Therapeutic implications of hypothalamic-pituitaryadrenal-axis modulation in Alzheimer’s disease: A narrative review of pharmacological and lifestyle interventions

Depression—an underrecognized target for prevention of dementia in Alzheimer’s disease

(2020) Forugh S. Dafsari et al.   Translational Psychiatry

Pathways Connecting Late-Life Depression and Dementia

(2020) Christoph Linnemann et al.   Frontiers in Pharmacology

β-amyloid and tau drive early Alzheimer’s disease decline while glucose hypometabolism drives late decline

(2020) Tyler C. Hammond et al.   Communications Biology

Aerobic Exercise Increases Cortisol Awakening Response in Older Adults

(2019) Lauren L. Drogos et al.   PSYCHONEUROENDOCRINOLOGY

High Cortisol and the Risk of Dementia and Alzheimer’s Disease: A Review of the Literature

(2019) Sami Ouanes et al.   Frontiers in Aging Neuroscience

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress

(2019) Matthew J. Horchar et al.   BRAIN BEHAVIOR AND IMMUNITY

Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain

(2019) M. Schouten et al.   MOLECULAR PSYCHIATRY

Stress, trauma, racial/ethnic group membership, and HPA function: Utility of hair cortisol.

(2019) Jessica Palmer-Bacon et al.   AMERICAN JOURNAL OF ORTHOPSYCHIATRY

Late glucocorticoid receptor antagonism changes the outcome of adult life stress

(2019) Jinlan Ding et al.   PSYCHONEUROENDOCRINOLOGY

Is AD a Stress-Related Disorder? Focus on the HPA Axis and Its Promising Therapeutic Targets

(2019) Geoffrey Canet et al.   Frontiers in Aging Neuroscience

Plasma cortisol is associated with cerebral hypometabolism across the Alzheimer's disease spectrum

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Longitudinal associations between diurnal cortisol variation and later-life cognitive impairment

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Sex differences in stress responses: a critical role for corticotropin-releasing factor

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Sex differences in Alzheimer disease — the gateway to precision medicine

(2018) Maria Teresa Ferretti et al.   Nature Reviews Neurology

Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man

(2018) K. Kalafatakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered ultradian cortisol rhythmicity as a potential neurobiologic substrate for chronic insomnia

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Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease

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Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice

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Vulnerability and resilience to Alzheimer’s disease: early life conditions modulate neuropathology and determine cognitive reserve

(2018) Sylvie L. Lesuis et al.   Alzheimers Research & Therapy

Circulating cortisol and cognitive and structural brain measures

(2018) Justin B. Echouffo-Tcheugui et al.   NEUROLOGY

Carbenoxolone Reverses the Amyloid Beta 1–42 Oligomer–Induced Oxidative Damage and Anxiety-Related Behavior in Rats

(2018) Sheetal Sharma et al.   NEUROTOXICITY RESEARCH

Levels of Cortisol in CSF Are Associated With SNAP-25 and Tau Pathology but Not Amyloid-β

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Design, synthesis and in vivo study of novel pyrrolidine-based 11β-HSD1 inhibitors for age-related cognitive dysfunction

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Does the diurnal cycle of cortisol explain the relationship between physical performance and cognitive function in older adults?

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Mindfulness-Based Stress Reduction for Older Adults With Stress Disorders and Neurocognitive Difficulties

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A Comprehensive Comparison of Quantifications of Intraindividual Variability in Response Times: A Measurement Burst Approach

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A users guide to HPA axis research

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Cortisol: Mediator of association between Alzheimer’s disease and diabetes mellitus?

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Proportion of dementia in Australia explained by common modifiable risk factors

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Race modifies the relationship between cognition and Alzheimer’s disease cerebrospinal fluid biomarkers

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Insulin Resistance and Alzheimer’s Disease: Bioenergetic Linkages

(2017) Bryan J. Neth et al.   Frontiers in Aging Neuroscience

The Effect of Glucocorticoid and Glucocorticoid Receptor Interactions on Brain, Spinal Cord, and Glial Cell Plasticity

(2017) Kathryn M. Madalena et al.   NEURAL PLASTICITY

Nutritional Ketosis Affects Metabolism and Behavior in Sprague-Dawley Rats in Both Control and Chronic Stress Environments

(2017) Milene L. Brownlow et al.   Frontiers in Molecular Neuroscience

Impact of age, sex and body mass index on cortisol secretion in 143 healthy adults

(2017) Ferdinand Roelfsema et al.   Endocrine Connections

Effects of Stress and Stress Hormones on Amyloid-β Protein and Plaque Deposition

(2017) Hongxin Dong et al.   JOURNAL OF ALZHEIMERS DISEASE

Ethical challenges in preclinical Alzheimer's disease observational studies and trials: Results of the Barcelona summit

(2016) José L. Molinuevo et al.   Alzheimers & Dementia

Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria

(2016) Bruno Dubois et al.   Alzheimers & Dementia

Yoga practice improves executive function by attenuating stress levels

(2016) Neha P. Gothe et al.   BIOLOGICAL PSYCHOLOGY

The functional and clinical significance of the 24-h rhythm of circulating glucocorticoids

(2016) Henrik Oster et al.   ENDOCRINE REVIEWS

Depression as a risk factor for Alzheimer’s disease: Genes, steroids, cytokines and neurogenesis – What do we need to know?

(2016) Joe Herbert et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Mindfulness Training for Older Adults with Subjective Cognitive Decline: Results from a Pilot Randomized Controlled Trial

(2016) Colette M. Smart et al.   JOURNAL OF ALZHEIMERS DISEASE

New selective glucocorticoid receptor modulators reverse amyloid-β peptide–induced hippocampus toxicity

(2016) Fanny Pineau et al.   NEUROBIOLOGY OF AGING

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

(2016) Clifford R. Jack et al.   NEUROLOGY

Cortisol Awakening Response and Walking Speed in Older People

(2016) Matias M. Pulopulos et al.   PLoS One

A randomized, double-blind, placebo-controlled, crossover trial of mifepristone in Gulf War veterans with chronic multisymptom illness

(2016) Julia A. Golier et al.   PSYCHONEUROENDOCRINOLOGY

The Effects of Mindfulness on Persons with Mild Cognitive Impairment: Protocol for a Mixed-Methods Longitudinal Study

(2016) Wee Ping Wong et al.   Frontiers in Aging Neuroscience

Does physical activity reduce risk for Alzheimer's disease through interaction with the stress neuroendocrine system?

(2016) J. Tortosa-Martínez et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Sleep Quality and Risk of Dementia Among Older Male Veterans

(2015) Kristine Yaffe et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease

(2015) Karen Sooy et al.   ENDOCRINOLOGY

Exercise Increases the Dynamics of Diurnal Cortisol Secretion and Executive Function in People with Amnestic Mild Cognitive Impairment

(2015) Juan Tortosa-Martínez et al.   JOURNAL OF AGING AND PHYSICAL ACTIVITY

Cerebrospinal fluid cortisol and clinical disease progression in MCI and dementia of Alzheimer's type

(2015) Julius Popp et al.   NEUROBIOLOGY OF AGING

Subchronic Glucocorticoid Receptor Inhibition Rescues Early Episodic Memory and Synaptic Plasticity Deficits in a Mouse Model of Alzheimer’s Disease

(2015) Fabien Lanté et al.   NEUROPSYCHOPHARMACOLOGY

Yoga and Cognition

(2015) Neha P. Gothe et al.   PSYCHOSOMATIC MEDICINE

Racial and Ethnic Differences in Diurnal Cortisol Rhythms

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High Cardiorespiratory Fitness Is Negatively Associated with Daily Cortisol Output in Healthy Aging Men

(2015) Francesco Lucertini et al.   PLoS One

The impact of exercise on the cognitive functioning of healthy older adults: A systematic review and meta-analysis

(2014) Michelle E. Kelly et al.   AGEING RESEARCH REVIEWS

Efficacy and safety evaluation of HSD-1 inhibitor ABT-384 in Alzheimer's disease

(2014) Gerard J. Marek et al.   Alzheimers & Dementia

The potential effects of meditation on age-related cognitive decline: a systematic review

(2014) Tim Gard et al.   Annals of the New York Academy of Sciences

Impact of sleep on the risk of cognitive decline and dementia

(2014) Adam P. Spira et al.   CURRENT OPINION IN PSYCHIATRY

Effect of Physical Exercise on Cognitive Performance in Older Adults with Mild Cognitive Impairment or Dementia: A Systematic Review

(2014) Hanna Öhman et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Decrease in blood pressure and improved psychological aspects through meditation training in hypertensive older adults: A randomized control study

(2014) Márcia de Fátima Rosas Marchiori et al.   Geriatrics & Gerontology International

Sleep deprivation potentiates HPA axis stress reactivity in healthy adults.

(2014) Jared Minkel et al.   HEALTH PSYCHOLOGY

Antiglucocorticoid therapy for older adults with anxiety and co-occurring cognitive dysfunction: results from a pilot study with mifepristone

(2014) Eric J. Lenze et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Physical Activity, Life Events Stress, Cortisol, and DHEA: Preliminary Findings That Physical Activity May Buffer Against the Negative Effects of Stress

(2014) Jennifer L.J. Heaney et al.   JOURNAL OF AGING AND PHYSICAL ACTIVITY

Stress and the Reproductive Axis

(2014) D. Toufexis et al.   JOURNAL OF NEUROENDOCRINOLOGY

The Consequences of Early-Life Adversity: Neurobiological, Behavioural and Epigenetic Adaptations

(2014) S. Maccari et al.   JOURNAL OF NEUROENDOCRINOLOGY

Potential for primary prevention of Alzheimer's disease: an analysis of population-based data

(2014) Sam Norton et al.   LANCET NEUROLOGY

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(2014) Brian J. Prendergast et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Effect of 1 Night of Total Sleep Deprivation on Cerebrospinal Fluid β-Amyloid 42 in Healthy Middle-Aged Men

(2014) Sharon Ooms et al.   JAMA Neurology

Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer’s disease: a 6-month, randomized, placebo-controlled, multicenter trial

(2014) Moshe Laudon et al.   Clinical Interventions in Aging

The Effect of Exercise Training on Cognitive Function in Older Adults with Mild Cognitive Impairment: A Meta-analysis of Randomized Controlled Trials

(2013) Nicola Gates et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Mifepristone Alters Amyloid Precursor Protein Processing to Preclude Amyloid Beta and Also Reduces Tau Pathology

(2013) David Baglietto-Vargas et al.   BIOLOGICAL PSYCHIATRY

Higher Adherence to a Diet Score Based on American Heart Association Recommendations Is Associated with Lower Odds of Allostatic Load and Metabolic Syndrome in Puerto Rican Adults

(2013) Josiemer Mattei et al.   JOURNAL OF NUTRITION

Glucocorticoid receptor protein expression in human hippocampus; stability with age

(2013) Qian Wang et al.   NEUROBIOLOGY OF AGING

The cortisol awakening response – Applications and implications for sleep medicine

(2013) Greg J. Elder et al.   SLEEP MEDICINE REVIEWS

Chronic stress exposure decreases the cortisol awakening response in healthy young men

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Sleep Quality and Preclinical Alzheimer Disease

(2013) Yo-El S. Ju et al.   JAMA Neurology

Cardiovascular risk factors, cortisol, and amyloid-β deposition in Alzheimer's Disease Neuroimaging Initiative

(2012) Jon B. Toledo et al.   Alzheimers & Dementia

A Randomized Trial to Examine the Effect of Mifepristone on Neuropsychological Performance and Mood in Patients with Bipolar Depression

(2012) Stuart Watson et al.   BIOLOGICAL PSYCHIATRY

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(2012) Ram B. Singh et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The cortisol awakening response is related to executive function in older age

(2012) Phil Evans et al.   INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY

Mifepristone, a Glucocorticoid Receptor Antagonist, Produces Clinical and Metabolic Benefits in Patients with Cushing's Syndrome

(2012) Maria Fleseriu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Central CRF system perturbation in an Alzheimer's disease knockin mouse model

(2012) Qinxi Guo et al.   NEUROBIOLOGY OF AGING

Age of major depression onset, depressive symptoms, and risk for subsequent dementia: results of the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe)

(2012) K. Heser et al.   PSYCHOLOGICAL MEDICINE

Dysregulation of the hypothalamic pituitary adrenal (HPA) axis and physical performance at older ages: An individual participant meta-analysis

