Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management
Authors
Keywords
-
Journal
Cells
Volume 10, Issue 11, Pages 2887
Publisher
MDPI AG
Online
2021-10-27
DOI
10.3390/cells10112887
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The umbilical cord mesenchymal stem cell‐derived exosomal lncRNA H19 improves osteochondral activity through miR‐29b‐3p/FoxO3 axis
- (2021) Litao Yan et al. Clinical and Translational Medicine
- The tissue origin effect of extracellular vesicles on cartilage and bone regeneration
- (2021) Qi Li et al. Acta Biomaterialia
- Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles
- (2021) Daniel E. Murphy et al. NANO LETTERS
- Amniotic membrane‐mesenchymal stromal cells secreted factors and extracellular vesicle ‐miRNAs : Anti‐inflammatory and regenerative features for musculoskeletal tissues
- (2021) Enrico Ragni et al. Stem Cells Translational Medicine
- Exosome-Encapsulated microRNA-127-3p Released from Bone Marrow-Derived Mesenchymal Stem Cells Alleviates Osteoarthritis Through Regulating CDH11-Mediated Wnt/β-Catenin Pathway
- (2021) Jisheng Dong et al. Journal of Pain Research
- Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles
- (2021) Mario Gimona et al. CYTOTHERAPY
- Exosome Traceability and Cell Source Dependence on Composition and Cell-Cell Cross Talk
- (2021) Rabab N. Hamzah et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mesenchymal Stem Cell-Derived Exosomes and Their Therapeutic Potential for Osteoarthritis
- (2021) Gi Beom Kim et al. Biology-Basel
- Role of extracellular vesicles from adipose tissue‐ and bone marrow‐mesenchymal stromal cells in endothelial proliferation and chondrogenesis
- (2021) Cansu Gorgun et al. Stem Cells Translational Medicine
- Enhancement of acellular cartilage matrix scaffold by Wharton's jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration
- (2021) Shuangpeng Jiang et al. Bioactive Materials
- Secreted Factors and EV-miRNAs Orchestrate the Healing Capacity of Adipose Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis
- (2020) Enrico Ragni et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Osteoarthritis year in review 2019: epidemiology and therapy
- (2020) M. Kloppenburg et al. OSTEOARTHRITIS AND CARTILAGE
- Integration of Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes with Hydroxyapatite-Embedded Hyaluronic Acid-Alginate Hydrogel for Bone Regeneration
- (2020) Shuo Yang et al. ACS Biomaterials-Science & Engineering
- Reduction of the therapeutic dose of silencing RNA by packaging it in extracellular vesicles via a pre-microRNA backbone
- (2020) Ryan Reshke et al. Nature Biomedical Engineering
- Intra-Articular Injections of Mesenchymal Stem Cell Exosomes and Hyaluronic Acid Improve Structural and Mechanical Properties of Repaired Cartilage in a Rabbit Model
- (2020) Keng Lin Wong et al. ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
- The use of large animals to facilitate the process of MSC going from laboratory to patient—‘bench to bedside’
- (2020) W. E. Hotham et al. CELL BIOLOGY AND TOXICOLOGY
- The Fibroblast-Like Synoviocyte Derived Exosomal Long Non-coding RNA H19 Alleviates Osteoarthritis Progression Through the miR-106b-5p/TIMP2 Axis
- (2020) Fengjin Tan et al. INFLAMMATION
- Exosomes derived from umbilical cord mesenchymal stem cells in mechanical environment show improved osteochondral activity via upregulation of LncRNA H19
- (2020) Litao Yan et al. Journal of Orthopaedic Translation
- Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy
- (2020) Yujie Liang et al. ACS Applied Materials & Interfaces
- Engineered-extracellular vesicles as an optimistic tool for microRNA delivery for osteoarthritis treatment
- (2020) Abazar Esmaeili et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis
- (2020) Lei He et al. Stem Cell Research & Therapy
- Extracellular vesicle–encapsulated IL-10 as novel nanotherapeutics against ischemic AKI
- (2020) Tao-Tao Tang et al. Science Advances
- Mesenchymal Stromal Cells and Exosomes: Progress and Challenges
- (2020) Matthew H. Forsberg et al. Frontiers in Cell and Developmental Biology
- Comparison of two ASC-derived therapeutics in an in vitro OA model: secretome versus extracellular vesicles
- (2020) Chiara Giannasi et al. Stem Cell Research & Therapy
- TGF-β1-containing exosomes derived from bone marrow mesenchymal stem cells promote proliferation, migration and fibrotic activity in rotator cuff tenocytes
- (2020) Jia Li et al. Regenerative Therapy
- Interaction with hyaluronan matrix and miRNA cargo as contributors for in vitro potential of mesenchymal stem cell-derived extracellular vesicles in a model of human osteoarthritic synoviocytes
- (2019) Enrico Ragni et al. Stem Cell Research & Therapy
- Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency
- (2019) Christina Schindler et al. PLoS One
- Exosome microRNA signatures in patients with complex regional pain syndrome undergoing plasma exchange
- (2019) Sujay Ramanathan et al. Journal of Translational Medicine
- Exosomes derived from mesenchymal stem cells inhibit mitochondrial dysfunction-induced apoptosis of chondrocytes via p38, ERK, and Akt pathways
- (2019) Hui Qi et al. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
- Inhibition of MMPs and ADAM/ADAMTS
- (2019) Charles J. Malemud BIOCHEMICAL PHARMACOLOGY
- MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis
- (2019) Shipin Zhang et al. BIOMATERIALS
- The Pros and Cons of Mesenchymal Stem Cell-Based Therapies
- (2019) Aleksandra Musiał-Wysocka et al. CELL TRANSPLANTATION
- Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes
- (2019) Sangiliyandi Gurunathan et al. Cells
- miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis
- (2019) Jiangyi Wu et al. BIOMATERIALS
- Comparison of the therapeutic effect of amniotic fluid stem cells and their exosomes on monoiodoacetate‐induced animal model of osteoarthritis
- (2019) Manuela Zavatti et al. BIOFACTORS
- Human bone mesenchymal stem cells-derived exosomes overexpressing microRNA-26a-5p alleviate osteoarthritis via down-regulation of PTGS2
- (2019) Zhe Jin et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- BMSCs‐Derived Exosomes Ameliorate Pain Via Abrogation of Aberrant Nerve Invasion in Subchondral Bone in Lumbar Facet Joint Osteoarthritis
- (2019) Jinsong Li et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Exosome surface glycans reflect osteogenic differentiation of mesenchymal stem cells: Profiling by an evanescent field fluorescence-assisted lectin array system
- (2019) Asako Shimoda et al. Scientific Reports
- Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity
- (2019) Litao Yan et al. CELL BIOLOGY AND TOXICOLOGY
- Kartogenin enhances the therapeutic effect of bone marrow mesenchymal stem cells derived exosomes in cartilage repair
- (2019) Chun Liu et al. Nanomedicine
- Methotrexate-Loaded Extracellular Vesicles Functionalized with Therapeutic and Targeted Peptides for the Treatment of Glioblastoma Multiforme
- (2018) Zhilan Ye et al. ACS Applied Materials & Interfaces
- MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity
- (2018) Shipin Zhang et al. BIOMATERIALS
- Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy
- (2018) Yu-Hsun Chang et al. CELL TRANSPLANTATION
- Microvesicles from Human Adipose Tissue-Derived Mesenchymal Stem Cells as a New Protective Strategy in Osteoarthritic Chondrocytes
- (2018) Miguel Tofiño-Vian et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Induction of osteoarthritis by injecting monosodium iodoacetate into the patellofemoral joint of an experimental rat model
- (2018) Ikufumi Takahashi et al. PLoS One
- Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy
- (2018) Xianjun Gao et al. Science Translational Medicine
- Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro
- (2018) Lucienne A. Vonk et al. Theranostics
- Comparison of exosome-mimicking liposomes with conventional liposomes for intracellular delivery of siRNA
- (2018) Mei Lu et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Expression of exosomal microRNAs during chondrogenic differentiation of human bone mesenchymal stem cells
- (2018) Hao Sun et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach
- (2018) Sander A. A. Kooijmans et al. Nanoscale
- Pro inflammatory stimuli enhance the immunosuppressive functions of adipose mesenchymal stem cells-derived exosomes
- (2018) Rossana Domenis et al. Scientific Reports
- Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A
- (2018) Guping Mao et al. Stem Cell Research & Therapy
- MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis
- (2018) Yubao Liu et al. CELL CYCLE
- Exosome-mediated delivery of functionally active miRNA-142-3p inhibitor reduces tumorigenicity of breast cancer in vitro and in vivo
- (2018) Zahra Naseri et al. International Journal of Nanomedicine
- Models of osteoarthritis: the good, the bad and the promising
- (2018) P.J. Cope et al. OSTEOARTHRITIS AND CARTILAGE
- Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting
- (2017) Seung Min Kim et al. JOURNAL OF CONTROLLED RELEASE
