Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 142, Issue 5, Pages 1423-1436Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2018.08.033
Keywords
Asthma; airway hyperreactivity; asthma biomarkers; asthma phenotypes; genetics; environment; respiratory viruses; allergens; eosinophils; helper T cells; B cells; innate lymphoid cells; neutrophils; biologic therapies; microbiome
Categories
Funding
- National Institutes of Health (NIH)
- Research Institute at Nationwide Children's Hospital
- NIH
- Patient-Centered Outcomes Research Institute
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This review summarizes some of the most significant advances in asthma research over the past year. We first focus on novel discoveries in the mechanism of asthma development and exacerbation. This is followed by a discussion of potential new biomarkers, including the use of radiographic markers of disease. Several new biologics have become available to the clinician in the past year, and we summarize these advances and how they can influence the clinical delivery of asthma care. After this, important findings in the genetics of asthma and heterogeneity in phenotypes of the disease are explored, as is the role the environment plays in shaping the development and exacerbation of asthma. Finally, we conclude with a discussion of advances in health literacy and how they will affect asthma care.
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