(2012) Michael P. Gardner et al.   PSYCHONEUROENDOCRINOLOGY

The Influence of Chronic Stress on Dementia-related Diagnostic Change in Older Adults

(2011) Guerry M. Peavy et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

ACTH-Dependent Ultradian Rhythm of Corticosterone Secretion

(2011) Francesca Spiga et al.   ENDOCRINOLOGY

Diurnal cortisol patterns are associated with physical performance in the Caerphilly Prospective Study

(2011) M. P. Gardner et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

The projected effect of risk factor reduction on Alzheimer's disease prevalence

(2011) Deborah E Barnes et al.   LANCET NEUROLOGY

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

(2011) Jason S. Snyder et al.   NATURE

Meditation training increases brain efficiency in an attention task

(2011) Elisa H. Kozasa et al.   NEUROIMAGE

Dynamic regulation of glucocorticoid signalling in health and disease

(2011) S. C. Biddie et al.   RHEUMATOLOGY

Effects of Aerobic Exercise on Mild Cognitive Impairment

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Aging diurnal rhythms and chronic stress: Distinct alteration of diurnal rhythmicity of salivary α-amylase and cortisol

(2010) Jana Strahler et al.   BIOLOGICAL PSYCHOLOGY

11β-Hydroxysteroid dehydrogenases and the brain: From zero to hero, a decade of progress

(2010) Caitlin S. Wyrwoll et al.   FRONTIERS IN NEUROENDOCRINOLOGY

The diurnal cortisol cycle and cognitive performance in the healthy old

(2010) P.D. Evans et al.   INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY

Partial Deficiency or Short-Term Inhibition of 11 -Hydroxysteroid Dehydrogenase Type 1 Improves Cognitive Function in Aging Mice

(2010) K. Sooy et al.   JOURNAL OF NEUROSCIENCE

Running reduces stress and enhances cell genesis in aged mice

(2010) Timal S. Kannangara et al.   NEUROBIOLOGY OF AGING

Interactions Between Age, Stress and Insulin on Cognition: Implications for Alzheimer's Disease

(2010) Maite Solas et al.   NEUROPSYCHOPHARMACOLOGY

Sex bias in neuroscience and biomedical research

(2010) Annaliese K. Beery et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease

(2010) Hyun-Sub Um et al.   NEUROSCIENCE RESEARCH

Identifying patterns in cortisol secretion in an older population. Findings from the Whitehall II study

(2010) Meena Kumari et al.   PSYCHONEUROENDOCRINOLOGY

Aerobic Exercise and Neurocognitive Performance: A Meta-Analytic Review of Randomized Controlled Trials

(2010) Patrick J. Smith et al.   PSYCHOSOMATIC MEDICINE

Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice

(2010) Klaus Fabel   Frontiers in Neuroscience

Race and Unhealthy Behaviors: Chronic Stress, the HPA Axis, and Physical and Mental Health Disparities Over the Life Course

(2009) James S. Jackson et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Subjective Sleep Quality and hormonal modulation in long-term yoga practitioners

(2009) Francisca M. Vera et al.   BIOLOGICAL PSYCHOLOGY

Bright light therapy for agitation in dementia: a randomized controlled trial

(2009) Alistair Burns et al.   INTERNATIONAL PSYCHOGERIATRICS

Elevation by Oxidative Stress and Aging of Hypothalamic-Pituitary-Adrenal Activity in Rats and Its Prevention by Vitamin E

(2009) Naoko Kobayashi et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Neuroendocrine and Immunological Correlates of Chronic Stress in ‘Strictly Healthy’ Populations

(2009) Cristina M. Moriguchi Jeckel et al.   NEUROIMMUNOMODULATION

Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia

(2009) Reisa A. Sperling et al.   NEURON

Assessing salivary cortisol in large-scale, epidemiological research

(2009) Emma K. Adam et al.   PSYCHONEUROENDOCRINOLOGY

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE

The significance of glucocorticoid pulsatility

(2008) Stafford L. Lightman et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Drug Insight: selective agonists and antagonists of the glucocorticoid receptor

(2008) Andrew McMaster et al.   Nature clinical practice. Endocrinology & metabolism

Glucocorticoid receptor variant and risk of dementia and white matter lesions

(2006) Elisabeth F.C. van Rossum et al.   NEUROBIOLOGY OF AGING