- Integration of stem cell-derived exosomes with in situ hydrogel glue as a promising tissue patch for articular cartilage regeneration
- (2017) Xiaolin Liu et al. Nanoscale
- ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’
- (2017) C.-Y. Yang et al. OSTEOARTHRITIS AND CARTILAGE
- Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Downregulate Senescence Features in Osteoarthritic Osteoblasts
- (2017) Miguel Tofiño-Vian et al. Oxidative Medicine and Cellular Longevity
- Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis
- (2017) Min Gong et al. Oncotarget
- Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis
- (2017) Stella Cosenza et al. Scientific Reports
- Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis
- (2017) Yu Zhu et al. Stem Cell Research & Therapy
- Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix
- (2017) Yafei Wang et al. Stem Cell Research & Therapy
- Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model
- (2017) Shi-Cong Tao et al. Theranostics
- Mesenchymal Stem Cell-Derived Extracellular Vesicles as Mediators of Anti-Inflammatory Effects: Endorsement of Macrophage Polarization
- (2017) Claudia Lo Sicco et al. Stem Cells Translational Medicine
- GMSC-Derived Exosomes Combined with a Chitosan/Silk Hydrogel Sponge Accelerates Wound Healing in a Diabetic Rat Skin Defect Model
- (2017) Quan Shi et al. Frontiers in Physiology
- Extracellular vesicles for drug delivery
- (2016) Pieter Vader et al. ADVANCED DRUG DELIVERY REVIEWS
- Exosomes: Fundamental Biology and Roles in Cardiovascular Physiology
- (2016) Ahmed Ibrahim et al. Annual Review of Physiology
- Synovial mesenchymal stem cells from osteo- or rheumatoid arthritis joints exhibit good potential for cartilage repair using a scaffold-free tissue engineering approach
- (2016) K. Koizumi et al. OSTEOARTHRITIS AND CARTILAGE
- Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration
- (2016) S. Zhang et al. OSTEOARTHRITIS AND CARTILAGE
- Economic and Humanistic Burden of Osteoarthritis: A Systematic Review of Large Sample Studies
- (2016) Feng Xie et al. PHARMACOECONOMICS
- Animal models of osteoarthritis: classification, update, and measurement of outcomes
- (2016) Emmanuel L. Kuyinu et al. Journal of Orthopaedic Surgery and Research
- Mesenchymal Stem Cell-Derived Exosomes Promote Fracture Healing in a Mouse Model
- (2016) Taisuke Furuta et al. Stem Cells Translational Medicine
- Quantitative analysis of the mRNA expression levels of BCL2 and BAX genes in human osteoarthritis and normal articular cartilage: An investigation into their differential expression
- (2015) GEORGIOS I. KARALIOTAS et al. Molecular Medicine Reports
- Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis
- (2015) Sarah E. Headland et al. Science Translational Medicine
- Osteoarthritis joint pain: The cytokine connection
- (2014) Rachel E. Miller et al. CYTOKINE
- Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state
- (2014) N. Fahy et al. OSTEOARTHRITIS AND CARTILAGE
- Functional significance of macrophage-derived exosomes in inflammation and pain
- (2014) Marguerite K. McDonald et al. PAIN
- Intra-articular injection of collagenase in the knee of rats as an alternative model to study nociception associated with osteoarthritis
- (2014) Sara Adães et al. ARTHRITIS RESEARCH & THERAPY
- Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes
- (2014) Tomohiro Kato et al. ARTHRITIS RESEARCH & THERAPY
- A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy
- (2013) Yanhua Tian et al. BIOMATERIALS
- Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells
- (2013) V Severino et al. Cell Death & Disease
- Osteoarthritis: A disease of the joint as an organ
- (2012) Richard F. Loeser et al. ARTHRITIS AND RHEUMATISM
- Clinical significance of bone changes in osteoarthritis
- (2012) Tuhina Neogi ARTHRITIS RESEARCH & THERAPY
- Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
- (2011) Lydia Alvarez-Erviti et al. NATURE BIOTECHNOLOGY
- Targeting subchondral bone for treating osteoarthritis: what is the evidence?
- (2010) Steeve Kwan Tat et al. BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
- Versican Facilitates Chondrocyte Differentiation and Regulates Joint Morphogenesis
- (2010) Kanyamas Choocheep et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cellular Internalization of Exosomes Occurs Through Phagocytosis
- (2010) Du Feng et al. TRAFFIC
- Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
- (2008) K. Trajkovic et al. SCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation