Secreted Factors and EV-miRNAs Orchestrate the Healing Capacity of Adipose Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis

Stem Cell-Derived Extracellular Vesicles as Immunomodulatory Therapeutics

(2019) Yoojin Seo et al.   Stem Cells International

Long-Lasting Anti-Inflammatory Activity of Human Microfragmented Adipose Tissue

(2019) Sara Nava et al.   Stem Cells International

Interaction with hyaluronan matrix and miRNA cargo as contributors for in vitro potential of mesenchymal stem cell-derived extracellular vesicles in a model of human osteoarthritic synoviocytes

(2019) Enrico Ragni et al.   Stem Cell Research & Therapy

An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)

(2019) Olivier Bruyère et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis

(2019) Jiangyi Wu et al.   BIOMATERIALS

Induction of Macrophage M2b/c Polarization by Adipose Tissue-Derived Mesenchymal Stem Cells

(2019) Meng Sun et al.   Journal of Immunology Research

Minimally Manipulated Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Systematic Review of Clinical Evidence

(2019) B. Di Matteo et al.   Stem Cells International

The Role of miRNAs in Immune Cell Development, Immune Cell Activation, and Tumor Immunity: With a Focus on Macrophages and Natural Killer Cells

(2019) Shi Jun Xu et al.   Cells

Comparison of the therapeutic effect of amniotic fluid stem cells and their exosomes on monoiodoacetate‐induced animal model of osteoarthritis

(2019) Manuela Zavatti et al.   BIOFACTORS

Exosomes: A Novel Therapeutic Agent for Cartilage and Bone Tissue Regeneration

(2019) Yanxin Liu et al.   Dose-Response

Secretome and Extracellular Vesicles as New Biological Therapies for Knee Osteoarthritis: A Systematic Review

(2019) Daniele D’Arrigo et al.   Journal of Clinical Medicine

A 24-Month Follow-Up Study of the Effect of Intra-Articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis

(2019) Igor Borić et al.   Genes

Elafin treatment rescues EGFR-Klf4 signaling and lung cell survival in ventilated newborn mice

(2018) Miguel A Alejandre Alcazar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

MSC exosome works through a protein-based mechanism of action

(2018) Wei Seong Toh et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A guide to chemokines and their receptors

(2018) Catherine E. Hughes et al.   FEBS Journal

Effects of microRNA-24 targeting C-myc on apoptosis, proliferation, and cytokine expressions in chondrocytes of rats with osteoarthritis via MAPK signaling pathway

(2018) Yuan-Hao Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases

(2018) Yufang Shi et al.   Nature Reviews Nephrology

Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections

(2018) Yang Song et al.   Regenerative Medicine

The microRNA regulatory landscape of MSC-derived exosomes: a systems view

(2018) Scott W. Ferguson et al.   Scientific Reports

Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro

(2018) Lucienne A. Vonk et al.   Theranostics

Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound-Guided Synovial Biopsies in Rheumatoid Arthritis

(2018) Arthur M. Mandelin et al.   Arthritis & Rheumatology

Intra-articular injection of autologous adipose-derived stromal vascular fractions for knee osteoarthritis: a double-blind randomized self-controlled trial

(2018) Zheping Hong et al.   INTERNATIONAL ORTHOPAEDICS

Effect of microfragmented adipose tissue on osteoarthritic synovial macrophage factors

(2018) Francesca Paolella et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis

(2018) K.M. Fisch et al.   OSTEOARTHRITIS AND CARTILAGE

Can mesenchymal stem cells and their conditioned medium assist inflammatory chondrocytes recovery?

(2018) Yu-Chun Chen et al.   PLoS One

Efficacy of intraoperatively prepared cell-based constructs for bone regeneration

(2018) Yang Zhang et al.   Stem Cell Research & Therapy

The Role of Wnt Pathway in the Pathogenesis of OA and Its Potential Therapeutic Implications in the Field of Regenerative Medicine

(2018) Maria De Santis et al.   Biomed Research International

Extracellular Vesicles and Matrix Remodeling Enzymes: The Emerging Roles in Extracellular Matrix Remodeling, Progression of Diseases and Tissue Repair

(2018) Muhammad Nawaz et al.   Cells

CXCR3/CXCL10 Axis Regulates Neutrophil–NK Cell Cross-Talk Determining the Severity of Experimental Osteoarthritis

(2017) Giorgia Benigni et al.   JOURNAL OF IMMUNOLOGY

Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis

(2017) Himanshu Bansal et al.   Journal of Translational Medicine

Adipose stromal cells mediated switching of the pro-inflammatory profile of M1-like macrophages is facilitated by PGE2: in vitro evaluation

(2017) C. Manferdini et al.   OSTEOARTHRITIS AND CARTILAGE

Stage-specific differences in secretory profile of mesenchymal stromal cells (MSCs) subjected to early- vs late-stage OA synovial fluid

(2017) A. Gómez-Aristizábal et al.   OSTEOARTHRITIS AND CARTILAGE

High synovial fluid interleukin-6 levels are associated with increased matrix metalloproteinase levels and severe radiographic changes in osteoarthritis patients

(2017) K. Vuolteenaho et al.   OSTEOARTHRITIS AND CARTILAGE

Extracellular vesicle-packaged miRNA release after short-term exposure to particulate matter is associated with increased coagulation

(2017) Laura Pergoli et al.   Particle and Fibre Toxicology

Osteoarthritis: the genesis of pain

(2017) Kai Fu et al.   RHEUMATOLOGY

MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment

(2017) Wei Seong Toh et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

(2017) Stella Cosenza et al.   Scientific Reports

Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis

(2017) Yu Zhu et al.   Stem Cell Research & Therapy

Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix

(2017) Yafei Wang et al.   Stem Cell Research & Therapy

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

(2017) Shi-Cong Tao et al.   Theranostics

Impact of total knee replacement practice: cost effectiveness analysis of data from the Osteoarthritis Initiative

(2017) Bart S Ferket et al.   BMJ-British Medical Journal

Impact of total knee replacement practice: cost effectiveness analysis of data from the Osteoarthritis Initiative

(2017) Bart S Ferket et al.   BMJ-British Medical Journal

Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice

(2017) Chia-Lung Wu et al.   Arthritis & Rheumatology

MicroRNA: Dynamic Regulators of Macrophage Polarization and Plasticity

(2017) Jezrom Bokcaerin Self-Fordham et al.   Frontiers in Immunology

Plasma and synovial fluid inflammatory cytokine profiles in primary knee osteoarthritis

(2016) Thomas Mabey et al.   BIOMARKERS

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

(2016) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages

(2016) Xiang Ying et al.   Oncotarget

Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial

(2016) Yves-Marie Pers et al.   Stem Cells Translational Medicine

Extracellular Vesicles: Evolving Factors in Stem Cell Biology

(2016) Muhammad Nawaz et al.   Stem Cells International

Comparison of Synovial Fluid Cytokine Levels between Traumatic Knee Injury and End-Stage Osteoarthritis

(2016) Marcelo Siqueira et al.   Journal of Knee Surgery

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

miR-24, miR-30b, and miR-142-3p Regulate Phagocytosis in Myeloid Inflammatory Cells

(2015) Afsar Raza Naqvi et al.   JOURNAL OF IMMUNOLOGY

Regulation of miR-24, miR-30b, and miR-142-3p during macrophage and dendritic cell differentiation potentiates innate immunity

(2015) Jezrom B. Fordham et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Randomized, Controlled Trial of Total Knee Replacement

(2015) Søren T. Skou et al.   NEW ENGLAND JOURNAL OF MEDICINE

ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap

(2015) Tauno Metsalu et al.   NUCLEIC ACIDS RESEARCH

Osteoarthritis joint pain: The cytokine connection

(2014) Rachel E. Miller et al.   CYTOKINE

CCL2 Shapes Macrophage Polarization by GM-CSF and M-CSF: Identification of CCL2/CCR2-Dependent Gene Expression Profile

(2014) E. Sierra-Filardi et al.   JOURNAL OF IMMUNOLOGY

Quantitative and stoichiometric analysis of the microRNA content of exosomes

(2014) J. R. Chevillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intra-Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof-of-Concept Clinical Trial

(2014) Chris Hyunchul Jo et al.   STEM CELLS

p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis

(2014) Didier Philipot et al.   ARTHRITIS RESEARCH & THERAPY

Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes

(2014) Anika I Tsuchida et al.   ARTHRITIS RESEARCH & THERAPY

Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance

(2014) Nan Wang et al.   Frontiers in Immunology

Mesenchymal Stem Cell Injections Improve Symptoms of Knee Osteoarthritis

(2013) Yong-Gon Koh et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

A systematic review of recommendations and guidelines for the management of osteoarthritis: The Chronic Osteoarthritis Management Initiative of the U.S. Bone and Joint Initiative

(2013) Amanda E. Nelson et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice

(2012) Hwanhee Oh et al.   ARTHRITIS AND RHEUMATISM

TIMP2 deficient mice develop accelerated osteoarthritis via promotion of angiogenesis upon destabilization of the medial meniscus

(2012) Meng Mi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

(2012) H. Kitade et al.   DIABETES

Mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic synovium and cartilage explant culture

(2012) G.M. van Buul et al.   OSTEOARTHRITIS AND CARTILAGE

Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee

(2011) Sumihisa Orita et al.   BMC MUSCULOSKELETAL DISORDERS

Biomarkers for identifying the early phases of osteoarthritis secondary to medial patellar luxation in dogs

(2011) Md. Rafiqul Alam et al.   Journal of Veterinary Science

Persistent pain after joint replacement: Prevalence, sensory qualities, and postoperative determinants

(2011) Vikki Wylde et al.   PAIN

The role of synovial fluid markers of catabolism and anabolism in osteoarthritis, rheumatoid arthritis and asymptomatic organ donors

(2011) Rediet Kokebie et al.   ARTHRITIS RESEARCH & THERAPY

Relation of synovitis to knee pain using contrast-enhanced MRIs

(2010) K. Baker et al.   ANNALS OF THE RHEUMATIC DISEASES

Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees

(2010) Lin-Hsiu Weng et al.   ARTHRITIS AND RHEUMATISM

Chemokine profile of synovial fluid from normal, osteoarthritis and rheumatoid arthritis patients: CCL25, CXCL10 and XCL1 recruit human subchondral mesenchymal progenitor cells

(2010) M. Endres et al.   OSTEOARTHRITIS AND CARTILAGE

Regulatory T-Cell Generation and Kidney Allograft Tolerance Induced by Mesenchymal Stem Cells Associated With Indoleamine 2,3-Dioxygenase Expression

(2010) Wei Ge et al.   TRANSPLANTATION

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

(2009) Eran Eden et al.   BMC BIOINFORMATICS

Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice

(2009) E. N. Blaney Davidson et al.   JOURNAL OF IMMUNOLOGY

Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease

(2009) C.R. Scanzello et al.   OSTEOARTHRITIS AND CARTILAGE

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

(2008) Mihaela Crisan et al.   Cell Stem Cell

Cartilage gene expression correlates with radiographic severity of canine elbow osteoarthritis

(2007) Dylan N. Clements et al.   VETERINARY JOURNAL