAL OF NANOBIOTECHNOLOGY

Association between chronic stress and Alzheimer’s disease: Therapeutic effects of Saffron

(2020) Mohammad Saeedi et al.   BIOMEDICINE & PHARMACOTHERAPY

Therapeutic implications of hypothalamic-pituitaryadrenal-axis modulation in Alzheimer’s disease: A narrative review of pharmacological and lifestyle interventions

(2020) Tamlyn Watermeyer et al.   FRONTIERS IN NEUROENDOCRINOLOGY

The Role of Glucocorticoids in the Management of COVID-19

(2020) Vasileia Ismini Alexaki et al.   HORMONE AND METABOLIC RESEARCH

The Glucocorticoid Receptor in Intestinal Epithelial Cells Alleviates Colitis and Associated Colorectal Cancer in Mice

(2020) Chiara Muzzi et al.   Cellular and Molecular Gastroenterology and Hepatology

Novel hybrid lipid nanocapsules loaded with a therapeutic monoclonal antibody – Bevacizumab – and Triamcinolone acetonide for combined therapy in neovascular ocular pathologies

(2020) María Lina Formica et al.   Materials Science & Engineering C-Materials for Biological Applications

Effects and Mechanism of Constitutive TL1A Expression on Intestinal Mucosal Barrier in DSS-Induced Colitis

(2019) Mingyue Yang et al.   DIGESTIVE DISEASES AND SCIENCES

Distinct fibroblast subsets drive inflammation and damage in arthritis

(2019) Adam P. Croft et al.   NATURE

Pathogenesis of Acute Respiratory Distress Syndrome

(2019) Laura Huppert et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Genetic implications in the pathogenesis of rheumatoid arthritis; an updated review

(2019) Jafar Karami et al.   GENE

Folate Conjugated Double Liposomes Bearing Prednisolone and Methotrexate for Targeting Rheumatoid Arthritis

(2019) Amit Verma et al.   PHARMACEUTICAL RESEARCH

The glucocorticoid receptor agonistic modulators CpdX and CpdX-D3 do not generate the debilitating effects of synthetic glucocorticoids

(2019) Guoqiang Hua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocorticoid receptor modulators CpdX and CpdX-D3 exhibit the same in vivo antiinflammatory activities as synthetic glucocorticoids

(2019) Guoqiang Hua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Dual-Specificity Phosphatase 1 in Glucocorticoid-Driven Anti-inflammatory Responses

(2019) Jessica Hoppstädter et al.   Frontiers in Immunology

Annexin-A1: Therapeutic Potential in Microvascular Disease

(2019) Gareth S. D. Purvis et al.   Frontiers in Immunology

Triamcinolone acetonide-loaded PLA/PEG-PDL microparticles for effective intra-articular delivery: synthesis, optimization, in vitro and in vivo evaluation

(2019) May Abou-ElNour et al.   JOURNAL OF CONTROLLED RELEASE

Vamorolone trial in Duchenne muscular dystrophy shows dose-related improvement of muscle function

(2019) Eric P. Hoffman et al.   NEUROLOGY

Update on Clinical Aspects of Chronic Obstructive Pulmonary Disease

(2019) Bartolomé R. Celli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glucocorticoid-Driven NLRP3 Inflammasome Activation in Hippocampal Microglia Mediates Chronic Stress-Induced Depressive-Like Behaviors

(2019) Xiujing Feng et al.   Frontiers in Molecular Neuroscience

Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor

(2019) Laura Escoter-Torres et al.   Frontiers in Immunology

Randomized Multicenter Trial of Sirolimus vs. Prednisone as Initial Therapy for Standard Risk Acute GVHD: BMT CTN 1501

(2019) Joseph Pidala et al.   BLOOD

Chitosan-modified lipid nanodrug delivery system for the targeted and responsive treatment of ulcerative colitis

(2019) Shao-qing Chen et al.   CARBOHYDRATE POLYMERS

Triamcinolone acetonide-loaded lipid nanocapsules for ophthalmic applications

(2019) M.L. Formica et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Glucocorticoid Therapy is Associated with a Lower Risk of Dementia

(2019) Michael Nerius et al.   JOURNAL OF ALZHEIMERS DISEASE

Glucocorticoid resistance of allogeneic T cells alters the gene expression profile in the inflamed small intestine of mice suffering from acute graft-versus-host disease

(2019) Hu Li et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis

(2018) Mascha Koenen et al.   ANNALS OF THE RHEUMATIC DISEASES

Glutathione-PEGylated liposomal methylprednisolone in comparison to free methylprednisolone: slow release characteristics and prolonged lymphocyte depression in a first-in-human study

(2018) K. M. S. Kanhai et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Endogenous glucocorticoid signaling in chondrocytes attenuates joint inflammation and damage

(2018) Jinwen Tu et al.   FASEB JOURNAL

New Insights into the Immune Molecular Regulation of the Pathogenesis of Acute Respiratory Distress Syndrome

(2018) Chin-Yao Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis

(2018) R.S. Hardy et al.   JOURNAL OF AUTOIMMUNITY

The role of microRNAs in glucocorticoid action

(2018) Sally A. Clayton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

(2018) Marlies Ballegeer et al.   JOURNAL OF CLINICAL INVESTIGATION

Pulmonary immunity and extracellular matrix interactions

(2018) David N. O'Dwyer et al.   MATRIX BIOLOGY

Impaired resolution of DSS-induced colitis in mice lacking the glucocorticoid receptor in myeloid cells

(2018) Garrit K. Meers et al.   PLoS One

Phase 1 trial of vamorolone, a first-in-class steroid, shows improvements in side effects via biomarkers bridged to clinical outcomes

(2018) Eric P. Hoffman et al.   STEROIDS

Therapeutic Mechanisms of Glucocorticoids

(2018) Jolien Vandewalle et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Local level of TGF-β1 determines the effectiveness of dexamethasone through regulating the balance of Treg/Th17 cells in TNBS-induced mouse colitis

(2018) Peng You et al.   Experimental and Therapeutic Medicine

TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons

(2018) Layal Maatouk et al.   Nature Communications

The glucocorticoid receptor in recipient cells keeps cytokine secretion in acute graft-versus-host disease at bay

(2018) Tina Baake et al.   Oncotarget

Vamorolone treatment improves skeletal muscle outcome in a critical illness myopathy rat model

(2018) Hazem Akkad et al.   Acta Physiologica

Clinical Approach to the Therapy of Asthma-COPD Overlap

(2018) Diego J. Maselli et al.   CHEST

Advances in asthma in 2017: Mechanism, biologics, and genetics

(2018) Mitchell H. Grayson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature

(2018) Antoine Louveau et al.   NATURE NEUROSCIENCE

Regulation of microRNA function in animals

(2018) Luca F. R. Gebert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug

(2018) Laurie S. Conklin et al.   PHARMACOLOGICAL RESEARCH

How Glucocorticoids Affect the Neutrophil Life

(2018) Simona Ronchetti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mucosal healing and bacterial composition in response to enteral nutrition versus steroid based induction therapy – a randomized prospective clinical trial in children with Crohn’s disease

(2018) Bénédicte Pigneur et al.   Journal of Crohns & Colitis

GILZ restrains neutrophil activation by inhibiting the MAPK pathway

(2018) Erika Ricci et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CNS infection and immune privilege

(2018) John V. Forrester et al.   NATURE REVIEWS NEUROSCIENCE

Non-genomic Effects of Glucocorticoids: An Updated View

(2018) Reynold A. Panettieri et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pathogenic Role of Immune Cells in Rheumatoid Arthritis: Implications in Clinical Treatment and Biomarker Development

(2018) Hooi-Yeen Yap et al.   Cells

Steroid treatment of acute graft- versus -host disease grade I: a randomized trial

(2017) Andrea Bacigalupo et al.   HAEMATOLOGICA

Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action

(2017) Kyu-Seon Oh et al.   IMMUNITY

Novel Drug Delivery Systems Tailored for Improved Administration of Glucocorticoids

(2017) Fred Lühder et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeted delivery of glucocorticoids to macrophages in a mouse model of multiple sclerosis using inorganic-organic hybrid nanoparticles

(2017) Elena Montes-Cobos et al.   JOURNAL OF CONTROLLED RELEASE

Airway Epithelial Cells Are Crucial Targets of Glucocorticoids in a Mouse Model of Allergic Asthma

(2017) Carina Klaßen et al.   JOURNAL OF IMMUNOLOGY

Glucocorticoid attenuates acute lung injury through induction of type 2 macrophage

(2017) Guo-wei Tu et al.   Journal of Translational Medicine

Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology

(2017) Karen Dubois-Camacho et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Regulation of Corticosteroidogenic Genes by MicroRNAs

(2017) Stacy Robertson et al.   International Journal of Endocrinology

Steroid treatment of acute graft- versus -host disease grade I: a randomized trial

(2017) Andrea Bacigalupo et al.   HAEMATOLOGICA

Deletion of the Mineralocorticoid Receptor in Myeloid Cells Attenuates Central Nervous System Autoimmunity

(2017) Elena Montes-Cobos et al.   Frontiers in Immunology

c-Jun regulates adipocyte differentiation via the KLF15-mediated mode

(2016) Da Som Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

VBP15, a novel dissociative steroid compound, reduces NFκB-induced expression of inflammatory cytokines in vitro and symptoms of murine trinitrobenzene sulfonic acid-induced colitis

(2016) Jesse M. Damsker et al.   INFLAMMATION RESEARCH

Maintenance of gut homeostasis by the mucosal immune system

(2016) Ryu OKUMURA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration

(2016) Sheela Vyas et al.   NEURAL PLASTICITY

The glucocorticoid receptor in inflammatory processes: transrepression is not enough

(2015) Sabine Hübner et al.   BIOLOGICAL CHEMISTRY

TALEN-mediated genetic inactivation of the glucocorticoid receptor in cytomegalovirus-specific T cells

(2015) Laurie Menger et al.   BLOOD

Epithelial cytokines and pulmonary allergic inflammation

(2015) Clare M Lloyd et al.   CURRENT OPINION IN IMMUNOLOGY

Glucocorticoid‐induced microRNA‐511 protects against TNF by down‐regulating TNFR1

(2015) Leen Puimège et al.   EMBO Molecular Medicine

Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo

(2015) Hee-Woong Lim et al.   GENOME RESEARCH

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glucocorticoids attenuate acute graft-versus-host disease by suppressing the cytotoxic capacity of CD8+T cells

(2015) Jennifer Theiss-Suennemann et al.   JOURNAL OF PATHOLOGY

Multifunctional Phosphate-Based Inorganic–Organic Hybrid Nanoparticles

(2015) Joachim G. Heck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation

(2015) L Dejager et al.   Mucosal Immunology

Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration

(2015) Fleur M. van der Valk et al.   Nanomedicine-Nanotechnology Biology and Medicine

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

Selective glucocorticoid receptor modulation: New directions with non-steroidal scaffolds

(2015) Nora Sundahl et al.   PHARMACOLOGY & THERAPEUTICS

Revisiting the Mechanisms of CNS Immune Privilege

(2015) Antoine Louveau et al.   TRENDS IN IMMUNOLOGY

Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1

(2015) Sabine Vettorazzi et al.   Nature Communications

GILZ as a Mediator of the Anti-Inflammatory Effects of Glucocorticoids

(2015) Simona Ronchetti et al.   Frontiers in Endocrinology

Nano-Drugs Based on Nano Sterically Stabilized Liposomes for the Treatment of Inflammatory Neurodegenerative Diseases

(2015) Keren Turjeman et al.   PLoS One

Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses

(2014) Nils Schweingruber et al.   ACTA NEUROPATHOLOGICA

Refractory asthma: mechanisms, targets, and therapy

(2014) J. L. Trevor et al.   ALLERGY

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

A Plant-Derived Ligand Favoring Monomeric Glucocorticoid Receptor Conformation with Impaired Transactivation Potential Attenuates Collagen-Induced Arthritis

(2014) P. Dewint et al.   JOURNAL OF IMMUNOLOGY

Peripheral T Cells Are the Therapeutic Targets of Glucocorticoids in Experimental Autoimmune Encephalomyelitis

(2014) S. Wust et al.   JOURNAL OF IMMUNOLOGY

Dexamethasone Palmitate Ameliorates Macrophages-Rich Graft-versus-Host Disease by Inhibiting Macrophage Functions

(2014) Satoshi Nishiwaki et al.   PLoS One

Nonclassical Ly6C− Monocytes Drive the Development of Inflammatory Arthritis in Mice

(2014) Alexander V. Misharin et al.   Cell Reports

GILZ Promotes Production of Peripherally Induced Treg Cells and Mediates the Crosstalk between Glucocorticoids and TGF-β Signaling

(2014) Oxana Bereshchenko et al.   Cell Reports

Divergent Effects of Endogenous and Exogenous Glucocorticoid-Induced Leucine Zipper in Animal Models of Inflammation and Arthritis

(2013) Devi Ngo et al.   ARTHRITIS AND RHEUMATISM

VBP15: Preclinical characterization of a novel anti-inflammatory delta 9,11 steroid

(2013) Erica K.M. Reeves et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation

(2013) M Á Carrillo-de Sauvage et al.   CELL DEATH AND DIFFERENTIATION

11β-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritis

(2013) Lei Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Glucocorticoids Induce Effector T Cell Depolarization via ERM Proteins, Thereby Impeding Migration and APC Conjugation

(2013) N. Muller et al.   JOURNAL OF IMMUNOLOGY

Changing glucocorticoid action: 11β-Hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation

(2013) Karen E. Chapman et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

VBP15, a Glucocorticoid Analogue, Is Effective at Reducing Allergic Lung Inflammation in Mice

(2013) Jesse M. Damsker et al.   PLoS One

The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis

(2012) Hetal B Patel et al.   ANNALS OF THE RHEUMATIC DISEASES

Dual-specificity phosphatase 1-null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis

(2012) Youridies Vattakuzhi et al.   ARTHRITIS AND RHEUMATISM

11β-Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus

(2012) C. D. Pereira et al.   DIABETES OBESITY & METABOLISM

Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation

(2012) Pieter J. Gaillard et al.   JOURNAL OF CONTROLLED RELEASE

A Dissociated Glucocorticoid Receptor Modulator Reduces Airway Hyperresponsiveness and Inflammation in a Mouse Model of Asthma

(2012) L. L. Reber et al.   JOURNAL OF IMMUNOLOGY

Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis

(2012) Juliana P. Vago et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Combined treatment with recombinant tissue plasminogen activator and dexamethasone phosphate-containing liposomes improves neurological outcome and restricts lesion progression after embolic stroke in rats

(2012) Ivo A. C. W. Tiebosch et al.   JOURNAL OF NEUROCHEMISTRY

Ulcerative colitis

(2012) Ingrid Ordás et al.   LANCET

Insights into Negative Regulation by the Glucocorticoid Receptor from Genome-wide Profiling of Inflammatory Cistromes

(2012) N. Henriette Uhlenhaut et al.   MOLECULAR CELL

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

Org 214007-0: A Novel Non-Steroidal Selective Glucocorticoid Receptor Modulator with Full Anti-Inflammatory Properties and Improved Therapeutic Index

(2012) Marie-José C. van Lierop et al.   PLoS One

Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor

(2011) Milan Surjit et al.   CELL

11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice

(2011) Agnes E. Coutinho et al.   ENDOCRINOLOGY

An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation

(2011) Alexander Rauch et al.   FASEB JOURNAL

Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow

(2011) Jesmond Dalli et al.   FASEB JOURNAL

Macrophages and liposomes in inflammatory disease: Friends or foes?

(2011) B.J. Crielaard et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Liposomal Encapsulation of Glucocorticoids Alters Their Mode of Action in the Treatment of Experimental Autoimmune Encephalomyelitis

(2011) Nils Schweingruber et al.   JOURNAL OF IMMUNOLOGY

Fabrication Principles and Their Contribution to the Superior In Vivo Therapeutic Efficacy of Nano-Liposomes Remote Loaded with Glucocorticoids

(2011) Yuval Avnir et al.   PLoS One

Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells

(2011) U. Baschant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis

(2010) Elaine Beaulieu et al.   ARTHRITIS AND RHEUMATISM

Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

(2010) Lisette Bevaart et al.   ARTHRITIS AND RHEUMATISM

Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor

(2010) Raoul Frijters et al.   BMC GENOMICS

Glucocorticoids Suppress Bone Formation by Attenuating Osteoblast Differentiation via the Monomeric Glucocorticoid Receptor

(2010) Alexander Rauch et al.   Cell Metabolism

Therapeutic strategies for severe acute lung injury

(2010) Janet V. Diaz et al.   CRITICAL CARE MEDICINE

Dissociation of Osteogenic and Immunological Effects by the Selective Glucocorticoid Receptor Agonist, Compound A, in Human Bone Marrow Stromal Cells

(2010) Martina Rauner et al.   ENDOCRINOLOGY

Steroid treatment alters adhesion molecule and chemokine expression in experimental acute graft-vs.-host disease of the intestinal tract

(2010) Abdellatif Bouazzaoui et al.   EXPERIMENTAL HEMATOLOGY

Asthma: Clinical expression and molecular mechanisms

(2010) Robert F. Lemanske et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

Transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuates K/BxN mouse serum-induced arthritis in vivo

(2009) Frank Buttgereit et al.   ARTHRITIS AND RHEUMATISM

Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide

(2009) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: A systematic review and meta-analysis*

(2009) Benjamin M. P. Tang et al.   CRITICAL CARE MEDICINE

Stable silencing of the glucocorticoid receptor in myelin-specific T effector cells by retroviral delivery of shRNA: Insight into neuroinflammatory disease

(2009) Denise Tischner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Compound A, a Plant Origin Ligand of Glucocorticoid Receptors, Increases Regulatory T Cells and M2 Macrophages to Attenuate Experimental Autoimmune Neuritis with Reduced Side Effects

(2009) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Stress is critical for LPS-induced activation of microglia and damage in the rat hippocampus

(2009) A.M. Espinosa-Oliva et al.   NEUROBIOLOGY OF AGING

Incidence and Outcomes of Pediatric Acute Lung Injury

(2009) J. J. Zimmerman et al.   PEDIATRICS

Therapeutic and Adverse Effects of a Non-Steroidal Glucocorticoid Receptor Ligand in a Mouse Model of Multiple Sclerosis

(2009) Simone Wüst et al.   PLoS One

The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene

(2008) David S. Waddell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dexamethasone augments CXCR4-mediated signaling in resting human T cells via the activation of the Src kinase Lck

(2008) M. C. Ghosh et al.   BLOOD

Liposomal glucocorticosteroids in treatment of chronic autoimmune demyelination: Long-term protective effects and enhanced efficacy of methylprednisolone formulations

(2008) Ralf A. Linker et al.   EXPERIMENTAL NEUROLOGY

Glucocorticoid Receptor Phosphorylation Differentially Affects Target Gene Expression

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