Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration

Microglial Markers are Elevated in the Prodromal Phase of Alzheimer's Disease and Vascular Dementia

(2018) Bob Olsson et al.   JOURNAL OF ALZHEIMERS DISEASE

Female Hippocampus Vulnerability to Environmental Stress, a Precipitating Factor in Tau Aggregation Pathology

(2018) Ioannis Sotiropoulos et al.   JOURNAL OF ALZHEIMERS DISEASE

The dynamics of the stress neuromatrix

(2016) N Sousa   MOLECULAR PSYCHIATRY

Nucleus Accumbens Medium Spiny Neuron Subtypes Mediate Depression-Related Outcomes to Social Defeat Stress

(2015) T. Chase Francis et al.   BIOLOGICAL PSYCHIATRY

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Methylation at the CpG island shore region upregulatesNr3c1promoter activity after early-life stress

(2015) Yvonne Bockmühl et al.   Epigenetics

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

(2015) Keith A. Vossel et al.   JOURNAL OF CELL BIOLOGY

60 YEARS OF NEUROENDOCRINOLOGY: Redefining neuroendocrinology: stress, sex and cognitive and emotional regulation

(2015) Bruce S McEwen et al.   JOURNAL OF ENDOCRINOLOGY

The Importance of Biological Oscillators for Hypothalamic-Pituitary-Adrenal Activity and Tissue Glucocorticoid Response: Coordinating Stress and Neurobehavioural Adaptation

(2015) G. M. Russell et al.   JOURNAL OF NEUROENDOCRINOLOGY

Stress effects on the neural substrates of motivated behavior

(2015) Nick G Hollon et al.   NATURE NEUROSCIENCE

Sex differences and stress across the lifespan

(2015) Tracy L Bale et al.   NATURE NEUROSCIENCE

Mechanisms of stress in the brain

(2015) Bruce S McEwen et al.   NATURE NEUROSCIENCE

Molecular mechanisms in the regulation of adult neurogenesis during stress

(2015) Martin Egeland et al.   NATURE REVIEWS NEUROSCIENCE

Toward Understanding How Early-Life Stress Reprograms Cognitive and Emotional Brain Networks

(2015) Yuncai Chen et al.   NEUROPSYCHOPHARMACOLOGY

Inflammation is genetically implicated in Parkinson’s disease

(2015) N. Dzamko et al.   NEUROSCIENCE

Glucocorticoid enhancement of dorsolateral striatum-dependent habit memory requires concurrent noradrenergic activity

(2015) J. Goodman et al.   NEUROSCIENCE

Microglial Malfunction: The Third Rail in the Development of Alzheimer's Disease

(2015) Siddhita D. Mhatre et al.   TRENDS IN NEUROSCIENCES

Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation

(2015) Paul J. Lucassen et al.   Cold Spring Harbor Perspectives in Biology

Work Stress as a Risk Factor for Cardiovascular Disease

(2015) Mika Kivimäki et al.   Current Cardiology Reports

Fetal Programming of the Human Brain: Is there a Link with Insurgence of Neurodegenerative Disorders in Adulthood?

(2014) G. Faa et al.   CURRENT MEDICINAL CHEMISTRY

Premotor and nonmotor features of Parkinsonʼs disease

(2014) Jennifer G. Goldman et al.   CURRENT OPINION IN NEUROLOGY

The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition

(2014) Mónica Morais et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

Glucocorticoids and fetal programming part 1: outcomes

(2014) Vasilis G. Moisiadis et al.   Nature Reviews Endocrinology

Glucocorticoids and fetal programming part 2: mechanisms

(2014) Vasilis G. Moisiadis et al.   Nature Reviews Endocrinology

Enhancing Depression Mechanisms in Midbrain Dopamine Neurons Achieves Homeostatic Resilience

(2014) A. K. Friedman et al.   SCIENCE

An Antidepressant Decreases CSF A  Production in Healthy Individuals and in Transgenic AD Mice

(2014) Y. I. Sheline et al.   Science Translational Medicine

Neuropathology of stress

(2013) Paul J. Lucassen et al.   ACTA NEUROPATHOLOGICA

Microglia actions in Alzheimer’s disease

(2013) Stefan Prokop et al.   ACTA NEUROPATHOLOGICA

Effects of Early Maternal Separation on Biobehavioral and Neuropathological Markers of Alzheimer's Disease in Adult Male Rats

(2013) Eva Martisova et al.   Current Alzheimer Research

The biology of the glucocorticoid receptor: New signaling mechanisms in health and disease

(2013) Robert H. Oakley et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Non-receptor-tyrosine Kinases Integrate Fast Glucocorticoid Signaling in Hippocampal Neurons

(2013) Silei Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress exacerbates experimental Parkinson’s disease

(2013) A M Hemmerle et al.   MOLECULAR PSYCHIATRY

Distinct Representations of Cognitive and Motivational Signals in Midbrain Dopamine Neurons

(2013) Masayuki Matsumoto et al.   NEURON

The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course

(2013) Bruce S. McEwen et al.   NEURON

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

(2013) Grietje Krabbe et al.   PLoS One

Chronic Stress Triggers Social Aversion via Glucocorticoid Receptor in Dopaminoceptive Neurons

(2013) J. Barik et al.   SCIENCE

A case of early onset Parkinson's disease after major stress

(2013) Zhong Zheng et al.   Neuropsychiatric Disease and Treatment

A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia

(2012) Ross J. Tynan et al.   BRAIN BEHAVIOR AND IMMUNITY

Quinolinic acid: neurotoxicity

(2012) Gilles J. Guillemin   FEBS Journal

APOE genotype alters glial activation and loss of synaptic markers in mice

(2012) Yuangui Zhu et al.   GLIA

How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering

(2012) Dariusz Ratman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens

(2012) Byung Kook Lim et al.   NATURE

Dopamine neurons modulate neural encoding and expression of depression-related behaviour

(2012) Kay M. Tye et al.   NATURE

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

(2012) Dipesh Chaudhury et al.   NATURE

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Supportive evidence for 11 loci from genome-wide association studies in Parkinson's disease

(2012) Lasse Pihlstrøm et al.   NEUROBIOLOGY OF AGING

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Gestational Restraint Stress and the Developing Dopaminergic System: An Overview

(2012) Carlos J. Baier et al.   NEUROTOXICITY RESEARCH

In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease

(2012) S. Iannaccone et al.   PARKINSONISM & RELATED DISORDERS

Disconnection and reconnection: the morphological basis of (mal)adaptation to stress

(2012) Nuno Sousa et al.   TRENDS IN NEUROSCIENCES

Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses

(2011) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Neurogenesis in Alzheimer’s disease

(2011) José J. Rodríguez et al.   JOURNAL OF ANATOMY

Chronic Stress Exacerbates Tau Pathology, Neurodegeneration, and Cognitive Performance through a Corticotropin-Releasing Factor Receptor-Dependent Mechanism in a Transgenic Mouse Model of Tauopathy

(2011) J. C. Carroll et al.   JOURNAL OF NEUROSCIENCE

Stress Acts Cumulatively To Precipitate Alzheimer's Disease-Like Tau Pathology and Cognitive Deficits

(2011) I. Sotiropoulos et al.   JOURNAL OF NEUROSCIENCE

 -Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

(2011) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Mechanisms of initiation and reversal of drug-seeking behavior induced by prenatal exposure to glucocorticoids

(2011) A J Rodrigues et al.   MOLECULAR PSYCHIATRY

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

(2011) Jason S. Snyder et al.   NATURE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

CSF tau markers are correlated with hippocampal volume in Alzheimer's disease

(2011) Leonardo C. de Souza et al.   NEUROBIOLOGY OF AGING

What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease

(2011) Olga Corti et al.   PHYSIOLOGICAL REVIEWS

Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism

(2011) F. Ros-Bernal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relationships between age and late progression of Parkinson's disease: a clinico-pathological study

(2010) P. A. Kempster et al.   BRAIN

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses

(2010) Tim F. Oberlander et al.   Epigenetics

Glucocorticoids, prenatal stress and the programming of disease

(2010) Anjanette Harris et al.   HORMONES AND BEHAVIOR

Glucocorticoids Exacerbate Lipopolysaccharide-Induced Signaling in the Frontal Cortex and Hippocampus in a Dose-Dependent Manner

(2010) C. D. Munhoz et al.   JOURNAL OF NEUROSCIENCE

Greater Prevalence and Incidence of Dementia in Older Veterans with Posttraumatic Stress Disorder

(2010) Salah U. Qureshi et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

The Role of Stress Factors during Aging of the Immune System

(2009) Moisés E. Bauer et al.   Annals of the New York Academy of Sciences

Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration

(2009) Shuei Sugama et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription

(2009) Diana A. Stavreva et al.   NATURE CELL BIOLOGY

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

(2009) Patrick O McGowan et al.   NATURE NEUROSCIENCE

Dynamic DNA methylation programs persistent adverse effects of early-life stress

(2009) Chris Murgatroyd et al.   NATURE NEUROSCIENCE

CSF biomarkers in relationship to cognitive profiles in Alzheimer disease

(2009) A. E. van der Vlies et al.   NEUROLOGY

Adverse Stress, Hippocampal Networks, and Alzheimer’s Disease

(2009) Sarah M. Rothman et al.   NEUROMOLECULAR MEDICINE

Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response

(2009) Robert J. Schloesser et al.   NEUROREPORT

Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making

(2009) E. Dias-Ferreira et al.   SCIENCE

Human innate immunosenescence: causes and consequences for immunity in old age

(2009) Alexander Panda et al.   TRENDS IN IMMUNOLOGY

Psychological distress and risk for dementia

(2009) Martine Simard et al.   Current Psychiatry Reports

Amyloid-Associated Depression

(2008) Xiaoyan Sun et al.   ARCHIVES OF GENERAL PSYCHIATRY

Central corticosteroid actions: Search for gene targets

(2008) Nicole A. Datson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau

(2008) Ioannis Sotiropoulos et al.   JOURNAL OF NEUROCHEMISTRY

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling

(2008) J M Bessa et al.   MOLECULAR PSYCHIATRY

Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole

(2008) M Banasr et al.   MOLECULAR PSYCHIATRY

Stress and glucocorticoid footprints in the brain—The path from depression to Alzheimer's disease

(2008) I. Sotiropoulos et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Maternal separation exaggerates the toxic effects of 6-hydroxydopamine in rats: Implications for neurodegenerative disorders

(2008) I. S. Pienaar et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE