A guide to changing paradigms of glucocorticoid receptor function—a model system for genome regulation and physiology

An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors

(2021) David A. Garcia et al.   MOLECULAR CELL

The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers

(2021) Franziska Greulich et al.   Cell Reports

Androgen and glucocorticoid receptor direct distinct transcriptional programs by receptor-specific and shared DNA binding sites

(2021) Marina Kulik et al.   NUCLEIC ACIDS RESEARCH

Myod1 and GR coordinate myofiber-specific transcriptional enhancers

(2021) Daniela Rovito et al.   NUCLEIC ACIDS RESEARCH

Impaired Glucocorticoid Receptor Dimerization Aggravates LPS-Induced Circulatory and Pulmonary Dysfunction

(2020) Martin Wepler et al.   Frontiers in Immunology

Glucocorticoid Regulates Mesenchymal Cell Differentiation Required for Perinatal Lung Morphogenesis and Function

(2020) James P Bridges et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Role of Glucocorticoid Receptor and Oxytocin Receptor in the Septic Heart in a Clinically Relevant, Resuscitated Porcine Model With Underlying Atherosclerosis

(2020) Tamara Merz et al.   Frontiers in Endocrinology

Seq-ing answers: current data integration approaches to uncover mechanisms of transcriptional regulation

(2020) Barbara Höllbacher et al.   Computational and Structural Biotechnology Journal

Identification of glucocorticoid receptor in Drosophila melanogaster

(2020) Gloria Bartolo et al.   BMC MICROBIOLOGY

A natural Ala610Val substitution causing glucocorticoid receptor hypersensitivity aggravates consequences of endotoxemia

(2020) Zhiwei Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Anti-inflammatory functions of the glucocorticoid receptor require DNA binding

(2020) Laura Escoter-Torres et al.   NUCLEIC ACIDS RESEARCH

Gene-Specific Actions of Transcriptional Coregulators Facilitate Physiological Plasticity: Evidence for a Physiological Coregulator Code

(2020) Michael R. Stallcup et al.   TRENDS IN BIOCHEMICAL SCIENCES

STAT3 and GR cooperate to drive gene expression and growth of basal-like triple-negative breast cancer

(2020) Megan E Conway et al.   CANCER RESEARCH

Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment

(2020) Nandini Acharya et al.   IMMUNITY

Glucocorticoid receptor activities in the zebrafish model: a review

(2020) Alberto Dinarello et al.   JOURNAL OF ENDOCRINOLOGY

E47 modulates hepatic glucocorticoid action

(2019) M. Charlotte Hemmer et al.   Nature Communications

Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus

(2019) Matthew D. Taves et al.   Cell Reports

FPbase: a community-editable fluorescent protein database

(2019) Talley J. Lambert   NATURE METHODS

Repetitive switching between DNA-binding modes enables target finding by the glucocorticoid receptor

(2019) Veer I. P. Keizer et al.   JOURNAL OF CELL SCIENCE

Clinical profile of the functionally selective glucocorticoid receptor agonist BI 653048 in healthy male subjects

(2019) Christian Harcken et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Glucocorticoid receptor quaternary structure drives chromatin occupancy and transcriptional outcome

(2019) Ville Paakinaho et al.   GENOME RESEARCH

Conditional deletion of glucocorticoid receptors in rat brain results in sex-specific deficits in fear and coping behaviors

(2019) Jessie R Scheimann et al.   eLife

A General Introduction to Glucocorticoid Biology

(2019) Steven Timmermans et al.   Frontiers in Immunology

Transcriptional Bursting and Co-bursting Regulation by Steroid Hormone Release Pattern and Transcription Factor Mobility

(2019) Diana A. Stavreva et al.   MOLECULAR CELL

Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor

(2019) Laura Escoter-Torres et al.   Frontiers in Immunology

Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet

(2019) Fabiana Quagliarini et al.   MOLECULAR CELL

Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis

(2018) Mascha Koenen et al.   ANNALS OF THE RHEUMATIC DISEASES

Induced global deletion of glucocorticoid receptor impairs fracture healing

(2018) Anna E. Rapp et al.   FASEB JOURNAL

Pioneer transcription factors shape the epigenetic landscape

(2018) Alexandre Mayran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired resolution of DSS-induced colitis in mice lacking the glucocorticoid receptor in myeloid cells

(2018) Garrit K. Meers et al.   PLoS One

Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility

(2018) Julia K Gjerstad et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements

(2018) William H. Hudson et al.   Nature Communications

Psychosocial Stress and Immunity—What Can We Learn From Pig Studies?

