Pathogenic Role of Immune Cells in Rheumatoid Arthritis: Implications in Clinical Treatment and Biomarker Development

Sarilumab: Review of a Second IL-6 Receptor Antagonist Indicated for the Treatment of Rheumatoid Arthritis

(2018) Eric G. Boyce et al.   ANNALS OF PHARMACOTHERAPY

Regulatory T-cell dynamics with abatacept treatment in rheumatoid arthritis

(2018) Kane Langdon et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Anti -citrullinated peptide antibodies profiling in established rheumatoid arthritis

(2018) Maria Laura Manca et al.   JOINT BONE SPINE

Experimental arthritis: Anti-TNF kills the macrophage response

(2018) Sarah Onuora   Nature Reviews Rheumatology

Investigational therapies targeting the granulocyte macrophage colony-stimulating factor receptor-α in rheumatoid arthritis: focus on mavrilimumab

(2018) Andrew D. Cook et al.   Therapeutic Advances in Musculoskeletal Disease

T Cells That Help B Cells in Chronically Inflamed Tissues

(2018) Deepak A. Rao   Frontiers in Immunology

Fc fragments of immunoglobulin G are an inductor of regulatory rheumatoid factor and a promising therapeutic agent for rheumatic diseases

(2017) Alexandr Sidorov et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

High levels of soluble GPR56/ADGRG1 are associated with positive rheumatoid factor and elevated tumor necrosis factor in patients with rheumatoid arthritis

(2017) Wen-Yi Tseng et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

(2017) Deepak A. Rao et al.   NATURE

Quantification of cartilage oligomeric matrix protein (COMP) and a COMP neoepitope in synovial fluid of patients with different joint disorders by novel automated assays

(2017) P. Lorenzo et al.   OSTEOARTHRITIS AND CARTILAGE

The function of myeloid dendritic cells in rheumatoid arthritis

(2017) Mary Beth Yu et al.   RHEUMATOLOGY INTERNATIONAL

The role of autoantibodies in the pathophysiology of rheumatoid arthritis

(2017) V. F. A. M. Derksen et al.   Seminars in Immunopathology

Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date

(2017) Chiara Crotti et al.   Drug Design Development and Therapy

Reanalysis of the Multi-Biomarker Disease Activity Score for Assessing Disease Activity in the Abatacept Versus Adalimumab Comparison in Biologic-Naive Rheumatoid Arthritis Subjects with Background Methotrexate Study: Comment on the Article by Fleischmann

(2017) Jeffrey R. Curtis et al.   Arthritis & Rheumatology

A Multi-Biomarker Disease Activity Score and the Choice of Second-Line Therapy in Early Rheumatoid Arthritis After Methotrexate Failure

(2017) Karen Hambardzumyan et al.   Arthritis & Rheumatology

FRI0209 MORAb-022, An Anti-Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Monoclonal Antibody (MAB): Results of The First Study in Patients with Mild-To-Moderate Rheumatoid Arthritis (RA): Table 1.

(2016) A. Kivitz et al.   ANNALS OF THE RHEUMATIC DISEASES

Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis

(2016) Somaiya Mateen et al.   CLINICA CHIMICA ACTA

Denosumab: targeting the RANKL pathway to treat rheumatoid arthritis

(2016) Yahui Grace Chiu et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Developments with investigational Janus kinase inhibitors for rheumatoid arthritis

(2016) Luca Semerano et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Phase 2, randomised placebo-controlled trial to evaluate the efficacy and safety of an anti-GM-CSF antibody (KB003) in patients with inadequately controlled asthma

(2016) Nestor A Molfino et al.   BMJ Open

Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis

(2016) Nida Meednu et al.   Arthritis & Rheumatology

The Proportion of Regulatory T Cells in Patients with Rheumatoid Arthritis: A Meta-Analysis

(2016) Takayoshi Morita et al.   PLoS One

Efficacy and safety of tabalumab, an anti-B-cell-activating factor monoclonal antibody, in patients with rheumatoid arthritis who had an inadequate response to methotrexate therapy: results from a phase III multicentre, randomised, double-blind study

(2015) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Effect of denosumab on Japanese patients with rheumatoid arthritis: a dose–response study of AMG 162 (Denosumab) in patients withRheumatoId arthritis on methotrexate toValidate inhibitory effect on boneErosion (DRIVE)—a 12-month, multicentre, randomised, double-blind, placebo-controlled, phase II clinical trial

(2015) Tsutomu Takeuchi et al.   ANNALS OF THE RHEUMATIC DISEASES

Keratin 8 is a novel autoantigen of rheumatoid arthritis

(2015) Xiaoxu Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of cytokines in the pathogenesis of rheumatoid arthritis – Practical and potential application of cytokines as biomarkers and targets of personalized therapy

(2015) Edyta Brzustewicz et al.   CYTOKINE

Rheumatoid arthritis vaccine therapies: perspectives and lessons from therapeutic ligand epitope antigen presentation system vaccines for models of rheumatoid arthritis

(2015) Kenneth S Rosenthal et al.   Expert Review of Vaccines

Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications

(2015) Alessia Alunno et al.   MEDIATORS OF INFLAMMATION

Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis

(2015) F. Ciccia et al.   RHEUMATOLOGY

Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients

(2015) Helen Benham et al.   Science Translational Medicine

The specificity of anti-carbamylated protein antibodies for rheumatoid arthritis in a setting of early arthritis

(2015) Jing Shi et al.   ARTHRITIS RESEARCH & THERAPY

SAT0070 Levels of 14-3-3Eta Predict Good Eular Response to Anti-TNF Treatment in Patients with Rheumatoid Arthritis

(2014) A. Marotta et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-CarP antibodies as promising marker to measure joint damage and disease activity in patients with rheumatoid arthritis

(2014) Alvin Yee et al.   IMMUNOLOGIC RESEARCH

Hyaluronan nanoparticles bearing γ-secretase inhibitor: In vivo therapeutic effects on rheumatoid arthritis

(2014) Roun Heo et al.   JOURNAL OF CONTROLLED RELEASE

Vaccination without Autoantigen Protects against Collagen II-Induced Arthritis via Immune Deviation and Regulatory T Cells

(2014) I. Kochetkova et al.   JOURNAL OF IMMUNOLOGY

Serum 14-3-3  is a Novel Marker that Complements Current Serological Measurements to Enhance Detection of Patients with Rheumatoid Arthritis

(2014) W. P. Maksymowych et al.   JOURNAL OF RHEUMATOLOGY

Cytokines as Biomarkers in Rheumatoid Arthritis

(2014) Agata Burska et al.   MEDIATORS OF INFLAMMATION

Bone Remodelling Markers in Rheumatoid Arthritis

(2014) Patrice Fardellone et al.   MEDIATORS OF INFLAMMATION

The Status of Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibody Are Not Associated with the Effect of Anti-TNFα Agent Treatment in Patients with Rheumatoid Arthritis: A Meta-Analysis

(2014) Qianwen Lv et al.   PLoS One

B Cells in Rheumatoid Arthritis: From Pathogenic Players to Disease Biomarkers

(2014) Serena Bugatti et al.   Biomed Research International

Therapeutic Effects of PADRE-BAFF Autovaccine on Rat Adjuvant Arthritis

(2014) Guo-dong Feng et al.   Biomed Research International

B cell resistance to Fas-mediated apoptosis contributes to their ineffective control by regulatory T cells in rheumatoid arthritis

(2013) Laetitia Rapetti et al.   ANNALS OF THE RHEUMATIC DISEASES

MRP8/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis

(2013) Ivy Y Choi et al.   ANNALS OF THE RHEUMATIC DISEASES

Autoimmune markers for the diagnosis of rheumatoid arthritis in primary care: primary care diagnostic technology update

(2013) Kamal R Mahtani et al.   BRITISH JOURNAL OF GENERAL PRACTICE

Risk of tuberculosis with anti-tumor necrosis factor-α therapy: substantially higher number of patients at risk in Asia

(2013) Sandra V. Navarra et al.   International Journal of Rheumatic Diseases

Development of a Multi-Biomarker Disease Activity Test for Rheumatoid Arthritis

(2013) Michael Centola et al.   PLoS One

B Cells Contribute to Heterogeneity of IL-17 Producing Cells in Rheumatoid Arthritis and Healthy Controls

(2013) Paul Martin Schlegel et al.   PLoS One

Rituximab for the treatment of rheumatoid arthritis: an update

(2013) Chi Chiu Mok   Drug Design Development and Therapy

Treg Cells in Rheumatoid Arthritis: An Update

(2013) Faye A. H. Cooles et al.   Current Rheumatology Reports

Tocilizumab in rheumatoid arthritis: efficacy, safety and its place in therapy

(2013) Atsushi Kaneko   Therapeutic Advances in Chronic Disease

The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases

(2012) Eric Meffre   Annals of the New York Academy of Sciences

Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now?

(2012) C. M. U. Hilkens et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Regulation of B-cell responses by Toll-like receptors

(2012) Edward P. Browne   IMMUNOLOGY

Clinical Significance of Cartilage Biomarkers for Monitoring Structural Joint Damage in Rheumatoid Arthritis Patients Treated with Anti-TNF Therapy

(2012) Yasuo Niki et al.   PLoS One

Targeting monocytes/macrophages in the treatment of rheumatoid arthritis

(2012) J.-L. Davignon et al.   RHEUMATOLOGY

Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis

(2012) E. Choy   RHEUMATOLOGY

Natural Killer Cells and Their Role in Rheumatoid Arthritis: Friend or Foe?

(2012) Hamid Shegarfi et al.   TheScientificWorldJOURNAL

Rheumatoid arthritis disease activity measures: American College of Rheumatology recommendations for use in clinical practice

(2012) Jaclyn Anderson et al.   ARTHRITIS CARE & RESEARCH

B-cell selection and the development of autoantibodies

(2012) Natalia V Giltiay et al.   ARTHRITIS RESEARCH & THERAPY

High Survivin Levels Predict Poor Clinical Response to Infliximab Treatment in Patients with Rheumatoid Arthritis

(2011) Anniella Isgren et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Active immunization against IL-23p19 improves experimental arthritis

(2011) Rojo Anthony Ratsimandresy et al.   VACCINE

Nanotherapeutic approaches for the treatment of rheumatoid arthritis

(2011) Christine T. N. Pham   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium

(2011) Jolien Suurmond et al.   ARTHRITIS RESEARCH & THERAPY

Inflammation-independent defective early B cell tolerance checkpoints in rheumatoid arthritis

(2010) Laurence Menard et al.   ARTHRITIS AND RHEUMATISM

Treatment of rheumatoid arthritis with tumour necrosis factor inhibitors

(2010) Devesh Mewar et al.   BRITISH JOURNAL OF PHARMACOLOGY

CEL-2000: A therapeutic vaccine for rheumatoid arthritis arrests disease development and alters serum cytokine/chemokine patterns in the bovine collagen type II induced arthritis in the DBA mouse model

(2010) Daniel H. Zimmerman et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The vasculature in rheumatoid arthritis: cause or consequence?

(2010) Ewa M. Paleolog   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Golimumab for Rheumatoid Arthritis: A Systematic Review

(2010) J. A. SINGH et al.   JOURNAL OF RHEUMATOLOGY

Targeted Delivery of siRNA to Macrophages for Anti-inflammatory Treatment

(2010) Sang-Soo Kim et al.   MOLECULAR THERAPY

Certolizumab pegol in the treatment of rheumatoid arthritis: a comprehensive review of its clinical efficacy and safety

(2010) P. J. Mease   RHEUMATOLOGY

Does anti-mutated citrullinated vimentin have additional value as a serological marker in the diagnostic and prognostic investigation of patients with rheumatoid arthritis? A systematic review

(2009) J J Luime et al.   ANNALS OF THE RHEUMATIC DISEASES

Drug-specific risk of tuberculosis in patients with rheumatoid arthritis treated with anti-TNF therapy: results from the British Society for Rheumatology Biologics Register (BSRBR)

(2009) W. G. Dixon et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of CTA1R7K-COL-DD as a novel therapeutic mucosal tolerance-inducing vector for treatment of collagen-induced arthritis

(2009) Annemarie Hasselberg et al.   ARTHRITIS AND RHEUMATISM

Anti-citrullinated peptide antibody assays and their role in the diagnosis of rheumatoid arthritis

(2009) Rohit Aggarwal et al.   ARTHRITIS AND RHEUMATISM

Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy

(2009) Joseph R. Podojil et al.   IMMUNOLOGICAL REVIEWS

Dendritic cells as targets for therapy in rheumatoid arthritis

(2009) Shaukat Khan et al.   Nature Reviews Rheumatology

Autoantibodies in rheumatoid arthritis: rheumatoid factors and anticitrullinated protein antibodies

(2009) Y.W. Song et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

The role of interleukin-17 in the pathogenesis of rheumatoid arthritis

(2009) Sarah L. Gaffen   Current Rheumatology Reports

Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial

(2008) Stanley B. Cohen et al.   ARTHRITIS AND RHEUMATISM

Regulatory T cells (Treg) in rheumatoid arthritis

(2008) Marie-Christophe Boissier et al.   JOINT BONE SPINE

T cells in rheumatoid arthritis

(2008) Andrew P Cope   ARTHRITIS RESEARCH & THERAPY