11β-hydroxysteroid dehydrogenases: A growing multi-tasking family

A novel mutation in the CYP27A1 gene in a family with cerebrotendinous xanthomatosis

(2020) Yi Tang et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Reciprocal Regulation of HSD11B1 and HSD11B2 Predicts Glucocorticoid Sensitivity in Childhood Acute Lymphoblastic Leukemia

(2020) Shuji Sai et al.   JOURNAL OF PEDIATRICS

Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography Study

(2020) Jason Bini et al.   MOLECULAR IMAGING AND BIOLOGY

Progress in 11β-HSD1 inhibitors for the treatment of metabolic diseases: A comprehensive guide to their chemical structure diversity in drug development

(2020) Zhong Chuanxin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecular mechanisms of posaconazole- and itraconazole-induced pseudohyperaldosteronism and assessment of other systemically used azole antifungals

(2020) Katharina R. Beck et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles’ heel conserved region to minimize probability of escape mutations and drug resistance

(2020) B. Robson   COMPUTERS IN BIOLOGY AND MEDICINE

Sex Differences in 11-Oxygenated Androgen Patterns Across Adulthood

(2020) Angela Davio et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

PLACENTAL 11β-HSD2 DOWNREGULATED IN HIV ASSOCIATED PREECLAMPSIA

(2020) Philemon Dauda Shallie et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

11β-hydroxysteroid dehydrogenase type 1 inhibitor use in human disease-a systematic review and narrative synthesis

(2020) Sarah Gregory et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

HSD11B1 is upregulated synergistically by IFNγ and TNFα and mediates TSG-6 expression in human UC-MSCs

(2020) Peiqing Huang et al.   Cell Death Discovery

Decreased 11β‐hydroxysteroid dehydrogenase 1 in lungs of steroid receptor coactivator ( Src ) ‐1/‐2 double‐deficient fetal mice is caused by impaired glucocorticoid and cytokine signaling

(2020) Jingfei Chen et al.   FASEB JOURNAL

Therapeutic implications of hypothalamic-pituitaryadrenal-axis modulation in Alzheimer’s disease: A narrative review of pharmacological and lifestyle interventions

(2020) Tamlyn Watermeyer et al.   FRONTIERS IN NEUROENDOCRINOLOGY

11β Hydroxysteroid dehydrogenase – 1 activity in type 2 diabetes mellitus: a comparative study

(2019) Ravindra Shukla et al.   BMC Endocrine Disorders

THE ROLE OF 11ß-HYDROXY STEROID DEHYDROGENASE TYPE 2 IN GLUCOCORTICOID PROGRAMMING OF AFFECTIVE AND COGNITIVE BEHAVIOURS

(2019) Fraser Shearer et al.   NEUROENDOCRINOLOGY

11-Oxygenated C19 Steroids Do Not Decline with Age in Women

(2019) Aya T Nanba et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1

(2019) Shivani Bhatt et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis

(2019) Rachelle Gent et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice

(2019) Robert H. Oakley et al.   Science Signaling

11β-hydroxysteroid dehydrogenases control access of 7β,27-dihydroxycholesterol to retinoid-related orphan receptor gamma

(2019) Katharina R. Beck et al.   JOURNAL OF LIPID RESEARCH

Glucocorticoids Shape Macrophage Phenotype for Tissue Repair

(2019) Thibaut Desgeorges et al.   Frontiers in Immunology

11β-HSD1 Inhibition Rescues SAMP8 Cognitive Impairment Induced by Metabolic Stress

(2019) Dolors Puigoriol-Illamola et al.   MOLECULAR NEUROBIOLOGY

Inflammatory and cell death mechanisms induced by 7-ketocholesterol in the retina. Implications for age-related macular degeneration

(2019) Ana Pariente et al.   EXPERIMENTAL EYE RESEARCH

Casting a Wider Net: Differentiating between Inner Nuclear Envelope and Outer Nuclear Envelope Transmembrane Proteins

(2019) Mark Tingey et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

11β-Hydroxysteroid Dehydrogenase 1 Human Tissue Distribution, Selective Inhibitor, and Role in Doxorubicin Metabolism

(2018) Xin Yang et al.   DRUG METABOLISM AND DISPOSITION

Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation

(2018) E.R. de Kloet et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Pseudohyperaldosteronism due to mumijo consumption during pregnancy: a licorice-like syndrome