(2018) Ulrike Gimsa et al.   Frontiers in Behavioral Neuroscience

Pre-established Chromatin Interactions Mediate the Genomic Response to Glucocorticoids

(2018) Anthony M. D'Ippolito et al.   Cell Systems

The Development and Enhancement of FRAP as a Key Tool for Investigating Protein Dynamics

(2018) Jennifer Lippincott-Schwartz et al.   BIOPHYSICAL JOURNAL

Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding

(2018) Ian C. McDowell et al.   GENOME RESEARCH

Joint profiling of chromatin accessibility and gene expression in thousands of single cells

(2018) Junyue Cao et al.   SCIENCE

A New Tool for Inducible Gene Expression in Caenorhabditis elegans

(2018) Gabriela C. Monsalve et al.   GENETICS

Non-genomic Effects of Glucocorticoids: An Updated View

(2018) Reynold A. Panettieri et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

NeuroD Factors Discriminate Mineralocorticoid From Glucocorticoid Receptor DNA Binding in the Male Rat Brain

(2017) Lisa T.C.M. van Weert et al.   ENDOCRINOLOGY

The glucocorticoid receptor in monocyte-derived macrophages is critical for cardiac infarct repair and remodeling

(2017) Paolo Galuppo et al.   FASEB JOURNAL

Glucocorticoid receptor binding to chromatin is selectively controlled by the coregulator Hic-5 and chromatin remodeling enzymes

(2017) Brian H. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages

(2017) Fansheng Kong et al.   JOURNAL OF IMMUNOLOGY

Quantifying transcription factor binding dynamics at the single-molecule level in live cells

(2017) Diego M. Presman et al.   METHODS

Glucocorticoid receptor control of transcription: precision and plasticity via allostery

(2017) Emily R. Weikum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes

(2017) Emily R. Weikum et al.   NUCLEIC ACIDS RESEARCH

DNA residence time is a regulatory factor of transcription repression

(2017) Karen Clauß et al.   NUCLEIC ACIDS RESEARCH

Conventional and pioneer modes of glucocorticoid receptor interaction with enhancer chromatin in vivo

(2017) Thomas A Johnson et al.   NUCLEIC ACIDS RESEARCH

Nuclear Receptor Function through Genomics: Lessons from the Glucocorticoid Receptor

(2017) Daniel M. Cohen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages

(2017) David A. Rollins et al.   Nature Communications

Single-molecule analysis of steroid receptor and cofactor action in living cells

(2017) Ville Paakinaho et al.   Nature Communications

Mapping the Dynamics of the Glucocorticoid Receptor within the Nuclear Landscape

(2017) Martin Stortz et al.   Scientific Reports

Guidelines for morpholino use in zebrafish

(2017) Didier Y. R. Stainier et al.   PLoS Genetics

The regulation of the mitochondrial apoptotic pathway by glucocorticoid receptor in collaboration with Bcl-2 family proteins in developing T cells

(2016) Lilla Prenek et al.   APOPTOSIS

Chronic Stress Increases Prefrontal Inhibition: A Mechanism for Stress-Induced Prefrontal Dysfunction

(2016) Jessica M. McKlveen et al.   BIOLOGICAL PSYCHIATRY

Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions

(2016) Erin E. Swinstead et al.   CELL

Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome

(2016) Christopher M. Vockley et al.   CELL

Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition

(2016) Kristina M. Mueller et al.   DIABETES

Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish

(2016) Maria Tsachaki et al.   JOURNAL OF ENDOCRINOLOGY

DNA binding triggers tetramerization of the glucocorticoid receptor in live cells

(2016) Diego M. Presman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic effects of glucocorticoids

(2016) Ivana Grbesa et al.   PROTOPLASMA

Corticosteroids

(2016) Sivapriya Ramamoorthy et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity

(2016) Stefanie Schöne et al.   Nature Communications

A naturally hypersensitive glucocorticoid receptor elicits a compensatory reduction of hypothalamus–pituitary–adrenal axis activity early in ontogeny

(2016) Eduard Muráni et al.   Open Biology

Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production

(2016) David J. Morgan et al.   Scientific Reports

Specificity and sensitivity of glucocorticoid signaling in health and disease

(2015) Derek W. Cain et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

The glucocorticoid receptor in inflammatory processes: transrepression is not enough

(2015) Sabine Hübner et al.   BIOLOGICAL CHEMISTRY

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo

(2015) Hee-Woong Lim et al.   GENOME RESEARCH

Dynamics of chromatin accessibility and long-range interactions in response to glucocorticoid pulsing

(2015) Diana A. Stavreva et al.   GENOME RESEARCH

Imaging Live-Cell Dynamics and Structure at the Single-Molecule Level

(2015) Zhe Liu et al.   MOLECULAR CELL

Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space

(2015) William H. Hudson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression

(2015) Guoqiang Hua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex

(2015) Guoqiang Hua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The novel strategy of glucocorticoid drug development via targeting nongenomic mechanisms

(2015) Chun-Lei Jiang et al.   STEROIDS

Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1

(2015) Sabine Vettorazzi et al.   Nature Communications

Skin and glucocorticoids: effects of local skin glucocorticoid impairment on skin homeostasis

(2014) Georgios Nikolakis et al.   EXPERIMENTAL DERMATOLOGY

A transgenic zebrafish model for monitoring glucocorticoid receptor activity

(2014) R. G. Krug et al.   GENES BRAIN AND BEHAVIOR

The selective glucocorticoid receptor antagonist CORT 108297 decreases neuroendocrine stress responses and immobility in the forced swim test

(2014) Matia B. Solomon et al.   HORMONES AND BEHAVIOR

Porcine glucocorticoid receptor (NR3C1) gene: Tissue-specificity of transcriptional strength and glucocorticoid responsiveness of alternative promoters

(2014) Zheng Jiang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

A living biosensor model to dynamically trace glucocorticoid transcriptional activity during development and adult life in zebrafish

(2014) Francesca Benato et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Heritable Multiplex Genetic Engineering in Rats Using CRISPR/Cas9

(2014) Yuanwu Ma et al.   PLoS One

Quantitation of Glucocorticoid Receptor DNA-Binding Dynamics by Single-Molecule Microscopy and FRAP

(2014) Femke L. Groeneweg et al.   PLoS One

Distinctly Different Dynamics and Kinetics of Two Steroid Receptors at the Same Response Elements in Living Cells

(2014) Hatice Z. Nenseth et al.   PLoS One

Glucocorticoid receptors in the nucleus of the solitary tract (NTS) decrease endocrine and behavioral stress responses

(2014) Sriparna Ghosal et al.   PSYCHONEUROENDOCRINOLOGY

Single-molecule analysis of transcription factor binding at transcription sites in live cells

(2014) Tatsuya Morisaki et al.   Nature Communications

Live Cell Imaging Unveils Multiple Domain Requirements for In Vivo Dimerization of the Glucocorticoid Receptor

(2014) Diego M. Presman et al.   PLOS BIOLOGY

Role of Prefrontal Cortex Glucocorticoid Receptors in Stress and Emotion

(2013) Jessica M. McKlveen et al.   BIOLOGICAL PSYCHIATRY

C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements

(2013) Lars Grøntved et al.   EMBO JOURNAL

Transcript variants of the porcine glucocorticoid receptor gene (NR3C1)

(2013) Henry Reyer et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Steroidogenesis in the skin: Implications for local immune functions

(2013) Andrzej Slominski et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Disrupting Hypothalamic Glucocorticoid Receptors Causes HPA Axis Hyperactivity and Excess Adiposity

(2013) Gloria Laryea et al.   MOLECULAR ENDOCRINOLOGY

Single-molecule imaging of transcription factor binding to DNA in live mammalian cells

(2013) J Christof M Gebhardt et al.   NATURE METHODS

FoxA1 Specifies Unique Androgen and Glucocorticoid Receptor Binding Events in Prostate Cancer Cells

(2012) B. Sahu et al.   CANCER RESEARCH

Analysis of Chromatin Dynamics during Glucocorticoid Receptor Activation

(2012) C. J. Burd et al.   MOLECULAR AND CELLULAR BIOLOGY

Insights into Negative Regulation by the Glucocorticoid Receptor from Genome-wide Profiling of Inflammatory Cistromes

(2012) N. Henriette Uhlenhaut et al.   MOLECULAR CELL

A Substitution in the Ligand Binding Domain of the Porcine Glucocorticoid Receptor Affects Activity of the Adrenal Gland

(2012) Eduard Murani et al.   PLoS One

Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids

(2012) Y. Chinenov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

It takes two to tango: Dimerisation of glucocorticoid receptor and its anti-inflammatory functions

(2012) Mark Nixon et al.   STEROIDS

A zebrafish model of glucocorticoid resistance shows serotonergic modulation of the stress response

(2012) Brian B. Griffiths et al.   Frontiers in Behavioral Neuroscience

Glucocorticoids induce mitochondrial gene transcription in HepG2 cells

(2011) Anna-Maria G. Psarra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor

(2011) Milan Surjit et al.   CELL

Dynamic Exchange at Regulatory Elements during Chromatin Remodeling Underlies Assisted Loading Mechanism

(2011) Ty C. Voss et al.   CELL

Extensive chromatin remodelling and establishment of transcription factor ‘hotspots’ during early adipogenesis

(2011) Rasmus Siersbaek et al.   EMBO JOURNAL

Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer

(2011) Biswajyoti Sahu et al.   EMBO JOURNAL

Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages

(2011) Anna Kleiman et al.   FASEB JOURNAL

Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements

(2011) O. Hakim et al.   GENOME RESEARCH

Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding

(2011) Simon C. Biddie et al.   MOLECULAR CELL

Chromatin accessibility pre-determines glucocorticoid receptor binding patterns

(2011) Sam John et al.   NATURE GENETICS

Maps and legends: The quest for dissociated ligands of the glucocorticoid receptor

(2011) Andrew R. Clark et al.   PHARMACOLOGY & THERAPEUTICS

Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells

(2011) U. Baschant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of molecular chaperones and TPR-domain proteins in the cytoplasmic transport of steroid receptors and their passage through the nuclear pore

(2011) Mario D. Galigniana et al.   Nucleus

Cross-Validating FRAP and FCS to Quantify the Impact of Photobleaching on In Vivo Binding Estimates

(2010) Timothy J. Stasevich et al.   BIOPHYSICAL JOURNAL

Glucocorticoids Suppress Bone Formation by Attenuating Osteoblast Differentiation via the Monomeric Glucocorticoid Receptor

(2010) Alexander Rauch et al.   Cell Metabolism

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

(2010) Qihuang Jin et al.   EMBO JOURNAL

Regulation of the Hypothalamic-Pituitary-Adrenal Axis Circadian Rhythm by Endocannabinoids Is Sexually Diergic

(2010) Helen C. Atkinson et al.   ENDOCRINOLOGY

Discovery of Glucocorticoid Receptor-β in Mice with a Role in Metabolism

(2010) Terry D. Hinds et al.   MOLECULAR ENDOCRINOLOGY

Insights on Glucocorticoid Receptor Activity Modulation through the Binding of Rigid Steroids

(2010) Diego M. Presman et al.   PLoS One

Mifepristone decreases depression-like behavior and modulates neuroendocrine and central hypothalamic–pituitary–adrenocortical axis responsiveness to stress

(2010) Aynara C. Wulsin et al.   PSYCHONEUROENDOCRINOLOGY

Glucocorticoid Production and Regulation in Thymus: Of Mice and Birds

(2009) Celso E. Gomez-Sanchez   ENDOCRINOLOGY

Mitochondrial translocation of the glucocorticoid receptor in double-positive thymocytes correlates with their sensitivity to glucocorticoid-induced apoptosis

(2009) Gergely Talabér et al.   INTERNATIONAL IMMUNOLOGY

Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription

(2009) Diana A. Stavreva et al.   NATURE CELL BIOLOGY

HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis

(2008) Georgyi V. Los et al.   ACS Chemical Biology

Glucocorticoids inhibit degranulation of mast cells in allergic asthma via nongenomic mechanism

(2008) J. Zhou et al.   ALLERGY

Evidence for a Common Mode of Transcription Factor Interaction with Chromatin as Revealed by Improved Quantitative Fluorescence Recovery after Photobleaching

(2008) Florian Mueller et al.   BIOPHYSICAL JOURNAL

Dexamethasone augments CXCR4-mediated signaling in resting human T cells via the activation of the Src kinase Lck

(2008) M. C. Ghosh et al.   BLOOD

Effects of minor laboratory procedures, adrenalectomy, social defeat or acute alcohol on regional brain concentrations of corticosterone

(2008) Adam P. Croft et al.   BRAIN RESEARCH

Controlling morpholino experiments: don't stop making antisense

(2008) J. S. Eisen et al.   DEVELOPMENT

Characterization of a Novel Gain of Function Glucocorticoid Receptor Knock-in Mouse

(2008) Junhui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis

(2008) G. Chamilos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocorticoid receptor dynamics and gene regulation

(2008) Simon C. Biddie et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Mapping the Number of Molecules and Brightness in the Laser Scanning Microscope

(2007) Michelle A. Digman et al.   BIOPHYSICAL JOURNAL

Discovery of a Functional Glucocorticoid Receptor β-Isoform in Zebrafish

(2007) Marcel J. M. Schaaf et al.   ENDOCRINOLOGY