(2018) Konstantinos Stavropoulos et al.   GYNECOLOGICAL ENDOCRINOLOGY

11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis

(2018) R.S. Hardy et al.   JOURNAL OF AUTOIMMUNITY

Design, synthesis, and biological evaluation of novel selective peptide inhibitors of 11β-hydroxysteroid dehydrogenase 1

(2018) Stephanie Boudon et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Clinical, Biochemical and Genetic Characteristics of “Non-Classical” Apparent Mineralocorticoid Excess Syndrome

(2018) Alejandra Tapia-Castillo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Harnessing the gatekeepers of glucocorticoids for chemoprevention of non-melanoma skin cancer

(2018) Anna M. Mancha-Ramirez et al.   MOLECULAR CARCINOGENESIS

Macrophage 11β-HSD-1 deficiency promotes inflammatory angiogenesis

(2017) Zhenguang Zhang et al.   JOURNAL OF ENDOCRINOLOGY

Glucocorticoids and gut bacteria: “The GALF Hypothesis” in the metagenomic era

(2017) David J. Morris et al.   STEROIDS

Hydroxysteroid dehydrogenase HSD1L is localised to the pituitary–gonadal axis of primates

(2017) A Daniel Bird et al.   Endocrine Connections

Conditional Deletion ofHsd11b2in the Brain Causes Salt Appetite and HypertensionCLINICAL PERSPECTIVE

(2016) Louise C. Evans et al.   CIRCULATION

Local cortisol/corticosterone activation in skin physiology and pathology

(2016) Mika Terao et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish

(2016) Maria Tsachaki et al.   JOURNAL OF ENDOCRINOLOGY

Species differences of 11beta-hydroxysteroid dehydrogenase type 2 function in human and rat term placenta determined via LC-MS/MS

(2016) Kirsten Heussner et al.   PLACENTA

Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease

(2015) Karen Sooy et al.   ENDOCRINOLOGY

Localisation of 11β-Hydroxysteroid Dehydrogenase Type 2 in Mineralocorticoid Receptor Expressing Magnocellular Neurosecretory Neurones of the Rat Supraoptic and Paraventricular Nuclei

(2015) M. Haque et al.   JOURNAL OF NEUROENDOCRINOLOGY

11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story

(2015) Alex Odermatt et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Origin of the response to adrenal and sex steroids: Roles of promiscuity and co-evolution of enzymes and steroid receptors

(2015) Michael E. Baker et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Efficacy and safety evaluation of HSD-1 inhibitor ABT-384 in Alzheimer's disease

(2014) Gerard J. Marek et al.   Alzheimers & Dementia

Expression of mineralocorticoid and glucocorticoid receptors in preautonomic neurons of the rat paraventricular nucleus

(2014) Jian Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Transcriptomics profiling and steroid production in mummichog (Fundulus heteroclitus) testes after treatment with 5α-dihydrotestosterone

(2014) A. Feswick et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Risk Factors for Pseudoaldosteronism with Rhabdomyolysis Caused by Consumption of Drugs Containing Licorice and Differences Between Incidence of These Conditions in Japan and Other Countries: Case Report and Literature Review

(2014) Tetsuhiro Yoshino et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

11 -HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess

(2014) S. A. Morgan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal Undernutrition and Fetal Developmental Programming of Obesity

(2014) Ana Correia-Branco et al.   Reproductive Sciences

Brain mineralocorticoid receptors in cognition and cardiovascular homeostasis

(2014) Elise P. Gomez-Sanchez   STEROIDS

11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice

(2014) Carlos A. Penno et al.   Molecular Metabolism

11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo

(2013) Tijana Mitić et al.   BIOCHEMICAL PHARMACOLOGY

Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity

(2013) Mi-Jeong Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Glucocorticoids in bone and joint disease: the good, the bad and the uncertain

(2013) M. S. Cooper   CLINICAL MEDICINE

Modulation of 11β-Hydroxysteroid Dehydrogenase as a Strategy to Reduce Vascular Inflammation

(2013) Patrick W. F. Hadoke et al.   Current Atherosclerosis Reports

Targeting 11β-hydroxysteroid dehydrogenases: a novel approach to manipulating local glucocorticoid levels with implications for rheumatic disease

(2013) Rowan S Hardy et al.   CURRENT OPINION IN PHARMACOLOGY

11β-Hydroxysteroid Dehydrogenase 1: Translational and Therapeutic Aspects

(2013) Laura L. Gathercole et al.   ENDOCRINE REVIEWS

11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors Still Improve Metabolic Phenotype in Male 11β-HSD1 Knockout Mice Suggesting Off-Target Mechanisms

(2013) Erika Harno et al.   ENDOCRINOLOGY

11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis

(2013) Tiina Kipari et al.   FASEB JOURNAL

Ovarian 11β-Hydroxysteroid Dehydrogenase (11βHSD) Activity Is Suppressed in Women With Anovulatory Polycystic Ovary Syndrome (PCOS): Apparent Role for Ovarian Androgens

(2013) Anthony E. Michael et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects

(2013) Ana Tiganescu et al.   JOURNAL OF CLINICAL INVESTIGATION

Changing glucocorticoid action: 11β-Hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation

(2013) Karen E. Chapman et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Evidence for expression of 11β-hydroxysteroid dehydrogenase type3 (HSD11B3/HSD11B1L) in neonatal pig testis

(2013) Shuji Ohno et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: A putative role in castration resistant prostate cancer?

(2013) Karl-Heinz Storbeck et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Pharmacophore Model Refinement for 11β-Hydroxysteroid Dehydrogenase Inhibitors: Search for Modulators of Intracellular Glucocorticoid Concentrations

(2013) Anna Vuorinen et al.   Molecular Informatics

11β-Hydroxyandrostenedione Returns to the Steroid Arena: Biosynthesis, Metabolism and Function

(2013) Liezl Bloem et al.   MOLECULES

11β-Hydroxysteroid Dehydrogenases: Intracellular Gate-Keepers of Tissue Glucocorticoid Action

(2013) Karen Chapman et al.   PHYSIOLOGICAL REVIEWS

Mast Cells Express 11β-hydroxysteroid Dehydrogenase Type 1: A Role in Restraining Mast Cell Degranulation

(2013) Agnes E. Coutinho et al.   PLoS One

Pro-Inflammatory Cytokine Induction of 11β-hydroxysteroid Dehydrogenase Type 1 in A549 Cells Requires Phosphorylation of C/EBPβ at Thr235

(2013) Cristina L. Esteves et al.   PLoS One

An alternative explanation of hypertension associated with 17α-hydroxylase deficiency syndrome

(2013) David J. Morris et al.   STEROIDS

11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol

(2012) Tijana Mitić et al.   BIOCHIMIE

Five decades with oxysterols

(2012) Ingemar Björkhem   BIOCHIMIE

Novel H6PDH mutations in two girls with premature adrenarche: ‘apparent’ and ‘true’ CRD can be differentiated by urinary steroid profiling

(2012) G G Lavery et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Expression profiles of cortisol-inactivating enzyme, 11β-hydroxysteroid dehydrogenase-2, in human epidermal tumors and its role in keratinocyte proliferation

(2012) Mika Terao et al.   EXPERIMENTAL DERMATOLOGY

Reconciling the nutritional and glucocorticoid hypotheses of fetal programming

(2012) Elizabeth C. Cottrell et al.   FASEB JOURNAL

Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells

(2012) Boonrat Chantong et al.   Journal of Neuroinflammation

Induction of 11β-HSD 1 and Activation of Distinct Mineralocorticoid Receptor- and Glucocorticoid Receptor-Dependent Gene Networks in Decidualizing Human Endometrial Stromal Cells

(2012) Keiji Kuroda et al.   MOLECULAR ENDOCRINOLOGY

Regulation of Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) by CCAAT/Enhancer-Binding Protein (C/EBP) β Isoforms, LIP and LAP

(2012) Cristina L. Esteves et al.   PLoS One

Virtual Screening as a Strategy for the Identification of Xenobiotics Disrupting Corticosteroid Action

(2012) Lyubomir G. Nashev et al.   PLoS One

Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour

(2012) A.P. Harris et al.   PSYCHONEUROENDOCRINOLOGY

Differential expression of placental 11β-hydroxysteroid dehydrogenases in pregnant women with diet-treated gestational diabetes mellitus

(2012) Rong Ma et al.   STEROIDS

Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1

(2011) Alex Odermatt et al.   BIOCHEMICAL JOURNAL

Expression of 11beta-hydroxysteroid dehydrogenase 2 contributes to glucocorticoid resistance in lymphoblastic leukemia cells

(2011) Shuji Sai et al.   LEUKEMIA RESEARCH

Environmental inhibitors of 11β-hydroxysteroid dehydrogenase type 2

(2011) Xue Ma et al.   TOXICOLOGY

Cerebrotendinous xanthomatosis: An inborn error in bile acid synthesis with defined mutations but still a challenge

(2010) Ingemar Björkhem et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of 11β-hydroxysteroid dehydrogenase 1 and 2 by IGF-1 in mice

(2010) Yadong Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

11β-Hydroxysteroid dehydrogenase-type 2 evolved from an ancestral 17β-Hydroxysteroid dehydrogenase-type 2

(2010) Michael E. Baker   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparative transcriptomic analysis of follicle-enclosed oocyte maturational and developmental competence acquisition in two non-mammalian vertebrates

(2010) Maella Gohin et al.   BMC GENOMICS

11β-Hydroxysteroid dehydrogenase type 1 inhibition in type 2 diabetes mellitus

(2010) G. Hollis et al.   DIABETES OBESITY & METABOLISM

11 -Hydroxysteroid Dehydrogenase Type 1 Expression Is Increased in the Aged Mouse Hippocampus and Parietal Cortex and Causes Memory Impairments

(2010) M. C. Holmes et al.   JOURNAL OF NEUROSCIENCE

A novel NADP+-dependent dehydrogenase activity for 7α/β- and 11β-hydroxysteroids in human liver nuclei: A third 11β-hydroxysteroid dehydrogenase

(2009) B. Robinzon et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The mineralocorticoid receptor as a novel player in skin biology: beyond the renal horizon?

(2009) Nicolette Farman et al.   EXPERIMENTAL DERMATOLOGY

Age-related changes in the expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat Leydig cells.

(2009) Yvetta Koeva et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

The balance between gluco- and mineralo-corticoid action critically determines inflammatory adipocyte responses

(2009) J Hoppmann et al.   JOURNAL OF ENDOCRINOLOGY

The mineralocorticoid receptor and its coregulators

(2009) Jun Yang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Hypothalamic-Pituitary-Adrenal Axis Abnormalities in Response to Deletion of 11β-HSD1 is Strain-Dependent

(2009) R. N. Carter et al.   JOURNAL OF NEUROENDOCRINOLOGY

Direct protein–protein interaction of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the endoplasmic reticulum lumen

(2008) Atanas G. Atanasov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

7-Oxysterols Modulate Glucocorticoid Activity in Adipocytes through Competition for 11β-Hydroxysteroid Dehydrogenase Type

(2008) Malgorzata Wamil et al.   ENDOCRINOLOGY

Preadipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Keto-Reductase and Contributes to Diet-Induced Visceral Obesityin Vivo

(2008) R. A. De Sousa Peixoto et al.   ENDOCRINOLOGY

Steroid Biomarkers and Genetic Studies Reveal Inactivating Mutations in Hexose-6-Phosphate Dehydrogenase in Patients with Cortisone Reductase Deficiency

(2008) Gareth G. Lavery et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Expression of glucocorticoid receptor, mineralocorticoid receptor, and 11β-hydroxysteroid dehydrogenase 1 and 2 in the fetal and postnatal ovine hippocampus: ontogeny and effects of prenatal glucocorticoid exposure

(2008) Deborah M Sloboda et al.   JOURNAL OF ENDOCRINOLOGY

Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11β-hydroxysteroid dehydrogenase 1

(2008) Zoltán Balázs et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Glucocorticoid Regulation of the Promoter of 11β-Hydroxysteroid Dehydrogenase Type 1 Is Indirect and Requires CCAAT/Enhancer-Binding Protein-β

(2008) Shuji Sai et al.   MOLECULAR ENDOCRINOLOGY

Aromatase and 11β-hydroxysteroid dehydrogenase 2 localisation in the testes of pigs from birth to puberty linked to changes of hormone pattern and testicular morphology

(2008) A. Wagner et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Hexose-6-Phosphate Dehydrogenase and 11β-Hydroxysteroid Dehydrogenase-1 Tissue Distribution in the Rat

(2007) Elise P. Gomez-Sanchez et al.   ENDOCRINOLOGY

Cyp11b1 Is Induced in the Murine Gonad by Luteinizing Hormone/Human Chorionic Gonadotropin and Involved in the Production of 11-Ketotestosterone, a Major Fish Androgen: Conservation and Evolution of the Androgen Metabolic Pathway

(2007) Takashi Yazawa et al.   ENDOCRINOLOGY

Leydig cells from neonatal pig testis abundantly express 11β-hydroxysteroid dehydrogenase (11β-HSD) type 2 and effectively inactivate cortisol to cortisone

(2007) Y. Honda et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY